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Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 591 - 599
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5418 - 5427
IFN-beta-1a has been used over the past 15 years as a primary therapy for relapsing-remitting multiple sclerosis (MS). However, the immunomodulatory mechanisms... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | GROWTH-FACTOR-BETA | T(H)17 CELLS | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MESSENGER-RNA EXPRESSION | CENTRAL-NERVOUS-SYSTEM | INTERFERON-BETA | IMMUNOLOGY | UP-REGULATION | T-CELLS | Receptors, CCR6 - immunology | Interleukin-12 Subunit p35 - metabolism | Interleukin-23 Subunit p19 - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Receptors, CCR6 - antagonists & inhibitors | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin - metabolism | Interleukin-23 Subunit p19 - metabolism | STAT1 Transcription Factor - metabolism | Interleukin-1beta - metabolism | Receptors, Retinoic Acid - immunology | Phosphorylation - immunology | Phosphorylation - drug effects | Receptors, Thyroid Hormone - immunology | Interleukin-1beta - antagonists & inhibitors | Nuclear Receptor Subfamily 1, Group F, Member 3 | Receptors, Interleukin - immunology | Receptors, Interleukin - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | Cell Differentiation - immunology | Interferon beta-1a | Up-Regulation - immunology | Interleukin-23 Subunit p19 - immunology | STAT3 Transcription Factor - immunology | Interleukin-10 - immunology | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | T-Lymphocytes, Helper-Inducer - drug effects | T-Lymphocytes, Helper-Inducer - immunology | Receptors, CCR6 - metabolism | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Interleukin-10 - agonists | STAT3 Transcription Factor - metabolism | Cells, Cultured | Interleukin-1beta - immunology | Interleukin-12 Subunit p35 - agonists | Down-Regulation - drug effects | STAT1 Transcription Factor - immunology | Receptors, Thyroid Hormone - metabolism | Up-Regulation - drug effects | Interferon-beta - pharmacology | Interleukin-12 Subunit p35 - immunology | Cell Differentiation - drug effects | Down-Regulation - immunology | STAT3 Transcription Factor - drug effects | Multiple Sclerosis - immunology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 250 - 262
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine... 
RNA-POLYMERASE-II | ACTIVATION | IFN-GAMMA | MEDIATOR | GENE-EXPRESSION | TRANSACTIVATION DOMAIN | IMMUNOLOGY | SERINE PHOSPHORYLATION | PROMOTER | INNATE IMMUNITY | P-TEFB | Transcription, Genetic - drug effects | Phosphorylation | Oligonucleotide Array Sequence Analysis | Humans | STAT5 Transcription Factor - immunology | Cyclin-Dependent Kinase 8 - immunology | RNA Polymerase II - immunology | STAT5 Transcription Factor - genetics | STAT1 Transcription Factor - metabolism | Cyclin-Dependent Kinase 8 - genetics | STAT3 Transcription Factor - genetics | Fibroblasts - metabolism | Fibroblasts - virology | Promoter Regions, Genetic | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Hep G2 Cells | Gene Expression Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Fibroblasts - drug effects | Interferon-gamma - immunology | Interleukin-6 - immunology | Cyclin-Dependent Kinase 8 - metabolism | RNA Polymerase II - genetics | Mice | STAT3 Transcription Factor - immunology | Vesiculovirus - physiology | Interferon-gamma - pharmacology | DNA microarrays | RNA | Analysis | Genes | Interferon | Universities and colleges | Biological response modifiers | Gene expression | Transcription factors | Cytokines | Cell cycle | Colleges & universities | Grants | RNA polymerase | Kinases | Experiments | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 29, Issue 1, pp. 138 - 149
After activation, CD4 helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T follicular... 
MOLIMMUNO | CELLIMMUNO | CXC CHEMOKINE RECEPTOR-5 | B-CELLS | RESPONSES | AUTOIMMUNITY | ROR-GAMMA | T(H)17 | GENE-EXPRESSION | DIFFERENTIATION | IMMUNOLOGY | IL-21 | BETA | Immunohistochemistry | T-Lymphocyte Subsets - immunology | Oligonucleotide Array Sequence Analysis | T-Lymphocyte Subsets - cytology | Germinal Center - immunology | Interleukin-17 - immunology | Gene Expression Profiling | Adoptive Transfer | Interleukins - metabolism | Signal Transduction - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Mice, Mutant Strains | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Germinal Center - cytology | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Transforming Growth Factor beta - immunology | Gene Expression | Reverse Transcriptase Polymerase Chain Reaction | Proteins - immunology | Cell Differentiation - immunology | Interleukin-17 - metabolism | Animals | B-Lymphocytes - immunology | Proteins - metabolism | Inducible T-Cell Co-Stimulator Ligand | Interleukin-6 - immunology | Mice | STAT3 Transcription Factor - immunology | Transforming Growth Factor beta - metabolism | Cell Lineage - immunology | Universities and colleges | Interleukins | Transforming growth factors | T cells | Gene expression | Medical research | Lymphocytes | Rodents | Chemokines | Immune system | Cancer | Index Medicus
Journal Article
by Tsoi, L.C and Spain, S.L and Knight, J and Ellinghaus, E and Stuart, P.E and Capon, F and Ding, J and Li, J and Tejasvi, T and Gudjonsson, J.E and Kang, H and Allen, M.H and McManus, R and Novelli, G and Samuelsson, L and Schalkwijk, J and Stahle, M and Burden, A.D and Smith, C.H and Cork, M.J and Estivill, X and Bowcock, A and Krueger, G.G and Weger, W and Worthington, J and Tazi-Ahnini, R and Nestle, F.O and Hayday, A and Hoffmann, P and Winkelmann, J and Wijmenga, C and Langford, C and Edkins, S and Anews, R and Blackburn, H and Strange, A and Band, G and Pearson, R and Vukcevic, D and Spencer, C.C and Deloukas, P and Mrowietz, U and Schreiber, S and Weidinger, S and Koks, S and Kingo, K and Esko, T and Metspalu, A and Lim, H.W and Voorhees, J.J and Weichenthal, M and Wichmann, H.E and Chanan, V and Rosen, C.F and Rahman, P and Gladman, D.D and Griffiths, C.E and Reis, A and Kere, J and Duffin, K.C and Helms, C and Goldgar, D and Li, Y and Paschall, J and Malloy, M.J and Pullinger, C.R and Kane, J.P and Gardner, J and Perlmutter, A and Miner, A and Feng, B.J and Hiremagalore, R and Ike, R.W and Christophers, E and Henseler, T and Ruether, A and Schrodi, S.J and Prahalad, S and Guthery, S.L and Hiregalore, R and Donnelly, P and Collaborative Assoc Study Psoriasi and Psoriasis Assoc Genetics Extension and Genetic Anal Psoriasis Consortium and Wellcome Trust Case Control Consor and Psoriasis Association Genetics Extension and Genetic Analysis of Psoriasis Consortium and Collaborative Association Study of Psoriasis (CASP) and Wellcome Trust Case Control Consortium 2 and Sahlgrenska akademin and Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik and Göteborgs universitet and Gothenburg University and Institute of Biomedicine, Department of Medical and Clinical Genetics and Sahlgrenska Academy
Nature Genetics, ISSN 1061-4036, 2012, Volume 44, Issue 12, pp. 1341 - 1348
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent... 
COMMON VARIANTS | SIGNALING PATHWAYS | MULTIPLE COMMON | INTERFERON-GAMMA | TH17 DIFFERENTIATION | GENETICS & HEREDITY | GENE-EXPRESSION | T-CELL DEVELOPMENT | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | NEGATIVE REGULATOR | Oligonucleotide Array Sequence Analysis | Humans | Immunity, Innate - genetics | Genetic Loci | CARD Signaling Adaptor Proteins - genetics | Psoriasis - genetics | Core Binding Factor Alpha 3 Subunit - immunology | STAT3 Transcription Factor - genetics | Skin - immunology | Psoriasis - immunology | CARD Signaling Adaptor Proteins - immunology | DEAD Box Protein 58 | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Guanylate Cyclase - immunology | Membrane Proteins - genetics | Membrane Proteins - immunology | GTPase-Activating Proteins - immunology | DEAD-box RNA Helicases - genetics | Core Binding Factor Alpha 3 Subunit - genetics | DEAD-box RNA Helicases - immunology | Guanylate Cyclase - genetics | T-Lymphocytes - immunology | Polymorphism, Single Nucleotide | GTPase-Activating Proteins - genetics | STAT3 Transcription Factor - immunology | Psoriasis | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Autoimmune diseases | Gene expression | Chromosomes | Risk factors | Index Medicus | genetic analysis | innate immunity | Dermatologi och venereologi | Dermatology and Venereal Diseases | psoriasis
Journal Article
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 697 - 710
Macrophages possess numerous mechanisms to combat microbial invasion, including sequestration of essential nutrients, like zinc (Zn). The pleiotropic cytokine... 
ACTIVATION | HOMEOSTASIS | METALLOTHIONEIN | GROWTH | GENE-EXPRESSION | CALPROTECTIN | IMMUNOLOGY | PROTEINS | ZINC | HISTOPLASMA-CAPSULATUM | FAMILY | Phagosomes - microbiology | Zinc - metabolism | Golgi Apparatus - drug effects | Humans | STAT5 Transcription Factor - immunology | NADPH Oxidases - immunology | Histoplasma - drug effects | Histoplasmosis - microbiology | Superoxides - immunology | Histoplasmosis - immunology | STAT5 Transcription Factor - genetics | Phagosomes - immunology | Superoxides - metabolism | NADPH Oxidases - genetics | Zinc - immunology | Cation Transport Proteins - genetics | Golgi Apparatus - immunology | Macrophages, Peritoneal - drug effects | STAT3 Transcription Factor - genetics | Metallothionein - immunology | Phagosomes - drug effects | Signal Transduction | Gene Expression Regulation | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Macrophages, Peritoneal - immunology | Mice, Transgenic | Macrophage Activation | Histoplasma - immunology | Host-Pathogen Interactions | Histoplasmosis - metabolism | Animals | Golgi Apparatus - microbiology | Macrophages, Peritoneal - microbiology | Metallothionein - genetics | Mice | STAT3 Transcription Factor - immunology | Cation Transport Proteins - immunology | Oxidases | Zinc compounds | Superoxide | Molecular genetics | Macrophages | Environmental health | Experiments | Exports | Proteomics | Streptococcus infections | Index Medicus
Journal Article