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by Cavalli, Florence M.G and Remke, Marc and Rampasek, Ladislav and Peacock, John and Shih, David J.H and Luu, Betty and Garzia, Livia and Torchia, Jonathon and Nor, Carolina and Morrissy, A. Sorana and Agnihotri, Sameer and Thompson, Reid C and Thompson, Yuan Yao and Kuzan-Fischer, Claudia M and Farooq, Hamza and Isaev, Keren and Daniels, Craig and Cho, Byung-Kyu and Kim, Seung-Ki and Wang, Kyu-Chang and Lee, Ji Yeoun and Grajkowska, Wieslawa A and Perek-Polnik, Marta and Vasiljevic, Alexandre and Faure-Conter, Cecile and Jouvet, Anne and Giannini, Caterina and Nageswara Rao, Amulya A and Li, Kay Ka Wai and Ng, Ho-Keung and Eberhart, Charles G and Pollack, Ian F and Hamilton, Ronald L and Gillespie, G. Yancey and Olson, James M and Leary, Sarah and Weiss, William A and Lach, Boleslaw and Chambless, Lola B and Cooper, Michael K and Vibhakar, Rajeev and Hauser, Peter and van Veelen, Marie-Lise C and Kros, Johan M and French, Pim J and Ra, Young Shin and Kumabe, Toshihiro and López-Aguilar, Enrique and Zitterbart, Karel and Sterba, Jaroslav and Finocchiaro, Gaetano and Massimino, Maura and Van Meir, Erwin G and Osuka, Satoru and Shofuda, Tomoko and Klekner, Almos and Zollo, Massimo and Leonard, Jeffrey R and Rubin, Joshua B and Jabado, Nada and Albrecht, Steffen and Mora, Jaume and Van Meter, Timothy E and Jung, Shin and Moore, Andrew S and Hallahan, Andrew R and Chan, Jennifer A and Tirapelli, Daniela P.C and Carlotti, Carlos G and Fouladi, Maryam and Pimentel, José and Faria, Claudia C and Saad, Ali G and Massimi, Luca and Liau, Linda M and Wheeler, Helen and Nakamura, Hideo and Elbabaa, Samer K and Perezpeña-Diazconti, Mario and Chico Ponce de León, Fernando and Robinson, Shenandoah and Zapotocky, Michal and Lassaletta, Alvaro and Huang, Annie and Hawkins, Cynthia E and Tabori, Uri and Bouffet, Eric and Bartels, Ute and Dirks, Peter B and Rutka, James T and Bader, Gary D and Reimand, Jüri and Goldenberg, Anna and Ramaswamy, Vijay and Taylor, Michael D
Cancer Cell, ISSN 1535-6108, 06/2017, Volume 31, Issue 6, pp. 737 - 754.e6
Journal Article
by Shih, David J H and Shih, David J. H and Northcott, Paul A and Northcott, Paul A and Remke, Marc and Remke, Marc and Korshunov, Andrey and Korshunov, Andrey and Ramaswamy, Vijay and Ramaswamy, Vijay and Kool, Marcel and Kool, Marcel and Luu, Betty and Luu, Betty and Yao, Yuan and Yao, Yuan and Wang, Xin and Wang, Xin and Dubuc, Adrian M and Dubuc, Adrian M and Garzia, Livia and Garzia, Livia and Peacock, John and Peacock, John and Mack, Stephen C and Mack, Stephen C and Wu, Xiaochong and Wu, Xiaochong and Rolider, Adi and Rolider, Adi and Morrissy, A. Sorana and Morrissy, A Sorana and Cavalli, Florence M. G and Cavalli, Florence M G and Jones, David T. W and Jones, David T W and Zitterbart, Karel and Zitterbart, Karel and Faria, Claudia C and Faria, Claudia C and Schüller, Ulrich and Schüller, Ulrich and Kren, Leos and Kren, Leos and Kumabe, Toshihiro and Kumabe, Toshihiro and Tominaga, Teiji and Tominaga, Teiji and Ra, Young Shin and Shin Ra, Young and Garami, Miklós and Garami, Miklós and Hauser, Peter and Hauser, Peter and Chan, Jennifer A and Chan, Jennifer A and Robinson, Shenandoah and Robinson, Shenandoah and Bognár, László and Bognár, László and Klekner, Almos and Klekner, Almos and Saad, Ali G and Saad, Ali G and Liau, Linda M and Liau, Linda M and Albrecht, Steffen and Albrecht, Steffen and Fontebasso, Adam and Fontebasso, Adam and Cinalli, Giuseppe and Cinalli, Giuseppe and De Antonellis, Pasqualino and De Antonellis, Pasqualino and Zollo, Massimo and Zollo, Massimo and Cooper, Michael K and Cooper, Michael K and Thompson, Reid C and Thompson, Reid C and Bailey, Simon and Bailey, Simon and Lindsey, Janet C and Lindsey, Janet C and Di Rocco, Concezio and Di Rocco, Concezio and Massimi, Luca and Massimi, Luca and Michiels, Erna M. C and Michiels, Erna M C and Scherer, Stephen W and Scherer, Stephen W and Phillips, Joanna J and Phillips, Joanna J and Gupta, Nalin and Gupta, Nalin and Fan, Xing and Fan, Xing and Muraszko, Karin M and Muraszko, Karin M and ...
Journal of Clinical Oncology, ISSN 0732-183X, 2014, Volume 32, Issue 9, pp. 886 - 896
Journal Article
Journal Article
by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer | Index Medicus
Journal Article
by Northcott, Paul A and Buchhalter, Ivo and Morrissy, A. Sorana and Hovestadt, Volker and Weischenfeldt, Joachim and Ehrenberger, Tobias and Gröbner, Susanne and Segura-Wang, Maia and Zichner, Thomas and Rudneva, Vasilisa A and Warnatz, Hans-Jörg and Sidiropoulos, Nikos and Phillips, Aaron H and Schumacher, Steven and Kleinheinz, Kortine and Waszak, Sebastian M and Erkek, Serap and Jones, David T. W and Worst, Barbara C and Kool, Marcel and Zapatka, Marc and Jäger, Natalie and Chavez, Lukas and Hutter, Barbara and Bieg, Matthias and Paramasivam, Nagarajan and Heinold, Michael and Gu, Zuguang and Ishaque, Naveed and Jäger-Schmidt, Christina and Imbusch, Charles D and Jugold, Alke and Hübschmann, Daniel and Risch, Thomas and Amstislavskiy, Vyacheslav and Gonzalez, Francisco German Roiguez and Weber, Ursula D and Wolf, Stephan and Robinson, Giles W and Zhou, Xin and Wu, Gang and Finkelstein, David and Liu, Yanling and Cavalli, Florence M. G and Luu, Betty and Ramaswamy, Vijay and Wu, Xiaochong and Koster, Jan and Ryzhova, Marina and Cho, Yoon-Jae and Pomeroy, Scott L and Herold-Mende, Christel and Schuhmann, Martin and Ebinger, Martin and Liau, Linda M and Mora, Jaume and McLendon, Roger E and Jabado, Nada and Kumabe, Toshihiro and Chuah, Eric and Ma, Yussanne and Moore, Richard A and Mungall, Anew J and Mungall, Karen L and Thiessen, Nina and Tse, Kane and Wong, Tina and Jones, Steven J. M and Witt, Olaf and Milde, Till and von Deimling, Aneas and Capper, David and Korshunov, Aney and Yaspo, Marie-Laure and Kriwacki, Richard and Gajjar, Amar and Zhang, Jinghui and Beroukhim, Rameen and Fraenkel, Ernest and Korbel, Jan O and Brors, Benedikt and Schlesner, Matthias and Eils, Roland and Marra, Marco A and Pfister, Stefan M and Taylor, Michael D and Lichter, Peter
Nature, ISSN 0028-0836, 2017, Volume 547, Issue 7663, pp. 311 - 317
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2014, Volume 20, Issue 4, pp. 912 - 925
Journal Article
by Morrissy, A. Sorana and Garzia, Livia and Shih, David J. H and Zuyderduyn, Scott and Huang, Xi and Skowron, Patryk and Remke, Marc and Cavalli, Florence M. G and Ramaswamy, Vijay and Lindsay, Patricia E and Jelveh, Salomeh and Donovan, Laura K and Wang, Xin and Luu, Betty and Zayne, Kory and Li, Yisu and Mayoh, Chelsea and Thiessen, Nina and Mercier, Eloi and Mungall, Karen L and Ma, Yusanne and Tse, Kane and Zeng, Thomas and Shumansky, Karey and Roth, Andrew J. L and Shah, Sohrab and Farooq, Hamza and Kijima, Noriyuki and Holgado, Borja L and Lee, John J. Y and Matan-Lithwick, Stuart and Liu, Jessica and Mack, Stephen C and Manno, Alex and Michealraj, K.A and Nor, Carolina and Peacock, John and Qin, Lei and Reimand, Juri and Rolider, Adi and Thompson, Yuan Y and Wu, Xiaochong and Pugh, Trevor and Ally, Adrian and Bilenky, Mikhail and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Young and Chuah, Eric and Corbett, Richard D and Dhalla, Noreen and He, An and Lee, Darlene and Li, Haiyan I and Long, William and Mayo, Michael and Plettner, Patrick and Qian, Jenny Q and Schein, Jacqueline E and Tam, Angela and Wong, Tina and Birol, Inanc and Zhao, Yongjun and Faria, Claudia C and Pimentel, José and Nunes, Sofia and Shalaby, Tarek and Grotzer, Michael and Pollack, Ian F and Hamilton, Ronald L and Li, Xiao-Nan and Bendel, Anne E and Fults, Daniel W and Walter, Andrew W and Kumabe, Toshihiro and Tominaga, Teiji and Collins, V. Peter and Cho, Yoon-Jae and Hoffman, Caitlin and Lyden, David and Wisoff, Jeffrey H and Garvin, James H and Stearns, Duncan S and Massimi, Luca and Schüller, Ulrich and Sterba, Jaroslav and Zitterbart, Karel and Puget, Stephanie and Ayrault, Olivier and Dunn, Sandra E and Tirapelli, Daniela P. C and Carlotti, Carlos G and Wheeler, Helen and Hallahan, Andrew R and Ingram, Wendy and MacDonald, Tobey J and Olson, Jeffrey J and Van Meir, Erwin G and Lee, Ji-Yeoun and Wang, Kyu-Chang and ...
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 351 - 357
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related... 
HETEROGENEITY | CANCER EVOLUTION | CELLS | IMPACT | MULTIDISCIPLINARY SCIENCES | SUBGROUP MEDULLOBLASTOMA | DYNAMICS | MUTATIONS | SEQUENCING DATA | LYMPHOBLASTIC-LEUKEMIA | GENOME | Clone Cells - drug effects | Humans | Male | Medulloblastoma - therapy | Radiotherapy, Image-Guided | Selection, Genetic - drug effects | Drosophila melanogaster - genetics | Neoplasm Recurrence, Local - pathology | Medulloblastoma - radiotherapy | DNA Mutational Analysis | Medulloblastoma - pathology | Female | Medulloblastoma - surgery | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Molecular Targeted Therapy - methods | Disease Models, Animal | Signal Transduction | Neoplasm Recurrence, Local - therapy | Drosophila melanogaster - cytology | Cerebellar Neoplasms - genetics | Clone Cells - metabolism | Genome, Human - genetics | Xenograft Model Antitumor Assays | Animals | Clone Cells - pathology | Craniospinal Irradiation | Neoplasm Recurrence, Local - genetics | Mice | Cerebellar Neoplasms - therapy | Cerebellar Neoplasms - surgery | Cerebellar Neoplasms - radiotherapy | Clonal selection theory | Care and treatment | Medulloblastoma | Oncology, Experimental | Genetic aspects | Research | Cancer | Genes | Cloning | Clinical trials | Cytotoxicity | Genomes | Radiation therapy | Metastasis | Cancer therapies | Rodents | Medical prognosis | Mutation | Tumors | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 508 - 522
The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant... 
LUNG-CANCER | ANGIOGENESIS | ONCOLOGY | PATHWAY | IN-VIVO | VINCRISTINE | TUMOR | CNS | CENTRAL-NERVOUS-SYSTEM | SUBGROUPS | CHEMOTHERAPY | CELL BIOLOGY | Humans | Neoplasm Proteins - physiology | Cerebellar Neoplasms - blood supply | Culture Media, Conditioned - pharmacology | Genetic Vectors - therapeutic use | Medulloblastoma - secretion | Recombinant Fusion Proteins - metabolism | Endothelium, Vascular - ultrastructure | Cerebellar Neoplasms - secretion | Wnt Proteins - genetics | Membrane Proteins - physiology | Pericytes - pathology | Glucose Transporter Type 1 - physiology | Antineoplastic Agents - pharmacokinetics | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Vincristine - pharmacokinetics | Disease Models, Animal | Carrier Proteins - physiology | Cerebellar Neoplasms - drug therapy | Transduction, Genetic | Genetic Association Studies | Genotype | Mice, Transgenic | Cerebellar Neoplasms - genetics | Tight Junctions - ultrastructure | Animals | Wnt Signaling Pathway - drug effects | Endothelium, Vascular - metabolism | Paracrine Communication - drug effects | Vincristine - therapeutic use | Medulloblastoma - blood supply | Mice | Wnt Proteins - physiology | Medulloblastoma - drug therapy | Drug Resistance, Neoplasm - physiology | Medulloblastoma - classification | Blood-Brain Barrier | Chemotherapy | Medulloblastoma | Brain tumors | Genetic aspects | Permeability | Cells | Cancer | Neurophysiology | Endothelium | Index Medicus
Journal Article
by Northcott, Paul A and Lee, Catherine and Zichner, Thomas and Stütz, Aian M and Erkek, Serap and Kawauchi, Daisuke and Shih, David J. H and Hovestadt, Volker and Zapatka, Marc and Sturm, Dominik and Jones, David T. W and Kool, Marcel and Remke, Marc and Cavalli, Florence M. G and Zuyderduyn, Scott and Bader, Gary D and VandenBerg, Scott and Esparza, Lourdes Aiana and Ryzhova, Marina and Wang, Wei and Wittmann, Anea and Stark, Sebastian and Sieber, Laura and Seker-Cin, Huriye and Linke, Linda and Kratochwil, Fabian and Jäger, Natalie and Buchhalter, Ivo and Imbusch, Charles D and Zipprich, Gideon and Raeder, Benjamin and Schmidt, Sabine and Diessl, Nicolle and Wolf, Stephan and Wiemann, Stefan and Brors, Benedikt and Lawerenz, Chris and Eils, Jürgen and Warnatz, Hans-Jörg and Risch, Thomas and Yaspo, Marie-Laure and Weber, Ursula D and Bartholomae, Cynthia C and von Kalle, Christof and Turányi, Eszter and Hauser, Peter and Sanden, Emma and Darabi, Anna and Siesjö, Peter and Sterba, Jaroslav and Zitterbart, Karel and Sumerauer, David and van Sluis, Peter and Versteeg, Rogier and Volckmann, Richard and Koster, Jan and Schuhmann, Martin U and Ebinger, Martin and Grimes, H. Leighton and Robinson, Giles W and Gajjar, Amar and Mynarek, Martin and von Hoff, Katja and Rutkowski, Stefan and Pietsch, Torsten and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Eils, Roland and Gilbertson, Richard J and Korshunov, Aney and Taylor, Michael D and Lichter, Peter and Korbel, Jan O and Wechsler-Reya, Robert J and Pfister, Stefan M and Neurosurgery and Neurokirurgi and Lund University and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Lunds universitet
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 428 - 434
Journal Article