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Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 900 - 907
The 70-kilodalton (kDa) heat-shock proteins (Hsp70s) are ubiquitous molecular chaperones essential for cellular protein folding and proteostasis. Each Hsp70... 
INTERDOMAIN COMMUNICATION | WILD-TYPE | PEPTIDE-BINDING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SHOCK COGNATE PROTEIN | MOLECULAR CHAPERONE DNAK | SUBSTRATE-BINDING | CONFORMATIONAL-CHANGES | BIOPHYSICS | STRUCTURE VALIDATION | STRUCTURAL BASIS | Allosteric Regulation | Molecular Sequence Data | Crystallography, X-Ray | Mutation, Missense | Recombinant Fusion Proteins - metabolism | Peptides - metabolism | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Conserved Sequence | HSP70 Heat-Shock Proteins - chemistry | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Models, Molecular | Escherichia coli Proteins - metabolism | HSP70 Heat-Shock Proteins - genetics | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | HSP70 Heat-Shock Proteins - metabolism | Protein Interaction Mapping | Sequence Homology, Amino Acid | Sequence Alignment | Hydrogen Bonding | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Conformation | Adenosine Triphosphatases - genetics | Escherichia coli Proteins - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Heat shock proteins | Physiological aspects | Homeostasis | Research | Structure | ABC transporters | Biochemistry | Polypeptides | Molecular biology
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 19, pp. 8838 - 8846
Inositol pentakisphosphate 2-kinase catalyzes the phosphorylation of the axial 2-OH of myo-inositol 1,3,4,5,6-pentakisphosphate for de novo synthesis of... 
PHOSPHATE | DIPHOSPHOINOSITOL PENTAKISPHOSPHATE | ACTIVATION | CHEMISTRY, MEDICINAL | SUBSTRATE-BINDING | HEXAKISPHOSPHATE | 1,3,4,5,6-PENTAKISPHOSPHATE 2-KINASE | KINASE | MESSENGER-RNA EXPORT | ARABIDOPSIS | POLYPHOSPHATES
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2018, Volume 62, Issue 11
Journal Article
Chemical Science, ISSN 2041-6520, 02/2015, Volume 6, Issue 2, pp. 956 - 963
Metallo-beta-lactamases (MBLs) catalyse the hydrolysis of almost all beta-lactam antibiotics. We report biophysical and kinetic studies on the Sao Paulo MBL... 
CONFORMATIONAL-CHANGES | SUBSTRATE-BINDING | SPM-1 | METALLO-BETA-LACTAMASE | PSEUDOMONAS-AERUGINOSA | CRYSTAL-STRUCTURE | CHEMICAL-EXCHANGE | BACILLUS-CEREUS | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | ZINC
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 06/2018, Volume 200, Issue 12
ATP-binding cassette (ABC) transport systems comprise two transmembrane domains/subunits that form a translocation path and two nucleotide-binding... 
ATP-binding cassette transporters | Geobacillus stearothermophilus | Mutational analysis | Transmembrane substrate binding sites | Type I ABC importer
Journal Article
Journal of Molecular Catalysis. A, Chemical, ISSN 1381-1169, 07/2015, Volume 403, pp. 43 - 51
[Display omitted] •Two trinuclear copper complexes were examined for phosphate hydrolysis.•Phosphate was found to bind tightly at the tricopper site.•Phosphate... 
Phosphate hydrolysis | Inhibition | X-ray structure | Trinuclear copper complex | Substrate binding | SYNTHETIC METALLONUCLEASES | PENICILLIUM-CITRINUM | CRYSTAL-STRUCTURE | ALKALINE-PHOSPHATASE | CHEMISTRY, PHYSICAL | ZINC(II) COMPLEXES | INORGANIC PYROPHOSPHATASE | P1 NUCLEASE | 3 METAL-IONS | ESTER HYDROLYSIS | Phosphates | Hydrolysis | Analysis
Journal Article