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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 6
For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they target PfATP4, a putative Na+... 
Transporters | PfATP4 | Antimalarial agents | KAE609 | TARGET | INTRAERYTHROCYTIC MALARIA PARASITE | antimalarial agents | ACID | transporters | MEMBRANE-PERMEABILITY | MICROBIOLOGY | SPIROINDOLONE ANTIMALARIALS | PLASMODIUM-FALCIPARUM | PHARMACOLOGY & PHARMACY | RED-BLOOD-CELLS | ERYTHROCYTE | CATION ATPASE PFATP4 | EXTRUSION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 9, pp. 4244 - 4273
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 03/2012, Volume 12, Issue 5, pp. 473 - 483
Antimalarial drug discovery has historically benefited from the whole-cell (phenotypic) screening approach to identify lead molecules in the search for new... 
Spiroindolones | Whole-cell screening | Malaria | Imidazolopiperazines | Lead-optimization | LIBRARIES | POTENT | CHEMISTRY, MEDICINAL | PLASMODIUM-FALCIPARUM | STARTING POINTS | KINASE | SPIROINDOLONES | MALARIA | IDENTIFICATION | DISCOVERY | Antimalarials | Humans | Molecular Targeted Therapy - methods | Drug Discovery - trends
Journal Article
Journal Article
MedChemComm, ISSN 2040-2503, 3/2018, Volume 9, Issue 3, pp. 437 - 453
Though morbidity and mortality due to malaria have declined in the last 15 years, emerging resistance to first-line artemisinin-based antimalarials, absence of... 
FALCIPARUM MALARIA | SINGLE-DOSE CURE | CHEMISTRY, MEDICINAL | PLASMODIUM-VIVAX MALARIA | ARTEMISININ RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMODIAQUINE-INDUCED AGRANULOCYTOSIS | DOUBLE-BLIND | CLINICAL CANDIDATE | OPEN-LABEL | IDENTIFICATION | SPIROINDOLONE KAE609
Journal Article
MedChemComm, ISSN 2040-2503, 01/2018, Volume 9, Issue 3, pp. 437 - 453
Though morbidity and mortality due to malaria have declined in the last 15 years, emerging resistance to first-line artemisinin-based antimalarials, absence of... 
Vector-borne diseases | Drugs | Chemotherapy | Consolidation | Malaria | Developmental stages | Liver | Artemisinin | Vaccines | Drug discovery | Drug development | Morbidity
Journal Article
Journal Article
Journal Article