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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Arthritis & rheumatology (Hoboken, N.J.), ISSN 2326-5191, 2016, Volume 68, Issue 10, pp. 2492 - 2502
... with autoantibody profiles combined with female sex, but other risk factors, including age, ANA titer, number of autoantibody specificities, and type I interferon (IFN... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | CYTOKINE PRODUCTION | RISK-FACTORS | DENDRITIC CELLS | ANTINUCLEAR ANTIBODIES | RHEUMATOLOGY | EXPRESSION | SLE | IG-LIKE RECEPTOR-1 | T-CELLS | Interferon-alpha - pharmacology | Multivariate Analysis | Phosphoproteins - drug effects | Interferon-beta - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | Centromere Protein B - immunology | Male | Monocytes - immunology | Ribosomal Proteins - immunology | Healthy Volunteers | Case-Control Studies | Leukocytes - immunology | Young Adult | Flow Cytometry | Autoimmunity - immunology | Lupus Erythematosus, Systemic - immunology | Ribonucleoproteins - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Interleukin-12 Subunit p40 - immunology | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Immunophenotyping | Logistic Models | Nuclear Proteins - immunology | STAT1 Transcription Factor - immunology | Stem Cell Factor - immunology | Interferon-alpha - immunology | Autoantibodies - immunology | Interferon-gamma - immunology | STAT3 Transcription Factor - drug effects | Sex Factors | Aged | Granulocyte Colony-Stimulating Factor - immunology | STAT3 Transcription Factor - immunology | Plasma Cells - immunology | Systemic Lupus Erythematosus
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 3, pp. 514 - 527
.... Here we show that IL-21 induced apoptosis of conventional dendritic cells (cDCs) via STAT3 and Bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (GM-CSF... 
NKT CELLS | HOMEOSTASIS | FOLLICULAR-HELPER-CELLS | HUMAN B-CELLS | STEADY-STATE | INTERLEUKIN-21 | DIFFERENTIATION | IMMUNOLOGY | IMMUNE TOLERANCE | T-CELLS | NEGATIVE REGULATOR | Natural Killer T-Cells - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Dendritic Cells - immunology | STAT5 Transcription Factor - immunology | Receptors, Interleukin-21 - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Gene Expression - immunology | STAT3 Transcription Factor - genetics | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | DNA, Intergenic - genetics | Protein Binding - immunology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Galactosylceramides - immunology | Mice | STAT3 Transcription Factor - immunology | Gene Expression - drug effects | Galactosylceramides - pharmacology | DNA-Binding Proteins - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptors, Interleukin-21 - deficiency | Flow Cytometry | Bcl-2-Like Protein 11 | Natural Killer T-Cells - metabolism | DNA, Intergenic - metabolism | Interleukins - immunology | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Interleukins - pharmacology | Dendritic Cells - metabolism | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Interleukin-21 - immunology | Mice, Inbred C57BL | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Animals | Apoptosis - immunology | Interferon-gamma - immunology | CD4-Positive T-Lymphocytes - drug effects | DNA, Intergenic - immunology | Natural Killer T-Cells - immunology | Interleukins | Dendritic cells | Analysis | Genomics | Macrophage colony stimulating factor | Biological response modifiers | T cells | Apoptosis | Cytokines | Genes | Genomes | Kinases | Binding sites | Deoxyribonucleic acid--DNA | apoptosis | dendritic cells | GM-CSF | IL-21
Journal Article
Nature immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 800 - 812
.... Here we found that TAZ, a coactivator of TEAD transcription factors of Hippo signaling, was expressed under T 17 cell-inducing conditions and was required for T 17 differentiation and T 17 cell... 
Forkhead Transcription Factors - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Sjogren's Syndrome - immunology | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | HEK293 Cells | Adaptor Proteins, Signal Transducing - immunology | Acetylation | Colitis - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | DNA-Binding Proteins - immunology | Smad Proteins - immunology | Mice, Transgenic | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Smad Proteins - metabolism | Microscopy, Fluorescence
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2012, Volume 36, Issue 3, pp. 362 - 373
...+ T cell effector functions. The IL-6-mediated activation of the transcription factor Stat3 and the TGF-β... 
GROWTH-FACTOR-BETA | EFFECTOR T-CELLS | TGF-BETA | T(H)17 CELLS | ROR-GAMMA-T | SIGNALING PATHWAY | IL-17 | ADENOSINE | GENERATION | IMMUNOLOGY | CANCER | 5'-Nucleotidase - genetics | RNA, Small Interfering - genetics | Antigens, CD - genetics | DNA-Binding Proteins - metabolism | Th17 Cells - drug effects | T-Lymphocytes - metabolism | Th17 Cells - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Transcription Factors - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promoter Regions, Genetic | DNA-Binding Proteins - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Binding Sites - genetics | Mice, Knockout | Transcription Factors - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-6 - pharmacology | Apyrase - genetics | Th17 Cells - immunology | T-Lymphocytes - immunology | Mice | STAT3 Transcription Factor - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Autoimmunity | DNA binding proteins | T cells | Transforming growth factors | Proteins | Transcription factors | Statistical analysis | Plasmids | Rodents | Cytotoxicity | Deoxyribonucleic acid--DNA | Immune system | Cancer | 5'-Nucleotidase | T-Lymphocytes | Interleukin-6 | Life Sciences | Lymphocytes, Tumor-Infiltrating | Immunology | Apyrase | RNA, Small Interfering | STAT3 Transcription Factor | Th17 Cells | Transcription Factors | Binding Sites | Transforming Growth Factor beta | Antigens, CD | DNA-Binding Proteins
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 2, pp. 250 - 262
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT... 
RNA-POLYMERASE-II | ACTIVATION | IFN-GAMMA | MEDIATOR | GENE-EXPRESSION | TRANSACTIVATION DOMAIN | IMMUNOLOGY | SERINE PHOSPHORYLATION | PROMOTER | INNATE IMMUNITY | P-TEFB | Transcription, Genetic - drug effects | Phosphorylation | Oligonucleotide Array Sequence Analysis | Humans | STAT5 Transcription Factor - immunology | Cyclin-Dependent Kinase 8 - immunology | RNA Polymerase II - immunology | STAT5 Transcription Factor - genetics | STAT1 Transcription Factor - metabolism | Cyclin-Dependent Kinase 8 - genetics | STAT3 Transcription Factor - genetics | Fibroblasts - metabolism | Fibroblasts - virology | Promoter Regions, Genetic | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Hep G2 Cells | Gene Expression Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Fibroblasts - drug effects | Interferon-gamma - immunology | Interleukin-6 - immunology | Cyclin-Dependent Kinase 8 - metabolism | RNA Polymerase II - genetics | Mice | STAT3 Transcription Factor - immunology | Vesiculovirus - physiology | Interferon-gamma - pharmacology | DNA microarrays | RNA | Analysis | Genes | Interferon | Universities and colleges | Biological response modifiers | Gene expression | Transcription factors | Cytokines | Cell cycle | Colleges & universities | Grants | RNA polymerase | Kinases | Experiments | Cancer
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 667 - 677.e7
...)–signal transducer and activator of transcription (STAT) pathway plays a critical role in skin barrier function and can be a therapeutic target for AD... 
Allergy and Immunology | keratinocyte differentiation | signal transducer and activator of transcription 3 | Atopic dermatitis | filaggrin | Janus kinase inhibitor | JAK INHIBITOR | MODEL | IMMUNOLOGY | CORNIFIED ENVELOPE | NC/NGA MICE | ATOPIC-DERMATITIS | RESPONSES | ALLERGY | FILAGGRIN MUTATIONS | STAT6 | DIFFERENTIATION | TH2 | RNA, Small Interfering - genetics | Dermatitis, Atopic - genetics | Humans | Interleukin-13 - immunology | Transplantation, Heterologous | STAT6 Transcription Factor - genetics | Interleukin-13 - genetics | RNA, Small Interfering - immunology | Skin, Artificial | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Skin Transplantation | STAT6 Transcription Factor - antagonists & inhibitors | Interleukin-4 - genetics | STAT3 Transcription Factor - genetics | Disease Models, Animal | Intermediate Filament Proteins - immunology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Dermatitis, Atopic - pathology | STAT6 Transcription Factor - immunology | Keratinocytes - immunology | Interleukin-4 - immunology | Keratinocytes - pathology | Animals | Dermatitis, Atopic - drug therapy | Keratinocytes - drug effects | Cell Differentiation - drug effects | Mice, Nude | Mice | Protein Kinase Inhibitors - pharmacology | Immunocompromised Host | STAT3 Transcription Factor - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Circuit components | Allergens | Mutual fund industry | Skin | Genetic transcription | Proteins | Cytokines | Genes | Skin & tissue grafts | Ligands | Kinases | Potassium | Chemokines
Journal Article
Blood, ISSN 1528-0020, 2015, Volume 125, Issue 4, pp. 591 - 599
Journal Article
Trends in immunology, ISSN 1471-4906, 2011, Volume 32, Issue 9, pp. 395 - 401
.... Ideally, better understanding of expression and action of key transcription factors and the epigenetic landscape of Th17 can help explain the flexibility and diversity of interleukin-17-producing cells. 
Allergy and Immunology | HYPER-IGE SYNDROME | GROWTH-FACTOR-BETA | TGF-BETA | T(H)17 CELLS | ROR-GAMMA-T | IN-VIVO | HUMAN TH17 CELLS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | T-H-17 CELLS | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - physiopathology | Species Specificity | Humans | Interleukin-17 - immunology | STAT5 Transcription Factor - immunology | Mycoses - microbiology | Cell Differentiation - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Interleukin-23 Subunit p19 - biosynthesis | Th17 Cells - metabolism | Bacterial Infections - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Th17 Cells - cytology | Genetic Variation - immunology | Autoimmune Diseases - pathology | Bacterial Infections - microbiology | STAT3 Transcription Factor - metabolism | Transforming Growth Factor beta - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Immunity, Cellular - genetics | Interleukin-17 - biosynthesis | Cell Differentiation - immunology | Animals | Th17 Cells - immunology | Mice | Interleukin-23 Subunit p19 - immunology | STAT3 Transcription Factor - immunology | Mycoses - immunology | Transforming Growth Factor beta - metabolism | Cell Lineage - immunology | T cells | Pathology | Transcription factors | Lymphocytes | Genes | Rodents | Rheumatoid arthritis | Autoimmune diseases | Kinases | Immune system | Crohns disease
Journal Article