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Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 01/2009, Volume 16, Issue 1, pp. 42 - 48
The spliceosome is a highly dynamic machine requiring multiple RNA-dependent ATPases of the DExD/H-box family. A fundamental unanswered question is how their... 
PROTEIN FAMILY | SPLICEOSOME ACTIVATION | DOMAIN | SPLICING FACTOR PRP8 | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | DOMINANT RETINITIS-PIGMENTOSA | CELL BIOLOGY | BIOPHYSICS | BOX RNA HELICASE | U6 SNRNAS | FACTOR GENES | RNA Helicases - metabolism | Spliceosomes - genetics | Saccharomyces cerevisiae - genetics | Humans | RNA-Binding Proteins | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | Ribonucleoprotein, U5 Small Nuclear | Saccharomyces cerevisiae - metabolism | Genes, Dominant | Adenosine Triphosphate - metabolism | RNA Splicing - genetics | Protein Denaturation | RNA Helicases - genetics | RNA, Fungal - genetics | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Recombinant Proteins - chemistry | Retinitis Pigmentosa - genetics | Saccharomyces cerevisiae Proteins - genetics | Carrier Proteins - genetics | Peptide Fragments - chemistry | Carrier Proteins - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - genetics | Saccharomyces cerevisiae Proteins - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | Mutation | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Nucleoproteins | Physiological aspects | Research | Structure | Helicases | Health aspects | Adenosine triphosphatase | Proteins | Adenosine | Catalysis | Ribonucleic acid--RNA | Molecular biology | retinitis pigmentosa | spliceosome | protein co-factor | pre-mRNA splicing
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2002, Volume 99, Issue 14, pp. 9145 - 9149
Prp8 is the largest and most highly conserved protein in the spliceosome yet its mechanism of function is poorly understood. Our previous studies implicate... 
Yeasts | Biological Sciences | RNA | Splicing | Plasmids | Genes | Medical genetics | Alleles | Amino acids | Spliceosomes | Genetic mutation | Prp31 | Small nuclear RNA | Pre-mRNA splicing | RNA helicases | Retinitis pigmentosa | SITE | PROTEIN | small nuclear RNA | SMALL NUCLEAR-RNA | U5 SNRNP | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | DOMINANT RETINITIS-PIGMENTOSA | GENE | IN-VIVO | retinitis pigmentosa | REQUIRES ATP | SUGGEST | pre-mRNA splicing | Fungal Proteins - chemistry | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Ribonucleoprotein, U4-U6 Small Nuclear | Ribonucleoprotein, U5 Small Nuclear | Saccharomyces cerevisiae - metabolism | Spliceosomes - metabolism | RNA Helicases | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA, Fungal - genetics | Repressor Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Cold Temperature | DEAD-box RNA Helicases | Repressor Proteins - genetics | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | RNA Nucleotidyltransferases - metabolism | RNA, Fungal - metabolism | Sequence Homology, Amino Acid | RNA Nucleotidyltransferases - genetics | Saccharomyces cerevisiae Proteins - metabolism | Mutation | RNA, Small Nuclear - metabolism | Fungal Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | RNA splicing | pre-mRNA splicing‖small nuclear RNA‖retinitis pigmentosa‖RNA helicases‖Prp31
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2018, Volume 46, Issue 8, pp. 3833 - 3840
Abstract Precursor message RNA (pre-mRNA) splicing is executed by the spliceosome, a large ribonucleoprotein (RNP) machinery that is comparable to the... 
GROUP-II INTRON | U4/U6.U5 TRI-SNRNP | SPLICING FACTOR PRP8 | U5 SNRNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR ARCHITECTURE | CONFORMATIONAL DYNAMICS | CRYO-EM STRUCTURE | SACCHAROMYCES-CEREVISIAE | CATALYTIC SPLICEOSOME | Survey and Summary
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 37, pp. 13817 - 13822
Journal Article
Genes and Development, ISSN 0890-9369, 11/2012, Volume 26, Issue 21, pp. 2422 - 2434
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