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Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 431 - 435
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer... 
METASTATIC MELANOMA | BRAF INHIBITOR | SUBPOPULATIONS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | SINGLE MAMMALIAN-CELLS | STATE | MECHANISMS | MUTATIONS | VEMURAFENIB | PLASTICITY | Transcription, Genetic - drug effects | Humans | Male | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Single-Cell Analysis | Cellular Reprogramming - genetics | ErbB Receptors - metabolism | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Signal Transduction - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Genetic Markers - drug effects | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Genetic Markers - genetics | Cell Line, Tumor | Oncogene Protein p65(gag-jun) - metabolism | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Antimitotic agents | Cell interaction | Dosage and administration | Antineoplastic agents | Drug resistance | Observations | Health aspects | Subpopulations | Transcription factors | Substance abuse treatment | Variability | Activator protein 1 | Melanoma | Genomes | Kinases | Gene expression | Sox10 protein | Signal transduction | Signaling | Converting | Population | Mutation | Differentiation | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Development, ISSN 0950-1991, 02/2008, Volume 135, Issue 4, pp. 637 - 646
Journal Article
Journal Article
Glia, ISSN 0894-1491, 07/2011, Volume 59, Issue 7, pp. 1022 - 1032
The transcription factor Sox10 functions during multiple consecutive stages of Schwann‐cell development in the peripheral nervous system (PNS). Although Sox10... 
myelin | Charcot–Marie–Tooth disease | transcriptional control | high‐mobility‐group | Sry | conditional mouse mutagenesis | glia | peripheral neuropathy | High-mobility-group | Myelin | Charcot-Marie-Tooth disease | Conditional mouse mutagenesis | Glia | Peripheral neuropathy | Transcriptional control | PROTEIN ZERO | NEUROSCIENCES | high-mobility-group | MICE HETEROZYGOUSLY DEFICIENT | NEURAL CREST DEVELOPMENT | CONNEXIN-32 | DEMYELINATION | TRANSCRIPTION FACTOR SOX10 | MOUSE MODEL | GENE-EXPRESSION | HIRSCHSPRUNG DISEASE | DIFFERENTIATION | Peripheral Nervous System Diseases - chemically induced | Action Potentials - genetics | Microscopy, Electron, Transmission - methods | SOXE Transcription Factors - physiology | Sciatic Nerve - ultrastructure | Peripheral Nervous System Diseases - physiopathology | Estrogen Antagonists - toxicity | Myelin Sheath - metabolism | Sciatic Nerve - metabolism | Cell Death - genetics | Time Factors | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Schwann Cells - physiology | Neural Conduction - drug effects | Peripheral Nervous System Diseases - pathology | Cell Death - drug effects | Homeostasis - drug effects | SOXE Transcription Factors - deficiency | Action Potentials - drug effects | Myelin Basic Protein - metabolism | Neural Conduction - genetics | Gene Expression Regulation - genetics | Sciatic Nerve - pathology | Mice, Inbred C57BL | Mice, Transgenic | In Situ Nick-End Labeling - methods | CD3 Complex - metabolism | Tamoxifen - toxicity | Gene Expression Regulation - drug effects | Animals | Myelin Proteolipid Protein - genetics | Cell Proliferation - drug effects | Mice | Homeostasis - genetics | Peripheral nervous system | Transcription factors | Cell survival | Peripheral nerves | Schwann cells | Homeostasis | Action potential | Inflammation | Sox10 protein | Developmental stages | Demyelination | Neurodegeneration | Differentiation | Structure-function relationships | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2008, Volume 28, Issue 47, pp. 12558 - 12569
The proneural transcription factor neurogenin 1 (neurog1) has been shown to be a key regulator of dorsal root ganglion (DRG) neuron development. Here we use a... 
Neurogenin 1 | Sensory neuron | Dorsal root ganglia | Glia | Neural crest | Fate restriction | PROGENITOR CELLS | STEM-CELLS | fate restriction | CREST CELLS | PRIMARY NEURONS | neural crest | dorsal root ganglia | SPECIFICATION | glia | PRONEURAL GENES | NEUROSCIENCES | sensory neuron | TRANSCRIPTION FACTOR SOX10 | SENSORY GANGLIA | neurogenin 1 | EMBRYONIC ZEBRAFISH | EXPRESSION | Cell Proliferation | Nerve Tissue Proteins - deficiency | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Ganglia, Spinal - cytology | Green Fluorescent Proteins - genetics | Neuroglia - drug effects | Chromosomes, Artificial, Bacterial - genetics | Time Factors | Neurons - physiology | Veratrum Alkaloids - pharmacology | Neurons - drug effects | Basic Helix-Loop-Helix Transcription Factors - deficiency | Basic Helix-Loop-Helix Transcription Factors - genetics | Animals, Genetically Modified | Ganglia, Spinal - embryology | SOXE Transcription Factors - metabolism | Zebrafish Proteins - metabolism | Neuroglia - physiology | Morpholines - pharmacology | Zebrafish | Mutation - genetics | Nerve Tissue Proteins - genetics | Zebrafish Proteins - deficiency | Animals | Analysis of Variance | Cell Differentiation - drug effects | Green Fluorescent Proteins - biosynthesis | Embryo, Nonmammalian | Stem Cells - drug effects | Stem Cells - physiology | Zebrafish Proteins - genetics | Cell Cycle - drug effects | Body Patterning - genetics | SOXE Transcription Factors - genetics | Index Medicus
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2008, Volume 19, Issue 4, pp. 1575 - 1586
Journal Article
Developmental Cell, ISSN 1534-5807, 08/2011, Volume 21, Issue 2, pp. 273 - 287
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2005, Volume 168, Issue 6, pp. 899 - 910
Journal Article
Journal Article
Glia, ISSN 0894-1491, 05/2012, Volume 60, Issue 5, pp. 806 - 819
Journal Article
Journal Article