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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2012, Volume 52, Issue 2, pp. 314 - 327
Enhanced oxidative stress due to high glucose contributes to pathological changes in diabetes-related liver complications. Reducing oxidative stress may... 
Anthocyanin | CREB | Free radicals | GSH | PKA | OXIDATIVE STRESS | METABOLIC SYNDROME | RISK-FACTORS | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ENDOTHELIAL-CELLS | RESPONSE ELEMENT | INSULIN-RESISTANCE | CELLULAR GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | GLUTAMATE-CYSTEINE LIGASE | SUBUNIT GENE-EXPRESSION | Up-Regulation | Liver - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Male | Hepatocytes - metabolism | fas Receptor - metabolism | Hyperglycemia - drug therapy | Glutathione - biosynthesis | MAP Kinase Kinase 4 - metabolism | fas Receptor - genetics | Anthocyanins - therapeutic use | Glucosides - therapeutic use | Glutamate-Cysteine Ligase - metabolism | Cyclic AMP - metabolism | Hepatocytes - drug effects | Cytoprotection | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Survival - drug effects | Anthocyanins - pharmacology | Gene Expression | Glucosides - pharmacology | Signal Transduction | Liver - metabolism | Fatty Liver - prevention & control | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Enzyme Activation - drug effects | Hep G2 Cells | Hyperglycemia - metabolism | Antioxidants - therapeutic use | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Glutamate-Cysteine Ligase - genetics | Mice, Obese | Mice | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2005, Volume 280, Issue 6, pp. 4617 - 4626
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2006, Volume 355, Issue 18, pp. 1903 - 1911
A 53-year-old woman with asthma and multilobar pneumonia is admitted with respiratory failure. She is intubated and treated with antibiotics, albuterol, and... 
DIABETIC-PATIENTS | MORTALITY | MEDICINE, GENERAL & INTERNAL | INFECTIOUS COMPLICATIONS | INSULIN INFUSION PROTOCOL | TIGHT GLYCEMIC CONTROL | INPATIENT GLUCOSE MANAGEMENT | BLOOD-GLUCOSE | ACUTE MYOCARDIAL-INFARCTION | STRESS HYPERGLYCEMIA | WOUND-INFECTION | Case studies | Hyperglycemia | Hospitalization | Heart attacks | Diabetes | Glucose | Mortality
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2014, Volume 171, Issue 2, pp. 523 - 535
Background and PurposeEndothelial dysfunction can be detected at an early stage in the development of diabetes-related microvascular disease and is associated... 
FoxO | 1 | reactive oxygen species | sirtuin1 | hyperglycaemia | metformin | forkhead box | vascular senescence | endothelial dysfunction | microvascular endothelial cells | O | 1 transcription factor | FoxO-1 | forkhead box O1 transcription factor | TRANSCRIPTION FACTORS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | MESENTERIC-ARTERIES | HEALTHY-SUBJECTS | CELLULAR SENESCENCE | PREMATURE SENESCENCE | NITRIC-OXIDE | DIABETIC DB/DB | PHARMACOLOGY & PHARMACY | HIGH-GLUCOSE | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Diabetes Mellitus, Type 2 - genetics | Cellular Senescence - drug effects | Capillaries - drug effects | Endothelium, Vascular - drug effects | Diabetes Mellitus, Type 2 - metabolism | Sirtuin 1 - genetics | Forkhead Transcription Factors - metabolism | Adenylate Kinase - metabolism | beta-Galactosidase - metabolism | Acetylation | Hyperglycemia - physiopathology | Metformin - pharmacology | Mice, Inbred C57BL | Gene Silencing | Blotting, Western | Hypoglycemic Agents - pharmacology | Animals | Signal Transduction - drug effects | Capillaries - cytology | Sirtuin 1 - physiology | Fluorescent Antibody Technique | Forkhead Box Protein O1 | Mice | Glucose metabolism | Hyperglycemia | Development and progression | Diabetes | Metformin | Glucose | Tumor proteins | Dextrose | Apoptosis | Endothelium | Index Medicus | Research Papers
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 11/2013, Volume 15, Issue 11, pp. 993 - 999
AimTo examine whether protein kinase C (PKC) and associated downstream mechanisms are involved in hyperglycaemia (HG)-evoked blood-brain barrier (BBB) damage.... 
blood‐brain barrier | hyperglycaemia | occludin | oxidative stress | protein kinase C | Oxidative stress | Protein kinase C | Hyperglycaemia | Blood-brain barrier | Occludin | blood-brain barrier | PKC-BETA | DIABETIC-RATS | BLOOD-BRAIN-BARRIER | STROKE | NAD(P)H OXIDASE | INHIBITION | ENDOCRINOLOGY & METABOLISM | MEDIATED DISRUPTION | NITRIC-OXIDE | EXPRESSION | Endothelium, Vascular - cytology | NADPH Oxidases - chemistry | Blood-Brain Barrier - cytology | Pericytes - drug effects | Coculture Techniques | Humans | Pericytes - cytology | Blood-Brain Barrier - physiopathology | Microvessels - metabolism | NADPH Oxidases - metabolism | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | Occludin - metabolism | Brain - metabolism | Brain - blood supply | Matrix Metalloproteinase 2 - chemistry | Hyperglycemia - physiopathology | Tight Junctions - drug effects | Astrocytes - cytology | Microvessels - cytology | Tight Junctions - metabolism | Astrocytes - drug effects | Brain - cytology | Matrix Metalloproteinase 2 - metabolism | Pericytes - metabolism | Cells, Cultured | Microvessels - drug effects | Electric Impedance | Down-Regulation - drug effects | Enzyme Activation - drug effects | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Brain - drug effects | Hyperglycemia - metabolism | Endothelium, Vascular - metabolism | Hyperglycemia - enzymology | Protein Kinase C beta - chemistry | Protein Kinase C beta - metabolism | Protein Kinase Inhibitors - pharmacology | Protein Kinase C beta - antagonists & inhibitors | Astrocytes - metabolism | Index Medicus
Journal Article