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CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 2016, Volume 52, Issue 54, pp. 8361 - 8364
[F-18]FMTEB, [F-18]FPEB, [F-18]flumazenil, [F-18]DAA1106, [F-18]MFBG, [F-18]FDOPA, [F-18]FMT and [F-18]FDA are prepared from the corresponding arylboronic... 
MONKEY | POSITRON-EMISSION-TOMOGRAPHY | RADIOFLUORINATION | ARENES | BUTYROPHENONE NEUROLEPTICS | VALIDATION | FLUORINATION | METABOTROPIC-GLUTAMATE-RECEPTOR-SUBTYPE-5 | CHEMISTRY, MULTIDISCIPLINARY | F-18 | FLUORIDE
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 03/2015, Volume 56, Issue 3, pp. 489 - 492
Translation of new methodologies for labeling nonactivated aromatic molecules with F-18 remains a challenge. Here, we report a one-step, regioselective,... 
F-18-FPEB | mGlu | TRACER | RADIOSYNTHESIS | iodonium ylide | fluorination | METABOTROPIC-GLUTAMATE-RECEPTOR-SUBTYPE-5 | SALTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | F-18
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 09/2018, Volume 140, Issue 35, pp. 11125 - 11132
Herein, we report a novel intramolecular ring-closing reaction of biaryl thioethers that give access to highly functionalized dibenzothiophene sulfonium salts... 
REARRANGEMENT | POSITRON-EMISSION-TOMOGRAPHY | RADIOFLUORINATION | MEDIATED F-18-FLUORINATION | ARENES | FLUORINATION | METABOTROPIC-GLUTAMATE-RECEPTOR-SUBTYPE-5 | RADIOTRACERS | CHEMISTRY, MULTIDISCIPLINARY | PET | F-18
Journal Article
ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, 10/2010, Volume 1, Issue 10, pp. 702 - 716
We previously discovered a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu(5)) termed 4... 
SITE | allosteric | ANTAGONIST | 2-METHYL-6-(PHENYLETHYNYL)-PYRIDINE | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPPHA | METABOTROPIC GLUTAMATE RECEPTORS | metabotropic | NEUROSCIENCES | mGlu | SUBTYPE-5 | POTENTIATORS | potentiator | glutamate | GLUTAMATE-RECEPTOR-SUBTYPE-5 | ACTS
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 12/2008, Volume 327, Issue 3, pp. 941 - 953
Previous clinical and animal studies suggest that selective activators of M-1 and/or M-4 muscarinic acetylcholine receptors (mAChRs) have potential as novel... 
SUBTYPE-5 | MODULATORS | IN-VIVO | HYPOTHESIS | STRIATAL CHOLINERGIC INTERNEURONS | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | METABOTROPIC GLUTAMATE RECEPTORS | AGONIST XANOMELINE | KNOCKOUT MICE | ANTIPSYCHOTIC-LIKE
Journal Article
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 11/2013, Volume 54, Issue 11, pp. 1954 - 1961
Abnormal glutamate transmission is involved in various neurologic disorders, such as epilepsy, schizophrenia, and Parkinson disease. At present, no imaging... 
BETA-PROBE | NMDA RECEPTORS | VALIDATION | MICROPROBE | SCANNER | binding potential | small-animal PET | POSITRON-EMISSION-TOMOGRAPHY | SUBTYPE-5 | SYSTEMS | beta-microprobes | mGluR5 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | glutamate | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 12/2015, Volume 56, Issue 12, pp. 1954 - 1959
The metabotropic glutamate receptor 5 (mGluR5) is a high-interest target for PET imaging because it plays a role in several pathologies, including addiction,... 
F-18-FPEB | rat | C-11-ABP688 | kinetic modeling | POSITRON-EMISSION-TOMOGRAPHY | SUBTYPE-5 | metabotropic glutamate receptor 5 | IN-VIVO | MGLUR5 | RAT-BRAIN | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 04/2010, Volume 37, Issue 4, pp. 722 - 727
To retrospectively evaluate the sensitivity, specificity and accuracy of Ga-68-DOTA-NOC PET/CT and CT alone for the evaluation of bone metastasis in patients... 
Ga-68-DOTA-NOC | SURVIVAL | CT | Neuroendocrine tumours | Bone lesions | GA-68-DOTA-TYR-OCTREOTIDE PET | SUBTYPE-5 | HIGH-AFFINITY | RADIOMETALS | SOMATOSTATIN RECEPTOR SCINTIGRAPHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
Heterocycles, ISSN 0385-5414, 2017, Volume 95, Issue 2, pp. 807 - 815
A commercial microfluidic reactor system has been used to synthesize the mGLUR5 receptor imaging agent [F-18]FPEB. To study the effect of leaving group... 
IN-VITRO | Fluourine-18 | FPEB | Radiochemistry | MGLUR5 | CHEMISTRY, ORGANIC | METABOTROPIC-GLUTAMATE-RECEPTOR-SUBTYPE-5 | RADIOTRACERS | PET
Journal Article
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, ISSN 0269-2813, 06/2018, Volume 47, Issue 12, pp. 1661 - 1672
Background: Dumping syndrome is a prevalent complication of oesophageal and gastric surgery characterised by early (postprandial tachycardia) and late... 
GASTRIC BYPASS | SOMATOSTATIN RECEPTOR SUBTYPE-5 | HYPERGLYCEMIA | RAT INTESTINAL CULTURES | HYPOGLYCEMIA | BARIATRIC SURGERY | CUSHINGS-DISEASE | PHARMACOLOGY & PHARMACY | GASTROENTEROLOGY & HEPATOLOGY | OCTREOTIDE ACETATE | GLUCOSE-TOLERANCE | SMS 201-995 | Life Sciences
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 2014, Volume 57, Issue 8, pp. 509 - 516
Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated... 
VITRO | CHEMISTRY, ANALYTICAL | CHEMISTRY, MEDICINAL | RAT | P2X7 | BIOCHEMICAL RESEARCH METHODS | radiolabelling | P2X receptor | IDENTIFICATION | NEUROPATHIC PAIN | SUBTYPE-5 | LIGANDS | neuroinflammation | RADIOSYNTHESIS | PHARMACOLOGY | IN-VIVO | carbon-11 | positron emission tomography | A-740003
Journal Article
Journal Article
Chemical Science, ISSN 2041-6520, 01/2012, Volume 3, Issue 1, pp. 131 - 135
The design, synthesis and evaluation of eight contrast agents for metabotropic glutamate receptors is reported. Each of the contrast agents contains a... 
POTENT | SUBTYPE-5 | MONKEY BRAIN | MGLU5 RECEPTOR | AGENTS | ANTAGONISTS | RELAXIVITY | ASTROCYTES | CHEMISTRY, MULTIDISCIPLINARY | GADOLINIUM COMPLEXES | AMIDES
Journal Article
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1824-4785, 03/2016, Volume 60, Issue 1, pp. 69 - 76
BACKGROUND: Localization of primary tumor in insulinoma is often difficult. We evaluated the role of Ga-68-DOTA-Nal(3)-Octreotide (DOTANOC) PET/CT for... 
Positron-emission tomography | NEUROENDOCRINE TUMORS | GLP-1 | Insulinoma | SCINTIGRAPHY | GASTRINOMAS | Ga-68-DOTANOC | Tomography, X-ray computed | SPECT | SUBTYPE-5 | EXENDIN-4 | ENDOSCOPIC ULTRASONOGRAPHY | Pancreas | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
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