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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Molecular carcinogenesis, ISSN 0899-1987, 2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2014, Volume 307, Issue 9, pp. E847 - E855
.... A key agent in GH-stimulated growth is the latent transcription factor signal transducer and activator of transcription (STAT... 
Insulin-like growth factor-I | Signal transducer and activator of transcription | Signal transduction | Gene transcription | gene transcription | ACTIVATION | PHYSIOLOGY | TYROSINE PHOSPHORYLATION | VIVO | signal transduction | RECEPTOR | BODY GROWTH | IDENTIFICATION | signal transducer and activator of transcription | INSULIN | insulin-like growth factor-I | DNA | ENDOCRINOLOGY & METABOLISM | BINDING-SITES | TRANSCRIPTION FACTOR | Up-Regulation | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Cercopithecus aethiops | STAT5 Transcription Factor - chemistry | Insulin-Like Growth Factor I - genetics | STAT3 Transcription Factor - chemistry | Recombinant Fusion Proteins - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | STAT1 Transcription Factor - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | STAT1 Transcription Factor - agonists | STAT1 Transcription Factor - chemistry | Conserved Sequence | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Response Elements | Growth Hormone - metabolism | Rats | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | STAT1 Transcription Factor - genetics | Protein Transport | STAT5 Transcription Factor - agonists | Sequence Homology, Amino Acid | Animals | Protein Processing, Post-Translational | COS Cells | Cell Nucleus | Insulin-Like Growth Factor I - metabolism | Tumor Suppressor Proteins - agonists | Cell research | Physiological aspects | Genetic research | Cellular signal transduction | Research | Cell differentiation | Gene expression
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10048 - 10060
IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several angioproliferative disorders. However, the detailed mechanisms of... 
APOPTOSIS | ACTIVATION | NETWORK | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TNF-ALPHA | INDUCTION | RAR-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic - pathology | Endopeptidases - chemistry | STAT1 Transcription Factor - metabolism | Interferon-alpha - genetics | RNA Interference | Human Umbilical Vein Endothelial Cells - cytology | STAT1 Transcription Factor - agonists | Promyelocytic Leukemia Protein - metabolism | Ubiquitin Thiolesterase - metabolism | Neovascularization, Pathologic - prevention & control | Ubiquitin Thiolesterase - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promyelocytic Leukemia Protein - genetics | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Interferon-alpha - metabolism | Cells, Cultured | STAT1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Mice, Knockout | STAT2 Transcription Factor - agonists | Animals | Endopeptidases - genetics | Endothelium, Vascular - metabolism | STAT2 Transcription Factor - genetics | Promyelocytic Leukemia Protein - antagonists & inhibitors | Endothelium, Vascular - pathology | Neovascularization, Pathologic - metabolism | Protein Processing, Post-Translational | STAT2 Transcription Factor - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Neovascularization, Physiologic | signal transducers and activators of transcription 1 (STAT1) | STAT transcription factor | Signal Transduction | interferon | angiogenesis | STAT3
Journal Article
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2013, Volume 127, Issue 4, pp. 476 - 485
Background-Platelet hyperactivity induced by inflammation is a known risk factor for atherosclerosis and thrombosis, but its underlying mechanisms remain poorly understood... 
Transcription factors | Platelets | Hemostasis | Thrombosis | Collagen | STAT3 | CANCER-CELLS | PHOSPHOLIPASE C-GAMMA-2 | CARDIAC & CARDIOVASCULAR SYSTEMS | TYROSINE PHOSPHORYLATION | SYK | transcription factors | TARGETING STAT3 | collagen | RECEPTOR | hemostasis | SERINE PHOSPHORYLATION | THROMBOPOIETIN | platelets | thrombosis | SHEAR-STRESS | MAXIMAL ACTIVATION | PERIPHERAL VASCULAR DISEASE | Phosphorylation - physiology | Vasculitis - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Blood Platelets - cytology | HEK293 Cells | Collagen - pharmacology | Blood Platelets - drug effects | Interleukin-6 - metabolism | Syk Kinase | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Phospholipase C gamma - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Platelet Aggregation - physiology | Atherosclerosis - metabolism | Mice, Knockout | Collagen - metabolism | Thrombosis - metabolism | Animals | Blood Platelets - metabolism | Signal Transduction - physiology | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | Blood platelets | Atherosclerosis | Physiological aspects | Inflammation | Cellular signal transduction | Research | Risk factors | Blood clot
Journal Article