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hela cells (42) 42
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interferon-stimulated gene factor 3, gamma subunit (42) 42
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interferon-alpha (40) 40
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signal transduction - physiology (40) 40
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abridged index medicus (39) 39
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ifn-gamma (39) 39
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innate immunity (38) 38
medicine (38) 38
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Journal of Leukocyte Biology, ISSN 0741-5400, 05/2017, Volume 101, Issue 5, pp. 1181 - 1190
The interferon and T cell receptor signaling pathways mediate specific and combined contributions to IL‐10 regulation via STAT and BATF transcription factors.... 
gene regulation | Tr1 cells | signaling | Signaling | Gene regulation | ACTIVATION | Tr 1 cells | PERSISTENT LCMV INFECTION | RECEPTOR | IMMUNOLOGY | CUTTING EDGE | BETA | CELL BIOLOGY | IRF INTERACTIONS | RESPONSES | GENE | DIFFERENTIATION | HEMATOLOGY | IFN-ALPHA | Interferon-alpha - pharmacology | RNA, Small Interfering - genetics | STAT2 Transcription Factor - immunology | Humans | Basic-Leucine Zipper Transcription Factors - immunology | CD4-Positive T-Lymphocytes - immunology | CD3 Complex - genetics | CD28 Antigens - genetics | CD28 Antigens - antagonists & inhibitors | Basic-Leucine Zipper Transcription Factors - antagonists & inhibitors | Phosphorylation - drug effects | Binding Sites | STAT3 Transcription Factor - genetics | Signal Transduction | CD4-Positive T-Lymphocytes - cytology | Gene Expression Regulation | CD28 Antigens - immunology | Basic-Leucine Zipper Transcription Factors - genetics | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - antagonists & inhibitors | Cycloheximide - pharmacology | STAT1 Transcription Factor - immunology | Interferon-alpha - immunology | Antibodies - pharmacology | Enhancer Elements, Genetic | STAT2 Transcription Factor - antagonists & inhibitors | Interleukin-10 - genetics | CD3 Complex - immunology | STAT2 Transcription Factor - genetics | Protein Binding | Primary Cell Culture | STAT3 Transcription Factor - immunology | Protein Isoforms - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Interleukin-10 - immunology | CD4-Positive T-Lymphocytes - drug effects | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Phosphorylation | Transcription factors | CD45RA antigen | Central nervous system | Lymphocytes T | Leucine | Recruitment | T-cell receptor | Signal transduction | Conserved sequence | Pathways | Lymphocytes | Stat1 protein | Immune system | Stat2 protein | RNA-mediated interference | Stat3 protein | Inflammation | T cell receptors | Gene expression | Ribonucleic acid--RNA | CD4 antigen | Leucine zipper proteins | Interleukin 10 | Interferon | Index Medicus | STAT2 Transcription Factor | Interleukin-10 | Interferon-alpha | CD3 Complex | Antibodies | Life Sciences | Cycloheximide | Immunology | Protein Isoforms | CD28 Antigens | STAT1 Transcription Factor | RNA, Small Interfering | STAT3 Transcription Factor | CD4-Positive T-Lymphocytes | Basic-Leucine Zipper Transcription Factors
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 55, Issue 2, pp. 289 - 298
Background & Aims The combination of pegylated interferon (IFN) α and ribavirin (RBV) is the standard therapy for patients with chronic HCV infection. However,... 
Gastroenterology and Hepatology | IL28B | STAT | HCV | JAK | IFNS | CLEARANCE | INNATE | RIBAVIRIN | GENOME | LAMBDA | GENETIC-VARIATION | ANTIVIRAL RESPONSES | INTERFERON-ALPHA | CELL-CULTURE | GASTROENTEROLOGY & HEPATOLOGY | RNA, Small Interfering - genetics | Humans | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | DNA Primers - genetics | Janus Kinases - metabolism | Interleukins - genetics | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Base Sequence | Hepacivirus - physiology | TYK2 Kinase - antagonists & inhibitors | Interleukins - pharmacology | Phosphorylation - drug effects | Hepacivirus - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Recombinant Proteins - pharmacology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Janus Kinase 1 - antagonists & inhibitors | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | STAT1 Transcription Factor - antagonists & inhibitors | Receptors, Interferon - metabolism | Janus Kinases - antagonists & inhibitors | STAT2 Transcription Factor - antagonists & inhibitors | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Polymorphism, Single Nucleotide | STAT Transcription Factors - antagonists & inhibitors | STAT2 Transcription Factor - metabolism | Virus Replication - physiology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Virus diseases | Genetic research | Precipitation (Meteorology) | Biological response modifiers | Hepatitis C virus | Health aspects | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2013, Volume 32, Issue 20, pp. 2751 - 2763
A single high dose of interferon‐β (IFNβ) activates powerful cellular responses, in which many anti‐viral, pro‐apoptotic, and anti‐proliferative proteins are... 
DNA damage resistance | interferon‐β | unphosphorylated interferon‐stimulated gene factor 3 (U‐ISGF3) | anti‐viral genes | interferon-β | anti-viral genes | unphosphorylated interferon-stimulated gene factor 3 (U-ISGF3) | PROTEIN | CANCER CELLS | IKK-EPSILON | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | RADIATION | CELL BIOLOGY | BREAST-CANCER | interferon-beta | ALPHA/BETA-INTERFERON-PRODUCTION | GENE-EXPRESSION | ANTIVIRAL ACTIVITY | UP-REGULATION | Tumor Escape - drug effects | Viruses - pathogenicity | Tumor Escape - genetics | Humans | Cercopithecus aethiops | STAT1 Transcription Factor - metabolism | DNA Damage - genetics | Virus Diseases - genetics | Disease Resistance - genetics | Vero Cells | DNA Damage - drug effects | Antiviral Agents - pharmacology | Virus Diseases - immunology | Cells, Cultured | Disease Resistance - drug effects | Gene Expression Regulation - physiology | Viruses - drug effects | Viruses - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Gene Expression Regulation - drug effects | Animals | Interferon-beta - pharmacology | STAT2 Transcription Factor - genetics | STAT2 Transcription Factor - metabolism | Virus Diseases - prevention & control | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10048 - 10060
IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several angioproliferative disorders. However, the detailed mechanisms of... 
APOPTOSIS | ACTIVATION | NETWORK | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TNF-ALPHA | INDUCTION | RAR-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic - pathology | Endopeptidases - chemistry | STAT1 Transcription Factor - metabolism | Interferon-alpha - genetics | RNA Interference | Human Umbilical Vein Endothelial Cells - cytology | STAT1 Transcription Factor - agonists | Promyelocytic Leukemia Protein - metabolism | Ubiquitin Thiolesterase - metabolism | Neovascularization, Pathologic - prevention & control | Ubiquitin Thiolesterase - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promyelocytic Leukemia Protein - genetics | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Interferon-alpha - metabolism | Cells, Cultured | STAT1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Mice, Knockout | STAT2 Transcription Factor - agonists | Animals | Endopeptidases - genetics | Endothelium, Vascular - metabolism | STAT2 Transcription Factor - genetics | Promyelocytic Leukemia Protein - antagonists & inhibitors | Endothelium, Vascular - pathology | Neovascularization, Pathologic - metabolism | Protein Processing, Post-Translational | STAT2 Transcription Factor - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Neovascularization, Physiologic | Index Medicus | signal transducers and activators of transcription 1 (STAT1) | STAT transcription factor | Signal Transduction | interferon | angiogenesis | STAT3
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2015, Volume 11, Issue 3, pp. 1 - 24
Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such... 
VIRAL GENE-EXPRESSION | MICROBIOLOGY | INTRINSIC IMMUNITY | STIMULATED TRANSCRIPTION | DNA-REPLICATION | NUCLEAR-BODIES | ANTIVIRAL DEFENSE | VIROLOGY | PML PROTEIN | IE1 PROTEIN | POLYMERASE-II | HISTONE DEACETYLASE | PARASITOLOGY | Humans | Immediate-Early Proteins - metabolism | STAT1 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Interferon Type I - metabolism | Nuclear Proteins - genetics | Histone Deacetylase 1 - genetics | Cytomegalovirus - genetics | Histone Deacetylase 2 - genetics | Tumor Suppressor Proteins - metabolism | Cytomegalovirus - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Transcription Factors - metabolism | Immediate-Early Proteins - genetics | STAT2 Transcription Factor - genetics | Interferon Type I - genetics | STAT2 Transcription Factor - metabolism | Histone Deacetylase 2 - metabolism | Promyelocytic Leukemia Protein | Histone Deacetylase 1 - metabolism | Interferon | Genetic aspects | Host-virus relationships | Viral proteins | Cytomegaloviruses | Health aspects | Index Medicus | Cytomegalovirus | Viruses | Infections | Genomes | Kinases | Gene expression | Proteins | Plasmids | Deoxyribonucleic acid | DNA | Viral infections | Immune system | Apoptosis
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4415 - 4420
Primary immunodeficiencies are often monogenic disorders characterized by vulnerability to specific infectious pathogens. Here, we performed whole-exome... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | ACTIVATOR | INTERFERON-GAMMA | MYCOBACTERIAL DISEASE | ALPHA/BETA | MENDELIAN SUSCEPTIBILITY | CLINICAL-FEATURES | DEFICIENCY | SIGNAL TRANSDUCER | INBORN-ERRORS | Bacteremia - immunology | Genetic Diseases, Inborn - microbiology | STAT2 Transcription Factor - immunology | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - virology | Male | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Bacteremia - microbiology | Streptococcal Infections - genetics | Phosphorylation - genetics | Female | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Fibroblasts - microbiology | Mycobacterium Infections, Nontuberculous - immunology | Immunologic Deficiency Syndromes - immunology | Receptors, Interferon - genetics | Fibroblasts - virology | Genetic Diseases, Inborn - immunology | Viremia - genetics | Viridans Streptococci - immunology | Bacteremia - genetics | Immunologic Deficiency Syndromes - virology | STAT1 Transcription Factor - genetics | Immunologic Deficiency Syndromes - microbiology | STAT1 Transcription Factor - immunology | Cytomegalovirus - immunology | Mycobacterium abscessus - immunology | Receptor, Interferon alpha-beta - immunology | Receptors, Interferon - immunology | Viremia - virology | STAT2 Transcription Factor - genetics | Immunologic Deficiency Syndromes - genetics | Fibroblasts - immunology | Viremia - immunology | Streptococcal Infections - immunology | Mutation | Mycobacterium Infections, Nontuberculous - genetics | Virus diseases | Usage | Immunotherapy | Genetic aspects | Disease susceptibility | Research | Mutation (Biology) | Stat2 protein | Cytomegalovirus | Phosphorylation | Viremia | Immunodeficiency | Stop codon | C-Terminus | Gene deletion | Bacteremia | Nuclear transport | α-Interferon | Clonal deletion | Fibroblasts | Interferon | Codons | Stat1 protein | Viral infections | Index Medicus | Abridged Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 09/2014, Volume 16, Issue 3, pp. 314 - 327
Journal Article
Brain, ISSN 0006-8950, 10/2015, Volume 138, Issue 10, pp. 2834 - 2846
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 210 - 216
Journal Article
Journal Article
Journal Article