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Peptide Science, ISSN 0006-3525, 11/2016, Volume 106, Issue 6, pp. 853 - 863
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 11/2015, Volume 218, pp. 29 - 35
Journal Article
Analyst, ISSN 0003-2654, 06/2019, Volume 144, Issue 12, pp. 3773 - 3781
MDM2 is a well-known oncoprotein overexpressed in a variety of cancers, and the identification of inhibitors that disrupt the MDM2/p53 interaction is of great... 
P53-MDM2 INTERACTION | CHEMISTRY, ANALYTICAL | ACTIVATION | AFFINITY | PATHWAY | MDMX | CHIRAL CENTER | STAPLED P53 | ANTAGONISTS | BINDING | STRUCTURE-BASED DESIGN
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle | Index Medicus
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 08/2017, Volume 85, Issue 8, pp. 1493 - 1506
Mdm2 and MdmX share high structural similarity in their N‐terminal domains, yet dual inhibitors are challenging to design due to differences in the... 
hydration | MdmX | Mdm2 | nutlin | aileron peptide | dual inhibitor | stapled peptide | p53 | SUPPRESSOR TRANSACTIVATION DOMAIN | PROTEIN HYDRATION | MOLECULAR-DYNAMICS | LIGAND-BINDING-SITES | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUTRON-SCATTERING | DRUG DESIGN | STAPLED P53 PEPTIDE | CRYSTAL-STRUCTURES | FUNCTIONAL-PROPERTIES | BIOPHYSICS | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Proto-Oncogene Proteins c-mdm2 - chemistry | Peptides, Cyclic - chemistry | Thermodynamics | Enzyme Inhibitors - chemistry | Drug Design | Water - chemistry | Protein Interaction Domains and Motifs | Binding Sites | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Tyrosine - chemistry | Proto-Oncogene Proteins - metabolism | Protein Conformation, alpha-Helical | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Water - metabolism | Nuclear Proteins - metabolism | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | Static Electricity | Molecular Dynamics Simulation | Tyrosine - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Binding | Ligands | Tumor Suppressor Protein p53 - chemistry | Kinetics | Molecular dynamics | Peptides | Tumor proteins | Structure | Analysis | Crystals | Dynamic structural analysis | Proteins | Coupling (molecular) | MDM2 protein | Inhibitors | p53 Protein | Crystal structure | Conformation | Index Medicus
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 04/2010, Volume 75, Issue 4, pp. 348 - 359
Reactivation of the p53 cell apoptosis pathway through inhibition of the p53-hDM2 interaction is a viable approach to suppress tumor growth in many human... 
hDM2 | α-helicity | molecular dynamic simulations | drug design | circular dichroism | stapled peptide | p53 | protein-protein interfaces | Crosslinked polymers | Peptides | Analysis | Hydrocarbons | Chemical properties | Tumor proteins | Investigations
Journal Article
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 09/2017, Volume 28, Issue 9, pp. 2316 - 2326
Journal Article