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Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 22, pp. 5585 - 5593
Purpose: CHD1 deletions and SPOP mutations frequently cooccur in prostate cancer with lower frequencies reported in castration-resistant prostate cancer... 
SPOP | RECEPTOR | MUTATIONS | ONCOLOGY
Journal Article
by Zhang, LL and Peng, S and Dai, XP and Gan, WJ and Nie, X and Wei, WY and Hu, GQ and Guo, JP
CANCER LETTERS, ISSN 0304-3835, 04/2017, Volume 390, pp. 11 - 20
Eg1N prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant... 
POZ PROTEIN SPOP | HIF | TRANSCRIPTION | Eg1N2 | PROLINE-HYDROXYLATION | HYPOXIA-INDUCIBLE FACTORS | PROLYL HYDROXYLASE | OXYGEN | Ubiquitination | ONCOLOGY | Androgen receptor | SPOP | GENE-EXPRESSION | Prostate cancer | PROGRESSION
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2019, Volume 48, Issue 3, pp. 345 - 360.e7
NANOG is an essential transcriptional factor for the maintenance of embryonic stem cells (ESCs) and cancer stem cells (CSCs) in prostate cancer (PCa). However,... 
SPOP | prostate cancer stem cell | AMPK-BRAF axis | NANOG | ubiquitination
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2018, Volume 98, Issue 6, pp. 856 - 869
Journal Article
by Abeshouse, Adam and Ahn, Jaeil and Akbani, Rehan and Ally, Adrian and Amin, Samirkumar and Andry, Christopher D and Annala, Matti and Aprikian, Armen and Armenia, Joshua and Arora, Arshi and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Barbieri, Christopher E and Bauer, Thomas and Benz, Christopher C and Bergeron, Alain and Beroukhim, Rameen and Berrios, Mario and Bivol, Adrian and Bodenheimer, Tom and Boice, Lori and Bootwalla, Moiz S and Borges dos Reis, Rodolfo and Boutros, Paul C and Bowen, Jay and Bowlby, Reanne and Boyd, Jeffrey and Bradley, Robert K and Breggia, Anne and Brimo, Fadi and Bristow, Christopher A and Brooks, Denise and Broom, Bradley M and Bryce, Alan H and Bubley, Glenn and Burks, Eric and Butterfield, Yaron S.N and Button, Michael and Canes, David and Carlotti, Carlos G and Carlsen, Rebecca and Carmel, Michel and Carroll, Peter R and Carter, Scott L and Cartun, Richard and Carver, Brett S and Chan, June M and Chang, Matthew T and Chen, Yu and Cherniack, Andrew D and Chevalier, Simone and Chin, Lynda and Cho, Juok and Chu, Andy and Chuah, Eric and Chudamani, Sudha and Cibulskis, Kristian and Ciriello, Giovanni and Clarke, Amanda and Cooperberg, Matthew R and Corcoran, Niall M and Costello, Anthony J and Cowan, Janet and Crain, Daniel and Curley, Erin and David, Kerstin and Demchok, John A and Demichelis, Francesca and Dhalla, Noreen and Dhir, Rajiv and Doueik, Alexandre and Drake, Bettina and Dvinge, Heidi and Dyakova, Natalya and Felau, Ina and Ferguson, Martin L and Frazer, Scott and Freedland, Stephen and Fu, Yao and Gabriel, Stacey B and Gao, Jianjiong and Gardner, Johanna and Gastier-Foster, Julie M and Gehlenborg, Nils and Gerken, Mark and Gerstein, Mark B and Getz, Gad and Godwin, Andrew K and Gopalan, Anuradha and Graefen, Markus and Graim, Kiley and Gribbin, Thomas and Guin, Ranabir and Gupta, Manaswi and Hadjipanayis, Angela and Haider, Syed and Hamel, Lucie and Hayes, D. Neil and Heiman, David I and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell, ISSN 0092-8674, 11/2015, Volume 163, Issue 4, pp. 1011 - 1025
Journal Article
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 10, pp. 3006 - 3018.e4
Gut mesenchyme provides key stem cell niche signals such as Wnt ligands, but how these signals are regulated is unclear. Because Hedgehog (Hh) signaling is... 
intestinal tumorigenesis | Sufu | Spop | villus formation | mesenchymal proliferation | WNT | GLI2
Journal Article
by Chen, L and Pei, H and Lu, SJ and Liu, ZJ and Yan, L and Zhao, XM and Hu, B and Lu, HG
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 02/2018, Volume 22, Issue 3, pp. 609 - 615
OBJECTIVE: Speckle-type POZ protein (SPOP), is an E3 ubiquitin ligase adaptor that is frequently mutated in prostate and endometrial cancers. SPOP has been... 
TARGET | CELLS | POZ PROTEIN SPOP | UBIQUITIN LIGASE | Invasion | Osteosarcoma | PI3K/Akt/NF-kappa B | PROSTATE-CANCER | SPOP | DEGRADATION | PHARMACOLOGY & PHARMACY | MUTATIONS | TUMORIGENESIS
Journal Article
by Chen, L and Pei, H and Lu, S.-J and Liu, Z.-J and Yan, L and Zhao, X.-M and Hu, B and Lu, H.-G
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2018, Volume 22, Issue 3, pp. 609 - 615
Journal Article
JOURNAL OF THORACIC ONCOLOGY, ISSN 1556-0864, 10/2018, Volume 13, Issue 10, pp. S924 - S924
Conference Proceeding
by Wang, XB and Jin, JL and Wan, FN and Zhao, LL and Chu, HS and Chen, C and Liao, GH and Liu, J and Yu, Y and Teng, HQ and Fang, L and Jiang, C and Pan, WJ and Xie, X and Li, J and Lu, XL and Jiang, XJ and Ge, X and Ye, DW and Wang, P
DEVELOPMENTAL CELL, ISSN 1534-5807, 02/2019, Volume 48, Issue 3, pp. 345 - 345
NANOG is an essential transcriptional factor for the maintenance of embryonic stem cells (ESCs) and cancer stem cells (CSCs) in prostate cancer (PCa). However,... 
UBIQUITINATION | ANDROGEN RECEPTOR | PROTEIN | PATHWAY | PHOSPHORYLATION | WILD-TYPE SPOP | RESISTANCE | PLURIPOTENCY | BRAF | DEVELOPMENTAL BIOLOGY | MUTATIONS | CELL BIOLOGY
Journal Article
Oncogene, ISSN 0950-9232, 8/2017, Volume 36, Issue 33, pp. 4767 - 4777
The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either somatic mutations or... 
SPOP | c-Myc turnover | tumor suppressor | Cullin-3 | CRPC | knockout mouse
Journal Article
Cancer Research, ISSN 0008-5472, 12/2018, Volume 78, Issue 24, pp. 6771 - 6784
Although renal cell carcinoma (RCC) is the most malignant urologic cancer, its pathogenesis remains unclear, and effective treatments for advanced RCC are... 
METASTASIS | TUMOR PROGRESSION | ONCOLOGY | POOR-PROGNOSIS | POZ PROTEIN | SPOP | CANCER STATISTICS | MICRORNAS | EXPRESSION | CELL CARCINOMA | FAMILY
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 02/2019, Volume 17, Issue 2, pp. 446 - 456
Among prostate cancers containing Gleason pattern 4, cribriform morphology is associated with unfavorable clinicopathologic factors, but its genetic features... 
2014 INTERNATIONAL SOCIETY | METHYLATION | ONCOLOGY | BIOPSY | SPOP | ARCHITECTURE | CANCER | ASSOCIATION | INTRADUCTAL CARCINOMA | GLEASON SCORE | PROGRESSION | CELL BIOLOGY
Journal Article