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Journal of Hepatology, ISSN 0168-8278, 2010, Volume 55, Issue 2, pp. 289 - 298
Background & Aims The combination of pegylated interferon (IFN) α and ribavirin (RBV) is the standard therapy for patients with chronic HCV infection. However,... 
Gastroenterology and Hepatology | IL28B | STAT | HCV | JAK | IFNS | CLEARANCE | INNATE | RIBAVIRIN | GENOME | LAMBDA | GENETIC-VARIATION | ANTIVIRAL RESPONSES | INTERFERON-ALPHA | CELL-CULTURE | GASTROENTEROLOGY & HEPATOLOGY | RNA, Small Interfering - genetics | Humans | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | DNA Primers - genetics | Janus Kinases - metabolism | Interleukins - genetics | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Base Sequence | Hepacivirus - physiology | TYK2 Kinase - antagonists & inhibitors | Interleukins - pharmacology | Phosphorylation - drug effects | Hepacivirus - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Recombinant Proteins - pharmacology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Janus Kinase 1 - antagonists & inhibitors | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | STAT1 Transcription Factor - antagonists & inhibitors | Receptors, Interferon - metabolism | Janus Kinases - antagonists & inhibitors | STAT2 Transcription Factor - antagonists & inhibitors | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Polymorphism, Single Nucleotide | STAT Transcription Factors - antagonists & inhibitors | STAT2 Transcription Factor - metabolism | Virus Replication - physiology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Virus diseases | Genetic research | Precipitation (Meteorology) | Biological response modifiers | Hepatitis C virus | Health aspects
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10048 - 10060
IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several angioproliferative disorders. However, the detailed mechanisms of... 
APOPTOSIS | ACTIVATION | NETWORK | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TNF-ALPHA | INDUCTION | RAR-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic - pathology | Endopeptidases - chemistry | STAT1 Transcription Factor - metabolism | Interferon-alpha - genetics | RNA Interference | Human Umbilical Vein Endothelial Cells - cytology | STAT1 Transcription Factor - agonists | Promyelocytic Leukemia Protein - metabolism | Ubiquitin Thiolesterase - metabolism | Neovascularization, Pathologic - prevention & control | Ubiquitin Thiolesterase - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promyelocytic Leukemia Protein - genetics | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Interferon-alpha - metabolism | Cells, Cultured | STAT1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Mice, Knockout | STAT2 Transcription Factor - agonists | Animals | Endopeptidases - genetics | Endothelium, Vascular - metabolism | STAT2 Transcription Factor - genetics | Promyelocytic Leukemia Protein - antagonists & inhibitors | Endothelium, Vascular - pathology | Neovascularization, Pathologic - metabolism | Protein Processing, Post-Translational | STAT2 Transcription Factor - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Neovascularization, Physiologic | signal transducers and activators of transcription 1 (STAT1) | STAT transcription factor | Signal Transduction | interferon | angiogenesis | STAT3
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 02/2013, Volume 45, Issue 2, pp. 164 - 171
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2013, Volume 32, Issue 20, pp. 2751 - 2763
A single high dose of interferon‐β (IFNβ) activates powerful cellular responses, in which many anti‐viral, pro‐apoptotic, and anti‐proliferative proteins are... 
DNA damage resistance | interferon‐β | unphosphorylated interferon‐stimulated gene factor 3 (U‐ISGF3) | anti‐viral genes | interferon-β | anti-viral genes | unphosphorylated interferon-stimulated gene factor 3 (U-ISGF3) | PROTEIN | CANCER CELLS | IKK-EPSILON | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | RADIATION | CELL BIOLOGY | BREAST-CANCER | interferon-beta | ALPHA/BETA-INTERFERON-PRODUCTION | GENE-EXPRESSION | ANTIVIRAL ACTIVITY | UP-REGULATION | Tumor Escape - drug effects | Viruses - pathogenicity | Tumor Escape - genetics | Humans | Cercopithecus aethiops | STAT1 Transcription Factor - metabolism | DNA Damage - genetics | Virus Diseases - genetics | Disease Resistance - genetics | Vero Cells | DNA Damage - drug effects | Antiviral Agents - pharmacology | Virus Diseases - immunology | Cells, Cultured | Disease Resistance - drug effects | Gene Expression Regulation - physiology | Viruses - drug effects | Viruses - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Gene Expression Regulation - drug effects | Animals | Interferon-beta - pharmacology | STAT2 Transcription Factor - genetics | STAT2 Transcription Factor - metabolism | Virus Diseases - prevention & control
Journal Article
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 09/2014, Volume 16, Issue 3, pp. 314 - 327
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2015, Volume 11, Issue 3, pp. 1 - 24
Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such... 
VIRAL GENE-EXPRESSION | MICROBIOLOGY | INTRINSIC IMMUNITY | STIMULATED TRANSCRIPTION | DNA-REPLICATION | NUCLEAR-BODIES | ANTIVIRAL DEFENSE | VIROLOGY | PML PROTEIN | IE1 PROTEIN | POLYMERASE-II | HISTONE DEACETYLASE | PARASITOLOGY | Humans | Immediate-Early Proteins - metabolism | STAT1 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Interferon Type I - metabolism | Nuclear Proteins - genetics | Histone Deacetylase 1 - genetics | Cytomegalovirus - genetics | Histone Deacetylase 2 - genetics | Tumor Suppressor Proteins - metabolism | Cytomegalovirus - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Transcription Factors - metabolism | Immediate-Early Proteins - genetics | STAT2 Transcription Factor - genetics | Interferon Type I - genetics | STAT2 Transcription Factor - metabolism | Histone Deacetylase 2 - metabolism | Promyelocytic Leukemia Protein | Histone Deacetylase 1 - metabolism | Interferon | Genetic aspects | Host-virus relationships | Viral proteins | Cytomegaloviruses | Health aspects | Cytomegalovirus | Viruses | Infections | Genomes | Kinases | Gene expression | Proteins | Plasmids | Deoxyribonucleic acid | DNA | Viral infections | Immune system | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157430 - e0157430
Sulforaphane (SFN) and moringin (GMG-ITC) are edible isothiocyanates present as glucosinolate precursors in cruciferous vegetables and in the plant Moringa... 
CANCER-CELLS | GLUCOMORINGIN ISOTHIOCYANATE | JAK-STAT PATHWAY | CHEMICAL BIOLOGY | TRANSCRIPTION 3 | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | IN-VIVO | DEACETYLASE INHIBITORS | MONOCYTE ADHESION | NF-KAPPA-B | Interferon-alpha - pharmacology | Gene Expression - drug effects | Humans | Precursor Cells, B-Lymphoid - metabolism | STAT Transcription Factors - metabolism | Cell Survival - genetics | Janus Kinases - metabolism | Precursor Cells, B-Lymphoid - drug effects | Interleukin-3 - pharmacology | Dose-Response Relationship, Drug | Moringa oleifera - chemistry | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | STAT1 Transcription Factor - metabolism | Isothiocyanates - chemistry | Molecular Structure | Seeds - chemistry | Isothiocyanates - isolation & purification | Phosphorylation - drug effects | Isothiocyanates - pharmacology | Cell Line | Cell Survival - drug effects | Janus Kinases - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | Blotting, Western | STAT Transcription Factors - genetics | Animals | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Mice | STAT2 Transcription Factor - metabolism | HeLa Cells | Biotechnology | Phosphorylation | Transformation | Vegetables | Seeds | Disorders | Kinases | Inflammatory diseases | Mimicry | Signal transduction | Toxicology | Cell growth | Immunology | Illnesses | Pathways | Interleukin 3 | Rodents | Stat1 protein | Sulforafan | Medicinal plants | Stat2 protein | NF-κB protein | Cell survival | Stat5 protein | Gene expression | Disease prevention | Studies | Signaling | Diet | Tumor necrosis factor | Cell death | Pharmacy | Prostate cancer | Binding sites | Cancer | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 1, pp. 93 - 105
Journal Article