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1. Full Text Kinetochore Stretching Inactivates the Spindle Assembly Checkpoint
by Kazuhiko S. K. Uchida and Kentaro Takagaki and Kazuki Kumada and Youko Hirayama and Tetsuo Noda and Toru Hirota
The Journal of Cell Biology, ISSN 0021-9525, 2/2009, Volume 184, Issue 3, pp. 383 - 390
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete.... 
Report | Kinetochores | Metaphase | Microtubules | Imaging | Cell lines | Centromeres | HeLa cells | Anaphase | Chromosomes | Cyclins | MITOSIS | CHROMOSOME | ANAPHASE | COMPLEX | ATTACHMENT | CONDENSIN-I | TENSION | CELL BIOLOGY | Autoantigens - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Adenosine Triphosphatases - metabolism | Fluorescent Dyes - metabolism | Stress, Mechanical | Multiprotein Complexes - genetics | DNA-Binding Proteins - genetics | Autoantigens - genetics | Nocodazole - metabolism | Recombinant Fusion Proteins - metabolism | Chromosomal Proteins, Non-Histone - genetics | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Centromere Protein A | Spindle Apparatus - metabolism | Cell Cycle - physiology | Recombinant Fusion Proteins - genetics | Tubulin Modulators - metabolism | Adenosine Triphosphatases - genetics | HeLa Cells | Spindle (Cell division) | Properties | Observations | Proteins | Cell division | Biochemistry | Cell cycle | Index Medicus
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2. Full Text Kinetic framework of spindle assembly checkpoint signalling
by Dick, Amalie E and Gerlich, Daniel W
Nature Cell Biology, ISSN 1465-7392, 11/2013, Volume 15, Issue 11, pp. 1370 - 1377
The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles(1,2). Here, we investigated SAC... 
CDC20 | ANEUPLOIDY | ANAPHASE | SATISFY | ROLES | DRIVES | CDK1 | MITOTIC CHECKPOINT | CHROMOSOMAL INSTABILITY | REVEALS | CELL BIOLOGY | M Phase Cell Cycle Checkpoints | Chromosomes, Human | Signal Transduction | Humans | Kinetochores | Spindle Apparatus | Spindle (Cell division) | Cell division | Aneuploidy | Genetic aspects | Cellular signal transduction | Properties | Testing | Index Medicus
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3. Full Text KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint
by Rosenberg, Jessica S and Cross, Frederick R and Funabiki, Hironori
Current Biology, ISSN 0960-9822, 06/2011, Volume 21, Issue 11, pp. 942 - 947
The spindle assembly checkpoint (SAC) delays anaphase onset until kinetochores accomplish bioriented microtubule attachments [ ]. Although several centromeric... 
AURORA-B KINASE | ACTIVATE | COMPLEX | PROTEIN PHOSPHATASE 1 | BUDDING YEAST | KINETOCHORE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROTUBULE ATTACHMENT | TENSION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Microtubule-Associated Proteins - chemistry | Protein Phosphatase 1 - physiology | Protein Structure, Tertiary | Phosphorylation | Mutagenesis, Site-Directed | Kinetochores - metabolism | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Genotype | Saccharomyces cerevisiae Proteins - genetics | Mitosis - genetics | Microtubule-Associated Proteins - physiology | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Protein Phosphatase 1 - metabolism | Spindle Apparatus - metabolism | Mitosis - physiology | Protein Phosphatase 1 - genetics | Saccharomyces cerevisiae Proteins - metabolism | Conserved Sequence | Saccharomyces cerevisiae Proteins - physiology | Anaphase | Saccharomyces cerevisiae Proteins - chemistry | Phosphatases | Molecular genetics | Phosphotransferases | Protein binding | Index Medicus
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4. Full Text Determinants of robustness in spindle assembly checkpoint signalling
by Heinrich, Stephanie and Geissen, Eva-Maria and Kamenz, Julia and Trautmann, Susanne and Widmer, Christian and Drewe, Philipp and Knop, Michael and Radde, Nicole and Hasenauer, Jan and Hauf, Silke
Nature Cell Biology, ISSN 1465-7392, 11/2013, Volume 15, Issue 11, pp. 1328 - 1339
The spindle assembly checkpoint is a conserved signalling pathway that protects genome integrity. Given its central importance, this checkpoint should... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | CHROMOSOME INSTABILITY | BIOLOGICAL NOISE | CRYSTAL-STRUCTURE | CYCLE-REGULATED GENES | CELL-CYCLE | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Schizosaccharomyces - metabolism | M Phase Cell Cycle Checkpoints | Signal Transduction | Spindle Apparatus | Schizosaccharomyces pombe Proteins - metabolism | Spindle (Cell division) | Cellular signal transduction | Genetic aspects | Gene expression | Testing | Index Medicus
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5. Full Text An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint
by Qian, Junbin and García-Gimeno, Maria Adelaida and Beullens, Monique and Manzione, Maria Giulia and Van der Hoeven, Gerd and Igual, Juan Carlos and Heredia, Miguel and Sanz, Pascual and Gelens, Lendert and Bollen, Mathieu
Molecular Cell, ISSN 1097-2765, 11/2017, Volume 68, Issue 4, pp. 715 - 730.e5
The spindle assembly checkpoint (SAC) generates a diffusible protein complex that prevents anaphase until all chromosomes are properly attached to spindle... 
biochemical timer | MPS1 | spindle assembly checkpoint | PP2A-B56 | microtubule-kinetochore attachment | mitosis | BUB1 | anti-mitotic therapy | MITOSIS | RECRUITMENT | KINETOCHORE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | B56-PP2A PHOSPHATASE | MITOTIC PROGRESSION | CHROMOSOME SEGREGATION | CELL BIOLOGY | Spindle Apparatus - metabolism | Kinetochores - metabolism | Humans | Spindle Apparatus - genetics | Cell Cycle Proteins - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - metabolism | HeLa Cells | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Phosphatases | Cell death | Therapeutics | Chromosomes | Cells | Homeopathy | Materia medica and therapeutics | Index Medicus
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6. Full Text The spindle assembly checkpoint works like a rheostat rather than a toggle switch
by Collin, Philippe and Nashchekina, Oxana and Walker, Rachael and Pines, Jonathon
Nature Cell Biology, ISSN 1465-7392, 11/2013, Volume 15, Issue 11, pp. 1378 - 1385
The spindle assembly checkpoint (SAC) is essential in mammalian mitosis to ensure the equal segregation of sister chromatids(1,2). The SAC generates a mitotic... 
CDC20 | MAD2 | FISSION YEAST | DESTRUCTION | CYCLIN-A | CHROMOSOME ALIGNMENT | CELL-CYCLE | MITOTIC CHECKPOINT | UNATTACHED KINETOCHORES | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | Anaphase-Promoting Complex-Cyclosome | Cell Line | M Phase Cell Cycle Checkpoints | Humans | Spindle Apparatus | Spindle (Cell division) | Gene targeting | Mitosis | Cellular control mechanisms | Genetic aspects | Methods | Testing | Index Medicus
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7. Full Text Molecular basis of APC/C regulation by the spindle assembly checkpoint
by Alfieri, Claudio and Chang, Leifu and Zhang, Ziguo and Yang, Jing and Maslen, Sarah and Skehel, Mark and Barford, David
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure | Index Medicus
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8. Full Text Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling
by Ruppert, Thomas and Lechner, Johannes and Ortiz, Jennifer and Stach, Manuel and Pfannstiel, Jens and Kemmler, Stefan and Knapp, Maria
The EMBO Journal, ISSN 0261-4189, 04/2009, Volume 28, Issue 8, pp. 1099 - 1110
The protein kinase Mps1 is, among others, essential for the spindle assembly checkpoint (SAC). We found that Saccharomyces cerevisiae Mps1 interacts physically... 
kinetochore | centromere | Mps1 | spindle assembly checkpoint | Ndc80 | Kinetochore | Centromere | Spindle assembly checkpoint | BI-ORIENTATION | COMPLEX | BUDDING YEAST | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLE BODY DUPLICATION | TENSION | CELL BIOLOGY | MPS1 KINASE | GENE MPS1 | MITOTIC CHECKPOINT | KINETOCHORE-MICROTUBULE ATTACHMENT | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Microtubules - metabolism | Protein-Tyrosine Kinases - genetics | Spindle Apparatus - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Kinetochores - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Alanine - metabolism | Nuclear Proteins - metabolism | Aurora Kinases | Saccharomyces cerevisiae Proteins - genetics | Animals | Saccharomyces cerevisiae Proteins - metabolism | Cell Cycle - physiology | Recombinant Fusion Proteins - genetics | Aspartic Acid - metabolism | Signal Transduction - physiology | Genes, cdc | Signal transduction | Biochemistry | Kinases | Molecular biology | Cell cycle | Index Medicus
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9. Full Text The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
by Pines, Jonathon and Nilsson, Jakob and Yekezare, Mona and Minshull, Jeremy
Nature Cell Biology, ISSN 1465-7392, 12/2008, Volume 10, Issue 12, pp. 1411 - 1420
The spindle assembly checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly attached to the mitotic apparatus.... 
MITOSIS | MAD2 | CELLS | ANAPHASE-PROMOTING COMPLEX | KINETOCHORES | PROTEIN BUBR1 | CYCLIN-A | CHROMOSOME ALIGNMENT | MITOTIC CHECKPOINT | BINDING | CELL BIOLOGY | Calcium-Binding Proteins - metabolism | Anaphase-Promoting Complex-Cyclosome | Humans | Cell Cycle Proteins - metabolism | Mutant Proteins - metabolism | Amino Acid Motifs | Cell Cycle Proteins - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Ubiquitin-Protein Ligase Complexes - metabolism | Protein Binding | Lysine - metabolism | Mad2 Proteins | Protein Processing, Post-Translational | Cdc20 Proteins | HeLa Cells | Chromatography, Gel | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Control | Ligases | Cell cycle | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Index Medicus
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10. Full Text The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling
by Aravamudhan, Pavithra and Goldfarb, Alan A and Joglekar, Ajit P
Nature Cell Biology, ISSN 1465-7392, 07/2015, Volume 17, Issue 7, pp. 868 - 879
The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC... 
NDC80 COMPLEX | RECRUITMENT | BUDDING YEAST | MPS1 | PHOSPHORYLATION | CHROMOSOME CONGRESSION | KINASE | MICROTUBULE ATTACHMENT | MITOTIC SPINDLE | PROTEIN ARCHITECTURE | CELL BIOLOGY | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Tubulin Modulators - pharmacology | Nocodazole - pharmacology | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae - metabolism | Microtubules - metabolism | Spindle Apparatus - metabolism | Cell Cycle Proteins - genetics | Cell Cycle Checkpoints - genetics | Time-Lapse Imaging - methods | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Aurora Kinases - metabolism | Kinetochores - metabolism | Aurora Kinases - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - physiology | Nuclear Proteins - metabolism | Signal Transduction - genetics | Saccharomyces cerevisiae Proteins - genetics | Sirolimus - pharmacology | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Luminescent Proteins - genetics | Signal Transduction - physiology | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Spindle (Cell division) | Cellular signal transduction | Genetic aspects | Properties | Kinetochores | Index Medicus
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11. Full Text Spindle assembly checkpoint silencing and beyond
by Bokros, Michael and Wang, Yanchang
Cell Cycle, ISSN 1538-4101, 07/2016, Volume 15, Issue 13, pp. 1661 - 1662
KINETOCHORES | ATTACHMENT | MPS1 | BUB1 | CELL BIOLOGY | M Phase Cell Cycle Checkpoints | Mitosis | Kinetochores | Cell Cycle Proteins | Spindle Apparatus | Index Medicus
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12. Full Text Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling
by Primorac, Ivana and Weir, John R and Chiroli, Elena and Gross, Fridolin and Hoffmann, Ingrid and van Gerwen, Suzan and Ciliberto, Andrea and Musacchio, Andrea
eLife, ISSN 2050-084X, 09/2013, Volume 2013, Issue 2, pp. e01030 - e01030
Regulation of macromolecular interactions by phosphorylation is crucial in signaling networks. In the spindle assembly checkpoint (SAC), which enables... 
CHROMOSOME BIORIENTATION | KINASE-ACTIVITY | BUDDING YEAST | MICROTUBULE-BINDING | UBIQUITIN LIGASE | STRUCTURAL-ANALYSIS | BIOLOGY | MULTISITE PHOSPHORYLATION | MITOTIC CHECKPOINT | PROTEIN-PHOSPHORYLATION | KINETOCHORE LOCALIZATION | Amino Acid Sequence | Phosphorylation | Signal Transduction | Humans | Cell Cycle Proteins - metabolism | Molecular Sequence Data | Oligopeptides - metabolism | Spindle Apparatus | Cell Cycle Proteins - chemistry | Sequence Homology, Amino Acid | Poly-ADP-Ribose Binding Proteins | Cell Cycle Proteins - genetics | Protein Conformation | Mutation | Oligopeptides - chemistry | Peptides | Kinetochores | Macromolecules | Cell division | Kinases | Recruitment | Proteins | Conserved sequence | Cell cycle | Standard deviation | Localization | Chromosomes | Index Medicus
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