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Tumor Biology, ISSN 1010-4283, 5/2018, Volume 40, Issue 5, p. 1010428318773652
SPAG9 is a novel tumor associated antigen, expressed in variety of malignancies. However, its role in ovarian cancer remains unexplored. SPAG9 expression was... 
and apoptosis | SPAG9 | therapeutic target | cell cycle arrest | CT antigen | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Paclitaxel - pharmacology | Genetic Vectors - administration & dosage | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | Epithelial-Mesenchymal Transition - drug effects | Neoplasm Proteins - antagonists & inhibitors | Genetic Vectors - therapeutic use | Cystadenocarcinoma, Serous - pathology | Molecular Targeted Therapy | Cystadenocarcinoma, Serous - drug therapy | RNA, Messenger - biosynthesis | Adenocarcinoma - metabolism | Cystadenocarcinoma, Papillary - pathology | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Injections, Intralesional | Adenocarcinoma, Papillary - metabolism | Female | Ovarian Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Ovarian Neoplasms - drug therapy | Adenocarcinoma, Papillary - pathology | Tumor Stem Cell Assay | Adenocarcinoma, Papillary - drug therapy | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Adenocarcinoma - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Cell Cycle Checkpoints | Animals | RNA, Neoplasm - biosynthesis | Cell Cycle | Mice, Nude | RNA, Small Interfering - therapeutic use | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | Cystadenocarcinoma, Papillary - drug therapy | Antineoplastic Agents, Phytogenic - pharmacology | Drug Resistance, Neoplasm - drug effects | Cell proliferation | Biotechnology | Mesenchyme | Authorship | Ovarian carcinoma | Sperm | Epithelial cells | Leukemia | DNA damage | Cytotoxicity | Metastasis | Cyclin D1 | Kinases | Caspase-3 | Experiments | Cyclin-dependent kinase 4 | Cyclin B1 | Ovarian cancer | Proteins | Cell cycle | Paclitaxel | Xenografts | Cyclin E | Localization | Medical research | Antigens | Data analysis | Immunoglobulins | RNA-mediated interference | Mortality | Caspase | Breast cancer | Gene expression | Cyclin-dependent kinase 2 | Polymerase chain reaction | Cytochrome c | Studies | Caspase-8 | Caspase-7 | Cell death | S phase | Tumor suppressor genes | Endoplasmic reticulum | Apoptosis
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2013, Volume 14, Issue 12, pp. 7635 - 7638
Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian,... 
Sperm-associated antigen 9 | Cancer testis antigens | Early diagnosis | Endometrial cancer | early diagnosis | SPAG9 | BIOMARKER | ONCOLOGY | IMMUNOTHERAPY | cancer testis antigens | TUMOR-GROWTH | sperm-associated antigen 9 | CLINICAL-SIGNIFICANCE | PREDICTION
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2005, Volume 389, Issue 1, pp. 73 - 82
We report a novel SPAG9 (sperm-associated antigen 9) protein having structural homology with JNK (c-Jun N-terminal kinase)-interacting protein 3. SPAG9, a... 
c-Jun N-terminal kinase | Sperm-associated antigen 9 | Acrosome | JNK-interacting protein (JIP) | Oocyte | Spermatozoa-egg interaction | spermatozoa-egg interaction | CELLS | FERTILIZATION | acrosome | BIOCHEMISTRY & MOLECULAR BIOLOGY | EGG INTERACTION | MOLECULES | TRANSPORT | oocyte | ZIPPER DIMERIZATION MOTIF | HUMAN-SPERMATOZOA | GENE-EXPRESSION | SECONDARY STRUCTURE | SCAFFOLD PROTEINS | sperm-associated antigen 9 | Adaptor Proteins, Signal Transducing - chemistry | Immunohistochemistry | Humans | Cercopithecus aethiops | Molecular Sequence Data | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Spermatozoa - metabolism | Nerve Tissue Proteins - chemistry | Fertilization - physiology | Membrane Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Membrane Proteins - genetics | Oocytes - metabolism | Gene Expression Regulation | Membrane Proteins - immunology | Chromosome Mapping | Protein Transport | Animals | Membrane Proteins - chemistry | Zona Pellucida - metabolism | Protein Binding | Structural Homology, Protein | COS Cells | SPAG9, sperm-associated antigen 9 | MHZ, matched hemizona | JNK, c-Jun N-terminal kinase | JIP, JNK-interacting protein | JBD, JNK-binding domain | ERK, extracellular-signal-regulated kinase | HSE, human sperm extract | SWM, sperm-washing medium | SPAG9ΔLZΔT, SPAG9 without JBD, leucine zipper and transmembrane domain | HZI, hemizona index | MAPK, mitogen-activated protein kinase | SPAG9ΔT, SPAG9 without transmembrane domain | spermatozoa–egg interaction
Journal Article
Oncology Letters, ISSN 1792-1074, 01/2018, Volume 15, Issue 1, pp. 415 - 422
The incidence and mortality rates of hepatocellular carcinoma (HCC) are higher in China compared with in other countries. Further research is required in order... 
Cell proliferation | Short interfering RNA | Cell migration | Cell cycle | Hepatoma carcinoma | Sperm‑associated antigen 9 | SPAG9 | cell proliferation | BIOMARKER | cell cycle | DOWN-REGULATION | OVARIAN-CANCER | short interfering RNA | BREAST-CANCER | OVEREXPRESSION | hepatoma carcinoma | THERAPY | ONCOLOGY | cell migration | TUMOR-GROWTH | EXPRESSION | sperm-associated antigen 9 | CLINICAL-SIGNIFICANCE
Journal Article
Leukemia Research, ISSN 0145-2126, 2010, Volume 34, Issue 7, pp. 858 - 863
Abstract Early diagnosis and cure for patients with chronic myeloid leukemia (CML) exhibit significant clinical challenges because of the disease progression... 
Hematology, Oncology and Palliative Medicine | SPAG9 | Biomarkers | Cancer testis antigen | Chronic myeloid leukemia | Immunotherapy | CHRONIC MYELOGENOUS LEUKEMIA | CELLS | PROTEIN | BCR-ABL | VACCINE | RESIDUAL DISEASE | CANCER-TESTIS ANTIGEN | MECHANISMS | ONCOLOGY | HEMATOLOGY | HEMATOLOGIC MALIGNANCIES | Antibody Specificity | Humans | Leukemia, Myeloid, Chronic-Phase - pathology | Antigens, Neoplasm - biosynthesis | Neoplasm Proteins - immunology | Male | Biomarkers, Tumor | RNA, Messenger - biosynthesis | Adaptor Proteins, Signal Transducing - immunology | Female | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Leukemia, Myeloid, Chronic-Phase - metabolism | Antibodies, Neoplasm - immunology | Blast Crisis - pathology | Enzyme-Linked Immunosorbent Assay | Antigens, Neoplasm - immunology | Neoplasm Proteins - biosynthesis | Antibodies, Neoplasm - blood | Antigens, Surface - biosynthesis | Gene Expression Regulation, Leukemic | Reverse Transcriptase Polymerase Chain Reaction | Leukemia, Myeloid, Chronic-Phase - immunology | K562 Cells - metabolism | RNA, Neoplasm - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Leukemia, Myeloid, Chronic-Phase - therapy | Adaptor Proteins, Signal Transducing - biosynthesis | Antigens, Surface - immunology | Leukemia, Myeloid, Chronic-Phase - genetics
Journal Article