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Trends in Biochemical Sciences, ISSN 0968-0004, 02/2015, Volume 40, Issue 2, pp. 72 - 78
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3391 - 3397
► CypM can methylate both α-N-terminal amino groups and lysine ε-amino groups. ► CypM methylates a variety of cyclic peptides such as nisin and haloduracin. ►... 
Catalytic promiscuity | Evolution | Lantibiotic | Peptide antibiotic | α-N-Methyltransferase | solid phase peptide synthesis | SPPS | Methyltransferase | MCMC | S-adenosylhomocysteine | S-adenosylmethionine | dehydrobutyrine | NRMT | Abu | Markov chain Monte Carlo | DMF | N-terminal RCC1 methyltransferase | MALDI | dimethylformamide | methyl morpholine | Avi-Cys | dehydroalanine | NMM | 2-aminobutyric acid | S- | 2-aminovinyl]-cysteine | SAH | Dha | matrix assisted laser desorption ionization | SAM | Dhb | NATURAL-PRODUCT | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BAYESIAN PHYLOGENETIC INFERENCE | RIBOSOMAL-PROTEIN L11 | IDENTIFICATION | CELL BIOLOGY | PLANTAZOLICIN | PEPTIDES | PRMA | BIOPHYSICS | BIOSYNTHESIS | BACILLUS-AMYLOLIQUEFACIENS FZB42 | alpha-N-Methyltransferase | Amino Acid Sequence | Peptides - chemistry | Bacteriocins - chemistry | Protein Methyltransferases - genetics | Bacterial Proteins - genetics | Substrate Specificity | Oligopeptides - metabolism | Phylogeny | Protein Methyltransferases - metabolism | Anti-Bacterial Agents - chemistry | Bacterial Proteins - metabolism | Anti-Bacterial Agents - biosynthesis | Protein Processing, Post-Translational | Methylation | Bacteriocins - biosynthesis | Oligopeptides - chemistry | Evolution, Molecular | Index Medicus | lantibiotic | α-N-methyltransferase | evolution | peptide antibiotic | catalytic promiscuity
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 2013, Volume 135, Issue 8, pp. 2899 - 2902
We report a sequence reconstruction analysis targeting several Precambrian nodes in the evolution of class-A beta-lactamases and the preparation and... 
EVOLUTIONARY | ENZYME | STABILITY | GENES | ANTIBIOTIC-RESISTANCE | ANCIENT | PROTEINS | SELECTION | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES | LIFE | Models, Molecular | Substrate Specificity | beta-Lactamases - chemistry | beta-Lactamases - metabolism | Enzyme Stability | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 22, pp. 10218 - 10227
Aminoglycoside antibiotics are a large family of antibiotics that can be divided into two distinct classes on the basis of the substitution pattern of the... 
PROTEIN DYNAMICS | CHEMISTRY, MEDICINAL | ENZYME | KANAMYCIN | RESISTANCE | MECHANISMS | INHIBITOR | N-ACETYLTRANSFERASE | BINDING | SOLVENT | SUBSTRATE PROMISCUITY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2006, Volume 103, Issue 37, pp. 13682 - 13687
Journal Article
Journal Article
Journal Article