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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2018, Volume 366, Issue 1, pp. 136 - 144
Tachykinin neurokinin 2 (NK2) receptor agonists may have potential to alleviate clinical conditions associated with bladder and gastrointestinal underactivity... 
ANTAGONIST | TACHYKININS | PHARMACOLOGY & PHARMACY | COLON | MECHANISMS | BLADDER | SUBSTANCE-P | NEUROKININ-A
Journal Article
Immunological Reviews, ISSN 0105-2896, 03/2018, Volume 282, Issue 1, pp. 87 - 113
Mast cells (MCs) are innate immune cells that are scattered in tissues throughout the organism being particularly abundant at sites exposed to the environment... 
CD63 | glucocorticoid receptor | CD151 | CD81 | neuropeptides | retinoic acid‐inducible gene‐I‐like receptors | alarmins | aryl hydrocarbon receptor | endothelin receptors | integrins | Fc receptor | PPAR | CD37 | vitamin D receptor | complement | nucleotide oligomerization domain‐like receptors | substance P | CD53 | IL‐1 | neurotensin | mast cell | free light chain | Toll‐like receptor | IL‐33 | sphingosine‐1 phosphate | CD9 | GPCR | CD48 | MAS‐related GPCR | ATP | pattern recognition receptor | nucleotide oligomerization domain-like receptors | MAS-related GPCR | Toll-like receptor | sphingosine-1 phosphate | IL-1 | IL-33 | retinoic acid-inducible gene-I-like receptors | IMMUNOLOGY | ARYL-HYDROCARBON RECEPTOR | TOLL-LIKE RECEPTORS | SUBSTANCE-P | FC-EPSILON-RI | DIFFERENTIAL EXPRESSION | CONTROLS ALLERGIC SENSITIZATION | HISTAMINE-RELEASE | FREE LIGHT-CHAINS | I-LIKE RECEPTORS | VASOACTIVE INTESTINAL POLYPEPTIDE | Receptors, Pattern Recognition - metabolism | Animals | Cytokines - metabolism | Humans | Immunoglobulin E - metabolism | Receptors, Fc - metabolism | Cellular Microenvironment | Mast Cells - physiology | Immunity, Innate | Receptors, Cytoplasmic and Nuclear - metabolism | Fc receptors | Vitamin D | Sphingosine | Immunoglobulin E | Calcifediol | Neuropeptides | Alfacalcidol | Integrins | Immunoglobulins | Cytokines | Mucosa | Effector cells | Inflammatory response | Activation | Inflammation | Hormones | Pattern recognition | Tissues | Nuclear receptors | Allergies | Receptors | Cell activation | Skin | Toxins | Mast cells | Chemokines | Immune system | Life Sciences | Immunology
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2003, Volume 24, Issue 11, pp. 580 - 588
The health burden of stress-related diseases, including depression and anxiety disorders, is rapidly increasing, whereas the range of available... 
CORTICOTROPIN-RELEASING HORMONE | ARGININE-VASOPRESSIN | ANTAGONIST R121919 | Y NPY | IN-VIVO | PHARMACOLOGY & PHARMACY | P NK1 RECEPTOR | ALCOHOL-CONSUMPTION | DORSAL RAPHE NUCLEUS | SUBSTANCE-P | ANXIOLYTIC-LIKE ACTION | Receptors, Galanin - agonists | Receptors, Corticotropin-Releasing Hormone - metabolism | Humans | Receptors, Vasopressin - metabolism | Receptors, Corticotropin-Releasing Hormone - agonists | Receptors, Neuropeptide Y - metabolism | Depressive Disorder - drug therapy | Receptors, Neuropeptide - metabolism | Receptors, Neurokinin-1 - agonists | Receptors, Neuropeptide - agonists | Receptors, Neurokinin-1 - metabolism | Receptors, Neuropeptide Y - antagonists & inhibitors | Anxiety Disorders - metabolism | Anxiety Disorders - drug therapy | Receptors, Neuropeptide Y - agonists | Receptors, Galanin - antagonists & inhibitors | Neurokinin-1 Receptor Antagonists | Receptors, Vasopressin - agonists | Receptors, Neuropeptide - antagonists & inhibitors | Clinical Trials as Topic | Depressive Disorder - metabolism | Animals | Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors | Receptors, Galanin - metabolism | Antidiuretic Hormone Receptor Antagonists | Neuropeptide Y | Care and treatment | Pharmacology, Experimental | Depression, Mental | Clinical trials | Vasopressin | Prevention | Antidepressants | Analysis | Tachykinins | Physiological aspects | Causes of | Anxiety | Health aspects | drug development
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2007, Volume 30, Issue 10, pp. 527 - 535
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 12/2011, Volume 17, Issue 6, pp. 742 - 749
SUMMARY Targets for antipruritic therapies are now expanding from the skin to the central nervous system. Recent studies demonstrate that various neuronal... 
Histamine | Itch | Spinal cord | Neurokinin‐1 receptor | Gastrin‐releasing peptide | Opioid | Skin | Pruritus | Neurokinin-1 receptor | Gastrin-releasing peptide | DORSAL-HORN NEURONS | PROTEINASE-ACTIVATED RECEPTOR-2 | GENE-RELATED PEPTIDE | KAPPA-OPIOID RECEPTORS | VASOACTIVE-INTESTINAL-PEPTIDE | INTRATHECAL MORPHINE | HISTAMINE H-1 RECEPTORS | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | MORPHINE-INDUCED ITCH | INDUCED SCRATCHING BEHAVIOR | SUBSTANCE-P RECEPTOR | Receptors, Histamine - physiology | Receptors, Serotonin - physiology | Gastrin-Secreting Cells - physiology | Receptors, Bradykinin - physiology | Humans | Receptors, Serotonin - drug effects | Receptors, Histamine - drug effects | Receptors, Bradykinin - drug effects | Receptors, Neurokinin-1 - physiology | Receptors, Glutamate - drug effects | Pruritus - physiopathology | Receptors, Opioid - physiology | Receptors, Neurokinin-1 - drug effects | Animals | Pruritus - drug therapy | Spinal Cord - physiology | Drug Design | Neurotransmitter Agents - physiology | Receptors, Opioid - drug effects | Receptors, Glutamate - physiology | Gastrin-Secreting Cells - drug effects | Antihistamines | Methyl aspartate | Gabapentin | Dermatology | Sulfonamides | Bradykinin | Formulae, receipts, prescriptions | Gastrin | Dermatologic agents | Glutamate | Drugs | pruritus | Opioid receptors | Glutamic acid receptors (ionotropic) | Substance P | Central nervous system | Opioid receptors (type mu) | N-Methyl-D-aspartic acid receptors | Antagonists | Glutamic acid receptors | Drug development | Side effects | gabapentin | Neurotransmission | Dorsal horn
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 2, pp. 447 - 453.e3
Abstract Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing... 
Allergy and Immunology | knockout mice | receptor antagonist | Substance P | calcium imaging | Mas-related G protein–coupled receptors | dorsal root ganglion neurons | PRURITUS | MOUSE | APREPITANT | Mas-related G protein-coupled receptors | IMMUNOLOGY | MRG RECEPTORS | FAMILY | PAIN | ALLERGY | GPCRS |