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Molecular carcinogenesis, ISSN 0899-1987, 2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10048 - 10060
IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several angioproliferative disorders. However, the detailed mechanisms of... 
APOPTOSIS | ACTIVATION | NETWORK | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TNF-ALPHA | INDUCTION | RAR-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic - pathology | Endopeptidases - chemistry | STAT1 Transcription Factor - metabolism | Interferon-alpha - genetics | RNA Interference | Human Umbilical Vein Endothelial Cells - cytology | STAT1 Transcription Factor - agonists | Promyelocytic Leukemia Protein - metabolism | Ubiquitin Thiolesterase - metabolism | Neovascularization, Pathologic - prevention & control | Ubiquitin Thiolesterase - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promyelocytic Leukemia Protein - genetics | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Interferon-alpha - metabolism | Cells, Cultured | STAT1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Mice, Knockout | STAT2 Transcription Factor - agonists | Animals | Endopeptidases - genetics | Endothelium, Vascular - metabolism | STAT2 Transcription Factor - genetics | Promyelocytic Leukemia Protein - antagonists & inhibitors | Endothelium, Vascular - pathology | Neovascularization, Pathologic - metabolism | Protein Processing, Post-Translational | STAT2 Transcription Factor - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Neovascularization, Physiologic | signal transducers and activators of transcription 1 (STAT1) | STAT transcription factor | Signal Transduction | interferon | angiogenesis | STAT3
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 10, p. e46082
.... It also induced the release of interleukin (IL)-17A by Th17 cells, but not the release of IL-10 and transforming growth factor (TGF... 
PREVENTS DEVELOPMENT | SUPPRESSOR | ACTIVATION | MULTIDISCIPLINARY SCIENCES | STAT3 | T(H)17 | CD4(+) T-CELLS | RECEPTOR | ABSENCE | INDUCTION | EXPRESSION | GATA3 Transcription Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Transforming Growth Factor beta1 - metabolism | STAT Transcription Factors - metabolism | Suppressor of Cytokine Signaling 1 Protein | Janus Kinases - metabolism | Interferon-gamma - metabolism | Cell Differentiation - genetics | Th17 Cells - metabolism | Base Sequence | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Th17 Cells - cytology | Interferon-gamma - genetics | Interleukin-4 - genetics | GATA3 Transcription Factor - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Signal Transduction | Interleukin-4 - metabolism | Gene Expression Regulation | Suppressor of Cytokine Signaling Proteins - genetics | Forkhead Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Interleukin-17 - metabolism | Animals | Mice | MicroRNAs - genetics | Smad Proteins - metabolism | Physiological aspects | Genetic aspects | MicroRNA | Research | Cell differentiation | T cells | Smad5 protein | Smad protein | Transcription factors | Transcription | Laboratories | Interleukin | Differentiation (biology) | Helper cells | Science | Homology | Lymphocytes T | Inflammatory diseases | Signal transduction | Immunology | Transfection | Lymphocytes | Smad2 protein | Atherosclerosis | CD25 antigen | Janus kinase | miRNA | Cardiology | Growth factors | Immune system | Function analysis | Lupus | Immune response | Cytokines | Cell lineage | T cell receptors | Gene expression | Ribonucleic acid--RNA | Suppressors | CD4 antigen | Signaling | MicroRNAs | Interleukin 10 | RNA | Ribonucleic acid
Journal Article
BMC infectious diseases, ISSN 1471-2334, 2019, Volume 19, Issue 1, pp. 52 - 11
.... The Role of transcription factors on the modulation of Th1 and Th2 responses by M. leprae antigens has not been adequately studied... 
Leprosy | CREB | STAT-4 | Th1/Th2 cytokine | STAT-6 | INFECTIOUS DISEASES | IFN-GAMMA | RECEPTOR | TH1 DEVELOPMENT | GATA-3 | IL-10 | T-CELL RESPONSES | INTERFERON-GAMMA | Th2 cytokine | Th1 | EXPRESSION | Humans | Middle Aged | STAT4 Transcription Factor - metabolism | Th2 Cells - immunology | Th1 Cells - immunology | Th2 Cells - drug effects | Case-Control Studies | Mycobacterium leprae - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Cyclic AMP Response Element-Binding Protein - immunology | Adult | STAT4 Transcription Factor - immunology | Leukocytes, Mononuclear - microbiology | Th1 Cells - drug effects | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | CD4-Positive T-Lymphocytes - metabolism | Leprosy - metabolism | Antigens, Bacterial - pharmacology | Leprosy - immunology | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | Th2 Cells - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Mycobacterium leprae - pathogenicity | CD4-Positive T-Lymphocytes - drug effects | Transcription factors | Analysis | Research | Diagnosis | Risk factors | STAT proteins | Cell culture | Flow cytometry | Phosphorylation | Disease | Stimulation | Leukocytes (mononuclear) | Infections | Activation | Lymphocytes T | Kinases | Interleukin 4 | Cell activation | Lymphocytes | Transcription activation | Peripheral blood mononuclear cells | Enzyme-linked immunosorbent assay | Immune system | Antigens | Immune response | Bacterial infections | Cytokines | Immunomodulation | Stat4 protein | T cell receptors | Roles | Cyclic AMP response element-binding protein | Patients | CD4 antigen | Tuberculosis | γ-Interferon | Interleukin 10 | Stat6 protein
Journal Article
Journal of hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 2, pp. 289 - 298
Background & Aims The combination of pegylated interferon (IFN) α and ribavirin (RBV) is the standard therapy for patients with chronic HCV infection. However,... 
Gastroenterology and Hepatology | IL28B | STAT | HCV | JAK | IFNS | CLEARANCE | INNATE | RIBAVIRIN | GENOME | LAMBDA | GENETIC-VARIATION | ANTIVIRAL RESPONSES | INTERFERON-ALPHA | CELL-CULTURE | GASTROENTEROLOGY & HEPATOLOGY | RNA, Small Interfering - genetics | Humans | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | DNA Primers - genetics | Janus Kinases - metabolism | Interleukins - genetics | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Base Sequence | Hepacivirus - physiology | TYK2 Kinase - antagonists & inhibitors | Interleukins - pharmacology | Phosphorylation - drug effects | Hepacivirus - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Recombinant Proteins - pharmacology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Janus Kinase 1 - antagonists & inhibitors | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | STAT1 Transcription Factor - antagonists & inhibitors | Receptors, Interferon - metabolism | Janus Kinases - antagonists & inhibitors | STAT2 Transcription Factor - antagonists & inhibitors | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Polymorphism, Single Nucleotide | STAT Transcription Factors - antagonists & inhibitors | STAT2 Transcription Factor - metabolism | Virus Replication - physiology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Virus diseases | Genetic research | Precipitation (Meteorology) | Biological response modifiers | Hepatitis C virus | Health aspects
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2009, Volume 30, Issue 6, pp. 832 - 844
.... The inability to differentiate was associated with decreased STAT transcription factor activation and failure to upregulate lineage-specific transcription factors... 
MOLIMMUNO | CELLIMMUNO | MAMMALIAN TARGET | RAPAMYCIN | FOXP3 EXPRESSION | MAINTENANCE | ACTIVATION | PATHWAY | AKT | INDUCTION | IMMUNOLOGY | TH17 | INSIGHTS | Phosphotransferases (Alcohol Group Acceptor) - immunology | STAT Transcription Factors - metabolism | STAT Transcription Factors - immunology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Interleukin-2 - immunology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - enzymology | Receptors, Antigen, T-Cell - immunology | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Transforming Growth Factor beta - immunology | Receptors, Antigen, T-Cell - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Transcription Factors - genetics | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Cell Differentiation - immunology | Animals | Carrier Proteins - metabolism | Trans-Activators - metabolism | Mice | TOR Serine-Threonine Kinases | Interleukin-2 - biosynthesis | Transforming Growth Factor beta - metabolism | T-Lymphocytes, Regulatory - enzymology | Genetic research | DNA binding proteins | Transforming growth factors | T cells | Proteins | Cell growth | Phosphorylation | T cell receptors | Kinases | Rodents
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2007, Volume 204, Issue 1, pp. 65 - 71
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 32, pp. 13463 - 13468
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 13, pp. 6714 - 6722
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered partners, as a part of their ubiquitous role in facilitating transcription of genes... 
ACTIVATION DOMAIN | UNSTRUCTURED PROTEINS | viral oncoprotein | intrinsically disordered protein | coupled folding and binding | intrinsically disordered region | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | STAT transcription factor | C-MYB | transcriptional coactivator | VIRAL-PROTEINS | transcriptional activation | P53 TRANSACTIVATION DOMAIN | COMPLEX-FORMATION | cAMP response element-binding protein (CREB) | hypoxia-inducible factor (HIF) | IDP | STRUCTURAL BASIS | IDR | KIX DOMAIN | TAZ2 DOMAIN | PEPTIDE MOTIFS | protein-protein interaction | Humans | E1A-Associated p300 Protein - genetics | STAT Transcription Factors - metabolism | CREB-Binding Protein - chemistry | NF-kappa B - metabolism | E1A-Associated p300 Protein - metabolism | NF-kappa B - chemistry | Viral Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Transcription, Genetic | Protein Interaction Domains and Motifs | Protein Structure, Secondary | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Viral Proteins - chemistry | E1A-Associated p300 Protein - chemistry | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Viral Proteins - genetics | Intrinsically Disordered Proteins - genetics | Protein Folding | STAT Transcription Factors - genetics | NF-kappa B - genetics | Intrinsically Disordered Proteins - chemistry | Protein Binding | STAT Transcription Factors - chemistry | Tumor Suppressor Protein p53 - chemistry | Intrinsically Disordered Proteins - metabolism | Minireviews
Journal Article