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Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2006, Volume 397, Issue 1, pp. 223 - 231
The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1... 
Hypertension | STE20/SPS1-related proline/alanine-rich kinase (SPAK) | Pseudohypoaldosteronism type II | Cation co-transporter | Gordon's syndrome | Protein kinase | K-CL COTRANSPORTER | SPAK | PHOSPHORYLATION | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+-K+-2CL(-) COTRANSPORTER | protein kinase | PROTEIN-KINASES | BLOOD-PRESSURE | ALANINE-RICH KINASE | TERMINUS | pseudohypoaldosteronism type II | cation co-transporter | hypertension | Phosphorylation | Threonine | Minor Histocompatibility Antigens | Humans | Serine | Cells, Cultured | Sodium-Potassium-Chloride Symporters | Intracellular Signaling Peptides and Proteins | Substrate Specificity | Kidney - cytology | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Hyperkalemia - genetics | Osmolar Concentration | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Enzyme Activation | Hypertension - genetics | Mutation | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | WNK, with no K (lysine) protein kinase | LDS, lithium dodecyl sulphate | MALDI–TOF | TBST, Tris-buffered saline with Tween 20 | TOF, matrix-assisted laser-desorption ionization–tandem time-of-flight | DTT, dithiothreitol | HEK-293, human embryonic kidney | PDK1, phosphoinositide-dependent kinase 1 | CCT domain, conserved C-terminal domain | NCC, Na+–Cl− co-transporter | SA, streptavidin-coated | KCC, K+–Cl− co-transporter | GST, glutathione S-transferase | NKCC, Na+–K+–2Cl− co-transporter | GSK3, glycogen synthase kinase 3 | alanine-rich kinase (SPAK) | SPAK, STE20 | CATCHtide, cation chloride co-transporter peptide substrate | OSR1, oxidative stress-responsive kinase-1 | SPS1-related proline | STE20 | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1868 - 1873
SPAK and OSR1 are two protein kinases that play important roles in regulating the function of numerous ion co-transporters. They are activated by two distinct... 
SPAK | MO25 | Phosphorylation | Kinase | OSR1 | SPAK/OSR1 | BIOPHYSICS | WNK | LKB1-STRAD-MO25 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | LKB1 | Drugstores | Protein kinases | Pharmacy | Protein binding | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 2, pp. 338 - 343
The binding of SPAK and OSR1 kinases to their upstream WNK kinases is mediated by the interaction of their highly conserved SPAK and OSR1 -terminal domain... 
Assignment | SPAK | NMR | Kinase | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-PRESSURE | SPAK/OSR1 | TRANSPORT | BIOPHYSICS | SPECTROSCOPY | WNK1 | MASTER REGULATOR | WEB SERVER | KINASES | Peptides | Analysis | Pharmacy | Crystals | Amino acids | Nuclear magnetic resonance | Structure
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 325 - 337
Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | Cl | 2Cl | Coiled-coil domain | Osmotic stress | KINASE-ACTIVITY | SPAK | coiled-coil domain | HOMEOSTASIS | Na+/K+/2Cl(-) co-transporter 1 (NKCC1) | signal transduction | PHOSPHORYLATION | PROTEIN-KINASE | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinase | BLOOD-PRESSURE | osmotic stress | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | MUTATIONS | HYPERTENSION | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Transcription Factors - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Protein Isoforms | HEK293 Cells | Embryonic Stem Cells | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CCD, coiled-coil domain | PI3K, phosphoinositide 3-kinase | WNK, with no lysine (K) kinase | 2Cl− co-transporter | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | ES, embryonic stem | DMEM, Dulbecco's modified Eagle's medium | CCT, conserved C-terminal | GST, glutathione transferase | HEK-293, human embryonic kidney 293 | 2Cl− co-transporter 1 (NKCC1) | Cl− co-transporter | NKCC, Na+ | SPAK, SPS1-related proline | Cl− co-transporter (NCC) | OSR, oxidative stress-responsive kinase | LRRK2, leucine-repeat-rich kinase 2 | CATCHtide, cation chloride co-transporter peptide substrate | Na+ | NCC, Na+ | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article
The journal of pain : official journal of the American Pain Society, ISSN 1526-5900, 05/2019
Our preliminary experiment indicated the activation of with-nolysine kinases 1 (WNK1) in bone cancer pain (BCP) rats. This study aimed to investigate the... 
Journal Article
ChemBioChem, ISSN 1439-4227, 03/2017, Volume 18, Issue 5, pp. 424 - 424
The cover picture shows the chemical structure of HK01, a small molecule that binds the scaffolding protein MO25 and inhibits its binding to SPAK/OSR1 kinases,... 
inhibitors | MO25 | SPAK | scaffolding | OSR1 | high-throughput screening | Proteins | Kinases
Journal Article
Stroke, ISSN 0039-2499, 07/2015, Volume 46, Issue 7, pp. 1956 - 1965
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 4/2017, Volume 74, Issue 7, pp. 1261 - 1280
Hypertension (high blood pressure) is a major public health problem affecting more than a billion people worldwide with complications, including stroke, heart... 
Life Sciences | Biomedicine, general | Biochemistry, general | Hypertension | Hyperkalemia | Life Sciences, general | Ubiquitin-E3 ligase complex | SPAK/OSR1 phosphorylation | WNK kinases | Cell Biology | NCC | Proteasome | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KELCH-LIKE 3 | NA+-K+-2CL(-) COTRANSPORTER | CELL BIOLOGY | POTASSIUM HOMEOSTASIS | NA+-CL-COTRANSPORTER | FAMILIAL HYPERTENSION | NACL COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | MOLECULAR PATHOGENESIS | GENOME-WIDE ASSOCIATION | Sodium Chloride Symporters - metabolism | Signal Transduction | Sodium Chloride Symporters - genetics | Pseudohypoaldosteronism - genetics | Receptors, Drug - genetics | Humans | Sodium-Potassium-Chloride Symporters - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Hypertension - pathology | Receptors, Drug - metabolism | Sodium Chloride Symporters - chemistry | Hypertension - metabolism | Receptors, Drug - chemistry | Animals | Pseudohypoaldosteronism - pathology | Cullin Proteins - metabolism | Blood Pressure - physiology | Hypertension - genetics | Neovascularization, Physiologic | Protein-Serine-Threonine Kinases - metabolism | Heart failure | Stroke (Disease) | Ubiquitin | Ligases | Diuretics | Genetic research | Blood pressure | Disease susceptibility | Phosphotransferases | Signal transduction | Kinases | Gene expression | OSR1 phosphorylation | SPAK | Review
Journal Article