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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 34, pp. 12426 - 12431
Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4... 
Phenotypes | Induced pluripotent stem cells | Somatic cells | Stem cells | Retroviridae | Embryonic stem cells | Pluripotent stem cells | Cellular differentiation | Cells | Mesenchymal stem cells | Epigenetics | Retrotransposon | Evolution | NONCODING RNA-ROR | ROADBLOCK | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | TRANSPOSABLE ELEMENTS | evolution | INDUCTION | epigenetics | IPS CELLS | PLURIPOTENT STEM-CELLS | PATHWAY | HUMAN FIBROBLASTS | retrotransposon | EXPRESSION | Octamer Transcription Factor-3 - physiology | Endogenous Retroviruses - physiology | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Humans | Endogenous Retroviruses - genetics | Pluripotent Stem Cells - virology | Gene Knockdown Techniques | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | RNA, Viral - antagonists & inhibitors | RNA, Viral - genetics | SOXB1 Transcription Factors - genetics | Embryonic Stem Cells - virology | SOXB1 Transcription Factors - physiology | Induced Pluripotent Stem Cells - cytology | Cell Differentiation - physiology | Cellular Reprogramming - genetics | Gene Expression | Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - physiology | Induced Pluripotent Stem Cells - virology | Pluripotent Stem Cells - physiology | Kruppel-Like Transcription Factors - physiology | RNA, Long Noncoding - genetics | Embryonic Stem Cells - physiology | RNA, Long Noncoding - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Cellular Reprogramming - physiology | Epigenetic inheritance | Transcription factors | Retroviruses | Physiological aspects | Genetic research | Genetic aspects | Research | Cell differentiation | Gene expression | Virus research | Biological Sciences
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2016, Volume 34, Issue 11, pp. 2721 - 2732
... translocates to the nucleus in response to FA, where it acts as a transcription factor. In this study, we examined if FA through interaction with FRα... 
Oct4 | Sox2 | Enhancer/promoters | Folate receptor alpha | miR‐138 | Multipotency | Klf4 | miR‐let‐7 | Cranial neural crest cells | miR-138 | miR-let-7 | SURVIVAL | TUBE | TRANSCRIPTIONAL NETWORK | MOUSE | PAX3 | PLURIPOTENCY | MICRORNAS | FOLIC-ACID | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | TARGET GENE | HEMATOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Folic Acid - pharmacology | MicroRNAs - antagonists & inhibitors | Transcriptional Activation | MicroRNAs - metabolism | Neural Stem Cells - cytology | SOXB1 Transcription Factors - agonists | Neural Crest - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | p300-CBP Transcription Factors - genetics | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - agonists | Kruppel-Like Transcription Factors - metabolism | PAX3 Transcription Factor - genetics | Female | Promoter Regions, Genetic | Neural Crest - cytology | Ribonuclease III - genetics | Ribonuclease III - metabolism | Signal Transduction | Neural Stem Cells - drug effects | PAX3 Transcription Factor - deficiency | Folate Receptor 1 - antagonists & inhibitors | Transcription Factors - genetics | Mice, Knockout | Neural Crest - drug effects | Octamer Transcription Factor-3 - agonists | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Histones - genetics | Folate Receptor 1 - genetics | Folate Receptor 1 - metabolism | Octamer Transcription Factor-3 - metabolism | Folic Acid - metabolism | Protein Binding | Mice | MicroRNAs - genetics | Histones - metabolism | Antagomirs - metabolism | Antagomirs - genetics | Kruppel-Like Transcription Factors - genetics | Neural Stem Cells - metabolism | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Embryonic development | Chromatin | Biosynthesis | MicroRNA | Folic acid | Stem cells | Genes | Cell proliferation | Immunoprecipitation | Oct-4 protein | Effector cells | Event-related potentials | Nuclei | Defects | Embryogenesis | KLF4 protein | Coding | miRNA | Supplementation | Prenatal experience | Neural tube defects | Neural crest | Promoters | Embryonic growth stage | Polymerase chain reaction | Gene silencing | Neural stem cells | Skull
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2016, Volume 354, Issue 6315, pp. aaf4445 - aaf4445
.... Senescence is a cellular response to damage, characterized by abundant production of cytokines and other secreted factors that, together with the recruitment of inflammatory cells, result in tissue remodeling... 
PLURIPOTENT STEM-CELLS | SECRETORY PHENOTYPE | THERAPY | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | GENERATION | INHIBITORS | SUPPRESSION | EXPRESSION | CANCER | IPS CELLS | Genetic Loci | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Antineoplastic Agents - pharmacology | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Interleukin-6 - metabolism | Induced Pluripotent Stem Cells - metabolism | Cellular Senescence - genetics | Aniline Compounds - pharmacology | Mice, Inbred C57BL | Gene Expression Regulation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Transcription Factors - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Transcription Factors - metabolism | Teratoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Teratoma - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Kruppel-Like Transcription Factors - genetics | Tissue | DNA damage | Cellular ceramic materials | Cytokines | Interleukin | Mathematical models | In vivo methods and tests | In vitro testing | Damage | Recruitment
Journal Article
Nature (London), ISSN 1476-4687, 2007, Volume 451, Issue 7175, pp. 141 - 146
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2013, Volume 31, Issue 2, pp. 259 - 268
...). In particular, we demonstrate a regulatory feedback loop between the miR‐302 cluster and two transcription factors, NR2F2 and OCT4... 
OCT4 | MicroRNA | Reprogramming | Induced pluripotent stem cells | CARCINOMA-CELLS | NUCLEAR RECEPTORS | TRANSCRIPTIONAL REGULATORY CIRCUITRY | SELF-RENEWAL | PLURIPOTENCY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MIR-302 | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | HUMAN FIBROBLASTS | HUMAN SOMATIC-CELLS | HEMATOLOGY | RNA, Small Interfering - genetics | Kruppel-Like Transcription Factors - pharmacology | Humans | Adipocytes - cytology | MicroRNAs - metabolism | Adipocytes - drug effects | MicroRNAs - pharmacology | COUP Transcription Factor II - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - pharmacology | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Luciferases | Microarray Analysis | Female | Proto-Oncogene Proteins c-myc - pharmacology | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Genes, Reporter | Induced Pluripotent Stem Cells - metabolism | Promoter Regions, Genetic | Induced Pluripotent Stem Cells - drug effects | Octamer Transcription Factor-3 - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Cellular Reprogramming - drug effects | Gene Expression Regulation - drug effects | Feedback, Physiological | Signal Transduction - drug effects | COUP Transcription Factor II - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Octamer Transcription Factor-3 - metabolism | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | COUP Transcription Factor II - metabolism | Primary Cell Culture | Kruppel-Like Transcription Factors - genetics | Genes | Luciferase | Information management | DNA binding proteins | Embryonic stem cells | Gene expression | Skin cancer | Financial disclosure | Stem cell research | Messenger RNA | Analysis | Universities and colleges | Cardiology | Medical research | Efficiency | Stem cells | reprogramming | microRNA | induced pluripotent stem cells
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13952
Background: In preimplantation mammalian development the transcription factor Sox2... 
PLURIPOTENT STEM-CELLS | DOUBLE-STRANDED-RNA | CELL SELF-RENEWAL | MULTIDISCIPLINARY SCIENCES | TROPHOBLAST DEVELOPMENT | GENE-EXPRESSION | PRIMITIVE ENDODERM | NANOG | TRANSCRIPTIONAL REGULATION | PROTEIN TRANSDUCTION | MOUSE EMBRYO | Immunohistochemistry | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Homeodomain Proteins - metabolism | Apoptosis - genetics | Male | Morula - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | RNA Interference | SOXB1 Transcription Factors - genetics | Gene Expression Regulation, Developmental | Muscle Proteins - metabolism | Female | Trophoblasts - cytology | Cell Lineage - genetics | Trophoblasts - metabolism | RNA, Messenger - genetics | Blastocyst - metabolism | Cells, Cultured | Blastocyst - cytology | Morula - cytology | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Octamer Transcription Factor-3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | CDX2 Transcription Factor | Embryonic development | Embryo | Fibroblast growth factors | Genetic transcription | RNA | Genes | Neurosciences | Transcription factors | Oct-4 protein | Neurobiology | CDX2 protein | Trophectoderm | Proteins | Embryogenesis | Restoration | Developmental stages | Cell fate | Life sciences | Trends | Growth factors | Fibroblast growth factor receptor 2 | Sox2 protein | RNA-mediated interference | Markers | Zebrafish | Implantation | Blastocysts | siRNA | Mammals | Gene expression | Ribonucleic acid--RNA | Embryos | Cavitation | Fibroblast growth factor 4 | Yes-associated protein | Stem cells | Pluripotency | Apoptosis | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132977
Cancer stem cells are cancer cells characterized by stem cell properties and represent a small population of tumor cells that drives tumor development,... 
TESTIS ANTIGEN BORIS | HEPATOCELLULAR-CARCINOMA | SIDE POPULATION | IN-VITRO | INDUCED APOPTOSIS | TELOMERASE | MULTIDISCIPLINARY SCIENCES | IMPRINTED SITES | CTCF | IDENTIFICATION | TUMOR-INITIATING CELLS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | RNA, Small Interfering - genetics | Cell Proliferation | Epithelial Cells - metabolism | Polycomb Repressive Complex 1 - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - genetics | Neoplasm Proteins - metabolism | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Polycomb Repressive Complex 1 - genetics | Telomerase - genetics | ATP-Binding Cassette Transporters - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Hyaluronan Receptors - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Telomerase - metabolism | Neoplasm Proteins - genetics | DNA-Binding Proteins - antagonists & inhibitors | Nanog Homeobox Protein | Signal Transduction | Isoenzymes - genetics | Spheroids, Cellular - metabolism | Epithelial Cells - pathology | Retinal Dehydrogenase - genetics | DNA-Binding Proteins - genetics | Organ Specificity | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Phenotype | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Movement | RNA, Small Interfering - metabolism | RNA | Genes | Colorectal cancer | Stem cells | Genetic aspects | Gene expression | Cancer | Protein binding | Neurosciences | Germ cells | Telomerase reverse transcriptase | Populations | Dyes | Mesenchyme | Oct-4 protein | Gene regulation | Oncology | Spheres | Drug resistance | Tissues | Metastases | DNA-binding protein | CD44 antigen | Cell cycle | Life sciences | Colon | Telomerase | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Antigens | Cell survival | Tumor cells | Invasiveness | Cervix | Survival | Brain research | Molecular modelling | Medical prognosis | Epigenetics | Breast | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal Article