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1. Full Text Programmed death-1-induced interleukin-10 production by monocytes impairs CD4 + T cell activation during HIV infection
by Bruneau, Julie and Fonseca, Simone G and Shoukry, Naglaa H and El-Far, Mohamed and Shi, Yu and Zhang, Yuwei and Boulassel, Mohamed R and Douek, Daniel C and Dupuy, Franck P and Ancuta, Petronela and Noto, Alessandra and Haddad, Elias K and Trautmann, Lydie and Van Grevenynghe, Julien and Said, Elias A and Hill, Brenna J and Routy, Jean-Pierre and Peretz, Yoav and Sekaly, Rafick-Pierre
Nature Medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 452 - 459
Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline... 
MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | CYTOKINE SIGNALING-3 | HUMAN MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIRETROVIRAL THERAPY | HUMAN-IMMUNODEFICIENCY-VIRUS | CHRONIC VIRAL-INFECTION | CELL BIOLOGY | IMMUNE ACTIVATION | SERUM IL-10 LEVELS | DISEASE PROGRESSION | PD-1 EXPRESSION | Phosphorylation | Antigens, CD - biosynthesis | Humans | Monocytes - immunology | CD4-Positive T-Lymphocytes - physiology | Interleukin-10 - physiology | Lymphocyte Subsets - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Lymphocyte Activation - immunology | STAT3 Transcription Factor - physiology | Up-Regulation - physiology | CD4-Positive T-Lymphocytes - virology | Monocytes - physiology | Lymphocyte Subsets - physiology | Receptors, IgG - physiology | Viremia - physiopathology | B7-H1 Antigen | Receptors, IgG - immunology | Antigens, CD - physiology | Interleukin-10 - biosynthesis | Viremia - immunology | HIV Infections - physiopathology | STAT3 Transcription Factor - immunology | Lymphocyte Activation - physiology | Immunology | Cellular biology | Cytokines | Microbiology | Human immunodeficiency virus--HIV | Index Medicus
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2. Full Text The activating effect of IFN-γ on monocytes/macrophages is regulated by the LIF-trophoblast-IL-10 axis via Stat1 inhibition and Stat3 activation
by Dallagi, Angham and Girouard, Julie and Hamelin-Morrissette, Jovane and Dadzie, Rachel and Laurent, Laetitia and Vaillancourt, Cathy and Lafond, Julie and Carrier, Christian and Reyes-Moreno, Carlos
Cellular and Molecular Immunology, ISSN 1672-7681, 05/2015, Volume 12, Issue 3, pp. 326 - 341
Interferon gamma (IFN-gamma) and leukemia inhibitory factor (LIF) are key gestational factors that may differentially affect leukocyte function during... 
macrophage deactivation | embryonic cell | gestational factors | cell migration/motility | inflammatory cell | INTERLEUKIN-10 | IMMUNOLOGY | MACROPHAGE ACTIVATION | INTERFERON-GAMMA | NK CELLS | IMPLANTATION | THP-1 CELLS | HUMAN TROPHOBLAST | GENE-EXPRESSION | CELL-LINE | ALTERNATIVE ACTIVATION | Humans | Gene Expression Regulation | Chorionic Villi - immunology | Monocytes - immunology | STAT1 Transcription Factor - genetics | Leukemia Inhibitory Factor - metabolism | Macrophage Activation | Pregnancy - immunology | Trophoblasts - immunology | STAT1 Transcription Factor - metabolism | Interferon-gamma - immunology | Cell Line, Tumor | Interleukin-10 - metabolism | Female | Interleukin-10 - immunology | Macrophages - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Index Medicus | Interferon-gamma | Interleukin-10 | Macrophages | Pregnancy | Life Sciences | Monocytes | Trophoblasts | Immunology | STAT1 Transcription Factor | STAT3 Transcription Factor | Chorionic Villi | Leukemia Inhibitory Factor | cell migration | motility
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3. Full Text IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L
by Kryczek, Ilona and Lin, Yanwei and Nagarsheth, Nisha and Peng, Dongjun and Zhao, Ende and Zhao, Lili and Vatan, Linda and Szeliga, Wojciech and Dou, Yali and Owens, Scott and Zgodzinski, Witold and Majewski, Marek and Wallner, Grzegorz and Fang, Jingyuan and Huang, Emina and Zou, Weiping
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient... 
COLON-CANCER | IMMUNE CELLS | HISTONE H3 | INTERLEUKIN 22 | INFLAMMATION | HOST-DEFENSE | IMMUNOLOGY | NF-KAPPA-B | IL-22 | EXPRESSION | OVARIAN-CARCINOMA | Receptors, CCR6 - immunology | Neoplasm Transplantation | Chemokine CCL20 - metabolism | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Methyltransferases - metabolism | Neoplastic Stem Cells - immunology | Homeodomain Proteins - immunology | Methyltransferases - immunology | Enzyme Activation - immunology | SOXB1 Transcription Factors - metabolism | CD4-Positive T-Lymphocytes - immunology | Chemokine CCL20 - immunology | SOXB1 Transcription Factors - immunology | Interleukins - immunology | Receptors, CCR6 - metabolism | Neoplastic Stem Cells - pathology | Octamer Transcription Factor-3 - immunology | STAT3 Transcription Factor - metabolism | Colorectal Neoplasms - mortality | Nanog Homeobox Protein | HT29 Cells | Animals | Colorectal Neoplasms - immunology | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Mice | STAT3 Transcription Factor - immunology | Colorectal Neoplasms - pathology | Medical research | Colon | Rodents | Colorectal cancer | Stem cells | Index Medicus | Th22 | colon cancer | DOT1L | STAT3 | ILC22 | Cancer stem cell | CCR6 | H3K79 | epigenetics
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4. Full Text A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells
by Liu, Sanhong and Sun, Xiaohua and Wang, Mingliang and Hou, Yingyong and Zhan, Yu and Jiang, Yuhang and Liu, Zhanjie and Cao, Xinwei and Chen, Pengfei and Liu, Zhi and Chen, Xi and Tao, Yu and Xu, Chen and Mao, Jie and Cheng, Chunyan and Li, Cuifeng and Hu, Yiming and Wang, Lunshan and Chin, Y. Eugene and Shi, Yufang and Siebenlist, Ulrich and Zhang, Xiaoren
Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 4, pp. 847 - 859.e11
Background & Aims Constitutive activation of the transcription factors nuclear factor κB (NF-κB) and STAT3 is involved in the development and progression of... 
Gastroenterology and Hepatology | microRNA 222 | microRNA 221 | Carcinogenesis | Colon Cancer | microRNA | 222 Colon | Cancer | COLITIS-ASSOCIATED CANCER | IKK-ALPHA | TRANSLATION | COLON-CANCER | PATHWAY | INFLAMMATION | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | TUMORIGENESIS | PROGRESSION | Cell Proliferation | Colitis - genetics | Colorectal Neoplasms - genetics | Humans | Open Reading Frames | Gene Expression Regulation, Neoplastic | Colitis - pathology | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | LIM Domain Proteins - metabolism | RNA, Messenger - metabolism | Transfection | Colitis - therapy | RNA Interference | Time Factors | Microfilament Proteins - metabolism | 3' Untranslated Regions | Binding Sites | Microfilament Proteins - genetics | Colorectal Neoplasms - metabolism | Genes, Reporter | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Signal Transduction | Cell Survival | HCT116 Cells | Mice, Inbred C57BL | Colorectal Neoplasms - prevention & control | Tumor Burden | HT29 Cells | Xenograft Model Antitumor Assays | Feedback, Physiological | Animals | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Mice, Nude | Colitis - metabolism | LIM Domain Proteins - genetics | Mice | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Index Medicus | Abridged Index Medicus
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5. Full Text GNAS -activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation
by Nault, Jean Charles and Fabre, Monique and Couchy, Gabrielle and Pilati, Camilla and Jeannot, Emmanuelle and Tran Van Nhieu, Jeanne and Saint-Paul, Marie-Christine and De Muret, Anne and Redon, Marie-José and Buffet, Catherine and Salenave, Sylvie and Balabaud, Charles and Prevot, Sophie and Labrune, Philippe and Bioulac-Sage, Paulette and Scoazec, Jean-Yves and Chanson, Philippe and Zucman-Rossi, Jessica
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 56, Issue 1, pp. 184 - 191
Background & Aims Mosaic G-protein alpha-subunit ( GNAS )-activating mutations are responsible for the McCune–Albright (MCA) syndrome. This oncogene that... 
Gastroenterology and Hepatology | CRP | interleukine 6 signal transducer | GTP | C-reactive protein | jun N-terminal kinase | serum amyloid A | JNK | macroregenerative nodule | complementary deoxyribonucleic acid | MRN | mitogen activated proteins kinase | cAMP | glycoprotein 130 | neuroendocrine secretory protein 55 | hepatocyte nuclear factor 1A | G-protein alpha stimulatory subunit | cDNA | gp130 | protein kinase A | hepatocellular carcinoma | β catenin | IHCA | McCune-Albright syndrome | HCA | PKA | HCC | MAP kinase | MCA | HNF1A | inflammatory hepatocellular adenoma | SAA | cyclic adenosine monophosphate | hepatocellular adenoma | GNAS | CTNNB1 | NESP55 | guanosine-5′-triphosphate | IL6ST | INACTIVATION | PATHWAY | HEPATOCELLULAR ADENOMA | GS-ALPHA | GROWTH | CLASSIFICATION | HUMAN CANCERS | MCCUNE-ALBRIGHT-SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | G-PROTEIN | BINDING | Liver Neoplasms - classification | Humans | Middle Aged | Adenoma, Liver Cell - pathology | Male | Fibrous Dysplasia, Polyostotic - genetics | GTP-Binding Protein alpha Subunits, Gs - genetics | Chromogranins | DNA Mutational Analysis | Base Sequence | Carcinoma, Hepatocellular - genetics | Adult | Female | Liver Neoplasms - pathology | Adenoma, Liver Cell - genetics | STAT3 Transcription Factor - metabolism | Liver Neoplasms - genetics | Signal Transduction | Adenoma, Liver Cell - metabolism | Models, Biological | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Aged | DNA, Neoplasm - genetics | Mutation | Carcinoma, Hepatocellular - metabolism | Liver cancer | Genetic aspects | Nucleic acids | Adenylic acid | Mitogens | Protein kinases | Index Medicus | GTP-Binding Protein alpha Subunits, Gs | Fibrous Dysplasia, Polyostotic | Liver Neoplasms | Life Sciences | Adenoma, Liver Cell | DNA, Neoplasm | STAT3 Transcription Factor | Carcinoma, Hepatocellular | Cancer
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6. Full Text Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase
by Jin, Yena and Yoon, Yae Jin and Jeon, Yoon Jung and Choi, Sangho and Choi, Jiyeon and Lee, Joonku and Lee, Yu-Jin and Nash, Oyekanmi and Han, Dong Cho and Kwon, Byoung-Mog
Biochemical Pharmacology, ISSN 0006-2952, 10/2017, Volume 142, pp. 46 - 57
The roles and significance of signal transducer and activator of transcription 3 (STAT3) in human cancers have been extensively studied and STAT3 is a... 
CETSA | DARTS | SHP-2 phosphatase | Geranylnaringenin | Prostate cancer | STAT3 | TRANSCRIPTION 3 | STABILITY | INDUCTION | BIOLOGICAL FUNCTIONS | PATHWAY | INFLAMMATION | PROSTATE-CANCER CELLS | PHARMACOLOGY & PHARMACY | TARGET IDENTIFICATION | CETSA DARTS | EXPRESSION | SIGNAL TRANSDUCER | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Artocarpus - chemistry | Phosphorylation | Humans | Dose-Response Relationship, Drug | Flow Cytometry | Transfection | Time Factors | Antineoplastic Agents, Phytogenic - therapeutic use | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Plant Leaves - chemistry | Cell Survival - drug effects | Flavanones - therapeutic use | Flavanones - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice, Inbred BALB C | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Antineoplastic Agents, Phytogenic - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - isolation & purification | Tyrosine | Phosphatases | Analysis | Drug discovery | Diagnosis | Cancer | Index Medicus
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7. Full Text Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
by Chakraborty, Debomita and Šumová, Barbora and Mallano, Tatjana and Chen, Chih-Wei and Distler, Alfiya and Bergmann, Christina and Ludolph, Ingo and Horch, Raymund E and Gelse, Kolja and Ramming, Andreas and Distler, Oliver and Schett, Georg and Šenolt, Ladislav and Distler, Jörg H. W
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1130 - 16
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast... 
SIGNALING ACTIVATION | GROWTH-FACTOR-BETA | IN-VITRO | TGF-BETA | CARCINOMA CELLS | TARGETING STAT3 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TYROSINE KINASES | SYSTEMIC-SCLEROSIS | DERMAL FIBROSIS | Phosphorylation | Skin - metabolism | Humans | Middle Aged | Collagen - chemistry | Male | Fibrosis - metabolism | Young Adult | Aminosalicylic Acids - chemistry | Adult | Female | STAT3 Transcription Factor - metabolism | Fibroblasts - metabolism | Scleroderma, Systemic - metabolism | Inflammation | Microscopy, Confocal | Animals | Benzenesulfonates - chemistry | Bleomycin - chemistry | Receptors, Transforming Growth Factor beta - metabolism | Biopsy | Adolescent | Signal Transduction - physiology | Aged | Mice | Enzyme Activation | Transforming Growth Factor beta - metabolism | Medical research | Animal models | Stat3 protein | Clinical trials | JNK protein | Activation | Pharmacology | Kinases | Ablation | Sclerosis | Convergence | Signal transduction | Signaling | Pathways | Systemic sclerosis | Rodents | Fibrosis | Fibroblasts | Skin | In vivo methods and tests | Inhibition | Aberration | Index Medicus
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8. Full Text HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis
by Prabhavathy, Devan and Prabhakar, Bandaru Niranjana and Karunagaran, Devarajan
Molecular and Cellular Biochemistry, ISSN 0300-8177, 9/2014, Volume 394, Issue 1, pp. 77 - 90
Human papilloma virus is associated with cervical and other tumors, and several cellular conditions also play an important role in carcinogenesis. Human... 
Life Sciences | Biochemistry, general | NF-κB | TNF-α | STAT3 | Medical Biochemistry | Oncology | HPV16 E2 | Cardiology | IL-6 | RelA | HUMAN-PAPILLOMAVIRUS TYPE-16 | TNF-alpha | NECROSIS-FACTOR-ALPHA | CERVICAL INTRAEPITHELIAL NEOPLASIA | UNPHOSPHORYLATED STAT3 | CELL BIOLOGY | UTERINE CERVIX | NF-kappa B | CANCER DEVELOPMENT | HELA-CELLS | HIGH-RISK | SQUAMOUS-CELL CARCINOMA | E2 PROTEIN | Epithelial Cells - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Human papillomavirus 16 - immunology | Transcription Factor RelA - genetics | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Papillomavirus Infections - pathology | Transfection | MCF-7 Cells | RNA Interference | HEK293 Cells | Papillomavirus Infections - immunology | Oncogene Proteins, Viral - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Oncogene Proteins, Viral - metabolism | Cell Survival - drug effects | Human papillomavirus 16 - pathogenicity | DNA-Binding Proteins - genetics | Human papillomavirus 16 - metabolism | Apoptosis Regulatory Proteins - metabolism | Papillomavirus Infections - genetics | Tumor Necrosis Factor-alpha - pharmacology | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Papillomavirus Infections - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | HeLa Cells | Human papillomavirus 16 - genetics | Index Medicus
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9. Full Text Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
by de Jonge, Wouter J and van der Zanden, Esmerij P and The, Frans O and Bijlsma, Maarten F and van Westerloo, David J and Bennink, Roelof J and Berthoud, Hans-Rudolf and Uematsu, Satoshi and Akira, Shizuo and van den Wijngaard, Rene M and Boeckxstaens, Guy E
Nature immunology, ISSN 1529-2908, 2005, Volume 6, Issue 8, pp. 844 - 851
Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation... 
POSTOPERATIVE ILEUS | NITRIC-OXIDE | ALPHA-7 SUBUNIT | SMALL-INTESTINE | FACTOR-KAPPA-B | MUSCLE LAYERS | IMMUNOLOGY | NICOTINIC ACETYLCHOLINE-RECEPTORS | INFLAMMATORY RESPONSE | MYELOID CELLS | MUSCULARIS EXTERNA | Immunohistochemistry | Phosphorylation | Immunoprecipitation | Protein-Tyrosine Kinases - metabolism | Transcriptional Activation | Immunoblotting | Male | Acetylcholine - metabolism | Intestines - metabolism | Nicotine - pharmacology | Vagus Nerve - pathology | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Janus Kinase 2 | Janus Kinase 3 | Transfection | Time Factors | Interleukin-10 - metabolism | Female | Phagocytes - cytology | Interleukin-6 - metabolism | Leukocytes - cytology | Proto-Oncogene Proteins - metabolism | Receptors, Nicotinic - metabolism | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Rats | Inflammation | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Macrophage Activation | Macrophages - metabolism | Animals | Vagus Nerve - immunology | Nicotine - chemistry | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | STAT3 Transcription Factor | alpha7 Nicotinic Acetylcholine Receptor | Index Medicus
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10. Full Text Noncanonical NF-kappa B Activation Mediates STAT3-Stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer
by Yu, JP and Wang, Y and Yan, F and Zhang, P and Li, H and Zhao, H and Yan, CH and Ren, XB
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2014, Volume 193, Issue 5, pp. 2574 - 2586
Immunotherapy for cancer treatment is achieved through the activation of competent immune effector cells and the inhibition of immunosuppressive cells, such as... 
LUNG-CANCER | STAT3 ACTIVATION | SIGNALING PATHWAYS | DENDRITIC CELLS | SYNERGISTIC INDUCTION | IFN-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | IKK-ALPHA | TNF-ALPHA | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | Cell Nucleus - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Triterpenes - pharmacology | Breast Neoplasms - immunology | Humans | Transcription Factor RelB - immunology | Neoplasm Proteins - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Cell Nucleus - pathology | Myeloid Cells - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Active Transport, Cell Nucleus - genetics | STAT3 Transcription Factor - genetics | Transcription Factor RelB - genetics | Interleukin-6 - genetics | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation, Neoplastic - immunology | Up-Regulation - drug effects | Breast Neoplasms - genetics | Cell Nucleus - genetics | Up-Regulation - immunology | Breast Neoplasms - pathology | Active Transport, Cell Nucleus - drug effects | Interleukin-6 - immunology | Protein-Serine-Threonine Kinases - immunology | Active Transport, Cell Nucleus - immunology | Myeloid Cells - pathology | STAT3 Transcription Factor - immunology | Index Medicus | Abridged Index Medicus | MDSCs | Breast cancer | IDO | STAT3 | Noncanonical NF-κB
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