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Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 501 - 510
.... We demonstrate that the development of T-bet+ Treg cells that potently inhibit T helper 1 (Th1) cell responses was dependent on the transcription factor STAT1 and occurred directly in response to interferon... 
Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | STAT4 Transcription Factor - metabolism | T-Box Domain Proteins - immunology | Interferon-gamma - metabolism | Mice, 129 Strain | Th1 Cells - immunology | T-Lymphocytes, Regulatory - immunology | Th1 Cells - metabolism | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | Time Factors | Forkhead Transcription Factors - metabolism | Interleukin-12 Receptor beta 2 Subunit - genetics | Interleukin-12 Receptor beta 2 Subunit - immunology | Cell Differentiation | Interferon-gamma - genetics | STAT4 Transcription Factor - immunology | Interleukin-12 - pharmacology | Receptors, CXCR3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | T-Box Domain Proteins - genetics | STAT1 Transcription Factor - immunology | T-Box Domain Proteins - metabolism | Mice, Knockout | Animals | Signal Transduction - drug effects | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Cell Proliferation - drug effects | Interleukin-12 Receptor beta 2 Subunit - metabolism | Mice | Interferon-gamma - pharmacology
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2012, Volume 37, Issue 3, pp. 511 - 523
Interferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies... 
BET | RESPONSES | TOXOPLASMA-GONDII INFECTION | DENDRITIC CELLS | IFN-GAMMA | IN-VIVO | REGULATORY T-CELLS | IL-27 | IMMUNOLOGY | EXPRESSION | VIRAL-INFECTION | Forkhead Transcription Factors - immunology | Toxoplasma - immunology | T-Lymphocytes, Regulatory - metabolism | Oligonucleotide Array Sequence Analysis | Interleukin-17 - immunology | Male | Gene Expression Profiling | T-Box Domain Proteins - immunology | Interleukin-17 - pharmacology | T-Lymphocytes, Regulatory - immunology | Salmonella Infections, Animal - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | Toxoplasmosis, Animal - parasitology | Forkhead Transcription Factors - metabolism | Mice, Inbred CBA | Female | Interferon-gamma - genetics | Receptors, CXCR3 - metabolism | Salmonella Infections, Animal - pathology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Cells, Cultured | Interleukin-17 - genetics | Mice, Transgenic | Forkhead Transcription Factors - genetics | STAT1 Transcription Factor - genetics | T-Box Domain Proteins - genetics | STAT1 Transcription Factor - immunology | T-Box Domain Proteins - metabolism | Mice, Knockout | Cell Differentiation - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Cell Differentiation - drug effects | Interferon-gamma - immunology | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Salmonella Infections, Animal - microbiology | Toxoplasmosis, Animal - immunology | Mice | Interferon-gamma - pharmacology | Toxoplasmosis, Animal - pathology
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 625 - 636
...es. Signal transducer and activator of transcription (STAT) 1 is a transcription factor that maintains T helper type 1 cell development... 
Carbon nanotubes | Nanomaterials | Airway remodeling | Allergen | Asthma | allergen | STAT1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | airway remodeling | CD4(+) T-CELLS | asthma | nanomaterials | CELL BIOLOGY | carbon nanotubes | RESPIRATORY SYSTEM | GROWTH | DIESEL EXHAUST | LUNG-DISEASE | MICE | UP-REGULATION | EXPRESSION | PULMONARY-FIBROSIS | Osteopontin - genetics | Eosinophils - drug effects | Ovalbumin - immunology | STAT1 Transcription Factor - deficiency | Epithelial Cells - drug effects | Tumor Necrosis Factor-alpha - genetics | Interleukin-13 - immunology | Goblet Cells - drug effects | Male | Eosinophils - immunology | Respiratory Hypersensitivity - pathology | Goblet Cells - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Transforming Growth Factor beta1 - immunology | Interleukin-13 - genetics | T-Lymphocytes, Helper-Inducer - immunology | Tumor Necrosis Factor-alpha - immunology | Eosinophils - pathology | T-Lymphocytes, Helper-Inducer - pathology | Transforming Growth Factor beta1 - pharmacology | Nanotubes - adverse effects | Neutrophils - pathology | Signal Transduction | Respiratory Hypersensitivity - etiology | Neutrophils - drug effects | Gene Expression Regulation | Neutrophils - immunology | Epithelial Cells - pathology | Transforming Growth Factor beta1 - genetics | Respiratory Hypersensitivity - immunology | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Mice, Knockout | Osteopontin - immunology | Respiratory Hypersensitivity - genetics | Animals | Epithelial Cells - immunology | Interleukin-10 - genetics | Allergens - pharmacology | Mice | Bronchoalveolar Lavage Fluid - chemistry | Goblet Cells - pathology | Interleukin-10 - immunology | Transcription factors | Cytokines | Mortality | Inflammation | Surfactants | Carbon | Nanoparticles | Lungs | Collagen | Fibroblasts | Growth factors | Apoptosis | Index Medicus
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2017, Volume 139, Issue 5, pp. 1629 - 1640.e2
Background Gain-of-function (GOF) mutations in the human signal transducer and activator of transcription 1 (STAT1... 
Allergy and Immunology | IFN-γ | autoimmunity | follicular T helper cell | TH1 cell | STAT1 gain of function | TH17 cell | T helper cell polarization | ruxolitinib | 17 cell | 1 cell | T(H)1 cell | IMMUNOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | DEFICIENCY | INBORN-ERRORS | IMMUNE DYSREGULATION | IFN-gamma | ALLERGY | T(H)17 cell | DNA | DISEASE | IL-17 IMMUNITY | DIFFERENTIATION | BINDING | IMMUNODEFICIENCY | Th1 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - genetics | Candidiasis, Chronic Mucocutaneous - genetics | Humans | Candidiasis, Chronic Mucocutaneous - immunology | Anemia, Hemolytic, Autoimmune - genetics | STAT1 Transcription Factor - genetics | Th1 Cells - immunology | STAT1 Transcription Factor - immunology | Janus Kinases - antagonists & inhibitors | Th17 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - immunology | Anemia, Hemolytic, Autoimmune - immunology | Th17 Cells - immunology | Female | Protein Kinase Inhibitors - pharmacology | Mutation | Child | Autoimmunity - drug effects | Cytokines - immunology | Pyrazoles - pharmacology | Autoimmunity | Medical colleges | Immunodeficiency | Stem cells | Bone marrow | Genetic aspects | Transplantation | Interferon | Genetic transcription | Cell differentiation | Polarization | Phosphorylation | Candidiasis | Inhibitor drugs | Transcription | Syngeneic grafts | Differentiation (biology) | Helper cells | Bone marrow transplantation | Stem cell transplantation | Infections | Lymphocytes T | Dephosphorylation | Kinases | Immunology | Lymphocytes | Janus kinase | Remission | Drug therapy | Stat1 protein | Chronic mucocutaneous candidiasis | Functional analysis | Disease control | Patients | Hemopoiesis | Inhibitors | Kinetics | Autoimmune diseases
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2010, Volume 185, Issue 12, pp. 7573 - 7582
In mammals, IFN regulatory factor (IRF) 3 is a critical player in modulating transcription of type I IFN and IFN-stimulated genes (ISGs... 
TRANSCRIPTION FACTORS | ANTIVIRAL RESPONSE | DOUBLE-STRANDED-RNA | ONCORHYNCHUS-MYKISS | INNATE IMMUNE-RESPONSE | FUNCTIONAL-ANALYSIS | PARALICHTHYS-OLIVACEUS | INDEPENDENT ACTIVATION | IMMUNOLOGY | NF-KAPPA-B | ATLANTIC SALMON | Cell Nucleus - immunology | Mammals - genetics | Transcription, Genetic - drug effects | Interferons - immunology | Interferon Regulatory Factor-3 - genetics | Fish Proteins - genetics | Goldfish - genetics | Phosphorylation - genetics | STAT1 Transcription Factor - metabolism | Cell Nucleus - metabolism | Mammals - immunology | Up-Regulation - physiology | Phosphorylation - immunology | Interferons - genetics | Phosphorylation - drug effects | Active Transport, Cell Nucleus - genetics | Interferon Regulatory Factor-3 - immunology | Fish Proteins - biosynthesis | Mammals - metabolism | Poly I-C - pharmacology | Goldfish - metabolism | Fish Proteins - immunology | STAT1 Transcription Factor - genetics | Goldfish - immunology | STAT1 Transcription Factor - immunology | Up-Regulation - drug effects | Animals | Cell Nucleus - genetics | Active Transport, Cell Nucleus - drug effects | Interferon Regulatory Factor-3 - biosynthesis | Interferons - metabolism | Transcription, Genetic - immunology | Active Transport, Cell Nucleus - immunology | Mutation | Transcription, Genetic - genetics | Evolution, Molecular | Interferon Inducers - pharmacology
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 6, pp. 1611 - 1623.e3
Background Mutations in signal transducer and activator of transcription (STAT) 1 cause a broad spectrum of disease, ranging from severe viral and bacterial infections (amorphic alleles... 
Allergy and Immunology | Signal transducer and activator of transcription 1 | regulatory T cell | immune dysregulation–polyendocrinopathy–enteropathy–X-linked | chronic mucocutaneous candidiasis | forkhead box protein 3 | aneurysms | immune dysregulation-polyendocrinopathy-enteropathy-X-linked | IMMUNOLOGY | DEFICIENCY | DISEASES | ALLERGY | REGULATORY T-CELLS | IPEX | EXPRESSION | IMMUNODEFICIENCY | T-Lymphocytes, Regulatory - metabolism | Polyendocrinopathies, Autoimmune - diagnosis | Humans | Transcriptional Activation | Interleukin-17 - immunology | Child, Preschool | Male | Intestinal Diseases - immunology | Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - immunology | Lymphocyte Subsets - metabolism | STAT1 Transcription Factor - metabolism | Genes, Dominant | Th17 Cells - metabolism | Interleukins - immunology | Female | Genetic Diseases, X-Linked - genetics | Polyendocrinopathies, Autoimmune - genetics | Phosphorylation - drug effects | Child | Intestinal Diseases - genetics | Immunophenotyping | DNA - metabolism | Forkhead Transcription Factors - genetics | STAT1 Transcription Factor - genetics | Genetic Diseases, X-Linked - diagnosis | Syndrome | Interferon-alpha - immunology | Polyendocrinopathies, Autoimmune - immunology | Genetic Diseases, X-Linked - immunology | Intestinal Diseases - diagnosis | Autoantibodies - immunology | Phenotype | Adolescent | Th17 Cells - immunology | Mutation | Cell Line, Transformed | Interferon-gamma - pharmacology | Autoimmunity | Medical colleges | Invisibility | Molecular genetics | Mycoses | Aneurysms | Genetic aspects | Children | Health aspects
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 2176 - 15
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic... 
AICARDI-GOUTIERES-SYNDROME | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVE ENZYME | MAMMALIAN DNA | MULTIDISCIPLINARY SCIENCES | ALPHA | INFLAMMATORY DISEASE | DEOXYRIBONUCLEASE-II | MUTATIONS | EXONUCLEASE TREX1 | NUCLEIC-ACIDS | Endodeoxyribonucleases - immunology | Phosphorylation | Deoxyribonucleases - deficiency | Humans | RNA, Messenger - analysis | Male | Gene Expression Profiling | Erythroblasts - immunology | Signal Transduction - immunology | Deoxyribonucleases - immunology | STAT1 Transcription Factor - metabolism | Female | Endodeoxyribonucleases - deficiency | Child | STAT3 Transcription Factor - metabolism | Interferon-alpha - metabolism | Antiviral Agents - pharmacology | Hereditary Autoinflammatory Diseases - blood | Hereditary Autoinflammatory Diseases - enzymology | Hereditary Autoinflammatory Diseases - immunology | Interferon-alpha - immunology | Up-Regulation - drug effects | Deoxyribonucleases - genetics | Hematopoiesis - immunology | Endodeoxyribonucleases - genetics | Sequence Analysis, RNA | Interferon-alpha - blood | Adolescent | Mutation | Hereditary Autoinflammatory Diseases - genetics | Glomerulonephritis | Neonates | Deformation | Liver | Antibodies | α-Interferon | Microorganisms | Lymphocytes | Hematopoiesis | Peripheral blood | Anti-DNA antibodies | Stat1 protein | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Deoxyribonuclease | Hematology | Anemia | Stat3 protein | Nucleic acids | Ribonucleic acid--RNA | Hemopoiesis | Signaling | Monocytes | Erythroblasts | Fibrosis | Interferon | Endonuclease | Life Sciences | Immunology
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 210 - 216
Journal Article
Current opinion in pediatrics, ISSN 1040-8703, 12/2013, Volume 25, Issue 6, pp. 708 - 714
Purpose of reviewTo summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related... 
ITCH | autoimmunity | STAT1 | T regulatory cells | STAT5 | CD25 | FOXP3 | tolerance | TGF-BETA | GROWTH-HORMONE INSENSITIVITY | STAT5B MUTATION | CHRONIC MUCOCUTANEOUS CANDIDIASIS | CUTTING EDGE | INTESTINAL INFLAMMATION | ALPHA-CHAIN | TRANSCRIPTION FACTOR FOXP3 | REGULATORY T-CELLS | PEDIATRICS | SCURFY MOUSE MUTANT | Forkhead Transcription Factors - immunology | Immunologic Deficiency Syndromes - pathology | Humans | STAT5 Transcription Factor - immunology | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - congenital | Male | Intestinal Diseases - immunology | Diarrhea - pathology | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - genetics | Ubiquitin-Protein Ligases - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Autoimmunity - immunology | Diarrhea - immunology | Female | Genetic Diseases, X-Linked - genetics | Polyendocrinopathies, Autoimmune - genetics | Immunologic Deficiency Syndromes - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Genetic Predisposition to Disease | Intestinal Diseases - genetics | Repressor Proteins - genetics | Polyendocrinopathies, Autoimmune - pathology | Forkhead Transcription Factors - genetics | Mutation - genetics | Polyendocrinopathies, Autoimmune - immunology | Genetic Diseases, X-Linked - immunology | Immune System Diseases - congenital | Autoantibodies - immunology | Diarrhea - genetics | Repressor Proteins - immunology | Genetic Diseases, X-Linked - pathology | Immunologic Deficiency Syndromes - genetics | Ubiquitin-Protein Ligases - genetics | Intestinal Diseases - pathology | Tolerance
Journal Article
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 6, pp. 1624 - 1634.e17
Journal Article