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Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 591 - 599
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e80908 - e80908
Macrophage polarization is increasingly recognised as an important pathogenetic factor in inflammatory and neoplastic diseases. Proinflammatory M1 macrophages... 
CD163 | ACTIVATION | SCAVENGER RECEPTOR | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | IDENTIFICATION | HUMAN MONOCYTES | TRANSCRIPTION FACTOR | EPSTEIN-BARR-VIRUS | Immunohistochemistry | Antigens, CD - immunology | Granuloma, Foreign-Body - immunology | Infectious Mononucleosis - immunology | Humans | Granuloma, Foreign-Body - pathology | Hypersensitivity - immunology | Antigens, CD - genetics | Oxyuriasis - pathology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Proto-Oncogene Proteins c-maf - immunology | Biomarkers - metabolism | Nasal Polyps - immunology | Gene Expression | Nasal Polyps - pathology | Macrophages - classification | Macrophages - pathology | Infectious Mononucleosis - pathology | Proto-Oncogene Proteins c-maf - genetics | Immunophenotyping | STAT1 Transcription Factor - genetics | Wound Healing - immunology | Crohn Disease - immunology | Receptors, Cell Surface - immunology | Antigens, Differentiation, Myelomonocytic - genetics | STAT1 Transcription Factor - immunology | Crohn Disease - pathology | Hypersensitivity - pathology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - immunology | Oxyuriasis - immunology | Cluster Analysis | Receptors, Cell Surface - genetics | Macrophages | Analysis | Cluster analysis | Polarization | Medical research | Antigens | Transcription factors | Immunoglobulins | Wound healing | Immune response | Cloning | Labelling | Lymphocytes T | Gene expression | Infectious mononucleosis | Diseases | Studies | CD163 antigen | Pathology | Mononucleosis | Polyps | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 250 - 262
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine... 
RNA-POLYMERASE-II | ACTIVATION | IFN-GAMMA | MEDIATOR | GENE-EXPRESSION | TRANSACTIVATION DOMAIN | IMMUNOLOGY | SERINE PHOSPHORYLATION | PROMOTER | INNATE IMMUNITY | P-TEFB | Transcription, Genetic - drug effects | Phosphorylation | Oligonucleotide Array Sequence Analysis | Humans | STAT5 Transcription Factor - immunology | Cyclin-Dependent Kinase 8 - immunology | RNA Polymerase II - immunology | STAT5 Transcription Factor - genetics | STAT1 Transcription Factor - metabolism | Cyclin-Dependent Kinase 8 - genetics | STAT3 Transcription Factor - genetics | Fibroblasts - metabolism | Fibroblasts - virology | Promoter Regions, Genetic | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Hep G2 Cells | Gene Expression Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Fibroblasts - drug effects | Interferon-gamma - immunology | Interleukin-6 - immunology | Cyclin-Dependent Kinase 8 - metabolism | RNA Polymerase II - genetics | Mice | STAT3 Transcription Factor - immunology | Vesiculovirus - physiology | Interferon-gamma - pharmacology | DNA microarrays | RNA | Analysis | Genes | Interferon | Universities and colleges | Biological response modifiers | Gene expression | Transcription factors | Cytokines | Cell cycle | Colleges & universities | Grants | RNA polymerase | Kinases | Experiments | Cancer | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5418 - 5427
IFN-beta-1a has been used over the past 15 years as a primary therapy for relapsing-remitting multiple sclerosis (MS). However, the immunomodulatory mechanisms... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | GROWTH-FACTOR-BETA | T(H)17 CELLS | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MESSENGER-RNA EXPRESSION | CENTRAL-NERVOUS-SYSTEM | INTERFERON-BETA | IMMUNOLOGY | UP-REGULATION | T-CELLS | Receptors, CCR6 - immunology | Interleukin-12 Subunit p35 - metabolism | Interleukin-23 Subunit p19 - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Receptors, CCR6 - antagonists & inhibitors | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin - metabolism | Interleukin-23 Subunit p19 - metabolism | STAT1 Transcription Factor - metabolism | Interleukin-1beta - metabolism | Receptors, Retinoic Acid - immunology | Phosphorylation - immunology | Phosphorylation - drug effects | Receptors, Thyroid Hormone - immunology | Interleukin-1beta - antagonists & inhibitors | Nuclear Receptor Subfamily 1, Group F, Member 3 | Receptors, Interleukin - immunology | Receptors, Interleukin - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | Cell Differentiation - immunology | Interferon beta-1a | Up-Regulation - immunology | Interleukin-23 Subunit p19 - immunology | STAT3 Transcription Factor - immunology | Interleukin-10 - immunology | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | T-Lymphocytes, Helper-Inducer - drug effects | T-Lymphocytes, Helper-Inducer - immunology | Receptors, CCR6 - metabolism | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Interleukin-10 - agonists | STAT3 Transcription Factor - metabolism | Cells, Cultured | Interleukin-1beta - immunology | Interleukin-12 Subunit p35 - agonists | Down-Regulation - drug effects | STAT1 Transcription Factor - immunology | Receptors, Thyroid Hormone - metabolism | Up-Regulation - drug effects | Interferon-beta - pharmacology | Interleukin-12 Subunit p35 - immunology | Cell Differentiation - drug effects | Down-Regulation - immunology | STAT3 Transcription Factor - drug effects | Multiple Sclerosis - immunology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 10/2016, Volume 68, Issue 10, pp. 2492 - 2502
ObjectiveAntinuclear antibodies (ANAs) are detected in approximate to 18% of females, yet autoimmune disease develops in only 5-8%. Immunologic differences... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | RISK-FACTORS | CYTOKINE PRODUCTION | DENDRITIC CELLS | ANTINUCLEAR ANTIBODIES | RHEUMATOLOGY | EXPRESSION | BLOOD MONONUCLEAR-CELLS | IG-LIKE RECEPTOR-1 | T-CELLS | Interferon-alpha - pharmacology | Multivariate Analysis | Phosphoproteins - drug effects | Interferon-beta - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | Centromere Protein B - immunology | Male | Monocytes - immunology | Ribosomal Proteins - immunology | Healthy Volunteers | Case-Control Studies | Leukocytes - immunology | Young Adult | Flow Cytometry | Autoimmunity - immunology | Lupus Erythematosus, Systemic - immunology | Ribonucleoproteins - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Interleukin-12 Subunit p40 - immunology | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Immunophenotyping | Logistic Models | Nuclear Proteins - immunology | STAT1 Transcription Factor - immunology | Stem Cell Factor - immunology | Interferon-alpha - immunology | Autoantibodies - immunology | Interferon-gamma - immunology | STAT3 Transcription Factor - drug effects | Sex Factors | Aged | Granulocyte Colony-Stimulating Factor - immunology | STAT3 Transcription Factor - immunology | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus | Systemic Lupus Erythematosus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2010, Volume 207, Issue 1, pp. 155 - 171
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 501 - 510
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 511 - 523
Interferon-γ (IFN-γ) promotes a population of T-bet CXCR3 regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies... 
BET | RESPONSES | TOXOPLASMA-GONDII INFECTION | DENDRITIC CELLS | IFN-GAMMA | IN-VIVO | REGULATORY T-CELLS | IL-27 | IMMUNOLOGY | EXPRESSION | VIRAL-INFECTION | Forkhead Transcription Factors - immunology | Toxoplasma - immunology | T-Lymphocytes, Regulatory - metabolism | Oligonucleotide Array Sequence Analysis | Interleukin-17 - immunology | Male | Gene Expression Profiling | T-Box Domain Proteins - immunology | Interleukin-17 - pharmacology | T-Lymphocytes, Regulatory - immunology | Salmonella Infections, Animal - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | Toxoplasmosis, Animal - parasitology | Forkhead Transcription Factors - metabolism | Mice, Inbred CBA | Female | Interferon-gamma - genetics | Receptors, CXCR3 - metabolism | Salmonella Infections, Animal - pathology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Cells, Cultured | Interleukin-17 - genetics | Mice, Transgenic | Forkhead Transcription Factors - genetics | STAT1 Transcription Factor - genetics | T-Box Domain Proteins - genetics | STAT1 Transcription Factor - immunology | T-Box Domain Proteins - metabolism | Mice, Knockout | Cell Differentiation - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Cell Differentiation - drug effects | Interferon-gamma - immunology | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Salmonella Infections, Animal - microbiology | Toxoplasmosis, Animal - immunology | Mice | Interferon-gamma - pharmacology | Toxoplasmosis, Animal - pathology | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 698 - 707
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 593 - 602
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and... 
IFN | MEMORY | CLONAL EXPANSION | STAT3 | PROLIFERATION | INFECTION | DIFFERENTIATION | IMMUNOLOGY | MODULATION | CUTTING EDGE | LYMPHOCYTES | Oligonucleotide Array Sequence Analysis | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | MicroRNAs - metabolism | Gene Expression Profiling | Interferon Regulatory Factor-7 - genetics | Interferons - immunology | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | RNA Interference | CD8-Positive T-Lymphocytes - metabolism | Gene Regulatory Networks - immunology | Immunologic Memory - genetics | Immunologic Memory - immunology | Gene Regulatory Networks - genetics | Interferons - pharmacology | Suppressor of Cytokine Signaling Proteins - immunology | Mice, Inbred C57BL | Suppressor of Cytokine Signaling Proteins - genetics | Interferon Regulatory Factor-7 - immunology | Signal Transduction - genetics | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | Interferon Regulatory Factor-7 - metabolism | STAT1 Transcription Factor - immunology | Mice, Knockout | Animals | Interferons - metabolism | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Index Medicus
Journal Article