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Journal of Hepatology, ISSN 0168-8278, 2010, Volume 55, Issue 2, pp. 289 - 298
Background & Aims The combination of pegylated interferon (IFN) α and ribavirin (RBV) is the standard therapy for patients with chronic HCV infection. However,... 
Gastroenterology and Hepatology | IL28B | STAT | HCV | JAK | IFNS | CLEARANCE | INNATE | RIBAVIRIN | GENOME | LAMBDA | GENETIC-VARIATION | ANTIVIRAL RESPONSES | INTERFERON-ALPHA | CELL-CULTURE | GASTROENTEROLOGY & HEPATOLOGY | RNA, Small Interfering - genetics | Humans | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | DNA Primers - genetics | Janus Kinases - metabolism | Interleukins - genetics | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Base Sequence | Hepacivirus - physiology | TYK2 Kinase - antagonists & inhibitors | Interleukins - pharmacology | Phosphorylation - drug effects | Hepacivirus - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Recombinant Proteins - pharmacology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Janus Kinase 1 - antagonists & inhibitors | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | STAT1 Transcription Factor - antagonists & inhibitors | Receptors, Interferon - metabolism | Janus Kinases - antagonists & inhibitors | STAT2 Transcription Factor - antagonists & inhibitors | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Polymorphism, Single Nucleotide | STAT Transcription Factors - antagonists & inhibitors | STAT2 Transcription Factor - metabolism | Virus Replication - physiology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Virus diseases | Genetic research | Precipitation (Meteorology) | Biological response modifiers | Hepatitis C virus | Health aspects
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2012, Volume 31, Issue 17, pp. 3513 - 3523
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 05/2017, Volume 101, Issue 5, pp. 1181 - 1190
The interferon and T cell receptor signaling pathways mediate specific and combined contributions to IL‐10 regulation via STAT and BATF transcription factors.... 
gene regulation | Tr1 cells | signaling | Signaling | Gene regulation | ACTIVATION | Tr 1 cells | PERSISTENT LCMV INFECTION | RECEPTOR | IMMUNOLOGY | CUTTING EDGE | BETA | CELL BIOLOGY | IRF INTERACTIONS | RESPONSES | GENE | DIFFERENTIATION | HEMATOLOGY | IFN-ALPHA | Interferon-alpha - pharmacology | RNA, Small Interfering - genetics | STAT2 Transcription Factor - immunology | Humans | Basic-Leucine Zipper Transcription Factors - immunology | CD4-Positive T-Lymphocytes - immunology | CD3 Complex - genetics | CD28 Antigens - genetics | CD28 Antigens - antagonists & inhibitors | Basic-Leucine Zipper Transcription Factors - antagonists & inhibitors | Phosphorylation - drug effects | Binding Sites | STAT3 Transcription Factor - genetics | Signal Transduction | CD4-Positive T-Lymphocytes - cytology | Gene Expression Regulation | CD28 Antigens - immunology | Basic-Leucine Zipper Transcription Factors - genetics | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - antagonists & inhibitors | Cycloheximide - pharmacology | STAT1 Transcription Factor - immunology | Interferon-alpha - immunology | Antibodies - pharmacology | Enhancer Elements, Genetic | STAT2 Transcription Factor - antagonists & inhibitors | Interleukin-10 - genetics | CD3 Complex - immunology | STAT2 Transcription Factor - genetics | Protein Binding | Primary Cell Culture | STAT3 Transcription Factor - immunology | Protein Isoforms - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Interleukin-10 - immunology | CD4-Positive T-Lymphocytes - drug effects | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Phosphorylation | Transcription factors | CD45RA antigen | Central nervous system | Lymphocytes T | Leucine | Recruitment | T-cell receptor | Signal transduction | Conserved sequence | Pathways | Lymphocytes | Stat1 protein | Immune system | Stat2 protein | RNA-mediated interference | Stat3 protein | Inflammation | T cell receptors | Gene expression | Ribonucleic acid--RNA | CD4 antigen | Leucine zipper proteins | Interleukin 10 | Interferon | STAT2 Transcription Factor | Interleukin-10 | Interferon-alpha | CD3 Complex | Antibodies | Life Sciences | Cycloheximide | Immunology | Protein Isoforms | CD28 Antigens | STAT1 Transcription Factor | RNA, Small Interfering | STAT3 Transcription Factor | CD4-Positive T-Lymphocytes | Basic-Leucine Zipper Transcription Factors
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 717 - 726
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 1, pp. 57 - 67
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2012, Volume 71, Issue 3, pp. 440 - 447
Objectives The objective of this study was to investigate the effect of the novel Janus kinase inhibitor CP-690,550 in fibroblast-like synoviocytes (FLSs) from... 
COLLAGEN-INDUCED ARTHRITIS | CELLS | SYNOVIAL FIBROBLASTS | ACTIVE RHEUMATOID-ARTHRITIS | INFLAMMATION | SOLUBLE IL-6 RECEPTOR | GENE-EXPRESSION | DOUBLE-BLIND | ALLOGRAFT RECIPIENTS | RHEUMATOLOGY | BETA | Interleukin-6 - antagonists & inhibitors | Humans | Synovial Membrane - pathology | Autocrine Communication - drug effects | Synovial Membrane - drug effects | Janus Kinase 3 - antagonists & inhibitors | Arthritis, Rheumatoid - metabolism | STAT1 Transcription Factor - metabolism | Piperidines | Interferon Type I - physiology | Antirheumatic Agents - pharmacology | Phosphorylation - drug effects | STAT3 Transcription Factor - metabolism | Drug Evaluation, Preclinical - methods | Chemokines - biosynthesis | Cells, Cultured | Pyrimidines - pharmacology | STAT1 Transcription Factor - antagonists & inhibitors | Arthritis, Rheumatoid - pathology | Tumor Necrosis Factor-alpha - pharmacology | Pyrroles - pharmacology | Animals | Interleukin-6 - pharmacology | Fibroblasts - drug effects | Mice | STAT3 Transcription Factor - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Tofacitinib | Rheumatoid arthritis | Physiological aspects | Dosage and administration | Interferon | Research | Drug therapy | Phosphorylation | Immunoglobulins | Disease | Cytokines | Lymphocytes | Laboratories | Fibroblasts | Tumor necrosis factor-TNF | Arthritis | Kinases | Gene expression | Chemokines
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10048 - 10060
IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several angioproliferative disorders. However, the detailed mechanisms of... 
APOPTOSIS | ACTIVATION | NETWORK | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TNF-ALPHA | INDUCTION | RAR-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic - pathology | Endopeptidases - chemistry | STAT1 Transcription Factor - metabolism | Interferon-alpha - genetics | RNA Interference | Human Umbilical Vein Endothelial Cells - cytology | STAT1 Transcription Factor - agonists | Promyelocytic Leukemia Protein - metabolism | Ubiquitin Thiolesterase - metabolism | Neovascularization, Pathologic - prevention & control | Ubiquitin Thiolesterase - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promyelocytic Leukemia Protein - genetics | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Interferon-alpha - metabolism | Cells, Cultured | STAT1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Mice, Knockout | STAT2 Transcription Factor - agonists | Animals | Endopeptidases - genetics | Endothelium, Vascular - metabolism | STAT2 Transcription Factor - genetics | Promyelocytic Leukemia Protein - antagonists & inhibitors | Endothelium, Vascular - pathology | Neovascularization, Pathologic - metabolism | Protein Processing, Post-Translational | STAT2 Transcription Factor - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Neovascularization, Physiologic | signal transducers and activators of transcription 1 (STAT1) | STAT transcription factor | Signal Transduction | interferon | angiogenesis | STAT3
Journal Article
International Immunopharmacology, ISSN 1567-5769, 2011, Volume 11, Issue 8, pp. 1095 - 1102
Arctigenin has been demonstrated to have an anti-inflammatory function, but the precise mechanisms of its action remain to be fully defined. In the present... 
Arctigenin | iNOS | JAK-STAT | Anti-inflammation | DIBENZYLBUTYROLACTONE LIGNANS | OXIDE SYNTHASE GENE | ACTIVATION | PHOSPHORYLATION | MACROPHAGES | TRANSCRIPTION | INDUCTION | IMMUNOLOGY | PROTECTS | TRANSDUCERS | PHARMACOLOGY & PHARMACY | REQUIREMENT | Interleukin-6 - antagonists & inhibitors | Furans - pharmacology | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Lignans - pharmacology | STAT1 Transcription Factor - metabolism | Drug Interactions | Mitochondrial Proteins - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Janus Kinase 2 - metabolism | Membrane Proteins - metabolism | Phosphorylation - drug effects | Janus Kinase 2 - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Mitochondrial Proteins - antagonists & inhibitors | Chemokine CCL2 - genetics | STAT1 Transcription Factor - antagonists & inhibitors | Macrophages - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Chemokine CCL2 - antagonists & inhibitors | STAT3 Transcription Factor - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Mitogens
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 4, pp. 2666 - 2677
IL-6 has been shown to play a major role in collagen up-regulation process during cardiac hypertrophy, although the precise mechanism is still not known. In... 
ISCHEMIA/REPERFUSION INJURY | PRESSURE-OVERLOAD | MYOCARDIAL FIBROSIS | JAK-STAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | ANGIOTENSIN-II | GROWTH-FACTOR | DILATED CARDIOMYOPATHY | UP-REGULATION | CELL-DEATH | Nitriles - pharmacology | Rats, Wistar | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Cardiomegaly - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Phosphorylation - genetics | STAT1 Transcription Factor - metabolism | MAP Kinase Signaling System - genetics | Antineoplastic Agents - pharmacology | Collagen - biosynthesis | Collagen - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Fibroblasts - metabolism | Butadienes - pharmacology | Interleukin-6 - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Interleukin-6 - adverse effects | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Vidarabine - analogs & derivatives | Down-Regulation - drug effects | Fibroblasts - pathology | STAT1 Transcription Factor - genetics | Down-Regulation - genetics | Vidarabine - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Interleukin-6 - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cardiomegaly - chemically induced | Pyridines - pharmacology | Cardiomegaly - genetics | STAT3 Transcription Factor - antagonists & inhibitors | Cardiomegaly - metabolism | Interleukin 6 | Molecular Bases of Disease | STAT Transcription Factor | Extracellular Matrix | Collagen | p38 MAPK | Cardiac Hypertrophy
Journal Article