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Biochimica et biophysica acta. Molecular basis of disease, 12/2018, Volume 1865, Issue 3, p. 587
Bone cancer pain (BCP) is the pain induced by primary bone cancer or tumor metastasis. Increasing evidence and our previous studies have shown that mammalian... 
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6124, pp. 1216 - 1219
Journal Article
American Journal of Translational Research, ISSN 1943-8141, 2018, Volume 10, Issue 7, pp. 2068 - 2077
Nanostructured calcium phosphate (CaP) and magnesium phosphate (MgP) are promising for the application as the nanocarriers in drug delivery. However, the... 
SRT1720 | Calcium phosphate | Endothelial cell senescence | Nanostucture | Magnesium phosphate
Journal Article
Cell Stem Cell, ISSN 1934-5909, 09/2018, Volume 23, Issue 3, pp. 355 - 369.e9
Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that... 
acetylation | SRT1720 | HSPCs | TET2 | myelodysplastic syndrome | SIRT1 | INHIBITION | DNA METHYLATION | ACETYLATION | MUTATION | LEADS | SELF-RENEWAL | ACUTE MYELOID-LEUKEMIA | EXPRESSION | MDS | P53 | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 1/2016, Volume 142, Issue 1, pp. 17 - 26
SIRT1-activating compounds (STACs) may have potential in the management of cancer. However, the best-studied STAC, the naturally occurring compound... 
Ewing’s sarcoma | SRT1720 | Medicine & Public Health | Hematology | Cancer therapy | Resveratrol | STACs | Oncology | Cancer Research | Internal Medicine | SIRT1
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 03/2019, Volume 1865, Issue 3, pp. 587 - 598
Bone cancer pain (BCP) is the pain induced by primary bone cancer or tumor metastasis. Increasing evidence and our previous studies have shown that mammalian... 
SRT1720 | Spinal cord | Silent information regulator 1 (SIRT1) | Dynamin-related protein 1 (Drp1) | Bone cancer pain | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROPATHIC PAIN | REGULATOR | BIOPHYSICS | BIOGENESIS | SIGNALING PATHWAY | INJECTION | EXPRESSION
Journal Article
by Han, WX and Wang, C and Yang, ZF and Mu, L and Wu, M and Chen, N and Du, CY and Duan, HJ and Shi, YH
JOURNAL OF ENDOCRINOLOGY, ISSN 0022-0795, 04/2019, Volume 241, Issue 1, pp. 85 - 98
Renal fibrosis is the major pathological characteristic of diabetic nephropathy (DN). Reportedly, increased SIRT1 expression played a renal protective role in... 
CELLS | RESVERATROL | renal fibrosis | HYPOXIA | HIF1A | SIRT1 | BETA | SRT1720 | TO-MESENCHYMAL TRANSITION | STIMULATED INSULIN-SECRETION | TISSUE GROWTH-FACTOR | HYPERGLYCEMIA | ENDOCRINOLOGY & METABOLISM | epithelial to mesenchymal transition | EXPRESSION | diabetic nephropathy
Journal Article
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ISSN 0003-9861, 07/2018, Volume 650, pp. 39 - 48
Ursolic Acid (UA), a pentacyclic triterpenoid compound, plays a vital role in aging process. However, the role of UA in the regulation of aging and longevity... 
IMPROVES HEALTH | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Sirtl activating compounds | PARTICLE MESH EWALD | SIRTUINS | SIRT1 | SRT1720 | BIOPHYSICS | Resveratrol | Ursolic acid | HEPATIC STEATOSIS | EXPRESSION | HISTONE DEACETYLASE | SMALL-MOLECULE ACTIVATORS
Journal Article
Antioxidants, 08/2019, Volume 8, Issue 8, p. 322
Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney... 
sirtuin 1 | SRT1720 | inflammation | apoptosis | acute kidney injury | cisplatin | oxidative stress
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 11/2013, Volume 10, Issue 9, pp. 793 - 797
We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from the optimization of a previously... 
SRT1720 | SRT2104 | Imidazothiazole | Activator | SIRT1 | Sirtuin | CHEMISTRY, MEDICINAL
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2013, Volume 273, Issue 2, pp. 345 - 354
Kidney ischemia–reperfusion (I/R) injury elicits cellular injury in the proximal tubule, and mitochondrial dysfunction is a pathological consequence of I/R.... 
SRT1720 | Proximal tubule | Mitochondrial biogenesis | Mitochondrial dysfunction | Ischemia–reperfusion | Acute kidney injury | Ischemia-reperfusion | PGC-1-ALPHA | EPITHELIAL POLARITY | SIRT1 | ENERGY-EXPENDITURE | OXIDANT INJURY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROMOTES RECOVERY | HISTONE DEACETYLASE | SMALL-MOLECULE ACTIVATORS | CALORIE RESTRICTION | Kidney - pathology | Recovery of Function - drug effects | Reperfusion Injury - drug therapy | Male | Heterocyclic Compounds, 4 or More Rings - pharmacology | Kidney - metabolism | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Recovery of Function - physiology | Homeostasis - drug effects | Kidney Tubules - pathology | Kidney Tubules - metabolism | Reperfusion Injury - metabolism | Kidney - drug effects | Kidney Tubules - drug effects | Reperfusion Injury - pathology | Sirtuin 1 - biosynthesis | Rats | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Rats, Sprague-Dawley | Animals | Homeostasis - physiology | Index Medicus | HOMEOSTASIS | INJURIES | EPITHELIUM | MITOCHONDRIA | CREATININE | RATS | RECEPTORS | 60 APPLIED LIFE SCIENCES | ATP | POTASSIUM IONS | SODIUM IONS | mitochondrial dysfunction | acute kidney injury | ischemia-reperfusion | proximal tubule | mitochondrial biogenesis
Journal Article
by Qin, RJ and Zhang, LN and Lin, D and Xiao, F and Guo, LX
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, ISSN 1107-3756, 07/2019, Volume 44, Issue 1, pp. 89 - 102
Journal Article
Journal Article