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Nature (London), ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by... 
E3 LIGASE | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | CONJUGATING ENZYME | CHAIN ELONGATION | REVEALS | SUBUNIT | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression
Journal Article
The Plant journal : for cell and molecular biology, ISSN 0960-7412, 2015, Volume 81, Issue 3, pp. 388 - 398
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
[Display omitted] Gαq inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their... 
UBO-QIC | Gαq inhibitor | GPCR | FR900359 | Gβγ subunits | G protein | inhibitor | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptor, Muscarinic M2 - agonists | Receptor, Muscarinic M2 - genetics | Cricetulus | Humans | GTP-Binding Protein beta Subunits - antagonists & inhibitors | GTP-Binding Protein gamma Subunits - antagonists & inhibitors | Depsipeptides - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | GTP-Binding Protein gamma Subunits - agonists | HEK293 Cells | Platelet Aggregation Inhibitors - pharmacology | Receptor, Muscarinic M2 - antagonists & inhibitors | GTP-Binding Protein beta Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Adenosine A1 - genetics | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Receptor, Muscarinic M2 - metabolism | Enzyme Inhibitors - pharmacology | GTP-Binding Protein beta Subunits - agonists | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A1 - metabolism | Animals | MAP Kinase Signaling System - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Proto-Oncogene Proteins c-akt - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Gβγsubunits
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2009, Volume 147, Issue S1, pp. S46 - S55
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2019, Volume 116, Issue 33, pp. 16347 - 16356
Protein kinase A (PKA) holoenzyme, comprised of a cAMP-binding regulatory (R)-subunit dimer and 2 catalytic (C)-subunits, is the master switch for... 
CATALYTIC SUBUNIT | isoform-specific quaternary structure | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | cAMP | STRUCTURE REVEALS | TARGETED DISRUPTION | I-ALPHA | allosteric and orthosteric regulation | SITE MUTATIONS DEFINE | structural biology | A REGULATORY SUBUNIT | protein kinase A | BETA-SUBUNIT | BINDING | Allosteric Regulation - genetics | Protein Binding - genetics | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Adenosine Triphosphate - genetics | Crystallography, X-Ray | Holoenzymes - chemistry | Signal Transduction - genetics | Amino Acid Sequence - genetics | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - genetics | Cyclic AMP - chemistry | Cyclic AMP-Dependent Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - chemistry | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Gene Expression Regulation, Enzymologic - genetics | Protein Structure, Quaternary | Cyclic AMP - genetics | Holoenzymes - genetics | Protein Subunits - chemistry | Adenosine Triphosphate - chemistry | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - chemistry | Protein Subunits - genetics | Protein kinase A | Crosstalk | Cyclic AMP | Activation | Kinases | Substrates | Interfaces | Allosteric properties | Isoforms | Dimers | Catalysis | Magnesium | ATP | Biological Sciences | PNAS Plus
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 1996 - 15
Journal Article
Nucleic acids research, ISSN 1362-4962, 2018, Volume 46, Issue 3, pp. 1541 - 1552
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2009, Volume 182, Issue 12, pp. 7389 - 7397
Journal Article
Nature immunology, ISSN 1529-2916, 2015, Volume 16, Issue 11, pp. 1124 - 1133
Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses to external pathogens. While ILCs can be phenotypically classified... 
IMMUNITY | ROR-GAMMA-T | ARYL-HYDROCARBON RECEPTOR | TRANSCRIPTION FACTOR GATA3 | IFN-GAMMA | DRIVES | NOTCH | NKP46(+) CELLS | DIFFERENTIATION | IMMUNOLOGY | TISSUE INDUCER CELLS | Core Binding Factor Alpha 3 Subunit - metabolism | Core Binding Factor beta Subunit - deficiency | Citrobacter rodentium - pathogenicity | Core Binding Factor beta Subunit - genetics | Lymphocyte Subsets - immunology | Enterobacteriaceae Infections - immunology | Intestinal Mucosa - cytology | Lymphocyte Subsets - metabolism | Lymphocyte Subsets - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Intestinal Mucosa - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Antigens, Ly - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Core Binding Factor beta Subunit - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Citrobacter rodentium - immunology | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Enterobacteriaceae Infections - etiology | Immunity, Innate | Mice, Knockout | Cell Differentiation - immunology | Animals | Core Binding Factor Alpha 3 Subunit - deficiency | Interleukin-7 Receptor alpha Subunit - metabolism | Core Binding Factor Alpha 3 Subunit - genetics | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Cell Lineage - immunology | Physiological aspects | Genetic aspects | Immune response | Research | B cells
Journal Article