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1. Full Text Nuclear Factor of Activated T Cells Regulates the Expression of Interleukin-4 in Th2 Cells in an All-or-none Fashion
by Köck, Juliana and Kreher, Stephan and Lehmann, Katrin and Riedel, René and Bardua, Markus and Lischke, Timo and Jargosch, Manja and Haftmann, Claudia and Bendfeldt, Hanna and Hatam, Farahnaz and Mashreghi, Mir-Farzin and Baumgrass, Ria and Radbruch, Andreas and Chang, Hyun-Dong
The Journal of biological chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 26752 - 26761
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Nucleus - immunology | GATA3 Transcription Factor - genetics | Phosphorylation - physiology | Active Transport, Cell Nucleus - physiology | E1A-Associated p300 Protein - immunology | GATA3 Transcription Factor - immunology | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - metabolism | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | DNA Helicases - immunology | Transcription Factor RelA - genetics | Interleukin-4 - biosynthesis | Cell Nucleus - metabolism | NFATC Transcription Factors - immunology | Adaptor Proteins, Signal Transducing - immunology | Transcription Factor RelA - immunology | Receptors, Antigen, T-Cell - immunology | Interleukin-4 - genetics | Nuclear Proteins - genetics | Response Elements - physiology | Transcription Factors - immunology | DNA Helicases - genetics | GATA3 Transcription Factor - metabolism | Receptors, Antigen, T-Cell - metabolism | NFATC Transcription Factors - metabolism | Gene Expression Regulation - physiology | Mice, Transgenic | Nuclear Proteins - metabolism | Th2 Cells - cytology | STAT6 Transcription Factor - metabolism | Transcription Factors - genetics | Nuclear Proteins - immunology | STAT6 Transcription Factor - immunology | Th2 Cells - metabolism | Transcription Factors - metabolism | DNA Helicases - metabolism | Interleukin-4 - immunology | Animals | Cell Nucleus - genetics | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Adaptor Proteins, Signal Transducing - metabolism | NFATC Transcription Factors - genetics | Index Medicus | NFAT Transcription Factor | Immunology | T-cell | T-cell Receptor (TCR) | Calcineurin | Cytokine
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2. Full Text Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
by Hu, Gangqing and Tang, Qingsong and Sharma, Suveena and Yu, Fang and Escobar, Thelma M and Muljo, Stefan A and Zhu, Jinfang and Zhao, Keji
Nature immunology, ISSN 1529-2908, 2013, Volume 14, Issue 11, pp. 1190 - 1198
Life Sciences & Biomedicine | Immunology | Science & Technology | GATA3 Transcription Factor - genetics | GATA3 Transcription Factor - immunology | STAT4 Transcription Factor - metabolism | STAT6 Transcription Factor - genetics | T-Box Domain Proteins - immunology | Th2 Cells - immunology | Transcriptome - immunology | Genetic Loci | Th1 Cells - immunology | RNA, Long Noncoding - immunology | Th1 Cells - metabolism | Th17 Cells - metabolism | Precursor Cells, T-Lymphoid - metabolism | Precursor Cells, T-Lymphoid - cytology | Th17 Cells - cytology | Cell Differentiation | GATA3 Transcription Factor - metabolism | STAT4 Transcription Factor - immunology | Signal Transduction | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Molecular Sequence Annotation | Th2 Cells - cytology | RNA, Long Noncoding - genetics | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | T-Box Domain Proteins - genetics | Th2 Cells - metabolism | T-Box Domain Proteins - metabolism | Animals | Protein Binding | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Mice | Th1 Cells - cytology | Precursor Cells, T-Lymphoid - immunology | Cell Movement | Physiological aspects | Genetic aspects | Research | Cell differentiation | Gene expression | T cells | Index Medicus | Cell migration
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3. Full Text Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells
by Schwartz, Anton M and Putlyaeva, Lidia V and Covich, Milica and Klepikova, Anna V and Akulich, Kseniya A and Vorontsov, Ilya E and Korneev, Kirill V and Dmitriev, Sergey E and Polanovsky, Oleg L and Sidorenko, Svetlana P and Kulakovskiy, Ivan V and Kuprash, Dmitry V
Biochimica et biophysica acta. Gene regulatory mechanisms, ISSN 1874-9399, 10/2016, Volume 1859, Issue 10, pp. 1259 - 1268
EBF1 | B cell | RNA isoform | Trascription factor | SLAMF | Transcriptional regulation | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Humans | Interferon Regulatory Factors - metabolism | NF-kappa B - metabolism | Sp1 Transcription Factor - metabolism | STAT6 Transcription Factor - genetics | Luciferases - genetics | Signaling Lymphocytic Activation Molecule Family Member 1 - genetics | Signaling Lymphocytic Activation Molecule Family Member 1 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | HEK293 Cells | Trans-Activators - genetics | Transcription, Genetic | Nuclear Proteins - genetics | Binding Sites | B-Lymphocytes - metabolism | Genes, Reporter | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | B-Lymphocytes - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | STAT6 Transcription Factor - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Enhancer Elements, Genetic | NF-kappa B - genetics | Sp1 Transcription Factor - genetics | Cell Line, Tumor | Protein Binding | Trans-Activators - metabolism | Mutation | Primary Cell Culture | Autoimmunity | Promoters (Genetics) | Leukemia | Genes | Genetic aspects | Genetic transcription | B cells | DNA binding proteins | Cell differentiation
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4. Full Text The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling
by Amano, Wataru, DVM and Nakajima, Saeko, MD, PhD and Kunugi, Hayato, PhD and Numata, Yasuharu, MS and Kitoh, Akihiko, MD, PhD and Egawa, Gyohei, MD, PhD and Dainichi, Teruki, MD, PhD and Honda, Tetsuya, MD, PhD and Otsuka, Atsushi, MD, PhD and Kimoto, Yukari, MS and Yamamoto, Yasuo, MS and Tanimoto, Atsuo, MS and Matsushita, Mutsuyoshi, PhD and Miyachi, Yoshiki, MD, PhD and Kabashima, Kenji, MD, PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 667 - 677.e7
Allergy and Immunology | keratinocyte differentiation | signal transducer and activator of transcription 3 | Atopic dermatitis | filaggrin | Janus kinase inhibitor | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | RNA, Small Interfering - genetics | Dermatitis, Atopic - genetics | Humans | Interleukin-13 - immunology | Transplantation, Heterologous | STAT6 Transcription Factor - genetics | Interleukin-13 - genetics | RNA, Small Interfering - immunology | Skin, Artificial | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Skin Transplantation | STAT6 Transcription Factor - antagonists & inhibitors | Interleukin-4 - genetics | STAT3 Transcription Factor - genetics | Disease Models, Animal | Intermediate Filament Proteins - immunology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Dermatitis, Atopic - pathology | STAT6 Transcription Factor - immunology | Keratinocytes - immunology | Interleukin-4 - immunology | Keratinocytes - pathology | Animals | Dermatitis, Atopic - drug therapy | Keratinocytes - drug effects | Cell Differentiation - drug effects | Mice, Nude | Mice | Protein Kinase Inhibitors - pharmacology | Immunocompromised Host | STAT3 Transcription Factor - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Circuit components | Allergens | Mutual fund industry | Skin | Genetic transcription | Proteins | Cytokines | Genes | Skin & tissue grafts | Ligands | Kinases | Potassium | Chemokines | Index Medicus | Abridged Index Medicus
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5. Full Text IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation
by Vento-Tormo, Roser and Vento-Tormo, Roser and Company, Carlos and Company, Carlos and Rodríguez-Ubreva, Javier and Rodríguez-Ubreva, Javier and de la Rica, Lorenzo and de la Rica, Lorenzo and Urquiza, José M and Urquiza, José M and Javierre, Biola M and Javierre, Biola M and Sabarinathan, Radhakrishnan and Sabarinathan, Radhakrishnan and Luque, Ana and Luque, Ana and Esteller, Manel and Esteller, Manel and Aran, Josep M and Aran, Josep M and Álvarez-Errico, Damiana and Álvarez-Errico, Damiana and Ballestar, Esteban and Ballestar, Esteban
Genome Biology, ISSN 1474-7596, 2016, Volume 17, Issue 1, pp. 4 - 4
IL-4 | TET2 | Dendritic cell | DNA demethylation | STAT6 | differentiation | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Monocytes - cytology | Humans | Interleukin-4 - metabolism | Gene Expression Regulation | Immunity, Innate - genetics | Monocytes - metabolism | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Macrophage Colony-Stimulating Factor - metabolism | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | DNA-Binding Proteins - genetics | Cell Differentiation - genetics | Dendritic Cells - cytology | Interleukin-4 - genetics | Macrophage Colony-Stimulating Factor - genetics | Transcription factors | Dendritic cells | Cytokines | Transcription | Granulocyte-macrophage colony-stimulating factor | Effector cells | Inflammation | Gene expression | Kinases | Signal transduction | Demethylation | Monocytes | Interleukin 4 | Cell activation | Stat6 protein | DNA methylation | Epigenetics | Tumor necrosis factor-TNF | Colony-stimulating factor | Genetic engineering | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus | Metilació | Cèl·lules dendrítiques | DNA | Diferenciació cel·lular | Transcripció genètica | ADN | Genetic transcription | Methylation | Cell diferentiation | Research
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6. Full Text Toxoplasma Rhoptry Protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
by Ong, Yi-Ching and Reese, Michael L and Boothroyd, John C
The Journal of biological chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 37, pp. 28731 - 28740
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Virulence Factors - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Toxoplasmosis - enzymology | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | Protozoan Proteins - genetics | Toxoplasma - enzymology | Toxoplasma - pathogenicity | Mice, Knockout | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | Toxoplasmosis - pathology | Animals | Protozoan Proteins - metabolism | Toxoplasma - genetics | Cell Line, Tumor | Toxoplasmosis - genetics | Virulence Factors - metabolism | Mice | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Index Medicus | Parasitology | Immunology | STAT Transcription Factor | Toxoplasma gondii | Microbiology | Signal Transduction | Tyrosine Protein Kinase (Tyrosine Kinase) | STAT6
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7. Full Text Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation
by Wei, Lai and Vahedi, Golnaz and Sun, Hong-Wei and Watford, Wendy T and Takatori, Hiroaki and Ramos, Haydee L and Takahashi, Hayato and Liang, Jonathan and Gutierrez-Cruz, Gustavo and Zang, Chongzhi and Peng, Weiqun and O'Shea, John J and Kanno, Yuka
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2010, Volume 32, Issue 6, pp. 840 - 851
SYSBIO | MOLIMMUNO | Life Sciences & Biomedicine | Immunology | Science & Technology | Gene Expression | T-Lymphocytes, Helper-Inducer - metabolism | Oligonucleotide Array Sequence Analysis | Gene Expression Regulation - immunology | Epigenesis, Genetic | Mice, Inbred C57BL | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | Chromatin Immunoprecipitation | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | STAT4 Transcription Factor - genetics | Transcription, Genetic | Mice | STAT4 Transcription Factor - immunology | Medical law | Chromatin | Anopheles | DNA binding proteins | T cells | Stem cells | Data analysis | Transcription factors | Cytokines | Genomics | Epigenetics | Software | Genomes | Gene expression | Recruitment | Index Medicus
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8. Full Text Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
by Villarino, Alejandro V and Tato, Cristina M and Stumhofer, Jason S and Yao, Zhengju and Cui, Yongzhi K and Hennighausen, Lothar and O'Shea, John J and Hunter, Christopher A
The Journal of experimental medicine, ISSN 0022-1007, 01/2007, Volume 204, Issue 1, pp. 65 - 71
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Ovalbumin - immunology | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | Th1 Cells - immunology | STAT Transcription Factors - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Feedback | T-Lymphocytes, Helper-Inducer - immunology | STAT5 Transcription Factor - deficiency | Immunization | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Mice, Transgenic | STAT6 Transcription Factor - metabolism | Receptors, Antigen, T-Cell, alpha-beta - genetics | Mice, Knockout | STAT Transcription Factors - genetics | Animals | STAT6 Transcription Factor - deficiency | Interleukin-2 - pharmacology | STAT4 Transcription Factor - genetics | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Interleukin-2 - biosynthesis | STAT4 Transcription Factor - deficiency | Index Medicus | Brief Definitive Reports
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9. Full Text PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation
by Mehrotra, Purvi and Riley, Jonathan P and Patel, Ravi and Li, Fang and Voss, Le'erin and Goenka, Shreevrat
The Journal of biological chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 3, pp. 1767 - 1776
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Histone Deacetylase 2 - genetics | T-Lymphocytes, Helper-Inducer - metabolism | Histone Deacetylases - genetics | Interleukin-4 - metabolism | Repressor Proteins - genetics | Histone Deacetylases - metabolism | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Transcription, Genetic - physiology | Animals | Poly(ADP-ribose) Polymerases - genetics | Promoter Regions, Genetic - physiology | T-Lymphocytes, Helper-Inducer - cytology | Mice | Histone Deacetylase 2 - metabolism | Interleukin-4 - genetics | Repressor Proteins - metabolism | Index Medicus | Histone deacetylase | Interleukin 4 | Lymphocytes B | Repressors | Transcription | Transcription activation | Helper cells | Stat6 protein | Poly(ADP-ribose) polymerase | Lymphocytes T | Promoters | ADP-ribosylation | Gene Regulation | Transcription Coactivators | Transcription Regulation | Interleukin-4 | STAT Transcription Factor | Transcriptional Switch | Stat6 | Interleukin | PARP-14 | Transcription Repressor
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