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STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 248 - 258
The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of tumorigenesis. Additionally, tumor‐associated macrophages (TAMs)... 
Side population cells | Transcription factors | STAT | Breast cancer | Cancer stem cells | Stem cell‐microenvironment interactions | Stem cell-microenvironment interactions | ELEGANS GERM-LINE | BONE-MARROW | PLURIPOTENCY | IDENTIFICATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | LUNG-CANCER | MICROENVIRONMENT | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NANOG | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | MAMMARY-GLAND | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Homeodomain Proteins - metabolism | Oleanolic Acid - analogs & derivatives | Antigens, Ly - genetics | Oleanolic Acid - pharmacology | SOXB1 Transcription Factors - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Receptor, Epidermal Growth Factor - metabolism | ATP-Binding Cassette Transporters - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | ATP-Binding Cassette Transporters - metabolism | Neoplastic Stem Cells - pathology | Antigens, Ly - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mammary Neoplasms, Animal - genetics | Nanog Homeobox Protein | Macrophages - pathology | Membrane Proteins - genetics | Imidazoles - pharmacology | Tyrphostins - pharmacology | Homeodomain Proteins - genetics | Macrophages - metabolism | Mammary Neoplasms, Animal - pathology | Animals | Signal Transduction - drug effects | Mammary Neoplasms, Animal - metabolism | Octamer Transcription Factor-3 - metabolism | Cell Communication - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Quinazolines - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Genes | DNA binding proteins | Metastasis | Macrophages | Gene expression | Stem cell research | Chemotherapy | Epidermal growth factor | Analysis | Stem cells | Research institutes | Cancer | Proteins | Medical research
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 667 - 679
The genetic landscape of classicalmyelopro-liferative neoplasm (MPN) is in large part elucidated. The MPN-restricted driver mutations, including those in JAK2,... 
POLYCYTHEMIA-VERA | LEUKEMIC TRANSFORMATION | ACTIVATING MUTATION | CLONAL HEMATOPOIESIS | MUTANT CALRETICULIN | ACQUIRED UNIPARENTAL DISOMY | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | SOMATIC MUTATIONS | THROMBOPOIETIN RECEPTOR | HEMATOPOIETIC STEM | Thrombocythemia, Essential - physiopathology | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | STAT Transcription Factors - metabolism | Polycythemia Vera - genetics | Receptors, Granulocyte Colony-Stimulating Factor - genetics | Thrombocythemia, Essential - genetics | Calreticulin - genetics | Receptors, Erythropoietin - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Polycythemia Vera - metabolism | Janus Kinase 2 - metabolism | Calreticulin - metabolism | Receptors, Granulocyte Colony-Stimulating Factor - metabolism | Polycythemia Vera - physiopathology | Primary Myelofibrosis - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Primary Myelofibrosis - physiopathology | Janus Kinase 2 - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Receptors, Thrombopoietin - metabolism | Disease Progression | DNA (Cytosine-5-)-Methyltransferases - genetics | Receptors, Thrombopoietin - genetics | Primary Myelofibrosis - genetics | STAT Transcription Factors - genetics | Mutation | Receptors, Erythropoietin - metabolism | Thrombocythemia, Essential - metabolism
Journal Article
Blood, ISSN 0006-4971, 03/2016, Volume 127, Issue 10, pp. 1325 - 1335
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2012, Volume 8, Issue 1, p. e1002473
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 832 - 844
Effector T cell differentiation requires the simultaneous integration of multiple, and sometimes opposing, cytokine signals. We demonstrated mTOR's role in... 
MOLIMMUNO | CELLIMMUNO | MAMMALIAN TARGET | RAPAMYCIN | FOXP3 EXPRESSION | MAINTENANCE | ACTIVATION | PATHWAY | AKT | INDUCTION | IMMUNOLOGY | TH17 | INSIGHTS | Phosphotransferases (Alcohol Group Acceptor) - immunology | STAT Transcription Factors - metabolism | STAT Transcription Factors - immunology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Interleukin-2 - immunology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - enzymology | Receptors, Antigen, T-Cell - immunology | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Transforming Growth Factor beta - immunology | Receptors, Antigen, T-Cell - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Transcription Factors - genetics | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Cell Differentiation - immunology | Animals | Carrier Proteins - metabolism | Trans-Activators - metabolism | Mice | TOR Serine-Threonine Kinases | Interleukin-2 - biosynthesis | Transforming Growth Factor beta - metabolism | T-Lymphocytes, Regulatory - enzymology | Genetic research | DNA binding proteins | Transforming growth factors | T cells | Proteins | Cell growth | Phosphorylation | T cell receptors | Kinases | Rodents
Journal Article