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Publication DatePLoS Genetics, ISSN 1553-7390, 05/2012, Volume 8, Issue 5, p. e1002717
Increasing evidence suggests that chromatin modifications have important roles in modulating constitutive or alternative splicing. Here we demonstrate that the...
CHROMATIN BINDING | GENE | HIV-1 INTEGRASE | IN-VIVO | SR PROTEINS | GENETICS & HEREDITY | MYELOID-LEUKEMIA | TRANSCRIPTIONAL COACTIVATOR P75 | LEDGF/P75 | MAMMALIAN-CELLS | PWWP DOMAIN | Protein Structure, Tertiary | Chromatin - metabolism | RNA-Binding Proteins - genetics | Alternative Splicing - genetics | Gene Expression Regulation | Nuclear Proteins - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Protein Isoforms - metabolism | Adaptor Proteins, Signal Transducing - genetics | Serine-Arginine Splicing Factors | Fibroblasts - cytology | Mice | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Nuclear Proteins - genetics | Chromatin - genetics | 3T3 Cells | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | Physiological aspects | Histones | Genetic aspects | Research | Genetic regulation | RNA splicing | Proteins | Chromatin | Biomedical research | Peptides | Genes | Genetics | Genomes | RNA polymerase | Mass spectrometry | Molecular weight
CHROMATIN BINDING | GENE | HIV-1 INTEGRASE | IN-VIVO | SR PROTEINS | GENETICS & HEREDITY | MYELOID-LEUKEMIA | TRANSCRIPTIONAL COACTIVATOR P75 | LEDGF/P75 | MAMMALIAN-CELLS | PWWP DOMAIN | Protein Structure, Tertiary | Chromatin - metabolism | RNA-Binding Proteins - genetics | Alternative Splicing - genetics | Gene Expression Regulation | Nuclear Proteins - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Protein Isoforms - metabolism | Adaptor Proteins, Signal Transducing - genetics | Serine-Arginine Splicing Factors | Fibroblasts - cytology | Mice | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Nuclear Proteins - genetics | Chromatin - genetics | 3T3 Cells | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | Physiological aspects | Histones | Genetic aspects | Research | Genetic regulation | RNA splicing | Proteins | Chromatin | Biomedical research | Peptides | Genes | Genetics | Genomes | RNA polymerase | Mass spectrometry | Molecular weight
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Loading RightsMolecular and Cellular Proteomics, ISSN 1535-9476, 11/2013, Volume 12, Issue 11, pp. 3184 - 3198
Protein-protein interactions can be modulated by the methylation of arginine residues. As a means of testing this, we recently described a conditional...
RNA-POLYMERASE-II | MESSENGER-RNA | BUDDING YEAST | HUB PROTEINS | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | INTERACTION MAP | SACCHAROMYCES-CEREVISIAE | SR-LIKE PROTEIN | MASS-SPECTROMETRY | POSTTRANSLATIONAL MODIFICATION | Adaptor Proteins, Signal Transducing - chemistry | Ribonucleoprotein, U1 Small Nuclear - metabolism | RNA-Binding Proteins - genetics | Proteome - genetics | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Substrate Specificity | Proteome - chemistry | Protein Interaction Maps | Saccharomyces cerevisiae - metabolism | Tandem Mass Spectrometry | Ribonucleoprotein, U1 Small Nuclear - chemistry | Chromatography, Liquid | Protein-Arginine N-Methyltransferases - genetics | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | DEAD-box RNA Helicases - chemistry | Protein-Arginine N-Methyltransferases - chemistry | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Repressor Proteins - chemistry | RNA-Binding Proteins - chemistry | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Ribonucleoprotein, U1 Small Nuclear - genetics | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Blotting, Western | Arginine - chemistry | Protein-Arginine N-Methyltransferases - metabolism | DEAD-box RNA Helicases - genetics | Two-Hybrid System Techniques | Adaptor Proteins, Signal Transducing - genetics | Proteomics | Saccharomyces cerevisiae Proteins - metabolism | Protein Processing, Post-Translational | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Proteome - metabolism | Arginine - metabolism | RNA-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Research
RNA-POLYMERASE-II | MESSENGER-RNA | BUDDING YEAST | HUB PROTEINS | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | INTERACTION MAP | SACCHAROMYCES-CEREVISIAE | SR-LIKE PROTEIN | MASS-SPECTROMETRY | POSTTRANSLATIONAL MODIFICATION | Adaptor Proteins, Signal Transducing - chemistry | Ribonucleoprotein, U1 Small Nuclear - metabolism | RNA-Binding Proteins - genetics | Proteome - genetics | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Substrate Specificity | Proteome - chemistry | Protein Interaction Maps | Saccharomyces cerevisiae - metabolism | Tandem Mass Spectrometry | Ribonucleoprotein, U1 Small Nuclear - chemistry | Chromatography, Liquid | Protein-Arginine N-Methyltransferases - genetics | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | DEAD-box RNA Helicases - chemistry | Protein-Arginine N-Methyltransferases - chemistry | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Repressor Proteins - chemistry | RNA-Binding Proteins - chemistry | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Ribonucleoprotein, U1 Small Nuclear - genetics | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Blotting, Western | Arginine - chemistry | Protein-Arginine N-Methyltransferases - metabolism | DEAD-box RNA Helicases - genetics | Two-Hybrid System Techniques | Adaptor Proteins, Signal Transducing - genetics | Proteomics | Saccharomyces cerevisiae Proteins - metabolism | Protein Processing, Post-Translational | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Proteome - metabolism | Arginine - metabolism | RNA-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Research
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Loading RightsScientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35195
FUS (Fused-in-Sarcoma) is a multifunctional DNA/RNA binding protein linked to familial amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). Since...
MOTOR-NEURONS | ANDROGEN RECEPTOR | RNA | GENE | DNA | MULTIDISCIPLINARY SCIENCES | SR PROTEINS | ALS | MOLECULAR-CLONING | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | Chromatin - metabolism | RNA-Binding Proteins - genetics | Receptors, Estrogen - metabolism | Spinal Cord - metabolism | Alternative Splicing | Humans | Male | Brain - metabolism | RNA-Binding Protein FUS - chemistry | HEK293 Cells | Transcription, Genetic | Protein Interaction Domains and Motifs | Amyotrophic Lateral Sclerosis - etiology | Protein Aggregation, Pathological - genetics | Nuclear Matrix - metabolism | Cell Line | Receptors, Estrogen - genetics | Matrix Attachment Region Binding Proteins - chemistry | Matrix Attachment Region Binding Proteins - metabolism | Amyotrophic Lateral Sclerosis - genetics | Mice, Inbred C57BL | RNA-Binding Proteins - chemistry | Mutant Proteins - genetics | Nuclear Matrix-Associated Proteins - metabolism | RNA-Binding Protein FUS - genetics | Mutant Proteins - metabolism | RNA-Binding Protein FUS - metabolism | Two-Hybrid System Techniques | Animals | Receptors, Estrogen - chemistry | Nuclear Matrix-Associated Proteins - genetics | Matrix Attachment Region Binding Proteins - genetics | Mutant Proteins - chemistry | Amyotrophic Lateral Sclerosis - metabolism | Ligands | Mice | Nuclear Matrix-Associated Proteins - chemistry | Protein Aggregation, Pathological - metabolism | RNA-Binding Proteins - metabolism | Chromatin | Transcription | Sarcoma | Splicing | Pathogenesis | Amyotrophic lateral sclerosis | Ribonucleic acid--RNA | Nuclei | SAP protein | Proteins | FUS protein | RNA-binding protein | Dementia disorders | Frontotemporal dementia | Localization | Deoxyribonucleic acid--DNA
MOTOR-NEURONS | ANDROGEN RECEPTOR | RNA | GENE | DNA | MULTIDISCIPLINARY SCIENCES | SR PROTEINS | ALS | MOLECULAR-CLONING | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | Chromatin - metabolism | RNA-Binding Proteins - genetics | Receptors, Estrogen - metabolism | Spinal Cord - metabolism | Alternative Splicing | Humans | Male | Brain - metabolism | RNA-Binding Protein FUS - chemistry | HEK293 Cells | Transcription, Genetic | Protein Interaction Domains and Motifs | Amyotrophic Lateral Sclerosis - etiology | Protein Aggregation, Pathological - genetics | Nuclear Matrix - metabolism | Cell Line | Receptors, Estrogen - genetics | Matrix Attachment Region Binding Proteins - chemistry | Matrix Attachment Region Binding Proteins - metabolism | Amyotrophic Lateral Sclerosis - genetics | Mice, Inbred C57BL | RNA-Binding Proteins - chemistry | Mutant Proteins - genetics | Nuclear Matrix-Associated Proteins - metabolism | RNA-Binding Protein FUS - genetics | Mutant Proteins - metabolism | RNA-Binding Protein FUS - metabolism | Two-Hybrid System Techniques | Animals | Receptors, Estrogen - chemistry | Nuclear Matrix-Associated Proteins - genetics | Matrix Attachment Region Binding Proteins - genetics | Mutant Proteins - chemistry | Amyotrophic Lateral Sclerosis - metabolism | Ligands | Mice | Nuclear Matrix-Associated Proteins - chemistry | Protein Aggregation, Pathological - metabolism | RNA-Binding Proteins - metabolism | Chromatin | Transcription | Sarcoma | Splicing | Pathogenesis | Amyotrophic lateral sclerosis | Ribonucleic acid--RNA | Nuclei | SAP protein | Proteins | FUS protein | RNA-binding protein | Dementia disorders | Frontotemporal dementia | Localization | Deoxyribonucleic acid--DNA
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Loading RightsThe FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2482 - 2500
Scaffold attachment factor B1 ( SAFB 1) is an integral component of the nuclear matrix of vertebrate cells. It binds to DNA on scaffold/matrix attachment...
ERH | nuclear matrix | SAFB | SRPK | protein | SR protein | SRPK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | TRANSCRIPTION | RECEPTOR | HET/SAF-B | IDENTIFICATION | BREAST-CANCER | DNA | SAF-B | HISTONE DEACETYLASE | Phosphorylation | Receptors, Estrogen - metabolism | Transcription Factors - chemistry | Humans | Protein Multimerization | Green Fluorescent Proteins - genetics | Serine-Arginine Splicing Factors - metabolism | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | RNA Interference | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Serine-Arginine Splicing Factors - chemistry | Cell Cycle Proteins - genetics | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Peptide Fragments - genetics | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Green Fluorescent Proteins - metabolism | Peptide Fragments - metabolism | Receptors, Estrogen - genetics | Matrix Attachment Region Binding Proteins - chemistry | Matrix Attachment Region Binding Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Matrix-Associated Proteins - metabolism | Rats | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Peptide Fragments - chemistry | Animals | Receptors, Estrogen - chemistry | Nuclear Matrix-Associated Proteins - genetics | Matrix Attachment Region Binding Proteins - genetics | Cell Line, Tumor | Protein Processing, Post-Translational | Protein-Serine-Threonine Kinases - chemistry | Nuclear Matrix-Associated Proteins - chemistry | Microscopy, Fluorescence | Proteins | Transcription | Splicing | Ordination | DNA damage | Homology | Attachment | C-Terminus | Kinases | Ribonucleic acid--RNA | Nuclei | DNA repair | Substrates | Repressors | Protein kinase | Cellular structure | Deoxyribonucleic acid--DNA
ERH | nuclear matrix | SAFB | SRPK | protein | SR protein | SRPK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | TRANSCRIPTION | RECEPTOR | HET/SAF-B | IDENTIFICATION | BREAST-CANCER | DNA | SAF-B | HISTONE DEACETYLASE | Phosphorylation | Receptors, Estrogen - metabolism | Transcription Factors - chemistry | Humans | Protein Multimerization | Green Fluorescent Proteins - genetics | Serine-Arginine Splicing Factors - metabolism | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | RNA Interference | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Serine-Arginine Splicing Factors - chemistry | Cell Cycle Proteins - genetics | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Peptide Fragments - genetics | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Green Fluorescent Proteins - metabolism | Peptide Fragments - metabolism | Receptors, Estrogen - genetics | Matrix Attachment Region Binding Proteins - chemistry | Matrix Attachment Region Binding Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Matrix-Associated Proteins - metabolism | Rats | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Peptide Fragments - chemistry | Animals | Receptors, Estrogen - chemistry | Nuclear Matrix-Associated Proteins - genetics | Matrix Attachment Region Binding Proteins - genetics | Cell Line, Tumor | Protein Processing, Post-Translational | Protein-Serine-Threonine Kinases - chemistry | Nuclear Matrix-Associated Proteins - chemistry | Microscopy, Fluorescence | Proteins | Transcription | Splicing | Ordination | DNA damage | Homology | Attachment | C-Terminus | Kinases | Ribonucleic acid--RNA | Nuclei | DNA repair | Substrates | Repressors | Protein kinase | Cellular structure | Deoxyribonucleic acid--DNA
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Loading RightsHuman Molecular Genetics, ISSN 0964-6906, 12/2007, Volume 16, Issue 24, pp. 3149 - 3159
Homozygous deletion or mutation of the survival of motor neuron 1 gene (SMN1) causes spinal muscular atrophy. SMN1 has been duplicated in humans to create...
RNA-BINDING | MISSENSE | SPINAL MUSCULAR-ATROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARFAN-SYNDROME | SR PROTEINS | GENETICS & HEREDITY | FIBRILLIN-1 GENE | ENHANCER | INCLUSION | NONSENSE MUTATION | SINGLE NUCLEOTIDE | RNA-Binding Proteins - genetics | Exons | Humans | Genetic Diseases, Inborn - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - physiology | Substrate Specificity | RNA, Messenger - metabolism | Repressor Proteins - physiology | Genes, BRCA1 | Nuclear Proteins - genetics | Binding Sites | Microfilament Proteins - genetics | Repressor Proteins - metabolism | Survival of Motor Neuron 1 Protein | RNA-Binding Proteins - physiology | Survival of Motor Neuron 2 Protein | RNA, Small Interfering - pharmacology | Cells, Cultured | Fibrillins | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | SMN Complex Proteins | Nerve Tissue Proteins - genetics | Heterogeneous Nuclear Ribonucleoprotein A1 | Nerve Tissue Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Point Mutation | Alternative Splicing - drug effects | Regulatory Elements, Transcriptional | Cyclic AMP Response Element-Binding Protein - metabolism | Serine-Arginine Splicing Factors | Protein Binding | Nuclear Proteins - physiology | HeLa Cells | RNA-Binding Proteins - metabolism
RNA-BINDING | MISSENSE | SPINAL MUSCULAR-ATROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARFAN-SYNDROME | SR PROTEINS | GENETICS & HEREDITY | FIBRILLIN-1 GENE | ENHANCER | INCLUSION | NONSENSE MUTATION | SINGLE NUCLEOTIDE | RNA-Binding Proteins - genetics | Exons | Humans | Genetic Diseases, Inborn - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - physiology | Substrate Specificity | RNA, Messenger - metabolism | Repressor Proteins - physiology | Genes, BRCA1 | Nuclear Proteins - genetics | Binding Sites | Microfilament Proteins - genetics | Repressor Proteins - metabolism | Survival of Motor Neuron 1 Protein | RNA-Binding Proteins - physiology | Survival of Motor Neuron 2 Protein | RNA, Small Interfering - pharmacology | Cells, Cultured | Fibrillins | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | SMN Complex Proteins | Nerve Tissue Proteins - genetics | Heterogeneous Nuclear Ribonucleoprotein A1 | Nerve Tissue Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Point Mutation | Alternative Splicing - drug effects | Regulatory Elements, Transcriptional | Cyclic AMP Response Element-Binding Protein - metabolism | Serine-Arginine Splicing Factors | Protein Binding | Nuclear Proteins - physiology | HeLa Cells | RNA-Binding Proteins - metabolism
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Loading RightsTrends in Plant Science, ISSN 1360-1385, 04/2018, Volume 23, Issue 4, pp. 352 - 365
Research into the regulation of gene expression underwent a shift from focusing on DNA-binding proteins as key transcriptional regulators to RNA-binding...
crosslinking and immunoprecipitation | RNA-binding protein | post-transcriptional regulation | RNA immunoprecipitation | HITS-CLIP | SPLICING-REGULATORY NETWORK | SHOCK DOMAIN PROTEINS | ARABIDOPSIS-THALIANA | BINDING PROTEINS | HNRNP-LIKE PROTEIN | FLUORESCENCE CORRELATION SPECTROSCOPY | SR-LIKE PROTEIN | TRANSCRIPTOME-WIDE IDENTIFICATION | PRE-MESSENGER-RNA | PLANT SCIENCES | RNA-Binding Proteins - genetics | Arabidopsis - physiology | Arabidopsis Proteins - genetics | DNA-Binding Proteins - physiology | Cold Shock Proteins and Peptides - metabolism | Cold Shock Proteins and Peptides - genetics | Transcriptome | RNA, Plant - genetics | DNA-Binding Proteins - genetics | RNA, Plant - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Plants - metabolism | Plants - genetics | RNA, Plant - physiology | RNA-Binding Proteins - metabolism
crosslinking and immunoprecipitation | RNA-binding protein | post-transcriptional regulation | RNA immunoprecipitation | HITS-CLIP | SPLICING-REGULATORY NETWORK | SHOCK DOMAIN PROTEINS | ARABIDOPSIS-THALIANA | BINDING PROTEINS | HNRNP-LIKE PROTEIN | FLUORESCENCE CORRELATION SPECTROSCOPY | SR-LIKE PROTEIN | TRANSCRIPTOME-WIDE IDENTIFICATION | PRE-MESSENGER-RNA | PLANT SCIENCES | RNA-Binding Proteins - genetics | Arabidopsis - physiology | Arabidopsis Proteins - genetics | DNA-Binding Proteins - physiology | Cold Shock Proteins and Peptides - metabolism | Cold Shock Proteins and Peptides - genetics | Transcriptome | RNA, Plant - genetics | DNA-Binding Proteins - genetics | RNA, Plant - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Plants - metabolism | Plants - genetics | RNA, Plant - physiology | RNA-Binding Proteins - metabolism
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Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence
Molecular Cell, ISSN 1097-2765, 04/2013, Volume 50, Issue 1, pp. 56 - 66
Splicing and translation are highly regulated steps of gene expression. Altered expression of proteins involved in these processes can be deleterious....
APOPTOSIS | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SR PROTEINS | TRANSCRIPTION | GENE-EXPRESSION | ONCOGENE-INDUCED SENESCENCE | RIBOSOMAL-PROTEIN L11 | TRANSLATION | FACTOR SF2/ASF | CELL BIOLOGY | RNA-Binding Proteins - genetics | Tumor Suppressor Proteins - metabolism | Cell Proliferation | Signal Transduction | Humans | Stress, Physiological | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Ribosomal Proteins - metabolism | Ribosomes - enzymology | Cell Cycle Checkpoints | Transfection | Cellular Senescence | Serine-Arginine Splicing Factors | Protein Binding | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | RNA-Binding Proteins - metabolism | Physiological aspects | Tumor proteins | Gene expression
APOPTOSIS | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SR PROTEINS | TRANSCRIPTION | GENE-EXPRESSION | ONCOGENE-INDUCED SENESCENCE | RIBOSOMAL-PROTEIN L11 | TRANSLATION | FACTOR SF2/ASF | CELL BIOLOGY | RNA-Binding Proteins - genetics | Tumor Suppressor Proteins - metabolism | Cell Proliferation | Signal Transduction | Humans | Stress, Physiological | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Ribosomal Proteins - metabolism | Ribosomes - enzymology | Cell Cycle Checkpoints | Transfection | Cellular Senescence | Serine-Arginine Splicing Factors | Protein Binding | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | RNA-Binding Proteins - metabolism | Physiological aspects | Tumor proteins | Gene expression
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 46, pp. 33361 - 33375
The intracellular Ca(2+) signaling pathway is important for the control of broad cellular processes from fertilization to cell death. ALG-2 is a Ca(2+)-binding...
Phosphorylation - physiology | RNA-Binding Proteins - genetics | Calcium - metabolism | Calcium Signaling - physiology | Humans | RNA Polymerase II - metabolism | Inositol 1,4,5-Trisphosphate Receptors - biosynthesis | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Apoptosis Regulatory Proteins - genetics | RNA Precursors - metabolism | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Membrane Proteins - genetics | Alternative Splicing - physiology | RNA Precursors - genetics | DNA-Binding Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Cell Nucleus - genetics | RNA Polymerase II - genetics | HeLa Cells | Inositol 1,4,5-Trisphosphate Receptors - genetics | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | Index Medicus | Alternative Splicing | Calcium | Subcellular Organelles | Calcium-binding Proteins | SR Proteins | Nuclear Speckles | RNA Polymerase II | Calcium Signaling | Cell Biology | Protein-Protein Interactions
Phosphorylation - physiology | RNA-Binding Proteins - genetics | Calcium - metabolism | Calcium Signaling - physiology | Humans | RNA Polymerase II - metabolism | Inositol 1,4,5-Trisphosphate Receptors - biosynthesis | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Apoptosis Regulatory Proteins - genetics | RNA Precursors - metabolism | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Membrane Proteins - genetics | Alternative Splicing - physiology | RNA Precursors - genetics | DNA-Binding Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Cell Nucleus - genetics | RNA Polymerase II - genetics | HeLa Cells | Inositol 1,4,5-Trisphosphate Receptors - genetics | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | Index Medicus | Alternative Splicing | Calcium | Subcellular Organelles | Calcium-binding Proteins | SR Proteins | Nuclear Speckles | RNA Polymerase II | Calcium Signaling | Cell Biology | Protein-Protein Interactions
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Loading RightsMolecular Cell, ISSN 1097-2765, 04/2008, Volume 30, Issue 2, pp. 179 - 189
The SR protein SF2/ASF has been initially characterized as a splicing factor but has also been shown to mediate postsplicing activities such as mRNA export and...
RNA | MESSENGER-RNA TRANSLATION | SR PROTEIN FUNCTIONS | DROSOPHILA CUP | FACTOR ASF/SF2 | CAP-DEPENDENT TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | GENE-EXPRESSION | S6 KINASE | REPRESSOR | RIBOSOMAL-SUBUNIT | CELL BIOLOGY | Protein Kinases - metabolism | Recombinant Proteins - metabolism | RNA, Small Interfering - genetics | Catalytic Domain | Phosphorylation | Humans | RNA, Small Interfering - pharmacology | Cytoplasm - metabolism | Nuclear Proteins - metabolism | Peptide Chain Initiation, Translational | Recombinant Proteins - genetics | RNA-Binding Proteins | Phosphoproteins - metabolism | RNA Caps - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Serine-Arginine Splicing Factors | Cell Extracts | TOR Serine-Threonine Kinases | Adaptor Proteins, Signal Transducing - metabolism | Nuclear Proteins - genetics | Binding proteins | Genetic translation | Protein binding
RNA | MESSENGER-RNA TRANSLATION | SR PROTEIN FUNCTIONS | DROSOPHILA CUP | FACTOR ASF/SF2 | CAP-DEPENDENT TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | GENE-EXPRESSION | S6 KINASE | REPRESSOR | RIBOSOMAL-SUBUNIT | CELL BIOLOGY | Protein Kinases - metabolism | Recombinant Proteins - metabolism | RNA, Small Interfering - genetics | Catalytic Domain | Phosphorylation | Humans | RNA, Small Interfering - pharmacology | Cytoplasm - metabolism | Nuclear Proteins - metabolism | Peptide Chain Initiation, Translational | Recombinant Proteins - genetics | RNA-Binding Proteins | Phosphoproteins - metabolism | RNA Caps - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Serine-Arginine Splicing Factors | Cell Extracts | TOR Serine-Threonine Kinases | Adaptor Proteins, Signal Transducing - metabolism | Nuclear Proteins - genetics | Binding proteins | Genetic translation | Protein binding
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Loading RightsMolecular Cell, ISSN 1097-2765, 01/2015, Volume 57, Issue 1, pp. 23 - 38
Alternative splicing of Fas/CD95 exon 6 generates either a membrane-bound receptor that promotes, or a soluble isoform that inhibits, apoptosis. Using an...
PYRUVATE-KINASE | RNA | GENE | PATHWAY | PROTEOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | SR PROTEINS | SPLICEOSOME | TOPOISOMERASE-I | ISOFORM | BINDING | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Spliceosomes - chemistry | Alternative Splicing | Apoptosis - drug effects | Exons | Humans | Homeostasis | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Gene Regulatory Networks | fas Receptor - metabolism | Spliceosomes - metabolism | Protein Isoforms - metabolism | Mitochondrial Proteins - metabolism | fas Receptor - genetics | Iron - pharmacology | Nuclear Proteins - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Deferoxamine - pharmacology | Genome-Wide Association Study | Introns | Molecular Sequence Annotation | fas Receptor - antagonists & inhibitors | Nuclear Proteins - metabolism | Iron - metabolism | Iron Chelating Agents - pharmacology | Serine-Arginine Splicing Factors | Protein Binding | Cell Proliferation - drug effects | HeLa Cells | Genome | Protein Isoforms - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Spliceosomes - drug effects | Genomics | Cells
PYRUVATE-KINASE | RNA | GENE | PATHWAY | PROTEOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | SR PROTEINS | SPLICEOSOME | TOPOISOMERASE-I | ISOFORM | BINDING | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Spliceosomes - chemistry | Alternative Splicing | Apoptosis - drug effects | Exons | Humans | Homeostasis | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Gene Regulatory Networks | fas Receptor - metabolism | Spliceosomes - metabolism | Protein Isoforms - metabolism | Mitochondrial Proteins - metabolism | fas Receptor - genetics | Iron - pharmacology | Nuclear Proteins - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Deferoxamine - pharmacology | Genome-Wide Association Study | Introns | Molecular Sequence Annotation | fas Receptor - antagonists & inhibitors | Nuclear Proteins - metabolism | Iron - metabolism | Iron Chelating Agents - pharmacology | Serine-Arginine Splicing Factors | Protein Binding | Cell Proliferation - drug effects | HeLa Cells | Genome | Protein Isoforms - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Spliceosomes - drug effects | Genomics | Cells
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Loading RightsNature Reviews Genetics, ISSN 1471-0056, 10/2014, Volume 15, Issue 10, pp. 689 - 701
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative splicing, but it is not yet possible to read the 'splicing code' that...
HITS-CLIP | CELL-FREE FORMATION | SR PROTEIN | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | EXON DEFINITION | PRE-MESSENGER-RNAS | REGULATORY NETWORK | COMBINATORIAL CONTROL | SECONDARY STRUCTURE | HNRNP-L | Organ Specificity - genetics | Animals | Alternative Splicing | RNA-Binding Proteins - physiology | Humans | Regulatory Elements, Transcriptional - physiology | Protein Binding | Binding Sites - genetics | Cellular Microenvironment - genetics | Genetic research | Research | Binding proteins | Properties | RNA splicing
HITS-CLIP | CELL-FREE FORMATION | SR PROTEIN | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | EXON DEFINITION | PRE-MESSENGER-RNAS | REGULATORY NETWORK | COMBINATORIAL CONTROL | SECONDARY STRUCTURE | HNRNP-L | Organ Specificity - genetics | Animals | Alternative Splicing | RNA-Binding Proteins - physiology | Humans | Regulatory Elements, Transcriptional - physiology | Protein Binding | Binding Sites - genetics | Cellular Microenvironment - genetics | Genetic research | Research | Binding proteins | Properties | RNA splicing
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