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rna, messenger - metabolism (136) 136
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article (132) 132
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reverse transcriptase polymerase chain reaction (109) 109
transfection (109) 109
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molecular sequence data (108) 108
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interleukin-13 - pharmacology (101) 101
blotting, western (100) 100
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1. Full Text Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
by Hu, Gangqing and Tang, Qingsong and Sharma, Suveena and Yu, Fang and Escobar, Thelma M and Muljo, Stefan A and Zhu, Jinfang and Zhao, Keji
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 11, pp. 1190 - 1198
Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the... 
STEM-CELLS | INTERFERON | INTEGRATIVE ANNOTATION | GENE-EXPRESSION | POPULATIONS | IMMUNOLOGY | GENOME-WIDE IDENTIFICATION | TRANSCRIPTION FACTOR | SEQ | CUTTING EDGE | REVEALS | GATA3 Transcription Factor - genetics | GATA3 Transcription Factor - immunology | STAT4 Transcription Factor - metabolism | STAT6 Transcription Factor - genetics | T-Box Domain Proteins - immunology | Th2 Cells - immunology | Transcriptome - immunology | Genetic Loci | Th1 Cells - immunology | RNA, Long Noncoding - immunology | Th1 Cells - metabolism | Th17 Cells - metabolism | Precursor Cells, T-Lymphoid - metabolism | Precursor Cells, T-Lymphoid - cytology | Th17 Cells - cytology | Cell Differentiation | GATA3 Transcription Factor - metabolism | STAT4 Transcription Factor - immunology | Signal Transduction | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Molecular Sequence Annotation | Th2 Cells - cytology | RNA, Long Noncoding - genetics | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | T-Box Domain Proteins - genetics | Th2 Cells - metabolism | T-Box Domain Proteins - metabolism | Animals | Protein Binding | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Mice | Th1 Cells - cytology | Precursor Cells, T-Lymphoid - immunology | Cell Movement | Physiological aspects | Genetic aspects | Research | Cell differentiation | Gene expression | T cells | Index Medicus | Cell migration
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2. Full Text STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
by Szanto, Attila and Balint, Balint L and Nagy, Zsuzsanna S and Nagy, Laszlo and Barta, Endre and Dezso, Balazs and Pap, Attila and Szeles, Lajos and Poliska, Szilard and Oros, Melinda and Evans, Ronald M and Barak, Yaacov and Schwabe, John
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 5, pp. 699 - 712
Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in... 
TRANSREPRESSION | PROLIFERATOR-ACTIVATED RECEPTORS | INSULIN-RESISTANCE | OXIDIZED LDL | ALPHA | FATTY-ACIDS | DIFFERENTIATION | IMMUNOLOGY | MYELOID CELLS | ALTERNATIVE ACTIVATION | REVEALS | Promoter Regions, Genetic | Macrophages - metabolism | Animals | Humans | Interleukin-4 - metabolism | Gene Expression Regulation | Inflammation Mediators - metabolism | Mice | Fatty Acid-Binding Proteins - metabolism | STAT6 Transcription Factor - metabolism | PPAR gamma - metabolism | Dendritic Cells - metabolism | Index Medicus
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3. Full Text IL-4 inhibits TGF-β-induced Foxp3 + T cells and, together with TGF-β, generates IL-9 + IL-10 + Foxp3 − effector T cells
by Oukka, Mohamed and Mitsdoerffer, Meike and Strom, Terry B and Kuchroo, Vijay K and Elyaman, Wassim and Dardalhon, Valérie and Galileos, George and Awasthi, Amit and Sobel, Raymond A and Ho, I-Cheng and Kwon, Hyoung and Gao, Wenda and Khoury, Samia
Nature Immunology, ISSN 1529-2908, 12/2008, Volume 9, Issue 12, pp. 1347 - 1355
Transcription factor Foxp3 is critical for generating regulatory T cells (T-reg cells). Transforming growth factor-beta (TGF-beta) induces Foxp3 and... 
SCHISTOSOMIASIS | TRANSCRIPTION FACTOR FOXP3 | CONTROL INTESTINAL INFLAMMATION | PROLIFERATION | INTERLEUKIN-10 | DIFFERENTIATION | INDUCTION | IMMUNOLOGY | EXPRESSION | HYPERRESPONSIVENESS | TRANSGENIC MICE | Forkhead Transcription Factors - immunology | T-Lymphocyte Subsets - immunology | Transforming Growth Factor beta - immunology | T-Lymphocyte Subsets - cytology | GATA3 Transcription Factor - immunology | Interleukin-4 - metabolism | Mice, Transgenic | Adoptive Transfer | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | T-Lymphocytes, Regulatory - immunology | Cell Differentiation - immunology | Interleukin-4 - immunology | Lymphocyte Activation - immunology | Animals | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Interleukin-9 - metabolism | Mice | GATA3 Transcription Factor - metabolism | Interleukin-10 - immunology | Interleukin-9 - immunology | Transforming Growth Factor beta - metabolism | Index Medicus
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4. Full Text Nuclear factor of activated t cells regulates the expression of interleukin-4 in Th2 cells in an All-or-none fashion
by Köck, Juliana and Kreher, Stephan and Lehmann, Katrin and Riedel, René and Bardua, Markus and Lischke, Timo and Jargosch, Manja and Haftmann, Claudia and Bendfeldt, Hanna and Hatam, Farahnaz and Mashreghi, Mir-Farzin and Baumgrass, Ria and Radbruch, Andreas and Chang, Hyun-Dong
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 26752 - 26761
Th2 memory lymphocytes have imprinted their Il4 genes epigenetically for expression in dependence of T cell receptor restimulation. However, in a given... 
LOCUS-CONTROL REGION | PROBABILISTIC REGULATION | MEMORY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR NFAT1 | HELPER-CELLS | DEPHOSPHORYLATION | GENE-EXPRESSION | IL-4 EXPRESSION | GATA-3 | LYMPHOCYTES | Cell Nucleus - immunology | GATA3 Transcription Factor - genetics | Phosphorylation - physiology | Active Transport, Cell Nucleus - physiology | E1A-Associated p300 Protein - immunology | GATA3 Transcription Factor - immunology | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - metabolism | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | DNA Helicases - immunology | Transcription Factor RelA - genetics | Interleukin-4 - biosynthesis | Cell Nucleus - metabolism | NFATC Transcription Factors - immunology | Adaptor Proteins, Signal Transducing - immunology | Transcription Factor RelA - immunology | Receptors, Antigen, T-Cell - immunology | Interleukin-4 - genetics | Nuclear Proteins - genetics | Response Elements - physiology | Transcription Factors - immunology | DNA Helicases - genetics | GATA3 Transcription Factor - metabolism | Receptors, Antigen, T-Cell - metabolism | NFATC Transcription Factors - metabolism | Gene Expression Regulation - physiology | Mice, Transgenic | Nuclear Proteins - metabolism | Th2 Cells - cytology | STAT6 Transcription Factor - metabolism | Transcription Factors - genetics | Nuclear Proteins - immunology | STAT6 Transcription Factor - immunology | Th2 Cells - metabolism | Transcription Factors - metabolism | DNA Helicases - metabolism | Interleukin-4 - immunology | Animals | Cell Nucleus - genetics | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Adaptor Proteins, Signal Transducing - metabolism | NFATC Transcription Factors - genetics | Index Medicus | NFAT Transcription Factor | Immunology | T-cell | T-cell Receptor (TCR) | Calcineurin | Cytokine
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5. Full Text Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
by Huang, Stanley Ching-Cheng and Smith, Amber M and Everts, Bart and Colonna, Marco and Pearce, Erika L and Pearce, Edward J and Schilling, Joel D
Immunity, ISSN 1074-7613, 10/2016, Volume 45, Issue 4, pp. 817 - 830
Macrophage activation status is intrinsically linked to metabolic remodeling. Macrophages stimulated by interleukin 4 (IL-4) to become alternatively (or, M2)... 
cytokine signaling | growth-factor signaling | macrophage | metabolism | cancer immunity | type 2 immunity | MAMMALIAN TARGET | PHOSPHORYLATION | KINASE | AKT | COMPLEX 2 | DIFFERENTIATION | IMMUNOLOGY | POLARIZATION | CANCER | T-CELLS | MTOR | Macrophage Activation - physiology | Macrophages - physiology | TOR Serine-Threonine Kinases - metabolism | Interleukin-4 - metabolism | Interferon Regulatory Factors - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Phosphatidylinositol 3-Kinases - metabolism | STAT6 Transcription Factor - metabolism | Mechanistic Target of Rapamycin Complex 2 | Multiprotein Complexes - metabolism | Macrophages - metabolism | Animals | Signal Transduction - physiology | Mice | Proto-Oncogene Proteins c-akt - metabolism | Glucose metabolism | Medical colleges | Interleukins | Immunotherapy | Physiological aspects | Macrophage colony stimulating factor | Glucose | Macrophages | Nematoda | Fatty acids | Dextrose | Synthesis | Bone marrow | Flow cytometry | Kinases | Metabolism | Gene expression | Cloning | Index Medicus
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6. Full Text Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
by Qiu, Yifu and Nguyen, Khoa D and Odegaard, Justin I and Cui, Xiaojin and Tian, Xiaoyu and Locksley, Richard M and Palmiter, Richard D and Chawla, Ajay
Cell, ISSN 0092-8674, 06/2014, Volume 157, Issue 6, pp. 1292 - 1308
Beige fat, which expresses the thermogenic protein UCP1, provides a defense against cold and obesity. Although a cold environment is the physiologic stimulus... 
WHITE | ACTIVATION | NONSHIVERING THERMOGENESIS | ADIPOCYTES | ADAPTIVE THERMOGENESIS | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | ADULT HUMANS | BROWN ADIPOSE-TISSUE | CELL BIOLOGY | Cold Temperature | Eosinophils - metabolism | Adipocytes, Brown - metabolism | Catecholamines - metabolism | Signal Transduction | Interleukin-4 - metabolism | Mice, Inbred C57BL | Male | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Obesity - metabolism | Interleukin-13 - genetics | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Thermogenesis | Myeloid Cells - metabolism | Adipose Tissue, Brown - metabolism | Mice | Interleukin-4 - genetics | Tyrosine | Physiological aspects | Obesity | Interleukins | Macrophages | Biosynthesis | Hydroxylases | Cytokines | Index Medicus
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7. Full Text The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development
by Stritesky, Gretta L and Muthukrishnan, Rajarajeswari and Sehra, Sarita and Goswami, Ritobrata and Pham, Duy and Travers, Jared and Nguyen, Evelyn T and Levy, David E and Kaplan, Mark H
Immunity, ISSN 1074-7613, 01/2011, Volume 34, Issue 1, pp. 39 - 49
Signal transducer and activator of transcription (STAT) family members direct the differentiation of T helper cells, with specific STAT proteins promoting... 
HYPER-IGE SYNDROME | B-CELLS | CONSTITUTIVELY ACTIVE STAT6 | ALLERGIC INFLAMMATION | TH2 DIFFERENTIATION | ALPHA-CHAIN EXPRESSION | REGULATORY T-CELLS | AIRWAY INFLAMMATION | IMMUNOLOGY | HELPER TYPE-2 DIFFERENTIATION | SIGNAL TRANSDUCER | Transcriptional Activation | Hypersensitivity - immunology | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | Signal Transduction - immunology | Hypersensitivity - metabolism | Th17 Cells - metabolism | Hypersensitivity - genetics | Cytokines - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Th2 Cells - pathology | Cytokines - immunology | Th17 Cells - pathology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | STAT6 Transcription Factor - metabolism | Protein Binding - immunology | Th2 Cells - metabolism | Mice, Knockout | Receptor Cross-Talk - immunology | Cell Differentiation - immunology | Animals | Th17 Cells - immunology | Mice | Antigens | Cell culture | Phosphorylation | Transcription factors | Cytokines | Rodents | T cell receptors | Deoxyribonucleic acid--DNA | Index Medicus
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8. Full Text Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages
by Wang, Cong-Yi and Wang, Yi and Zhu, Jianghui and Zhang, Lei and Zhang, Shu and Zhang, Zhijun and He, Long and Mou, Yong and Deng, Yanhan and Cao, Yong and Yang, Ping and Su, Yunchao and Zhao, Jianping and Yu, Qilin and Hu, Jifa and Chen, Zhishui and Ning, Qin and Xiang, Xudong and Xu, Yongjian and Xiong, Weining
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 12/2017, Volume 140, Issue 6, pp. 1550 - 1561.e8
C/EBP homologous protein (Chop), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during asthma development. However, its... 
macrophage | asthma | C/EBP homologous protein | endoplasmic reticulum stress | FIBROSIS | HOMEOSTASIS | AIRWAY INFLAMMATION | MURINE ASTHMA | IMMUNOLOGY | DEFICIENCY | PATHOGENESIS | ALLERGY | MICE | DIFFERENTIATION | POLARIZATION | LUNG INFLAMMATION | CCAAT-Enhancer-Binding Proteins - metabolism | Transcription Factor CHOP - genetics | Humans | Interleukin-4 - metabolism | Middle Aged | Cells, Cultured | Receptors, Cell Surface - metabolism | Male | STAT6 Transcription Factor - metabolism | Disease Progression | Endoplasmic Reticulum Stress - immunology | Mice, Knockout | Feedback, Physiological | Animals | Asthma - immunology | Adult | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Female | Cell Differentiation | Mice | Transcription Factor CHOP - metabolism | Macrophages - immunology | Phosphorylation | Transcription factors | Pathogenesis | Programming | Homology | Feedback loops | CCAAT/enhancer-binding protein | Macrophages | Positive feedback | Respiratory tract | Proteins | Airway management | Interleukin 4 | Feedback | Rodents | Respiratory tract diseases | Stresses | Ovalbumin | Inflammation | Patients | Allergies | Stress | Asthma | Signaling | Lungs | Software | Aberration | Endoplasmic reticulum | Index Medicus | Abridged Index Medicus
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9. Full Text Krüppel-like factor 4 regulates macrophage polarization
by Liao, Xudong and Sharma, Nikunj and Kapadia, Fehmida and Zhou, Guangjin and Lu, Yuan and Hong, Hong and Paruchuri, Kaavya and Mahabeleshwar, Ganapati H and Dalmas, Elise and Venteclef, Nicolas and Flask, Chris A and Kim, Julian and Doreian, Bryan W and Lu, Kurt Q and Kaestner, Klaus H and Hamik, Anne and Clément, Karine and Jain, Mukesh K
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2736 - 2749
Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and... 
MEDICINE, RESEARCH & EXPERIMENTAL | MEDIATED INFLAMMATION | ADIPOSE-TISSUE MACROPHAGES | INSULIN-RESISTANCE | PROINFLAMMATORY ACTIVATION | TUMOR-ASSOCIATED MACROPHAGES | PPAR-GAMMA | ANTIGEN-PRESENTING CELLS | TRANSCRIPTION FACTOR | RAW264.7 MACROPHAGES | MONOCYTE DIFFERENTIATION | Cell Line | Cell Polarity | Gene Expression | Adipose Tissue - physiology | Macrophage Activation - immunology | Humans | Adipose Tissue - cytology | Escherichia coli - immunology | NF-kappa B - metabolism | Obesity - physiopathology | STAT6 Transcription Factor - genetics | Macrophages - cytology | STAT6 Transcription Factor - metabolism | Mice, Knockout | Animals | Insulin Resistance - physiology | Kruppel-Like Transcription Factors - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Wound Healing - physiology | Macrophage Activation - drug effects | Kruppel-Like Transcription Factors - genetics | Macrophages - immunology | Index Medicus | Abridged Index Medicus
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10. Full Text Toxoplasma Rhoptry Protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
by Ong, Yi-Ching and Reese, Michael L and Boothroyd, John C
Journal of Biological Chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 37, pp. 28731 - 28740
The obligate intracellular parasite, Toxoplasma gondii, modulates host immunity in a variety of highly specific ways. Previous work revealed a polymorphic,... 
PATHWAYS | TRANSFORMATION | CELLS | TARGET GENES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GAMMA-INTERFERON | TRANSCRIPTION | GENE-EXPRESSION | GONDII | IDENTIFICATION | REVEALS | Virulence Factors - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Toxoplasmosis - enzymology | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | Protozoan Proteins - genetics | Toxoplasma - enzymology | Toxoplasma - pathogenicity | Mice, Knockout | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | Toxoplasmosis - pathology | Animals | Protozoan Proteins - metabolism | Toxoplasma - genetics | Cell Line, Tumor | Toxoplasmosis - genetics | Virulence Factors - metabolism | Mice | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Index Medicus | Parasitology | Immunology | STAT Transcription Factor | Toxoplasma gondii | Microbiology | Signal Transduction | Tyrosine Protein Kinase (Tyrosine Kinase) | STAT6
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11. Full Text STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation
by Yan, Dongyao and Wang, Hao-Wei and Bowman, Robert L and Joyce, Johanna A
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 11, pp. 2914 - 2927
Tumor-associated macrophages play critical roles during tumor progression by promoting angiogenesis, cancer cell proliferation, invasion, and metastasis.... 
METASTASIS | MOUSE MODEL | GROWTH | TRANSCRIPTION FACTOR XBP-1 | TUMOR-ASSOCIATED MACROPHAGES | PLASMA-CELL DIFFERENTIATION | CANCER | ALTERNATIVE ACTIVATION | PROGRESSION | MULTISTAGE TUMORIGENESIS | CELL BIOLOGY | Transcription, Genetic - drug effects | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Signal Transduction | Neoplasm Invasiveness | STAT6 Transcription Factor - metabolism | Carcinogenesis - metabolism | Cathepsins - secretion | Th2 Cells - drug effects | Th2 Cells - metabolism | Carcinogenesis - pathology | Gene Expression Regulation - drug effects | Macrophages - secretion | Phenotype | Animals | Cathepsins - genetics | Gene Deletion | Mice | Cytokines - pharmacology | Protein-Serine-Threonine Kinases - metabolism | STAT3 Transcription Factor - metabolism | Index Medicus
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12. Full Text Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
by Das, Jyoti and Ren, Guangwen and Zhang, Liying and Roberts, Arthur I and Zhao, Xin and Bothwell, Alfred L. M and Van Kaer, Luc and Shi, Yufang and Das, Gobardhan
Journal of Experimental Medicine, ISSN 0022-1007, 10/2009, Volume 206, Issue 11, pp. 2407 - 2416
Interleukin (IL)-17-producing T helper (Th17) cells play a critical role in the pathophysiology of several autoimmune disorders. The differentiation of Th17... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TGF-BETA | T(H)17 CELLS | TH2 CELLS | PATHWAY | INFLAMMATION | IL-17-PRODUCING T-CELLS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | INTERLEUKIN-6 | LINEAGE | Index Medicus
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