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1. Full Text Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign
by Poschke, Isabel and Mougiakakos, Dimitrios and Hansson, Johan and Masucci, Giuseppe V and Kiessling, Rolf
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4335 - 4345
Myeloid-derived suppressor cells (MDSC) have emerged as key immune modulators in various tumor models and human malignancies, but their characteristics in... 
Melanoma - blood | Antigens, CD - immunology | Cell Communication - immunology | Immunoglobulins - immunology | Antigens, CD - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Middle Aged | Lectins, C-Type - immunology | Oxidative Stress - immunology | Male | Lectins, C-Type - biosynthesis | Cell Adhesion Molecules - immunology | Interleukin-4 Receptor alpha Subunit - biosynthesis | Myeloid Cells - immunology | Calgranulin B - immunology | Aged, 80 and over | Adult | Female | Receptors, Cell Surface - biosynthesis | B7-1 Antigen - biosynthesis | Membrane Glycoproteins - immunology | Immunoglobulins - biosynthesis | Calgranulin B - biosynthesis | B7-1 Antigen - immunology | Cell Adhesion Molecules - biosynthesis | Lymphocyte Activation | Lipopolysaccharide Receptors - immunology | Interleukin-4 Receptor alpha Subunit - immunology | Receptors, Cell Surface - immunology | STAT3 Transcription Factor - biosynthesis | Melanoma - immunology | Interferon-gamma - immunology | T-Lymphocytes - immunology | Aged | HLA-DR Antigens - immunology | STAT3 Transcription Factor - immunology | Interferon-gamma - biosynthesis | Index Medicus
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2. Full Text Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway
by Agrawal, Sudhanshu and Gollapudi, Sastry and Su, Houfen and Gupta, Sudhir
Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
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3. Full Text Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling
by Calvert, John W and Jha, Saurabh and Gundewar, Susheel and Elrod, John W and Ramachandran, Arun and Pattillo, Christopher B and Kevil, Christopher G and Lefer, David J
Circulation Research, ISSN 0009-7330, 08/2009, Volume 105, Issue 4, pp. 365 - 374
RATIONALE:The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective... 
Hydrogen sulfide | Myocardial infarction | Cardioprotection | Nrf2 | Antioxidant signaling | PROTEIN-KINASE-C | OXIDATIVE STRESS | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | myocardial infarction | INDUCTION | antioxidant signaling | ISCHEMIA-REPERFUSION INJURY | JAK-STAT PATHWAY | hydrogen sulfide | ANTIOXIDANT | cardioprotection | PERIPHERAL VASCULAR DISEASE | MYOCARDIAL INJURY | RAT-HEART | HEMATOLOGY | HSP90 Heat-Shock Proteins - biosynthesis | Oxidative Stress | Air Pollutants - pharmacology | Male | Cyclooxygenase 2 - biosynthesis | bcl-Associated Death Protein - biosynthesis | Cell Nucleus - metabolism | Thioredoxins - biosynthesis | Time Factors | Protein Kinase C - metabolism | bcl-X Protein - biosynthesis | Phosphorylation - drug effects | HSP70 Heat-Shock Proteins - biosynthesis | Hydrogen Sulfide - pharmacology | Heme Oxygenase-1 - biosynthesis | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Mice, Inbred ICR | Mice, Knockout | Gene Expression Regulation - drug effects | STAT3 Transcription Factor - biosynthesis | Myocardial Reperfusion Injury - metabolism | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | NF-E2-Related Factor 2 - metabolism | Mice | Myocardial Infarction - prevention & control | Troponin I - metabolism | Myocardial Reperfusion Injury - prevention & control | Index Medicus
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4. Full Text Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κb signaling in glioblastoma cancer stem cells regulates the notch pathway
by Garner, Jo Meagan and Fan, Meiyun and Yang, Chuan He and Du, Ziyun and Sims, Michelle and Davidoff, Andrew M and Pfeffer, Lawrence M
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26167 - 26176
Malignant gliomas are locally aggressive, highly vascular tumors that have a dismal prognosis, and present therapies provide little improvement in the disease... 
BREAST-CANCER | SURVIVAL | IN-VITRO | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENE-EXPRESSION | RECEPTOR | PROTEINS | LINES | Cell Proliferation | Signal Transduction | Receptors, Notch - metabolism | Humans | Spheroids, Cellular - metabolism | Spheroids, Cellular - pathology | Cell Survival - genetics | NF-kappa B - metabolism | Receptors, Notch - genetics | Up-Regulation - genetics | Neoplasm Proteins - metabolism | STAT3 Transcription Factor - biosynthesis | Animals | Glioblastoma - genetics | NF-kappa B - genetics | Neoplastic Stem Cells - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Mice | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Index Medicus | Molecular Bases of Disease | Glioma | Glioblastoma | STAT3 | Notch Pathway | NF-κB (NF-κB) | Cancer Stem Cells
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5. Full Text Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC
by Chaib, Imane and Karachaliou, Niki and Pilotto, Sara and Codony Servat, Jordi and Cai, Xueting and Li, Xuefei and Drozdowskyj, Ana and Servat, Carles Codony and Yang, Jie and Hu, Chunping and Cardona, Andres Felipe and Vivanco, Guillermo Lopez and Vergnenegre, Alain and Sanchez, Jose Miguel and Provencio, Mariano and de Marinis, Filippo and Passaro, Antonio and Cao, Peng and Reguart, Noemi and Campelo, Charo Garcia and Teixido, Cristina and Sperduti, Isabella and Rodriguez, Sonia and Lazzari, Chiara and Verlicchi, Alberto and de Aguirre, Itziar and Queralt, Cristina and Wei, Jia and Estrada, Roger and de la Bellacasa, Raimon Puig and Ramirez, Jose Luis and Jacobsen, Kirstine and Ditzel, Henrik J and Santarpia, Mariacarmela and Viteri, Santiago and Molina, Miguel Angel and Zhou, Caicun and Cao, Peng and Ma, Patrick C and Bivona, Trever G and Rosell, Rafael
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2017, Volume 109, Issue 9
Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is... 
SURVIVAL | ACTIVATION | INHIBITION | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | SENSITIVITY | LUNG-CANCER CELLS | DRUG-RESISTANCE | MUTATIONS | NF-KAPPA-B | FACTOR RECEPTOR | Lung Neoplasms - drug therapy | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Middle Aged | ErbB Receptors - genetics | Male | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - biosynthesis | Adenocarcinoma - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Retrospective Studies | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Phosphoproteins - biosynthesis | Signal Transduction | RNA, Messenger - genetics | Phosphoproteins - genetics | Adenocarcinoma - drug therapy | STAT3 Transcription Factor - biosynthesis | Protein Kinase Inhibitors - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Aged | Mice | Adaptor Proteins, Signal Transducing - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Index Medicus
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6. Full Text A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma
by Yuan, Ji-hang and Yang, Yuan and Yang, Fu and Yang, Ning and Yang, Guang-shun and Wang, Shao-bing and Wang, Yu-zhao and Wang, Fang and Wang, Tian-tian and Ma, Jin-zhao and Guo, Ying-jun and Tao, Qi-fei and Liu, Feng and Pan, Wei and Zhou, Wei-ping and Zhou, Chuan-chuan and Sun, Shu-han
Cancer Cell, ISSN 1535-6108, 05/2014, Volume 25, Issue 5, pp. 666 - 681
The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β... 
EPITHELIAL-MESENCHYMAL TRANSITION | CELLS | GROWTH-FACTOR-BETA | REPRESSION | ONCOLOGY | VENOUS METASTASES | CANCER METASTASIS | TUMOR-SUPPRESSOR | MIR-200 FAMILY | TUMORIGENESIS | EXPRESSION | CELL BIOLOGY | Neoplasm Transplantation | Up-Regulation | Prognosis | Homeodomain Proteins - metabolism | Humans | Male | MicroRNAs - metabolism | Transplantation, Heterologous | Gene Expression Profiling | Epithelial-Mesenchymal Transition - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Neoplasm Metastasis | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Repressor Proteins - metabolism | STAT3 Transcription Factor - metabolism | Homeodomain Proteins - biosynthesis | Liver Neoplasms - genetics | Neoplasm Invasiveness | Interleukin-11 - genetics | Transcription Factors - biosynthesis | RNA, Long Noncoding - genetics | Transcription Factors - metabolism | Animals | Repressor Proteins - biosynthesis | Mice, Nude | Carcinoma, Hepatocellular - pathology | Mice | Mice, Inbred BALB C | Transforming Growth Factor beta - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
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7. Full Text The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors
by Thevenot, Paul T and Sierra, Rosa A and Raber, Patrick L and Al-Khami, Amir A and Trillo-Tinoco, Jimena and Zarreii, Parisa and Ochoa, Augusto C and Cui, Yan and Del Valle, Luis and Rodriguez, Paulo C
Immunity, ISSN 1074-7613, 09/2014, Volume 41, Issue 3, pp. 389 - 401
Adaptation of malignant cells to the hostile milieu present in tumors is an important determinant of their survival and growth. However, the interaction... 
LUNG-CANCER | OXIDATIVE STRESS | ER STRESS | LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | AUTOPHAGY | IMMUNOLOGY | EXPRESSION | HOMOLOGOUS PROTEIN CHOP | T-CELLS | Transcription Factor CHOP - genetics | Cell Proliferation | Neoplasms | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Female | Neovascularization, Pathologic - immunology | Transcription Factor CHOP - biosynthesis | Tumor Escape - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Activating Transcription Factor 4 - genetics | Mice, Knockout | STAT3 Transcription Factor - biosynthesis | Animals | Activating Transcription Factor 4 - metabolism | CCAAT-Enhancer-Binding Protein-beta - immunology | Cell Line, Tumor | Interleukin-6 - biosynthesis | Neovascularization, Pathologic - genetics | T-Lymphocytes - immunology | Mice | Reactive Nitrogen Species - immunology | T cells | Tumors | Protein binding | Interleukins | Cancer | Proteins | Flow cytometry | Lymphocytes | Rodents | Immunotherapy | Deoxyribonucleic acid--DNA | Immune system | Index Medicus | MDSCs | C | peroxynitrite (PNT) | Chop | Reactive oxygen species (ROS) | integrated stress responses | EBPβ | Interleukin-6
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8. Full Text Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages
by Williams, Lynn and Bradley, Laura and Smith, Alexandra and Foxwell, Brian
The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
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9. Full Text IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner
by Lai Wei and Arian Laurence and Kevin M. Elias and John J. O'Shea
Journal of Biological Chemistry, ISSN 0021-9258, 11/2007, Volume 282, Issue 48, pp. 34605 - 34610
CD4 + helper T cells can differentiate into several possible fates including: Th1, Th2, T regulatory, and Th17 cells. Although, cytokine production by non-T... 
INTERFERON | ACTIVATION | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | RECEPTOR | CYTOKINE | MECHANISMS | DIFFERENTIATION | INTERLEUKIN-21 | T-CELLS | Nuclear Receptor Subfamily 1, Group F, Member 3 | Promoter Regions, Genetic | Cytokines - metabolism | Oligonucleotide Array Sequence Analysis | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | Receptors, Retinoic Acid - metabolism | Spleen - cytology | Interleukin-17 - biosynthesis | Receptors, Thyroid Hormone - metabolism | STAT3 Transcription Factor - biosynthesis | Cell Lineage | Animals | T-Lymphocytes - metabolism | Cell Differentiation | Mice | Interleukins - biosynthesis | STAT3 Transcription Factor - genetics | Index Medicus
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10. Full Text IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
by Yao, Chao and Su, Li and Shan, Juanjuan and Zhu, Chuanlin and Liu, Limei and Liu, Chungang and Xu, Yanmin and Yang, Zhi and Bian, Xiuwu and Shao, Jimin and Li, Jianming and Lai, Maode and Shen, Junjie and Qian, Cheng
Stem Cells, ISSN 1066-5099, 04/2016, Volume 34, Issue 4, pp. 820 - 831
Discovery of epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are two milestones in people exploring the nature of malignant tumor in... 
Signal transduction | Self-renewal | Insulin-like growth factors | Cancer stem cells | EMT | Stem cell-microenvironment interactions | Nanog Homeobox Protein - genetics | Insulin-Like Growth Factor I - biosynthesis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Nanog Homeobox Protein - biosynthesis | Insulin-Like Growth Factor I - genetics | Snail Family Transcription Factors - biosynthesis | Epithelial-Mesenchymal Transition - genetics | STAT3 Transcription Factor - biosynthesis | Neoplasm Metastasis | Receptors, Somatomedin - biosynthesis | Snail Family Transcription Factors - genetics | Neoplastic Stem Cells - metabolism | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Receptors, Somatomedin - genetics | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | Cellular signal transduction | Metastasis | Stem cells | Colorectal cancer | Index Medicus
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11. Full Text The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney
by O’Brown, Zach K and Van Nostrand, Eric L and Higgins, John P and Kim, Stuart K
PLoS Genetics, ISSN 1553-7390, 2015, Volume 11, Issue 12, pp. e1005734 - e1005734
Human kidney function declines with age, accompanied by stereotyped changes in gene expression and histopathology, but the mechanisms underlying these changes... 
EPITHELIAL-MESENCHYMAL TRANSITION | CELLS | ACTIVATION | INTEGRATIVE ANALYSIS | REGULATED GENES | IFN-GAMMA | DISEASE | GENETICS & HEREDITY | GROWTH-FACTOR | UP-REGULATION | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Genetic Association Studies | Humans | Tumor Necrosis Factor-alpha - genetics | Interferon-gamma - metabolism | NF-kappa B p50 Subunit - genetics | STAT1 Transcription Factor - genetics | Transcription Factor RelA - genetics | Aging - pathology | Interleukin-6 | Renal Insufficiency, Chronic - pathology | STAT3 Transcription Factor - biosynthesis | Aging - genetics | NF-kappa B - genetics | Renal Insufficiency, Chronic - genetics | Inflammation - genetics | Transcription, Genetic | Interferon-gamma - genetics | STAT1 Transcription Factor - biosynthesis | STAT3 Transcription Factor - genetics | Index Medicus
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12. Full Text Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
by Fuchs, Bryan C and Fujii, Tsutomu and Dorfman, Jon D and Goodwin, Jonathan M and Zhu, Andrew X and Lanuti, Michael and Tanabe, Kenneth K
Cancer Research, ISSN 0008-5472, 04/2008, Volume 68, Issue 7, pp. 2391 - 2399
Hepatocellular carcinoma (HCC) is associated with a poor prognosis due to late diagnoses and a lack of effective treatment options. Epidermal growth factor... 
ADVANCED HEPATOCELLULAR-CARCINOMA | LUNG-CANCER | THERAPY | GENE | ONCOLOGY | PROTEIN-KINASE | E-CADHERIN EXPRESSION | RESISTANCE | GEFITINIB IRESSA | LINES | ERLOTINIB | Erlotinib Hydrochloride | Receptor, IGF Type 1 - metabolism | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Cadherins - biosynthesis | Antibodies, Monoclonal, Humanized | Carcinoma, Hepatocellular - drug therapy | Mesoderm - enzymology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Liver Neoplasms - pathology | Cetuximab | Liver Neoplasms - enzymology | Protein-Serine-Threonine Kinases - metabolism | Vimentin - biosynthesis | Antibodies, Monoclonal - pharmacology | Liver Neoplasms - drug therapy | Epithelial Cells - pathology | Carcinoma, Hepatocellular - enzymology | Insulin-Like Growth Factor II - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | STAT3 Transcription Factor - biosynthesis | Animals | Carcinoma, Hepatocellular - pathology | Epithelial Cells - enzymology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Quinazolines - pharmacology | Mesoderm - pathology | Index Medicus
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13. Full Text Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration
by Haynes, Tracy and Luz-Madrigal, Agustin and Reis, Edimara S and Echeverri Ruiz, Nancy P and Grajales-Esquivel, Erika and Tzekou, Apostolia and Tsonis, Panagiotis A and Lambris, John D and Del Rio-Tsonis, Katia
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2312 - 2312
Identifying the initiation signals for tissue regeneration in vertebrates is one of the major challenges in regenerative biology. Much of the research thus far... 
HEMATOPOIETIC STEM/PROGENITOR CELLS | STEM-CELLS | ACTIVATION | 3RD COMPONENT | MICE DEFICIENT | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | STAT3 | RECEPTOR | SERINE PHOSPHORYLATION | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Retina - metabolism | Retina - growth & development | Homeodomain Proteins - metabolism | Retina - embryology | MAP Kinase Signaling System | SOXB1 Transcription Factors - metabolism | Wnt3 Protein - metabolism | Interleukin-8 - metabolism | Complement C3a - metabolism | Interleukin-6 - metabolism | Organ Culture Techniques | STAT3 Transcription Factor - metabolism | Tissue Engineering - methods | Interleukin-8 - biosynthesis | Regeneration - physiology | Chick Embryo | Nerve Tissue Proteins - metabolism | STAT3 Transcription Factor - biosynthesis | Animals | Eye Proteins - metabolism | Interleukin-6 - biosynthesis | Enzyme Activation | Tumor Necrosis Factor-alpha - biosynthesis | Guided Tissue Regeneration | Regeneration - immunology | Index Medicus
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14. Full Text Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators
by Hui-Wen Lo and Xinyu Cao and Hu Zhu and Francis Ali-Osman
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 19, pp. 6042 - 6054
Purpose: The goals of this study are to elucidate the relationship of the oncogenic transcription factor signal transducer and activator of transcription 3... 
EGFRvIII | cancer therapeutics | gliomas | EGFR | STAT3 | POTENT ANTITUMOR-ACTIVITY | CANCER-CELLS | MOLECULAR TARGETS | HUMAN BRAIN-TUMORS | ONCOLOGY | GLIOBLASTOMA-MULTIFORME | JSI-124 CUCURBITACIN-I | MALIGNANT GLIOMAS | GENE-REGULATION | LARGE-CELL LYMPHOMA | TRANSCRIPTION-3 SIGNALING PATHWAY | Receptor, Epidermal Growth Factor - biosynthesis | Alkylating Agents - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - metabolism | Glioma - metabolism | STAT3 Transcription Factor - biosynthesis | Animals | Janus Kinase 2 - metabolism | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Mice | DNA Damage | Quinazolines - pharmacology | STAT3 Transcription Factor - genetics | Index Medicus
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