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EMBO reports, ISSN 1469-221X, 08/2017, Volume 18, Issue 8, pp. 1331 - 1351
Journal Article
Cancer research, ISSN 0008-5472, 3/2017, Volume 77, Issue 5, pp. 1155 - 1167
Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA... 
Alternative splicing | MALAT1 | Oncogene | SRSF1 | S6K1
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 12/2019, Volume 1866, Issue 12, p. 118550
Alternative splicing (AS) constitutes a pivotal mechanism for expanding the transcriptome and proteome diversity in higher eukaryotes. In contrast,... 
Alternative splicing | RBM4 | HIF-1α | A549 | SRSF1
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 09/2015, Volume 15, Issue 10, pp. 593 - 607
Journal Article
by Liu, Y and Zhang, YM and Ma, FB and Pan, SR and Liu, BZ
WORLD JOURNAL OF GASTROENTEROLOGY, ISSN 1007-9327, 06/2019, Volume 25, Issue 22, pp. 2763 - 2775
BACKGROUND Gastric cancer (GC) is the fourth most frequent malignancy all over the world. The diagnosis of GC is challenging and the prognosis of GC is very... 
DIAGNOSIS | Biomarker | PROGNOSIS | SRSF1 | HOXA11-AS | Long noncoding RNA | GASTROENTEROLOGY & HEPATOLOGY | Gastric cancer | Basic Study
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2014, Volume 457, Issue 2, pp. 231 - 242
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events... 
Cap-binding complex (CBC) | 7-methylguanosine cap (7mG) | Translation | Splicing | Transcription | U-SNRNA EXPORT | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | PRE-MESSENGER-RNA | PROTEIN COMPLEX | POLYMERASE-II CTD | NONSENSE-MEDIATED DECAY | XENOPUS OOCYTE NUCLEI | translation | CARBOXYL-TERMINAL DOMAIN | CAPPING ENZYME | splicing | TRANSLATION INITIATION-FACTOR | cap-binding complex (CBC) | Guanosine - analogs & derivatives | Nuclear Cap-Binding Protein Complex - chemistry | Humans | RNA, Messenger - genetics | Gene Expression Regulation | RNA Cap-Binding Proteins - chemistry | Guanosine - genetics | Signal Transduction - genetics | Guanosine - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Nuclear Cap-Binding Protein Complex - genetics | Nuclear Cap-Binding Protein Complex - metabolism | RNA Cap-Binding Proteins - metabolism | RNA Cap-Binding Proteins - genetics | Animals | Guanosine - chemistry | RNA Caps - chemistry | RNA Caps - genetics | SRSF1, serine | TREX, transcription export complex | PHAX, phosphorylated adaptor of RNA export | hnRNP, heterogeneous nuclear ribonucleoprotein | PARN, poly(A)-specific ribonuclease | Review | ABA, abscisic acid | CBC, cap-binding complex | arginine-rich splicing factor 1 | NMD, nonsense-mediated decay | RNMT, RNA (guanine-7-)methyltransferase | MIF4G, middle domain of eIF4G | 7mG, 7-methylguanosine cap | RRM, RNA-recognition motif | CTIF, CBC-dependent translation initiation factor | P-TEFb, positive transcription elongation factor b | Cbp, cap-binding protein | NELF, negative elongation factor | RAM, RNMT-activating mini-protein | eIF, eukaryotic initiation factor | Cdk9, cyclin-dependent kinase 9 | CF IA, cleavage factor IA | PTC, premature termination codon | TMG, 2,2,7-trimethylguanosine cap | Ars2, arsenite-resistance protein 2 | CTD, C-terminal domain | DSIF, DRB sensitivity-inducing factor | mTORC1, mammalian target of rapamycin complex 1 | snRNP, small nuclear ribonucleoprotein | PABP, poly(A)-binding protein | mRNP, messenger ribonucleoprotein | RNA pol II, RNA polymerase II
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 07/2019, Volume 216, Issue 7, pp. 1509 - 1524
The oncogenic c-MYC (MYC) transcription factor has broad effects on gene expression and cell behavior. We show that MYC alters the efficiency and quality of... 
SPLICING FACTOR SRSF1 | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLISM | TRANSCRIPTION | GENE-EXPRESSION | RIBOSOMAL DNA | CELL-PROLIFERATION | SF2/ASF | IMMUNOLOGY | PROTEIN-SYNTHESIS | REVEALS
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7558, pp. 96 - 100
Journal Article
Cancer Science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 3805 - 3815
Serine/arginine‐rich splicing factor 1 ( SRSF 1) has been linked to various human cancers including pediatric acute lymphoblastic leukemia ( ALL ). Our... 
tyrosine phosphorylation | childhood | SRSF | Tie2 kinase | acute lymphoblastic leukemia | splicing factor | splicing factor SRSF1 | FACTOR ASF/SF2 | BONE-MARROW | KINASE | SRSF1 | TRANSLATION INITIATION | FACTOR SF2/ASF | PRE-MESSENGER-RNA | ANGIOPOIETIN-1 EXPRESSION | ONCOLOGY | SR PROTEINS | RS DOMAIN | Phosphorylation | Cell Proliferation | Humans | Cytoplasm - metabolism | Serine-Arginine Splicing Factors - metabolism | Mutation, Missense | Serine-Arginine Splicing Factors - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Tyrosine - metabolism | Cell Nucleus - metabolism | Cell Cycle | Mass Spectrometry | Cell Line, Tumor | HeLa Cells | Mutation | Child | Tyrosine | Phenols | Pediatrics | Acute lymphocytic leukemia | Analysis | Cell proliferation | Immunoprecipitation | Pathogenesis | Leukemia | Serine | Cytotoxicity | Kinases | Proteins | Cell growth | Arginine | Cell cycle | Bone marrow | Conflicts of interest | Remission | Localization | Acute lymphatic leukemia | Colonies | Therapeutic applications | Mass spectroscopy | Lymphatic leukemia | Patients | Bone mass | Plasmids | Medical prognosis | Cell lines | Leukemogenesis | Scientific imaging | Immunofluorescence | Splicing factors | Mass spectrometry | Cancer | Apoptosis | Original
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2014, Volume 71, Issue 1, pp. 245 - 259
Abstract Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with... 
Neurology | Nociceptors | Neuropathy | Vascular endothelial growth factor A | Alternative mRNA splicing | SYMPATHETIC MODULATION | P2X(2/3) RECEPTOR | FACTOR EXPRESSION | OVARIAN-CANCER | NEUROSCIENCES | PROTEIN-KINASES | FACTOR SRSF1 | NEUROPATHIC PAIN | IN-VIVO | AFFERENT-FIBERS | ENDOTHELIAL GROWTH-FACTOR | Quinolines | Pain Threshold - physiology | Rats, Wistar | Neuralgia - metabolism | Male | Ganglia, Spinal - cytology | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Benzofurans | TRPV Cation Channels - deficiency | Sensory Receptor Cells - metabolism | Disease Models, Animal | Antibodies - therapeutic use | DNA, Recombinant - genetics | Hyperalgesia - metabolism | Neural Conduction - genetics | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Enzyme Inhibitors - therapeutic use | TRPV Cation Channels - genetics | Antibodies - pharmacology | Animals | Sensory Receptor Cells - drug effects | Mice | Neuralgia - therapy | Pain Measurement | Analgesia | Messenger RNA | Analgesics | Laws, regulations and rules | Neovascularization | Vascular endothelial growth factor | Health aspects | SRPK1, serine arginine protein kinase 1 | DRG, dorsal root ganglia | VEGF-A, vascular endothelial growth factor-A | PSNI, partial saphenous nerve ligation injury | IB4, isolectin B4 | SRSF1, serine arginine splice factor 1 | CV, conduction velocity | TRPV1, transient receptor potential vanilloid 1 | VEGFR2, vascular endothelial growth factor receptor 2
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 03/2019, Volume 240, Issue 3, pp. 379 - 392
Puberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty-related QTL regio n down to a... 
Ectopic expression in hypothalamus | Srsf1 | miR-505-3p | Mouse | Puberty onset | Gene knockout | MECHANISM | MENARCHE | MICRORNAS | mouse | gene knockout | ectopic expression in hypothalamus | ENDOCRINOLOGY & METABOLISM | RPL36 | puberty onset | MUTATIONS | HYPOGONADOTROPIC HYPOGONADISM | MIR505-3P | AGE
Journal Article