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1. Full Text Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice
by Mari Kono and Inna A. Belyantseva and Athanasia Skoura and Gregory I. Frolenkov and Matthew F. Starost and Jennifer L. Dreier and Darcy Lidington and Steffen-Sebastian Bolz and Thomas B. Friedman and Timothy Hla and Richard L. Proia
Journal of Biological Chemistry, ISSN 0021-9258, 04/2007, Volume 282, Issue 14, pp. 10690 - 10696
The S1P 2 receptor is a member of a family of G protein-coupled receptors that bind the extracellular sphingolipid metabolite sphingosine 1-phosphate with high... 
Epithelium - blood supply | Lysophospholipids - metabolism | Stria Vascularis - pathology | Epithelium - pathology | Deafness - genetics | Epithelial Cells - metabolism | Stria Vascularis - metabolism | Receptors, Lysosphingolipid - deficiency | Deafness - physiopathology | Epithelial Cells - pathology | Deafness - pathology | Sphingosine - analogs & derivatives | Animals | Time Factors | Deafness - metabolism | Mice, Mutant Strains | Evoked Potentials, Auditory, Brain Stem - genetics | Mice | Sphingosine - metabolism | Receptors, Lysosphingolipid - metabolism | Index Medicus
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2. Full Text Estrogen-Related Receptor β/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis
by Chen, Jichao and Nathans, Jeremy
Developmental Cell, ISSN 1534-5807, 2007, Volume 13, Issue 3, pp. 325 - 337
In the mammalian inner ear, endolymph is produced and resorbed by a complex series of epithelia. We show here that estrogen-related receptor β (ERR-β; NR3B2),... 
DEVBIO | Immunohistochemistry | Gene Expression | Epithelial Cells - metabolism | Stria Vascularis - metabolism | Ear, Inner - cytology | Deafness - etiology | Mice, Knockout | Deafness - pathology | Estrogen Receptor beta - metabolism | Epithelial Cells - physiology | Ear, Inner - metabolism | Endolymph - metabolism | Animals | In Situ Hybridization | Stria Vascularis - cytology | Models, Biological | Alleles | Mosaicism | Cell Differentiation | Mice | Index Medicus
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3. Full Text Connexin30 Deficiency Causes Instrastrial Fluid-Blood Barrier Disruption within the Cochlear Stria Vascularis
by Martine Cohen-Salmon and Béatrice Regnault and Nadège Cayet and Dorothée Caille and Karine Demuth and Jean-Pierre Hardelin and Nathalie Janel and Paolo Meda and Christine Petit
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 15, pp. 6229 - 6234
The endocochlear potential (EP) is essential to hearing, because it provides approximately half of the driving force for the mechanoelectrical transduction... 
Spiral ligament of cochlea | Deafness | Epithelial cells | Hair cells | Genes | Cochlea | Organ of corti | Capillaries | Down regulation | Endothelial cells | Endocochlear potential | endocochlear potential | TIGHT JUNCTIONS | HOMOCYSTEINE | CELLS | HEARING IMPAIRMENT | INNER-EAR | MULTIDISCIPLINARY SCIENCES | ELECTRICAL-PROPERTIES | GAP-JUNCTION HEMICHANNELS | LATERAL WALL | deafness | EXPRESSION | Connexins - deficiency | Microscopy, Electron, Transmission | Stria Vascularis - metabolism | Stria Vascularis - ultrastructure | Connexins - genetics | Connexin 30 | Gene Expression Profiling | Chromatography, High Pressure Liquid | DNA Primers | Mice, Knockout | Freeze Fracturing | Hearing Loss - genetics | Hearing Loss - metabolism | Animals | Endothelium, Vascular - metabolism | Microarray Analysis | Fluorescent Antibody Technique | Cochlear Microphonic Potentials - genetics | Mice | Betaine-Homocysteine S-Methyltransferase - metabolism | Cysteine - blood | Research | Risk factors | Electrical currents | Proteins | Signal transduction | Enzymes | Rodents | Fluorescence | Ears & hearing | Biochemistry | Ligaments | Cells | Index Medicus | Biological Sciences
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4. Full Text Slc26a4 -insufficiency causes fluctuating hearing loss and stria vascularis dysfunction
by Ito, Taku and Li, Xiangming and Kurima, Kiyoto and Choi, Byung Yoon and Wangemann, Philine and Griffith, Andrew J
Neurobiology of Disease, ISSN 0969-9961, 2014, Volume 66, pp. 53 - 65
Abstract SLC26A4 mutations can cause a distinctive hearing loss phenotype with sudden drops and fluctuation in patients. Existing Slc26a4 mutant mouse lines... 
Neurology | Inducible | Fluctuation | Doxycycline | Transgenic | Stria vascularis | Conditional | Endocochlear potential | SLC26A4 | Vestibular aqueduct | Hypomorph | Hearing loss | GENOTYPE-PHENOTYPE CORRELATION | K-CL COTRANSPORTER | PENDRED-SYNDROME | OUTER HAIR-CELLS | ENDOLYMPHATIC HYDROPS | KCNJ10 PROTEIN EXPRESSION | INNER-EAR | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | VESTIBULAR AQUEDUCT SYNDROME | SYNDROME MOUSE MODEL | Immunohistochemistry | Macrophages - physiology | Stria Vascularis - pathology | Gene Expression | Hair Cells, Auditory - pathology | Hearing Loss - physiopathology | Macrophages - pathology | Cochlea - physiopathology | Mice, Transgenic | Hearing Loss - pathology | Anion Transport Proteins - metabolism | Auditory Threshold | Stria Vascularis - physiology | Animals | Evoked Potentials, Auditory, Brain Stem | Hair Cells, Auditory - physiology | Membrane Potentials | Cochlea - pathology | Mice | Otoacoustic Emissions, Spontaneous | Real-Time Polymerase Chain Reaction | Anion Transport Proteins - genetics | Analysis | Genetic engineering | Index Medicus | endocochlear potential | inducible | vestibular aqueduct | transgenic | hearing loss | hypomorph | doxycycline | fluctuation | stria vascularis
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5. Full Text The Endocochlear Potential Depends on Two K⁺ Diffusion Potentials and an Electrical Barrier in the Stria Vascularis of the Inner Ear
by Fumiaki Nin and Hiroshi Hibino and Katsumi Doi and Toshihiro Suzuki and Yasuo Hisa and Yoshihisa Kurachi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 5, pp. 1751 - 1756
An endocochlear potential (EP) of +80 mV is essential for audition. Although the regulation of K⁺ concentration ([K⁺]) in various compartments of the cochlear... 
Electrodes | Endolymph | Anoxia | Cochlea | Stria vascularis | Giant cells | Internet service providers | Perilymph | Inner ear | P branes | Ion transport | Potassium | Hearing | MARGINAL CELLS | LOCALIZATION | potassium | ION-TRANSPORT MECHANISMS | MULTIDISCIPLINARY SCIENCES | ion transport | TIGHT JUNCTIONS | GERBIL COCHLEA | IN-VITRO | INTERMEDIATE CELLS | COTRANSPORTER | hearing | COCHLEAR LATERAL WALL | POTASSIUM CHANNEL | Potassium - metabolism | Stria Vascularis - physiology | Animals | Guinea Pigs | Membrane Potentials | Stria Vascularis - metabolism | Ear, Inner - physiology | Ion Transport | Cochlea - physiology | Electric Impedance | Ears & hearing | Membranes | Cellular biology | Index Medicus | Biological Sciences
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6. Full Text Organ of corti and stria vascularis: Is there an interdependence for survival?
by Liu, Huizhan and Li, Yi and Chen, Lei and Zhang, Qian and Pan, Ning and Nichols, David H and Zhang, Weiping J and Fritzsch, Bernd and He, David Z. Z
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0168953 - e0168953
Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the... 
OUTER HAIR-CELLS | COCHLEAR | INTERMEDIATE CELLS | FINE-STRUCTURE | FUROSEMIDE | MULTIDISCIPLINARY SCIENCES | POTASSIUM | MUTATIONS | WAARDENBURG SYNDROME | INNER | Hair Cells, Auditory - cytology | Basic Helix-Loop-Helix Transcription Factors - physiology | Microphthalmia-Associated Transcription Factor - metabolism | Mice, Inbred C57BL | Organ of Corti - physiology | Male | Mice, Knockout | Mechanotransduction, Cellular | Stria Vascularis - physiology | Animals | Stria Vascularis - cytology | Hair Cells, Auditory - physiology | Organ of Corti - cytology | Female | Hearing - physiology | Mice | Disease Models, Animal | Physiological aspects | Development and progression | Hair cells (Mechanoreceptors) | Models | Research | Hearing disorders | Animal models | Transcription factors | Organ of Corti | Hair cells | Otolaryngology | Hearing protection | Reduction | Endolymph | Stria vascularis | MITF gene | Microphthalmia-associated transcription factor | Hair | Cell survival | Hearing impairment | Gene expression | Survival | Medicine | Cell death | Morphology | Electrochemistry | Cochlea | Mechanotransduction | Mutation | Mechanical stimuli | Potassium | Ligaments | Index Medicus
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7. Full Text Isolation, cultivation, and characterization of primary bovine cochlear pericytes: A new in vitro model of stria vascularis
by Giurdanella, Giovanni and Montalbano, Giuseppe and Gennuso, Florinda and Brancati, Serena and Lo Furno, Debora and Augello, Antonio and Bucolo, Claudio and Drago, Filippo and Salomone, Salvatore
Journal of Cellular Physiology, ISSN 0021-9541, 03/2019, Volume 234, Issue 3, pp. 1978 - 1986
The study of strial pericytes has gained great interest as they are pivotal for the physiology of stria vascularis. To provide an easily accessible in vitro... 
gentamicin | cisplatin | ototoxicity | primary culture | stria vascularis | pericytes | WALLS | PHYSIOLOGY | BARRIER | MECHANISMS | BLOOD-FLOW | CULTURE | DAMAGE | CELL BIOLOGY | ENDOTHELIAL-CELLS | CAPILLARY DIAMETER | GENERATION | Physiological aspects | Aminoglycosides | Platelet-derived growth factor | Analysis | Von Willebrand factor | Sensitivity analysis | Cultivation | Gentamicin | Muscles | Retina | Smooth muscle | Drug development | Neuronal-glial interactions | Cisplatin | Endothelial cells | Lipopolysaccharides | Biomedical materials | Actin | Cochlea | Pericytes | Stria vascularis | Biocompatibility | In vivo methods and tests | Viability | Growth factors | Ototoxicity
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8. Full Text Progressive irreversible hearing loss is caused by stria vascularis degeneration in an Slc26a4 -insufficient mouse model of large vestibular aqueduct syndrome
by Ito, T and Nishio, A and Wangemann, P and Griffith, A.J
Neuroscience, ISSN 0306-4522, 2015, Volume 310, pp. 188 - 197
Highlights • SLC26A4 mutations can cause fluctuating and progressive hearing loss in humans. • Slc26a4 -insufficient mice have irreversible hearing loss after... 
Neurology | deafness | doxycycline | hypomorphic | SLC26A4 | fluctuation | stria vascularis | Deafness | Stria vascularis | Hypomorphic | Fluctuation | Doxycycline | PENDRED-SYNDROME | MARGINAL CELLS | KCNJ10 PROTEIN EXPRESSION | INNER-EAR | ENLARGEMENT | MECHANISMS | NEUROSCIENCES | CAUSES DEAFNESS | INHIBITION | MUTATIONS | CONTRIBUTES | Stria Vascularis - pathology | Hair Cells, Auditory - pathology | KCNQ1 Potassium Channel - genetics | Vestibular Diseases - complications | Hearing Loss - etiology | KCNQ1 Potassium Channel - metabolism | Cell Death - genetics | Anion Transport Proteins - deficiency | Disease Models, Animal | Hearing Loss - physiopathology | Acoustic Stimulation | Gene Expression Regulation - genetics | Genotype | Mice, Transgenic | Potassium Channels, Inwardly Rectifying - genetics | Mutation - genetics | Hearing Loss - genetics | Animals | Vestibular Aqueduct - pathology | Evoked Potentials, Auditory, Brain Stem - genetics | Auditory Threshold - physiology | Mice | Vestibular Diseases - genetics | Potassium Channels, Inwardly Rectifying - metabolism | Anion Transport Proteins - genetics | Evoked Potentials, Auditory, Brain Stem - physiology | Physiological aspects | Hearing loss | Index Medicus | DFNB4 | presbycusis | pendrin
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9. Full Text Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo
by Ihler, Fritz and Bertlich, Mattis and Sharaf, Kariem and Strieth, Sebastian and Strupp, Michael and Canis, Martin
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39086 - e39086
Objective: Betahistine is a histamine H-1-receptor agonist and H-3-receptor antagonist that is administered to treat Meniere's disease. Despite widespread use,... 
VELOCITY | INNER-EAR | MULTIDISCIPLINARY SCIENCES | DISEASE | LASER-DOPPLER | RECEPTORS | DOSAGE | Dose-Response Relationship, Drug | Betahistine - pharmacology | Animals | Guinea Pigs | Vasodilator Agents - pharmacology | Cochlea - drug effects | Arterial Pressure - drug effects | Capillaries - drug effects | Female | Measurement | Histamine | Blood pressure | Fluorescence microscopy | Blood flow | Plasma | Body weight | Otolaryngology | Fluorescence | Clinical trials | Dosage | Experiments | Blood | Vertigo | Lasers | Rodents | Surgery | Stria vascularis | Capillaries | Drug dosages | Medical treatment | Pharmacology | Sodium chloride | Variance analysis | Flow | Mode of action | Medicine | Studies | Hospitals | Microscopy | Guinea pigs | Cochlea | In vivo methods and tests | Circulatory system | Veins & arteries | Index Medicus
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10. Full Text Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss
by Locher, Heiko and de Groot, John C.M.J and van Iperen, Liesbeth and Huisman, Margriet A and Frijns, Johan H.M and Chuva de Sousa Lopes, Susana M
Developmental Neurobiology, ISSN 1932-8451, 11/2015, Volume 75, Issue 11, pp. 1219 - 1240
Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of... 
sensorineural hearing loss | development | melanocytes | human | stria vascularis | Human | Development | Melanocytes | Stria vascularis | Sensorineural hearing loss | DOMINANT | DEVELOPMENTAL BIOLOGY | PENDRED SYNDROME | NEUROSCIENCES | IMPAIRMENT | CAUSES DEAFNESS | W-LOCUS | GENE | MUTATIONS | PRETERM | EXPRESSION | Immunohistochemistry | Potassium - metabolism | Cochlea - embryology | Hearing Loss, Sensorineural - metabolism | Microphthalmia-Associated Transcription Factor - metabolism | Connexin 43 - metabolism | SOXE Transcription Factors - metabolism | Humans | KCNQ1 Potassium Channel - metabolism | Connexin 30 | Cochlea - cytology | Cochlea - physiology | Melanocytes - physiology | Proto-Oncogene Proteins c-kit - metabolism | Connexins - metabolism | Connexin 26 | Microscopy, Confocal | Sodium-Potassium-Exchanging ATPase - metabolism | Stria Vascularis - physiology | Stria Vascularis - cytology | Image Processing, Computer-Assisted | Melanocytes - cytology | Potassium Channels, Inwardly Rectifying - metabolism | Cell Movement | Proteins | Embryonic development | Genetic disorders | Hearing loss | Index Medicus
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11. Full Text Age‑associated variation in the expression and function of TMEM16A calcium‑activated chloride channels in the cochlear stria vascularis of guinea pigs
by Zhou, Ying and Song, Jia and Wang, Yan‑Ping and Zhang, Ai‑Mei and Tan, Chao‑Yang and Liu, Yan‑Hui and Zhang, Zhi‑Ping and Wang, Yang and Ma, Ke‑Tao and Li, Li and Si, Jun‑Qiang
Molecular Medicine Reports, ISSN 1791-2997, 06/2019, Volume 20, Issue 2, pp. 1593 - 1604
The present study was designed to investigate the expression and function of transmembrane protein 16 (TMEM16A), a calcium-activated chloride channel (CaCC),... 
Deafness | Superoxide | Galactose | Analysis | Diabetic retinopathy | Oxidative stress | Brain stem | Spatial discrimination learning | Homeostasis | Reverse transcription | Superoxide dismutase | Smooth muscle | Chloride | Aging | Stria vascularis | D-Galactose | Age | Calcium channels | Injection | Hearing impairment | Metabolism | Malondialdehyde | Chloride channels (calcium-gated) | Hearing loss | Calcium chloride | Studies | Hearing | Animals | Cochlea | Immunofluorescence | Spatial memory | endocochlear potential | calcium- activated chloride channels | age-associated deafness | transmembrane protein 16 | presbycusis | stria vascularis
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12. Full Text Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea
by Uetsuka, Satoru and Ogata, Genki and Nagamori, Shushi and Isozumi, Noriyoshi and Nin, Fumiaki and Yoshida, Takamasa and Komune, Shizuo and Kitahara, Tadashi and Kikkawa, Yoshiaki and Inohara, Hidenori and Kanai, Yoshikatsu and Hibino, Hiroshi
European Journal of Neuroscience, ISSN 0953-816X, 08/2015, Volume 42, Issue 3, pp. 1984 - 2002
Stria vascularis of the mammalian cochlea transports K + to establish the electrochemical property in the endolymph crucial for hearing. This epithelial tissue... 
mass spectrometry | proteomics | rat | ion channel | transporter | Rat | Ion channel | Mass spectrometry | Transporter | Proteomics | K-CL COTRANSPORTER | MARGINAL CELLS | INNER-EAR | IMMUNOHISTOCHEMICAL LOCALIZATION | ULTRASTRUCTURAL-LOCALIZATION | GUINEA-PIG | NEUROSCIENCES | AMINO-ACID TRANSPORTER | BETA-SUBUNIT ISOFORMS | PROTEIN-KINASE-II | POTASSIUM CHANNEL | Deafness - genetics | Stria Vascularis - metabolism | Humans | Databases, Genetic | Molecular Sequence Data | Rats | Deafness - physiopathology | Male | Animals | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Mice | Physiological aspects | Deafness | Liquid chromatography | Analysis | Membrane proteins | Index Medicus
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