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Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18980
Background: Age-related cataract is a worldwide health care problem whose progression has been linked to oxidative stress and the accumulation of redox-active... 
OSMOTIC CHANGES | OXIDATIVE STRESS | VITAMIN-E | RADIATION CATARACTS | CHAIN-BREAKING ANTIOXIDANTS | LIPID-PEROXIDATION | BUTYLATED HYDROXYTOLUENE | BIOLOGY | ALDOSE REDUCTASE INHIBITOR | AGE-RELATED CATARACT | LENS | Gamma Rays | Antioxidants - chemistry | Streptozocin | Humans | Rats, Long-Evans | Cataract - pathology | Body Weight - drug effects | Hyperglycemia - complications | Fluorenes - pharmacology | Diabetes Mellitus, Type 1 - complications | Lens Capsule, Crystalline - drug effects | Endoplasmic Reticulum - pathology | Endoplasmic Reticulum - drug effects | Hyperglycemia - pathology | Stress, Physiological - drug effects | Pigmentation - drug effects | Hydantoins - pharmacology | Administration, Oral | Heat-Shock Proteins - metabolism | Diabetes Mellitus, Type 1 - pathology | Rats | Rats, Sprague-Dawley | Disease Progression | Cataract - complications | Antioxidants - therapeutic use | Animals | Lens Capsule, Crystalline - pathology | Antioxidants - administration & dosage | Cataract - prevention & control | Sorbitol | Antioxidants | Gamma rays | Cytokinins | Cataract | Aldose reductase | Sulfonamides | Ophthalmology | Free radicals (Chemistry) | Sugars | Monosaccharides | Cataracts | Health care | Dimethyl | Oxidative stress | Animal models | Dehydrogenases | Hydrogen peroxide | Metals | Radiation | Irradiated | Iron | Phospholipids | Delay | Western blotting | Proteins | Hyperglycemia | Rodents | Sugar | Pharmaceutical sciences | Age | Animal care | Radiation effects | γ Radiation | Free radicals | Diabetes mellitus | Cortex | Xylose | Gamma radiation | Aldehyde reductase | Irradiation | Diabetes | Laboratory animals | Endoplasmic reticulum | Lenses | Reductase
Journal Article
Experimental Eye Research, ISSN 0014-4835, 08/2012, Volume 101, pp. 36 - 43
In sugar cataract formation in rats, aldose reductase (AR) activity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation... 
growth factors | P-42/44 MAPK | lens | iso-osmotic culture | bFGF | aldose reductase inhibitors | P-Akt | P-SAPK/JNK | in vitro lens culture | cell signaling | TGF-β | sorbitol dehydrogenase inhibitors | diabetes | cataracts | Cataracts | In vitro lens culture | Sorbitol dehydrogenase inhibitors | Cell signaling | Aldose reductase inhibitors | Iso-osmotic culture | Lens | Diabetes | BFGF | Growth factors | AQUEOUS-HUMOR | FACTOR RECEPTORS | CULTURED RAT LENSES | TGF-beta | GLUCOSE | OXIDATIVE STRESS | in vitro lens culture | LENS EPITHELIAL-CELLS | FIBER DIFFERENTIATION | DIABETIC-RATS | POLYOL PATHWAY | OPHTHALMOLOGY | BETA-INDUCED CATARACT | Osmotic Pressure | MAP Kinase Signaling System - physiology | Galactose - pharmacology | Glutathione - metabolism | Cataract - pathology | Stress, Physiological | Male | Sorbitol - metabolism | Fibroblast Growth Factor 2 - metabolism | Aldehyde Reductase - metabolism | Diabetes Mellitus, Experimental - metabolism | Organ Culture Techniques | Aldehyde Reductase - antagonists & inhibitors | Electrophoresis, Polyacrylamide Gel | Lens, Crystalline - metabolism | Rats | Glucose - pharmacology | Cataract - metabolism | Rats, Sprague-Dawley | Blotting, Western | Hyperglycemia - metabolism | Animals | Diabetes Mellitus, Experimental - pathology | Lens, Crystalline - drug effects | Transforming Growth Factor beta - metabolism | Sorbitol | Cataract | Aldose reductase | Glucose | Carbonates | Galactose | Transforming growth factors | Polyols | Fructose | Dextrose | Sugars | Monosaccharides | b-FGF | P-SAPK | JNK | 44 MAPK | P-42
Journal Article
Experimental Eye Research, ISSN 0014-4835, 2008, Volume 87, Issue 5, pp. 454 - 461
Diabetes is a major contributing factor in cataract development. In animal models where cataracts develop within days or weeks of diabetes it is well... 
sorbitol dehydrogenase | osmotic stress | cataract | diabetes | oxidative stress | vitamin E | SORBITOL DEHYDROGENASE-DEFICIENCY | LIPID-PEROXIDATION | LENS EPITHELIAL-CELLS | DIABETIC-RATS | POLYOL PATHWAY | VOLUME REGULATION | OPHTHALMOLOGY | RABBIT LENS | MOUSE LENS | SUGAR CATARACT | ALDOSE REDUCTASE | Aldehyde Reductase - genetics | Glutathione - metabolism | Antioxidants - metabolism | Oxidative Stress - physiology | Aldehyde Reductase - physiology | Sorbitol - metabolism | Osmosis - physiology | Vitamin E - therapeutic use | Diabetes Mellitus, Experimental - complications | Glutathione Peroxidase - deficiency | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Aldehyde Reductase - deficiency | Cataract - etiology | RNA, Messenger - genetics | Lens, Crystalline - metabolism | Cataract - metabolism | Disease Progression | Glutathione Peroxidase - genetics | Mice, Knockout | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Glutathione Peroxidase - physiology | L-Iditol 2-Dehydrogenase - deficiency | Cataract - prevention & control | Mice | Mutation | Cataract - physiopathology | Aging - metabolism | Sorbitol | Oxidative stress | Hyperglycemia | Aldose reductase | Blood sugar | Vitamin E | Analysis | Universities and colleges | Adenosine triphosphatase | Sugars | Glutathione | Monosaccharides
Journal Article
国际眼科杂志:英文版, ISSN 2222-3959, 2016, Volume 9, Issue 12, pp. 1719 - 1724
AIM: To determine the role of microRNA (miRNA)-29a and miRNA-29c in the regulation of apoptosis in early rat diabetic cataract formation.METHODS:... 
microRNA-29c | LENS EPITHELIAL-CELLS | diabetic cataract | OPHTHALMOLOGY | BCL2-modifying factor | apoptosis | microRNA-29a | SUGAR CATARACT
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0174542
Cataract, a leading cause of blindness, is of special concern in diabetics as it occurs at earlier onset. Polyol accumulation and increased... 
VITAMIN-E | LENS EPITHELIAL-CELLS | NITRIC-OXIDE SYNTHASE | PHENOLIC-COMPOUNDS | MULTIDISCIPLINARY SCIENCES | CATARACT FORMATION | LONG-TERM INCIDENCE | NF-KAPPA-B | ALDOSE REDUCTASE | ALPHA-CRYSTALLIN | K+-ATPASE ACTIVITY | Gene Expression - drug effects | Glutathione - metabolism | Body Weight - drug effects | Male | NF-kappa B - metabolism | Lens, Crystalline - pathology | Tocotrienols - pharmacology | Diabetes Mellitus, Experimental - blood | Time Factors | Adenosine Triphosphate - metabolism | Diabetes Mellitus, Experimental - complications | Superoxide Dismutase - metabolism | Tocotrienols - administration & dosage | Adenosine Triphosphatases - metabolism | Lens, Crystalline - metabolism | Calpain | Antioxidants - pharmacology | Rats, Sprague-Dawley | Catalase - metabolism | Cataract - complications | Pilot Projects | Animals | Nitric Oxide Synthase Type II - genetics | Nitrosation - drug effects | Antioxidants - administration & dosage | Cataract - prevention & control | Oxidative Stress - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Administration, Topical | Nitric Oxide Synthase Type II - metabolism | Oxidative stress | Cataract | Care and treatment | Research | Diabetes | Cataracts | Cytochrome | Brain | Estrogens | Body weight | Erythrocytes | Nervous system | Biochemistry | Glucose | Eye | Proteins | Toxicology | Alterations | Vitamin E | Aging | Eye (anatomy) | Membrane potential | Inhibition | Calcium homeostasis | Enzymes | Materials handling | Adenosine diphosphate | Gene expression | Studies | Diet | Nitric oxide | Aldehyde reductase | Mice | Bedding | Viability | Kidney transplantation | Lenses | Neutralization | Neuroimaging | Senescence | Carbofuran | Membranes | Calcium | Homeostasis | Infections | Activation | Visual perception | Ca2+-transporting ATPase | Mathematical models | Oxidation | Heart diseases | Crystal structure | Food | Calcium (intracellular) | Kidneys | Diabetes mellitus | Aging (artificial) | Ion transport | Cardiomyocytes | Pharmacology | Nitrogen | Medicine | Cell death | ATP | Calcium (reticular) | Apoptosis
Journal Article
Journal Article