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CELL, ISSN 0092-8674, 01/2018, Volume 172, Issue 3, pp. 454 - 454
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 318 - 323
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron... 
2ND STEP | ANGSTROM RESOLUTION | I SPLICEOSOME | U4/U6.U5 TRI-SNRNP | ELECTRON CRYOMICROSCOPY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | CATALYTIC CORE | SACCHAROMYCES-CEREVISIAE | PRE-MESSENGER-RNA | Spliceosomes - chemistry | Humans | Cell Cycle Proteins - ultrastructure | RNA Splicing Factors - chemistry | RNA, Messenger - metabolism | RNA Splicing Factors - metabolism | Cell Cycle Proteins - chemistry | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | Base Sequence | Protein Domains | Ribonucleoproteins, Small Nuclear - chemistry | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Biocatalysis | Introns - genetics | Movement | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Exons - genetics | Spliceosomes - ultrastructure | RNA Stability | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Adenosine - metabolism | Saccharomyces cerevisiae - enzymology | RNA, Messenger - chemistry | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Ribonuclease H - metabolism | Genetic research | Genetic engineering | Research | Methods | RNA splicing | Proteins | Yeast | Catalysis | Molecular structure | Microscopy | Ribonucleic acid--RNA | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, pp. 617 - 621
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome's catalytic centre. Here we... 
ANGSTROM RESOLUTION | U4/U6.U5 TRI-SNRNP | MESSENGER-RNA | SMALL NUCLEAR-RNA | MULTIDISCIPLINARY SCIENCES | ELECTRON-MICROSCOPY | B-COMPLEX | U2 SNRNP | CRYO-EM STRUCTURE | SACCHAROMYCES-CEREVISIAE | ACTIVATED SPLICEOSOME | RNA Helicases - metabolism | Ribonucleoprotein, U2 Small Nuclear - chemistry | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoprotein, U2 Small Nuclear - metabolism | Base Sequence | Protein Domains | RNA Precursors - metabolism | Ribonucleoproteins, Small Nuclear - chemistry | Protein Stability | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | Introns - genetics | RNA Splice Sites - genetics | Models, Molecular | Nuclear Proteins - metabolism | RNA Precursors - genetics | Spliceosomes - ultrastructure | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Yeast | Ribonucleoproteins (small nuclear) | Molecular structure | mRNA | Saccharomyces | Ribonucleoproteins (U2 small nuclear) | Electron microscopy | Ribonucleic acid--RNA | snRNA | Proteins | DNA helicase | Transmission electron microscopy | Ribonucleic acids | Catalysis | Atomic structure | Saccharomyces cerevisiae | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 537, Issue 7619, pp. 197 - 201
Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat-intron intermediate. Here we present the 3.8 angstrom... 
U4/U6.U5 TRI-SNRNP | IN-VITRO | ELECTRON CRYOMICROSCOPY | ACTIVE-SITE | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | PRE-MESSENGER-RNA | CATALYTIC ACTIVATION | RNA Precursors - chemistry | RNA Helicases - metabolism | Spliceosomes - chemistry | RNA, Fungal - ultrastructure | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA Precursors - metabolism | RNA, Fungal - genetics | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Introns - genetics | RNA Splice Sites - genetics | RNA, Fungal - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Exons - genetics | Magnesium - metabolism | Nuclear Proteins - metabolism | Spliceosomes - ultrastructure | Esterification | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Base Pairing | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Structure | Brewer's yeast | Methods | RNA splicing | Proteins | Enzymes | Molecular structure | Microscopy | Catalysis | Ribonucleic acid--RNA | Binding sites | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 12/2015, Volume 29, Issue 24, pp. 2576 - 2587
The Brr2 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA... 
X-ray crystallography | Spliceosome catalytic activation | RNA helicase structure and function | Pre-mRNA splicing | Remodeling of RNA-protein complexes | spliceosome catalytic activation | DOMAIN | PROTEIN | DEVELOPMENTAL BIOLOGY | remodeling of RNA-protein complexes | SNRNP | PRP8 | CELL BIOLOGY | YEAST | SNU114P | STRUCTURAL BASIS | GENETICS & HEREDITY | U4/U6 RNA | MACROMOLECULAR CRYSTALLOGRAPHY | pre-mRNA splicing | RNA Helicases - metabolism | Spliceosomes - genetics | Saccharomyces cerevisiae - genetics | Humans | Ribonucleoprotein, U5 Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - genetics | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | Protein Structure, Quaternary | RNA Helicases - genetics | Spliceosomes - enzymology | Ribonucleoproteins, Small Nuclear - chemistry | Ribonucleoprotein, U5 Small Nuclear - chemistry | Protein Structure, Tertiary | RNA-Binding Proteins - chemistry | Crystallization | Protein Splicing | Adenosine Triphosphatases - metabolism | Models, Molecular | Chaetomium - enzymology | Saccharomyces cerevisiae Proteins - genetics | Chaetomium - genetics | Protein Folding | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | Saccharomyces cerevisiae - enzymology | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Helicases | Analysis | RNA splicing | Index Medicus | remodeling of RNA–protein complexes | Research Paper
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6026, pp. 238 - 240
Journal Article
Cell Research, ISSN 1001-0602, 03/2018, Volume 28, Issue 3, pp. 307 - 322
Journal Article