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GENES & DEVELOPMENT, ISSN 0890-9369, 05/2016, Volume 30, Issue 9, pp. 989 - 1001
Genomic analyses of the myeloid malignancies and clonal disorders of hematopoiesis that may give rise to these disorders have identified that mutations in... 
leukemia | EXONIC SPLICING ENHANCER | RING SIDEROBLASTS | U12-TYPE INTRONS | REFRACTORY-ANEMIA | U2AF1 | DEVELOPMENTAL BIOLOGY | SRSF2 MUTATIONS | TRACT-BINDING-PROTEINS | PRE-MESSENGER-RNA | CELL BIOLOGY | U2AF1 MUTATIONS | mRNA splicing | GENETICS & HEREDITY | SRSF2 | INTRON RETENTION | SF3B1 | ERYTHROID-DIFFERENTIATION
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 02/2018, Volume 48, pp. 57 - 66
Pre-mRNA splicing factors recognize consensus signals within preliminary transcripts, and as cogs of the spliceosome machine, orchestrate the excision and... 
U2AF1 MUTATIONS | SITE RECOGNITION | RECURRENT MUTATIONS | SR PROTEINS | SPLICEOSOME | GENES | GENETICS & HEREDITY | SF3B1 MUTATIONS | CRYO-EM STRUCTURE | SRSF2 MUTATIONS | MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | Gene expression | Messenger RNA | Cancer | myeloid neoplasm | SRSF2 | U2AF1 | spliceosome | myelodysplastic syndrome | MDS | SF3B1
Journal Article
by Seiler, Michael and Peng, Shouyong and Agrawal, Anant A and Palacino, James and Teng, Teng and Zhu, Ping and Smith, Peter G and Smith, Jennifer and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Linghua and Wang, Timothy and Wang, Jioajiao and Wang, Min and Wang, Zhining and Wang, Jing and Yang, Hannah and Yang, Ju Dong and Yang, Liming and Yang, Ian and Zenklusen, Jean C and Zhang, Hailei and Zhang, Jiashan (Julia) and Zhang, Hongzheng and Zhang, Lizhi and Zhang, Wei and Zhang, Hongxin and Zhang, Jiexin and Chudamani, Sudha and Liu, Wenbin and Liu, Jia and Liu, Xiuping and Liu, Yuexin and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Sun, Yichao and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Christopher A and Miller, Judy and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Ju, Zhenlin and Kanchi, Rupa S and Korkut, Anil and Li, Wei and Li, Jun and Liang, Han and Ling, Shiyun and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Ryan, Michael and Weinstein, John N and Abeshouse, Adam and Armenia, Joshua and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Galen F and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Luna, Augustin and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 282 - 296.e4
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2019, Volume 76, Issue 1, pp. 82 - 95.e7
, which encodes an essential spliceosomal protein, is frequently mutated in myelodysplastic syndromes (MDS) and many cancers. However, the defect of mutant... 
leukemia | p14 | U2AF2 | myelodysplastic syndromes | U2 snRNP | SRSF2 | branch point | U2AF1 | spliceosome | SF1
Journal Article
by Yu, SS and Jiang, T and Jia, DN and Han, YD and Liu, F and Huang, YW and Qu, Z and Zhao, YT and Tu, JY and Lv, YX and Li, JZ and Hu, XB and Lu, ZJ and Han, SS and Qin, YY and Liu, XL and Xie, SL and Wang, QK and Tang, ZH and Luo, DJ and Liu, MG
BLOOD, ISSN 0006-4971, 02/2019, Volume 133, Issue 8, pp. 805 - 815
Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium via the endothelial-to-hematopoietic transition, are self-renewing,... 
GENE-MUTATIONS | ACTIVATION | COMPLEX | IMPACT | PROTEIN | MDMX | SRSF2 | LINKS | HEMATOLOGY | PRE-MESSENGER-RNA | P53
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, p. 14060
Somatic mutations in spliceosome genes are detectable in similar to 50% of patients with myelo-dysplastic syndromes (MDS). We hypothesize that cells harbouring... 
TARGET | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SRSF2 | U2AF1 | MUTATIONS | LEUKEMIA | SELECTION | CANCER | MYELODYSPLASTIC SYNDROMES | PRE-MESSENGER-RNA
Journal Article
Cancer research, ISSN 0008-5472, 9/2018, Volume 78, Issue 18, pp. 5363 - 5374
Heterozygous somatic mutations in spliceosome genes ( U2AF1 , SF3B1 , ZRSR2 , or SRSF2 ) occur in >50% of myelodysplastic syndrome (MDS) patients. These... 
R loop | targeted therapy | Myelodysplastic Syndrome | SRSF2 | U2AF1 | RNA:DNA hybrids | ATR
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 18, pp. 5363 - 5374
Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of patients with myelodysplastic syndrome (MDS). These... 
U2AF1 MUTATIONS | RNA-BINDING | RECOGNITION | ONCOLOGY | MYELOID NEOPLASMS | BRANCH POINT | DNA-DAMAGE | GENOME INTEGRITY | GENES | SRSF2 | CANCER
Journal Article
by Robertson, A. Gordon and Shih, Juliann and Yau, Christina and Gibb, Ewan A and Oba, Junna and Mungall, Andrew J and Mungall, Karen L and Hess, Julian M and Uzunangelov, Vladislav and Walter, Vonn and Danilova, Ludmila and Lichtenberg, Tara M and Kucherlapati, Melanie and Kucherlapati, Raju and Kimes, Patrick K and Tang, Ming and Tang, Jiabin and Penson, Alexander and Babur, Ozgun and Akbani, Rehan and Bristow, Christopher A and Hoadley, Katherine A and Iype, Lisa and Chang, Matthew T and Abdel-Rahman, Mohamed H and Ally, Adrian and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Benz, Christopher and Beroukhim, Rameen and Birol, Inanc and Bodenheimer, Tom and Bowen, Jay and Bowlby, Reanne and Brooks, Denise and Carlsen, Rebecca and Cebulla, Colleen M and Cherniack, Andrew D and Chin, Lynda and Cho, Juok and Chuah, Eric and Chudamani, Sudha and Cibulskis, Carrie and Cibulskis, Kristian and Cope, Leslie and Coupland, Sarah E and Defreitas, Timothy and Demchok, John A and Desjardins, Laurence and Dhalla, Noreen and Esmaeli, Bita and Felau, Ina and Ferguson, Martin L and Frazer, Scott and Gabriel, Stacey B and Gastier-Foster, Julie M and Gehlenborg, Nils and Gerken, Mark and Gershenwald, Jeffrey E and Getz, Gad and Griewank, Klaus G and Grimm, Elizabeth A and Hayes, D. Neil and Hegde, Apurva M and Heiman, David I and Helsel, Carmen and Hobensack, Shital and Holt, Robert A and Hoyle, Alan P and Hu, Xin and Hutter, Carolyn M and Jager, Martine J and Jefferys, Stuart R and Jones, Corbin D and Jones, Steven J.M and Kandoth, Cyriac and Kasaian, Katayoon and Kim, Jaegil and Lander, Eric and Lawrence, Michael S and Lazar, Alexander J and Lee, Semin and Leraas, Kristen M and Lin, Pei and Liu, Jia and Liu, Wenbin and Lolla, Laxmi and Lu, Yiling and Ma, Yussanne and Mahadeshwar, Harshad S and Mariani, Odette and Marra, Marco A and Mayo, Michael and Meier, Sam and Meng, Shaowu and Meyerson, Matthew and Mieczkowski, Piotr A and Mills, Gordon B and Moore, Richard A and ... and TCGA Res Network and TCGA Research Network
Cancer Cell, ISSN 1535-6108, 08/2017, Volume 32, Issue 2, pp. 204 - 220.e15
Journal Article