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RSC Advances, ISSN 2046-2069, 2014, Volume 4, Issue 23, pp. 11962 - 11966
A series of forty two adamantyl based cyclohexane diamine derivatives were synthesized and the antibacterial activities of these compounds were assessed... 
ANTITUBERCULAR DRUG | THERAPY | SQ109 | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Cell, ISSN 0092-8674, 01/2019, Volume 176, Issue 3, pp. 636 - 648.e13
Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis (TB), it remains as a major threat to global human health. For this... 
MYCOBACTERIUM-TUBERCULOSIS | ISONIAZID RESISTANCE | MYCOLIC ACID TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTITUBERCULAR DRUG | CATALASE-PEROXIDASE GENE | SQ109 | INHIBITORS | DISCOVERY | INSIGHTS | FAMILY | CELL BIOLOGY | Drugs | Tuberculosis | Crystals | Antitubercular agents | Drug discovery | Structure | Cells | Membrane proteins
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2014, Volume 57, Issue 7, pp. 3126 - 3139
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 10/2019, Volume 63, Issue 10
1H-benzo[d]imidazole derivatives exhibit antitubercular activity in vitro at a nanomolar range of concentrations and are not toxic to human cells, but their... 
TARGET | MYCOLIC ACID TRANSPORTER | MECHANISM | MmpL3 | tuberculosis | DRUG DISCOVERY | MICROBIOLOGY | MEMBRANE TRANSPORTER | SQ109 | Mycobacterium tuberculosis inhibitors | IN-VITRO | CELL-WALL | INHIBITION | GROWTH | benzimidazole | PHARMACOLOGY & PHARMACY | drug resistance
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 10/2019, Volume 63, Issue 10
The Mycobacterium tuberculosis mycolate flippase MmpL3 has been the proposed target for multiple inhibitors with diverse chemical scaffolds. This diversity in... 
MYCOBACTERIUM-TUBERCULOSIS | DRUG | MYCOLIC ACID TRANSPORTER | TREHALOSE MONOMYCOLATE | MECHANISM | cell envelope | MICROBIOLOGY | MEMBRANE TRANSPORTER | antimicrobials | SQ109 | DISCOVERY | mechanisms of resistance | Mycobacterium tuberculosis | GROWTH | GENES | phenotypic screening | PHARMACOLOGY & PHARMACY | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6413 - 6423
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2007, Volume 13, Issue 3, pp. 290 - 294
Journal Article
Medicina Clinica, ISSN 0025-7753, 10/2013, Volume 141, Issue 7, pp. 306 - 313
Drug-resistant tuberculosis is a globally emerging problem with a rising incidence. According to the WHO in 2008, 17% of strains of Mycobacterium tuberculosis,... 
Multidrug-resistant tuberculosis | Oxazolidinone | New drugs | Diarylquinoline | Fluoroquinolone | SQ109 | Nitroimidazole
Journal Article
JOURNAL OF ANTIBIOTICS, ISSN 0021-8820, 10/2019, Volume 72, Issue 10, pp. 719 - 728
The rise of multi- and extensively drug-resistant Mycobacterium tuberculosis (M. tb) strains and co-infection with human immunodeficiency virus has escalated... 
Q203 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ANTITUBERCULAR DRUG | CLINICAL CANDIDATE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | SQ109 | OPPORTUNITIES | FUTURE | IMMUNOLOGY | CHALLENGES | Phenotypic screening | Drug discovery and development | Review
Journal Article