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srebp-1c (351) 351
index medicus (261) 261
animals (255) 255
mice (194) 194
biochemistry & molecular biology (151) 151
humans (146) 146
liver (134) 134
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sterol regulatory element binding protein 1 - metabolism (113) 113
liver - metabolism (106) 106
insulin (99) 99
sterol regulatory element binding protein 1 - genetics (99) 99
gene-expression (98) 98
fatty acids (97) 97
lipogenesis (95) 95
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lipids (91) 91
metabolism (91) 91
expression (89) 89
gene expression (84) 84
rats (84) 84
insulin resistance (76) 76
cholesterol (73) 73
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glucose (69) 69
mice, inbred c57bl (66) 66
physiological aspects (66) 66
hepatic steatosis (65) 65
protein binding (65) 65
cell biology (64) 64
endocrinology & metabolism (61) 61
lipid metabolism (61) 61
proteins (59) 59
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steatosis (49) 49
synthesis (49) 49
liver diseases (48) 48
triglycerides (48) 48
activation (47) 47
gene expression regulation (47) 47
hepatocytes - metabolism (47) 47
transcription (47) 47
female (46) 46
liver - drug effects (46) 46
transcription factors (46) 46
cells, cultured (45) 45
sterol regulatory element-binding protein (45) 45
fatty-acid synthesis (41) 41
pharmacology & pharmacy (41) 41
rodents (41) 41
signal transduction (40) 40
metabolic syndrome (39) 39
research (39) 39
medicine, research & experimental (37) 37
rna, messenger - metabolism (37) 37
sterol regulatory element binding protein 1 (37) 37
insulin - metabolism (36) 36
lipid-metabolism (36) 36
phosphorylation (36) 36
diet (35) 35
biophysics (34) 34
liver - pathology (34) 34
analysis (33) 33
cell line (33) 33
element-binding protein-1c (33) 33
fatty liver-disease (33) 33
rats, sprague-dawley (33) 33
research article (33) 33
transcription factors - metabolism (33) 33
transgenic mice (33) 33
triglycerides - metabolism (33) 33
gene expression regulation - drug effects (32) 32
glucose - metabolism (32) 32
lxr (32) 32
ampk (31) 31
fatty liver - metabolism (31) 31
genes (31) 31
cells (30) 30
dna-binding proteins - metabolism (29) 29
hep g2 cells (29) 29
oxidative stress (29) 29
physiology (29) 29
diabetes (28) 28
gene (28) 28
hepatocytes - drug effects (28) 28
lipid metabolism - drug effects (28) 28
liver-disease (28) 28
promoter regions, genetic (28) 28
rna, messenger - genetics (28) 28
diabetes-mellitus (27) 27
food science & technology (27) 27
genetic aspects (27) 27
hepatocytes (27) 27
inflammation (27) 27
nonalcoholic steatohepatitis (27) 27
disease (26) 26
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Journal of Cell Science, ISSN 0021-9533, 09/2005, Volume 118, Issue 17, pp. 3905 - 3915
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2018, Volume 499, Issue 1, pp. 66 - 70
Non-alcoholic fatty liver disease and steatohepatitis (NAFLD and NASH) account for the majority of liver disease in industrialized countries. However, the... 
LncARSR | NASH | Lipogensis | SREBP-1c. Akt/mTOR
Journal Article
Journal of Clinical Biochemistry and Nutrition, ISSN 0912-0009, 2017, Volume 61, Issue 2, pp. 85 - 90
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 12/2019, Volume 1864, Issue 12, p. 158521
Although SREBP-1c regulates key enzymes required for hepatic lipogenesis, the mechanisms underlying transcriptional regulation of SREBP-1c in pathogenesis of... 
CB1 receptor | Alcoholic fatty liver | SREBP-1c | Gene regulation | Hepatic lipogenesis | ERRγ
Journal Article
Journal of Clinical Biochemistry and Nutrition, ISSN 0912-0009, 2017
Soy isoflavone has benefits for metabolic syndrome but the mechanism is not completely understood. This study was designed to determine the effects of soy... 
NAFLD | soy isoflavone | PPARα | steatosis | SREBP-1c
Journal Article
JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN 0022-202X, 05/2008, Volume 128, Issue 5, pp. 1286 - 1293
Understanding the factors that regulate sebum production is important in identifying therapeutic targets for acne therapy. Insulin and IGF-1 stimulate... 
CELLS | SEBACEOUS GLANDS | ADD1/SREBP-1C | CHOLESTEROL | ELEMENT-BINDING PROTEIN-1 | ENZYMES | TRANSCRIPTION | INVOLVEMENT | GENE-EXPRESSION | MAP | DERMATOLOGY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2019, Volume 513, Issue 2, pp. 509 - 514
Abnormal liver lipid metabolism results in a series of liver diseases and contributes to tumourigenesis. The expression and activity of Cytochrome P450 1A2... 
PTEN | Alcohol | Lipid metabolism | SREBP-1c | CYP1A2 | ACTIVATION | INHIBITION | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED FATTY LIVER | STEATOHEPATITIS | PROGRESSION
Journal Article
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 09/2019, Volume 33, Issue 9, pp. 10077 - 10088
Bone morphogenetic protein ( )-9 has been reported to regulate energy balance . However, the mechanisms underlying -mediated regulation of energy balance... 
cytokine | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN | BMP9 | INSULIN SENSITIVITY | SREBP-1C | CELL BIOLOGY | BMP-9 | BIOLOGY | metabolism | DIFFERENTIATION | PROMOTER | insulin resistance | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
by Zhang, M and Chi, XM and Qu, N and Wang, CY
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 04/2018, Volume 499, Issue 1, pp. 66 - 70
Non-alcoholic fatty liver disease and steatohepatitis (NAFLD and NASH) account for the majority of liver disease in industrialized countries. However, the... 
LncARSR | HEPATOCELLULAR-CARCINOMA | LIPID-METABOLISM | BIOPHYSICS | Lipogensis | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | RESISTANCE | MICE | NASH | TRIGLYCERIDE CONTENT | SREBP-1c. Akt/mTOR
Journal Article
Experimental Cell Research, ISSN 0014-4827, 07/2019, Volume 380, Issue 1, pp. 1 - 8
Islet stellate cells (ISCs) activation is mainly associated with islet fibrosis, which contributes to the progression of type 2 diabetes. However, the... 
β cell | Lipid metabolism | Islet stellate cell | Lipotoxicity | SREBP-1c | FIBROSIS | beta cell | RATS | FATTY-ACIDS | IDENTIFICATION | CELL BIOLOGY | OBESITY | ONCOLOGY | STRESS | IMMUNOHISTOCHEMISTRY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2008, Volume 283, Issue 26, pp. 18411 - 18421
Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid receptor-related orphan receptor alpha (ROR alpha) expression. We observed... 
SKELETAL-MUSCLE | SREBP-1C PROMOTER | GLUCOSE-METABOLISM | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | FATTY-ACID SYNTHASE | MUTANT MOUSE | DEFICIENT MICE | TRANSCRIPTIONAL REGULATION | LIVER-X-RECEPTOR
Journal Article
EXPERIMENTAL BIOLOGY AND MEDICINE, ISSN 1535-3702, 05/2007, Volume 232, Issue 5, pp. 614 - 621
We investigated the effect of tumor necrosis factor-alpha (TNF-alpha), a member of the proinflammatory cytokine family, on steatosis of the mouse liver by... 
MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | FATTY-ACID SYNTHESIS | CHOLESTEROL | TNF-alpha | liver | RECEPTOR | NONALCOHOLIC STEATOHEPATITIS | MECHANISMS | SREBP-1c | LPS | TUMOR-NECROSIS-FACTOR | INSULIN-RESISTANCE | IN-VIVO | ADIPOSE-TISSUE
Journal Article
Hepatology Research, ISSN 1386-6346, 11/2008, Volume 38, Issue 11, pp. 1122 - 1129
Aim:  Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver dysfunction and its incidence has increased markedly. However, the... 
ACC | FAS | ChREBP | NAFLD | SREBP‐1c | LXR | SREBP-1c | CHOLESTEROL | NUCLEAR RECEPTORS | ELEMENT-BINDING PROTEIN-1C | KINASE | CARBOHYDRATE | INSULIN | GLUCOSE-METABOLISM | LIPOGENIC GENES | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2016, Volume 788, pp. 306 - 314
Journal Article
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