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Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 6, p. 1483
Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress,... 
Type 2 diabetes | Low-grade inflammation | Oxidative stress | Fatty acid-stimulated insulin secretion | GPR40 | Lipotoxicity | Pancreatic β-cells | Fatty acids | PRO-INFLAMMATORY CYTOKINES | fatty acids | ENZYME GENE-EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LONG-TERM EXPOSURE | pancreatic beta-cells | low-grade inflammation | ENDOPLASMIC-RETICULUM STRESS | CHEMISTRY, MULTIDISCIPLINARY | fatty acid-stimulated insulin secretion | PALMITATE-INDUCED APOPTOSIS | type 2 diabetes | lipotoxicity | ANTIOXIDATIVE DEFENSE STATUS | ACTIVATED PROTEIN-KINASES | TYPE-2 DIABETES-MELLITUS | oxidative stress | Hyperinsulinism - metabolism | Hyperinsulinism - pathology | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Oxidative Stress | Humans | Insulin Resistance | Insulin-Secreting Cells - pathology | Fatty Acids - metabolism | Insulin Secretion | Hyperinsulinemia | Glucose | Macrophages | Exocytosis | Inductors | Overnutrition | Oxidation resistance | Mitochondria | Glycerol-3-phosphate | Etiology | Intestine | Pancreas | Diabetes mellitus (non-insulin dependent) | Cell survival | Secretion | Diabetes mellitus | Glycerol | Metabolism | Insulin | Phospholipase | Diet | Insulin resistance | Islets of Langerhans | Endoplasmic reticulum | Apoptosis | Peptides | Biosynthesis | Kinases | Proteins | Sensors | Inflammation | Gene expression | Diabetes | Respiration | pancreatic β-cells
Journal Article
Metabolism, ISSN 0026-0495, 08/2019, Volume 97, pp. 87 - 91
We have reported that partial PERK attenuation using PERK inhibitors (PI) enhanced glucose-stimulated insulin secretion (GSIS) from pancreatic islets and mice... 
Glucose-stimulated insulin secretion | PERK | PERK inhibitor | Type 2 diabetes mellitus | ENDOCRINOLOGY & METABOLISM | Type 2 diabetes | Hyperglycemia | Blood sugar | Insulin | Analysis | Body weight
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 04/2019, Volume 20, Issue 8, p. 1995
Vitamin K2 is indispensable for blood coagulation and bone metabolism. Menaquinone-4 (MK-4) is the predominant homolog of vitamin K2, which is present in large... 
GLYCEMIC CONTROL | DIETARY PHYLLOQUINONE | Epac pathway | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-K SUPPRESSES | cAMP | CHEMISTRY, MULTIDISCIPLINARY | DIRECT TARGET | SUPPLEMENTATION | menaquinone-4 | glucose-stimulated insulin secretion | GLUCAGON-LIKE PEPTIDE-1 | RESISTANCE | BONE | GASTRIC-INHIBITORY POLYPEPTIDE | cAMP/Epac pathway
Journal Article
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 11/2015, Volume 14, Issue 11, pp. 4635 - 4646
As central tissue of glucose homeostasis, islet has been an important focus of diabetes research. Phosphorylation plays pivotal roles in islet function,... 
mass spectrometry | glucose-stimulated insulin secretion | SILAC | islet | phosphorylation | CELLS | ACTIN | PROTEIN-KINASE | QUANTIFICATION | BIOCHEMICAL RESEARCH METHODS | MECHANISMS | PANCREATIC-ISLETS | ARCHITECTURE | DYNAMICS | GENE-TRANSCRIPTION | Islets of Langerhans - drug effects | Protein Biosynthesis | Rats, Wistar | Cytoskeletal Proteins - genetics | Carbon Isotopes | Male | Cytoskeletal Proteins - isolation & purification | Muscle Proteins - isolation & purification | Phosphoproteins - metabolism | Insulin - biosynthesis | Nitrogen Isotopes | Islets of Langerhans - metabolism | Muscle Proteins - metabolism | Cytoskeletal Proteins - metabolism | Transcription, Genetic | Microfilament Proteins - metabolism | Proteomics - methods | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Insulin Secretion | Microfilament Proteins - genetics | Microfilament Proteins - isolation & purification | Tissue Culture Techniques | Molecular Sequence Annotation | Gene Expression Regulation | Rats | Glucose - pharmacology | Phosphoproteins - genetics | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - isolation & purification | Muscle Proteins - genetics | Insulin - metabolism | Isotope Labeling - methods | Animals | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Glucose - metabolism | Phosphoproteins - isolation & purification
Journal Article
Journal Article