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Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 431 - 435
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer... 
METASTATIC MELANOMA | BRAF INHIBITOR | SUBPOPULATIONS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | SINGLE MAMMALIAN-CELLS | STATE | MECHANISMS | MUTATIONS | VEMURAFENIB | PLASTICITY | Transcription, Genetic - drug effects | Humans | Male | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Single-Cell Analysis | Cellular Reprogramming - genetics | ErbB Receptors - metabolism | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Signal Transduction - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Genetic Markers - drug effects | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Genetic Markers - genetics | Cell Line, Tumor | Oncogene Protein p65(gag-jun) - metabolism | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Antimitotic agents | Cell interaction | Dosage and administration | Antineoplastic agents | Drug resistance | Observations | Health aspects | Subpopulations | Transcription factors | Substance abuse treatment | Variability | Activator protein 1 | Melanoma | Genomes | Kinases | Gene expression | Sox10 protein | Signal transduction | Signaling | Converting | Population | Mutation | Differentiation | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6683 - 6683
Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of... 
TRANSCRIPTION FACTOR-BINDING | ENCYCLOPEDIA | R/BIOCONDUCTOR PACKAGE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PHENOTYPE | ENHANCER | MITF | DIFFERENTIATION | CHROMOSOME CONFORMATION CAPTURE | TAZ | Chromatin - metabolism | RNA, Small Interfering - genetics | Transcription Factor AP-1 - genetics | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Gene Regulatory Networks | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Protein Isoforms - metabolism | Cell Transformation, Neoplastic - genetics | Melanoma - genetics | Transcription, Genetic | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Cellular Reprogramming - genetics | Chromatin - chemistry | Melanoma - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Neoplasm Invasiveness | SOXE Transcription Factors - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Melanoma - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Histones - genetics | Melanoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Cell Transformation, Neoplastic - pathology | Microphthalmia-Associated Transcription Factor - genetics | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | SOXE Transcription Factors - genetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Current Biology, ISSN 0960-9822, 03/2015, Volume 25, Issue 6, pp. 764 - 771
Transcription factors related to the insect sex-determination gene (DMRT proteins) control sex determination and/or sexual differentiation in diverse metazoans... 
DM-DOMAIN GENE | TESTIS DIFFERENTIATION | EVOLUTION | MAMMALIAN TESTIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | MICE | SOX9 | MEDAKA FISH | EXPRESSION | REVERSAL | CELL BIOLOGY | Humans | Male | Gene Expression Profiling | Sex Differentiation | Mice, 129 Strain | Ovary - cytology | RNA, Messenger - metabolism | Granulosa Cells - metabolism | Ovary - growth & development | Forkhead Transcription Factors - metabolism | Sertoli Cells - cytology | Cell Transdifferentiation | Female | Sex Determination Processes - physiology | Single-Cell Analysis | Cellular Reprogramming - genetics | X Chromosome - genetics | Forkhead Box Protein L2 | Ovary - metabolism | SOX9 Transcription Factor - metabolism | Sertoli Cells - metabolism | SOXE Transcription Factors - metabolism | Sex Determination Processes - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Silencing | Mice, Transgenic | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | Mice | Mutation | SOX9 Transcription Factor - genetics | Cellular Reprogramming - physiology | Granulosa Cells - cytology | SOXE Transcription Factors - genetics | Proteins | Evolution | RNA | Analysis | Cells | Ovarian cancer | RNA sequencing | Developmental biology | Genes | Index Medicus | cell fate reprogramming | ovary | DMRT1 | transdifferentiation | FOXL2 | testis | sex determination
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2016, Volume 19, Issue 5, pp. 678 - 689
Journal Article
Nature neuroscience, ISSN 1097-6256, 10/2014, Volume 17, Issue 10, pp. 1322 - 1329
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e92596 - e92596
Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure... 
CANCER-CELLS | METASTATIC MELANOMA | FACTOR-BETA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | EPIGENETIC REGULATION | NEURAL CREST | SOX10 | PROMOTES | TUMOR MICROENVIRONMENT | CD133 | Meta-Analysis as Topic | Antigens, CD - biosynthesis | Humans | Peptides - genetics | Male | Antigens, CD - genetics | Gene Knockdown Techniques | Neoplastic Stem Cells - metabolism | Melanoma - genetics | Nerve Tissue Proteins - biosynthesis | Neoplastic Stem Cells - pathology | Female | Neoplasm Proteins - genetics | SOXE Transcription Factors - biosynthesis | Glycoproteins - genetics | Melanoma - metabolism | Receptors, Nerve Growth Factor - biosynthesis | Neoplasm Proteins - biosynthesis | Melanoma - pathology | AC133 Antigen | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Glycoproteins - biosynthesis | Animals | Cell Line, Tumor | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Biomarkers, Tumor - biosynthesis | SOXE Transcription Factors - genetics | Nerve growth factor | Drug resistance | Analysis | Genomics | Stem cells | Transcription factors | Laboratories | Genes | Genomes | Metastasis | Cell surface | Metastases | Genotype & phenotype | Heterogeneity | Rodents | Fibroblasts | Growth factors | Antigens | Colonies | Markers | Melanoma | Cell division | Tumorigenicity | Gene expression | Neural crest | Sox10 protein | Pathology | Properties (attributes) | Cell lines | Epigenetics | Neural stem cells | Surface markers | Cancer | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170568 - e0170568
Primary auditory neurons (PANs) connect cochlear sensory hair cells in the mammalian inner ear to cochlear nucleus neurons in the brainstem. PANs develop from... 
SENSORY EPITHELIA | PERIPHERIN | SPIRAL GANGLION NEURONS | HAIR CELL-DIFFERENTIATION | INNER-EAR | CREST CELLS | MULTIDISCIPLINARY SCIENCES | INNERVATION | MICE | TRANSCRIPTION FACTOR | HDR SYNDROME | GATA3 Transcription Factor - genetics | Cochlea - embryology | Peripherins - genetics | MafB Transcription Factor - biosynthesis | GATA3 Transcription Factor - biosynthesis | Neural Crest - metabolism | Neurogenesis - genetics | Cell Nucleus - metabolism | SOXB1 Transcription Factors - genetics | Cochlea - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Nerve Tissue Proteins - biosynthesis | Sensory Receptor Cells - metabolism | Genes, Reporter | SOXE Transcription Factors - biosynthesis | Recombinant Fusion Proteins - biosynthesis | Peripherins - biosynthesis | Homeodomain Proteins - biosynthesis | MafB Transcription Factor - genetics | Cochlea - growth & development | Spiral Ganglion - metabolism | SOXB1 Transcription Factors - biosynthesis | Gestational Age | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Gene Knock-In Techniques | Animals | Sensory Receptor Cells - classification | Neuroglia - metabolism | Spiral Ganglion - embryology | Mice | Tumor Suppressor Proteins - biosynthesis | Neural Stem Cells - metabolism | SOXE Transcription Factors - genetics | Cochlea | Hair cells (Mechanoreceptors) | Transcription factors | Research | Gene expression | Spiral ganglion | Neurosciences | Laboratories | Brain stem | Hair cells | Otolaryngology | Cochlear nuclei | Glial cells | Neurogenesis | Inner ear | Neuronal-glial interactions | Neuroblasts | Rodents | Sensory neurons | Hair | Immunoglobulins | Neurons | Outer hair cells | Mammals | Neural crest | Sox10 protein | Embryos | Neurology | Otology | Pans | GATA-3 protein | Peripherin | Nuclei (cytology) | Cell migration | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 01/2015, Volume 138, Issue 1, pp. 120 - 135