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STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 248 - 258
The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of tumorigenesis. Additionally, tumor‐associated macrophages (TAMs)... 
Side population cells | Transcription factors | STAT | Breast cancer | Cancer stem cells | Stem cell‐microenvironment interactions | Stem cell-microenvironment interactions | ELEGANS GERM-LINE | BONE-MARROW | PLURIPOTENCY | IDENTIFICATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | LUNG-CANCER | MICROENVIRONMENT | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NANOG | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | MAMMARY-GLAND | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Homeodomain Proteins - metabolism | Oleanolic Acid - analogs & derivatives | Antigens, Ly - genetics | Oleanolic Acid - pharmacology | SOXB1 Transcription Factors - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Receptor, Epidermal Growth Factor - metabolism | ATP-Binding Cassette Transporters - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | ATP-Binding Cassette Transporters - metabolism | Neoplastic Stem Cells - pathology | Antigens, Ly - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mammary Neoplasms, Animal - genetics | Nanog Homeobox Protein | Macrophages - pathology | Membrane Proteins - genetics | Imidazoles - pharmacology | Tyrphostins - pharmacology | Homeodomain Proteins - genetics | Macrophages - metabolism | Mammary Neoplasms, Animal - pathology | Animals | Signal Transduction - drug effects | Mammary Neoplasms, Animal - metabolism | Octamer Transcription Factor-3 - metabolism | Cell Communication - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Quinazolines - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Genes | DNA binding proteins | Metastasis | Macrophages | Gene expression | Stem cell research | Chemotherapy | Epidermal growth factor | Analysis | Stem cells | Research institutes | Cancer | Proteins | Medical research
Journal Article
Science, ISSN 0036-8075, 01/2017, Volume 355, Issue 6320, pp. 78 - 83
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity... 
PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SMALL-CELL CARCINOMA | PTEN | GENERATION | TUMORIGENESIS | EXPRESSION | DEFICIENCY | DELETION | EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Epigenesis, Genetic | Humans | SOXB1 Transcription Factors - antagonists & inhibitors | Male | Retinoblastoma-Like Protein p107 - genetics | Tumor Suppressor Protein p53 - genetics | Neoplasms, Experimental - pathology | Neoplasm Metastasis | Prostatic Neoplasms - genetics | SOXB1 Transcription Factors - genetics | Neoplasms, Experimental - genetics | Adenocarcinoma - genetics | Prostatic Neoplasms - drug therapy | Neuroendocrine Tumors - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Enhancer of Zeste Homolog 2 Protein - genetics | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Neuroendocrine Tumors - genetics | Cell Lineage | Drug Resistance, Neoplasm - genetics | Animals | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Neuroendocrine Tumors - drug therapy | Cell Plasticity | Mice | Mutation | Neoplasms, Experimental - drug therapy | Prevention | Antimitotic agents | Epigenetic inheritance | Development and progression | Genetic aspects | Dosage and administration | Metastasis | Gene expression | Antineoplastic agents | Drug resistance | Health aspects | Prostate cancer | Drugs | Therapy | Deprivation | Histology | Hormones | Suppressors | Switching | Signal transduction | Sensitivity | Androgens | Inhibitors | Rodents | Plasticity | Epigenetics | Tumor suppressor genes | Plastic properties | Prostate | Cancer | Tumors | Mutations
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 139 - 151
We report that two oncogenes coamplified on chromosome 3q26, and , cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein... 
INITIATING CELLS | DETECTS FREQUENT | STEM-CELLS | PROTEIN | CANCER CELLS | EPITHELIUM | ONCOLOGY | TRANSFORMED GROWTH | PKC-IOTA | KINASE-C-IOTA | BASAL-CELLS | CELL BIOLOGY | Acyltransferases - antagonists & inhibitors | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | SOXB1 Transcription Factors - antagonists & inhibitors | Lung Neoplasms - pathology | Acyltransferases - metabolism | Acyltransferases - genetics | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Cell Transformation, Neoplastic - genetics | Isoenzymes - metabolism | Protein Kinase C - metabolism | Neoplastic Stem Cells - pathology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein Kinase C - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | High-Throughput Nucleotide Sequencing | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - antagonists & inhibitors | Apoptosis | Squamous cell carcinoma | Genetic aspects | Cancer
Journal Article
The FEBS Journal, ISSN 1742-464X, 10/2016, Volume 283, Issue 20, pp. 3791 - 3806
Neural crest‐derived stem cells (NCSCs) are tissue‐specific stem cells derived from multipotent neural crest cells. NCSCs are present in some adult tissues... 
FoxD3 | BMP2/Wnt3a signaling | CHD7 | mouse neural crest‐derived stem cells | pluripotent stem cell‐related genes | pluripotent stem cell-related genes | mouse neural crest-derived stem cells | TRANSCRIPTION FACTORS | COMPLEX | METHYLTRANSFERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLURIPOTENCY | CHARGE-SYNDROME | GENE REGULATORY NETWORK | MAINTENANCE | CHIP | DIFFERENTIATION | ES CELLS | Wnt3A Protein - metabolism | Nanog Homeobox Protein - antagonists & inhibitors | SOXB1 Transcription Factors - antagonists & inhibitors | Gene Regulatory Networks | Neural Stem Cells - cytology | Gene Knockdown Techniques | Neural Crest - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Base Sequence | Bone Morphogenetic Protein 2 - metabolism | Conserved Sequence | Repressor Proteins - metabolism | Nanog Homeobox Protein - genetics | SOX9 Transcription Factor - metabolism | Neural Crest - cytology | DNA-Binding Proteins - antagonists & inhibitors | SOXE Transcription Factors - metabolism | Cells, Cultured | Repressor Proteins - genetics | Binding Sites - genetics | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Octamer Transcription Factor-3 - antagonists & inhibitors | Animals | Neural Crest - embryology | Octamer Transcription Factor-3 - metabolism | Mice | Histones - metabolism | Methylation | Neural Stem Cells - metabolism | Nanog Homeobox Protein - metabolism | Genetic research | Analysis | Stem cells | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, p. 4511
Although the principles that balance stem cell self-renewal and differentiation in normal tissue homeostasis are beginning to emerge, it is still unclear... 
FOLLICLE STEM-CELLS | PROGENITOR CELLS | SURVIVAL | MAINTENANCE | HAIR FOLLICLE | REGENERATION | MULTIDISCIPLINARY SCIENCES | NICHE | SELF-RENEWAL | DIFFERENTIATION | SKIN TUMORS | Neuropilin-1 - genetics | Neoplasm Transplantation | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Neuropilin-1 - metabolism | Skin - metabolism | Stromal Cells - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | SOXB1 Transcription Factors - antagonists & inhibitors | Stem Cells - cytology | Vascular Endothelial Growth Factor A - metabolism | Stem Cells - metabolism | Vascular Endothelial Growth Factor A - genetics | Neuropilin-1 - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Tumor Microenvironment - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | HEK293 Cells | Neoplastic Stem Cells - pathology | Female | Transcription, Genetic | Skin - pathology | Skin Neoplasms - pathology | Signal Transduction | Stromal Cells - metabolism | Epithelial Cells - pathology | Organ Specificity | Skin Neoplasms - metabolism | Animals | Mice, Nude | Skin Neoplasms - genetics | Cell Line, Tumor | Mice | Primary Cell Culture | RNA, Small Interfering - metabolism
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2008, Volume 98, Issue 4, pp. 824 - 831
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 962 - 970
Highlights •  MiR-1181 is downregulated in pancreatic cancer and associated with short survival and high recurrence.  •  Overexpressing miR-1181 inhibited,... 
Hematology, Oncology and Palliative Medicine | SOX2 | Cancer stem cells | miR-1181 | Pancreatic cancer | STAT3 | MiR-1181 | ACTIVATION | INITIATION | IDENTIFICATION | BIOMARKERS | GENE | ONCOLOGY | PATHWAY | GROWTH | EXPRESSION | PROGRESSION | SIGNAL TRANSDUCER | RNA, Small Interfering - genetics | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | SOXB1 Transcription Factors - antagonists & inhibitors | Neoplasm Recurrence, Local - mortality | Immunoenzyme Techniques | SOXB1 Transcription Factors - metabolism | Neoplasm Recurrence, Local - pathology | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Neoplastic Stem Cells - pathology | Pancreatic Neoplasms - mortality | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreas - pathology | Pancreatic Neoplasms - genetics | Survival Rate | Pancreas - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Xenograft Model Antitumor Assays | Phenotype | Animals | Mice, Nude | Neoplasm Recurrence, Local - genetics | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Neoplasm Staging | STAT3 Transcription Factor - antagonists & inhibitors | Apoptosis | Genetic aspects | Stem cells | Studies | Signal transduction | Survival analysis | Plasmids | Cloning | Medical prognosis | Metastasis | Gene expression | Cancer therapies
Journal Article
Cell Cycle, ISSN 1538-4101, 09/2013, Volume 12, Issue 18, pp. 3109 - 3124
Energy metabolism plasticity enables stemness programs during the reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state. This... 
reprogramming | SOX2 | mTOR | AMPK | breast cancer | cancer stem cells | Breast cancer | Reprogramming | Cancer stem cells | MTOR | SOMATIC-CELLS | SELF-RENEWAL | PLURIPOTENCY | E-CADHERIN | TUMORIGENICITY | TUMOR-INITIATING CELLS | IPS CELLS | CELL BIOLOGY | IN-VITRO | REGENERATIVE MEDICINE | ENERGY-METABOLISM | Up-Regulation | AMP-Activated Protein Kinases - metabolism | Neoplastic Stem Cells - cytology | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Transcriptional Activation | SOXB1 Transcription Factors - antagonists & inhibitors | Breast Neoplasms | Cellular Reprogramming | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Neoplastic Stem Cells - metabolism | RNA Interference | SOXB1 Transcription Factors - genetics | Receptor, Insulin - genetics | Kinesin - genetics | Female | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Down-Regulation | Intracellular Signaling Peptides and Proteins | Transcription Factors - genetics | Fatty Acid Synthase, Type I - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Kinesin - metabolism | Transcription Factors - metabolism | Octamer Transcription Factor-3 - metabolism | Receptor, Insulin - metabolism | Proto-Oncogene Proteins c-myc - genetics | AMP-Activated Protein Kinases - genetics | RNA, Small Interfering - metabolism | Report
Journal Article
Journal Article