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by Li, SJ and Wan, CX and Zheng, RB and Fan, JY and Dong, X and Meyer, CA and Liu, XS
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 07/2019, Volume 47, Issue W1, pp. W206 - W211
Characterizing the ontologies of genes directly regulated by a transcription factor (TF), can help to elucidate the TF's biological role. Previously, we... 
CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 | Web Server Issue
Journal Article
European Journal of Immunology, ISSN 0014-2980, 2011, Volume 41, Issue 1, pp. 47 - 59
IL-27 has been shown to exhibit both pro-and anti-inflammatory properties; it favors mouse naive CD4(+) T-cell differentiation into Th1 cells to the detriment... 
Human | STAT | SOCS | Cytokines | Cytotoxic T cells | ACTIVATION | STAT1 | RECEPTOR | IMMUNOLOGY | HUMAN MONOCYTES | AUTOIMMUNE ENCEPHALOMYELITIS | TH1 DIFFERENTIATION | RESPONSES | INHIBITION | INTERLEUKIN-27 | EXPRESSION | Cell Proliferation | Granzymes - metabolism | Humans | STAT1 Transcription Factor - analysis | Interleukin-17 - immunology | STAT5 Transcription Factor - immunology | T-Box Domain Proteins - immunology | Interferon-gamma - metabolism | Th1 Cells - immunology | Th1 Cells - metabolism | STAT5 Transcription Factor - metabolism | Lymphocyte Activation - immunology | STAT1 Transcription Factor - metabolism | Antigens, Neoplasm - metabolism | CD8-Positive T-Lymphocytes - metabolism | T-Box Domain Proteins - analysis | Granzymes - immunology | Antigens, Neoplasm - analysis | Carrier Proteins - analysis | Carrier Proteins - immunology | STAT3 Transcription Factor - metabolism | T-Lymphocytes, Cytotoxic - immunology | Granzymes - analysis | Cytokine Receptor gp130 - metabolism | Antigens, Neoplasm - immunology | Cells, Cultured | Cytokine Receptor gp130 - immunology | STAT3 Transcription Factor - analysis | Cytokine Receptor gp130 - analysis | STAT1 Transcription Factor - immunology | T-Box Domain Proteins - metabolism | Interleukin-17 - metabolism | Interferon-gamma - analysis | Carrier Proteins - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Interferon-gamma - immunology | CD3 Complex - immunology | STAT3 Transcription Factor - immunology | CD8-Positive T-Lymphocytes - immunology | Index Medicus
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Journal Article
Molecular Cancer, ISSN 1476-4598, 12/2011, Volume 10, Issue 1, pp. 150 - 150
Background: The Th17 subset and IL-17 have been found in increased frequencies within certain tumors. However, their relevance in cancer biology remains... 
IMMUNITY | INTERLEUKIN-17 | ONCOLOGY | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RECEPTOR | CYTOKINE | CANCER | EXPRESSION | T-CELLS | TH17 CELLS | Interleukin-6 - analysis | Humans | Male | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - metabolism | Interleukin-17 - pharmacology | Liver Neoplasms - chemistry | Proto-Oncogene Proteins c-akt - genetics | Janus Kinase 2 - metabolism | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Janus Kinase 2 - analysis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasm Invasiveness | Kaplan-Meier Estimate | STAT3 Transcription Factor - analysis | Chi-Square Distribution | Disease Progression | Up-Regulation - drug effects | Cell Movement - drug effects | Interleukin-17 - metabolism | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Immunohistochemistry | Medical research | Carcinoma | Endothelial growth factors | Oncology, Experimental | Research | Hepatoma | Liver cancer | Medicine, Experimental | Vascular endothelial growth factor | Enzyme-linked immunosorbent assay | Cancer | Tumors | Studies | Proteins | Index Medicus
Journal Article
Journal Article
Human Pathology, ISSN 0046-8177, 2012, Volume 43, Issue 6, pp. 921 - 931
Summary Increased gene copy number (high polysomy or amplification) of EGFR and HER2 has evolved as a predictor for response to targeted therapy. STAT3 and the... 
Pathology | pSTAT3 | Prognosis | Survivin | HER2 | Salivary gland cancer | EGFR | IN-SITU HYBRIDIZATION | CYTOPLASMIC EXPRESSION | PATHOLOGY | BREAST-CANCER | POOR-PROGNOSIS | COLORECTAL-CANCER | EPIDERMAL-GROWTH-FACTOR | ADENOID CYSTIC CARCINOMA | SQUAMOUS-CELL CARCINOMAS | GENE COPY NUMBER | FACTOR RECEPTOR GENE | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Inhibitor of Apoptosis Proteins - genetics | Salivary Gland Neoplasms - genetics | Tissue Array Analysis | Humans | Male | Salivary Gland Neoplasms - metabolism | Female | Carcinoma - pathology | Inhibitor of Apoptosis Proteins - analysis | STAT3 Transcription Factor - genetics | Inhibitor of Apoptosis Proteins - biosynthesis | Receptor, Epidermal Growth Factor - biosynthesis | Receptor, ErbB-2 - biosynthesis | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | Proportional Hazards Models | In Situ Hybridization, Fluorescence | STAT3 Transcription Factor - analysis | Gene Dosage | Receptor, Epidermal Growth Factor - analysis | STAT3 Transcription Factor - biosynthesis | Genes, erbB-1 | Genes, erbB-2 | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Receptor, ErbB-2 - analysis | Neoplasm Staging | Salivary Gland Neoplasms - pathology | Immunohistochemistry | Genes | Tumors | Cancer | Confidence intervals | Gene amplification | Lung cancer | Cell cycle | Breast cancer | Histology | Kinases | Multivariate analysis | Microwave heating | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2010, Volume 120, Issue 1, pp. 303 - 314
Journal Article