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Cochrane library, ISSN 1465-1858, 2014, Volume 2016, Issue 9, p. CD005590
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2013, Volume 340, Issue 6135, pp. 987 - 991
The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood,... 
Pyridines | Symptomatology | Side effects | Hydrogen bonds | Sulfonamides | REPORTS | Atoms | Biosynthesis | Inhibitory concentration 50 | Dosage | Crystal structure | TRIMETHOPRIM | PHARMACOKINETICS | PSYCHOSIS | MULTIDISCIPLINARY SCIENCES | PNEUMOCYSTIS-JIROVECII PNEUMONIA | SULFASALAZINE | SULFONAMIDE | REDUCTASE DEFICIENCY | SULFAMETHOXAZOLE | DISCOVERY | REVEALS | Nausea - chemically induced | Levodopa - biosynthesis | Sulfamethoxazole - adverse effects | Anti-Infective Agents - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Biopterin - analogs & derivatives | NADP - chemistry | Alcohol Oxidoreductases - antagonists & inhibitors | Sulfamethoxazole - therapeutic use | Adult | Fibroblasts - metabolism | Cell Line | Anti-Infective Agents - adverse effects | Pneumonia, Pneumocystis - drug therapy | Anti-Infective Agents - therapeutic use | Biopterin - biosynthesis | 5-Hydroxytryptophan - biosynthesis | Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use | Vomiting - chemically induced | Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology | Sulfamethoxazole - pharmacology | Alcohol Oxidoreductases - chemistry | Fibroblasts - drug effects | Central Nervous System - drug effects | Protein Conformation | Physiological aspects | Amino acids | Dosage and administration | Research | Pharmacokinetics | Health aspects | Enzymes | Pneumonia | Pharmacology | Antibiotics | Drugs | Biotechnology | Neurotransmitters | Serotonin | Central nervous system
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2017, Volume 376, Issue 26, pp. 2545 - 2555
There are limited data on the role of antimicrobials in the treatment of skin abscesses. In this trial, clindamycin or trimethoprim–sulfamethoxazole was found... 
CLINICAL-PRACTICE GUIDELINES | SOFT-TISSUE INFECTIONS | MEDICINE, GENERAL & INTERNAL | AMERICA | MANAGEMENT | STAPHYLOCOCCUS-AUREUS INFECTIONS | ADULTS | RISK | DISEASES SOCIETY | TRIMETHOPRIM-SULFAMETHOXAZOLE | CHILDREN | Prospective Studies | Humans | Child, Preschool | Infant | Male | Skin Diseases, Bacterial - drug therapy | Anti-Bacterial Agents - therapeutic use | Clindamycin - adverse effects | Staphylococcal Skin Infections - drug therapy | Abscess - therapy | Adult | Female | Abscess - drug therapy | Anti-Bacterial Agents - adverse effects | Child | Double-Blind Method | Staphylococcus aureus - isolation & purification | Combined Modality Therapy | Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects | Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use | Clindamycin - therapeutic use | Drainage | Skin Diseases, Bacterial - therapy | Adolescent | Intention to Treat Analysis | Methicillin-Resistant Staphylococcus aureus - isolation & purification | Care and treatment | Usage | Clindamycin | Patient outcomes | Surgery | Abscess | Staphylococcus aureus infections | Causes of | Dosage and administration | Drug therapy | Complications | Hypersensitivity | Clinical trials | Trimethoprim | Staphylococcus infections | Antimicrobial agents | Wound drainage | Cellulitis | Drug resistance | Clinical outcomes | Methicillin | Studies | Trimethoprim-sulfamethoxazole | Sulfamethoxazole | Side effects | Motivation | Antibiotics | Abscesses | Skin | Children | Drug dosages
Journal Article
Expert review of anti-infective therapy, ISSN 1744-8336, 2014, Volume 6, Issue 5, pp. 593 - 600
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent... 
aminoglycoside | Acinetobacter baumannii | multiple-drug resistant | fusidic acid | polymyxin B | Pseudomonas aeruginosa | chloramphenicol | fosfomycin | colistin | Colistin | Aminoglycoside | Fusidic acid | Chloramphenicol | Polymyxin B | Fosfomycin | Multiple-drug resistant | VENTILATOR-ASSOCIATED PNEUMONIA | NATURAL-PRODUCTS | RESISTANT STAPHYLOCOCCUS-AUREUS | ANTIBACTERIAL DRUG DISCOVERY | GRAM-NEGATIVE BACTERIA | INTENSIVE-CARE-UNIT | PSEUDOMONAS-AERUGINOSA | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | CRITICALLY-ILL PATIENTS | TRIMETHOPRIM-SULFAMETHOXAZOLE | Fusidic Acid - administration & dosage | Humans | Drug Resistance, Bacterial | Drug Utilization | Anti-Bacterial Agents - therapeutic use | Aminoglycosides - administration & dosage | Colistin - therapeutic use | Anti-Bacterial Agents - adverse effects | Colistin - adverse effects | Fosfomycin - therapeutic use | Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage | Bacterial Infections - drug therapy | Fosfomycin - adverse effects | Colistin - administration & dosage | Fusidic Acid - adverse effects | Chloramphenicol - therapeutic use | Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects | Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use | Fusidic Acid - therapeutic use | Chloramphenicol - adverse effects | Anti-Bacterial Agents - classification | Fosfomycin - administration & dosage | Aminoglycosides - adverse effects | Anti-Bacterial Agents - administration & dosage | Aminoglycosides - therapeutic use | Chloramphenicol - administration & dosage | Drug resistance in microorganisms | Pseudomonas aeruginosa infections | Usage | Antibiotics | Research | Drug therapy | Health aspects | Risk factors | Index Medicus
Journal Article
Journal Article
Cochrane library, ISSN 1465-1858, 2012, Volume 2018, Issue 7, p. CD004386
Background Bacterial infections are a major cause of morbidity and mortality in patients who are neutropenic following chemotherapy for malignancy. Trials have... 
'ORPHAN' TOPICS CURRENTLY BEING ADDRESSED | Infections in neutropenic cancer patients | Supportive care: neutropenia | Drug Resistance, Bacterial | Antibiotic Prophylaxis | Bacteremia | Cause of Death | Fever | Neoplasms | Quinolones | Randomized Controlled Trials as Topic | Gram‐Negative Bacterial Infections | Trimethoprim, Sulfamethoxazole Drug Combination | Infections in neutropenic patients | Bacterial Infections | Anti‐Bacterial Agents | Child health | Gram‐Positive Bacterial Infections | Medicine General & Introductory Medical Sciences | General cancer treatments | Neutropenia | Cancer | RANDOMIZED CONTROLLED TRIAL | MEDICINE, GENERAL & INTERNAL | COLONY-STIMULATING FACTOR | SELECTIVE ANTIMICROBIAL MODULATION | GRAM-POSITIVE INFECTIONS | ACUTE NONLYMPHOCYTIC LEUKEMIA | BONE-MARROW-TRANSPLANTATION | ORAL TRIMETHOPRIM-SULFAMETHOXAZOLE | HIGH-DOSE CHEMOTHERAPY | PLACEBO-CONTROLLED TRIAL | BROAD-SPECTRUM ANTIBIOTICS | Humans | Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects | Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use | Antibiotic Prophylaxis - adverse effects | Neoplasms - drug therapy | Neutropenia - complications | Anti-Bacterial Agents - therapeutic use | Bacterial Infections - prevention & control | Bacteremia - prevention & control | Quinolones - adverse effects | Quinolones - therapeutic use | Gram-Negative Bacterial Infections - prevention & control | Fever - prevention & control | Anti-Bacterial Agents - adverse effects | Neutropenia - chemically induced | Gram-Positive Bacterial Infections - prevention & control | Bacterial Infections - mortality
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 335, Issue 6072, pp. 1110 - 1114
The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However,... 
Molecules | Enzymes | Antibacterials | Active sites | Pterins | REPORTS | Crystals | Diphosphates | Catalysis | Drug resistance | Crystal structure | MECHANISM | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SULFONAMIDE | STAPHYLOCOCCUS-AUREUS | INHIBITORS | FARNESYLPYROPHOSPHATE SYNTHETASE | TRIMETHOPRIM-SULFAMETHOXAZOLE | Diphosphates - metabolism | Models, Chemical | Dihydropteroate Synthase - genetics | Sulfathiazoles - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Crystallography, X-Ray | Bacillus anthracis - enzymology | Parabens - metabolism | Anti-Bacterial Agents - chemistry | Yersinia pestis - drug effects | Sulfathiazoles - chemistry | Bacillus anthracis - drug effects | Sulfamethoxazole - metabolism | Amino Acid Sequence | Catalytic Domain | Biocatalysis | 4-Aminobenzoic Acid - chemistry | Crystallization | Models, Molecular | Sulfathiazoles - metabolism | Anti-Bacterial Agents - metabolism | Sulfamethoxazole - chemistry | Diphosphates - chemistry | Magnesium - chemistry | Mutagenesis | Sulfamethoxazole - pharmacology | Dihydropteroate Synthase - chemistry | Parabens - chemistry | Protein Conformation | Anti-Bacterial Agents - pharmacology | Dihydropteroate Synthase - metabolism | 4-Aminobenzoic Acid - metabolism | Yersinia pestis - enzymology | Drug resistance in microorganisms | Research | Properties | Sulfonamides | Health aspects | Bacteria | Mutation | Antibiotics | Index Medicus | CATALYSIS | REACTION KINETICS | ANTIBIOTICS | BACTERIA | MUTAGENESIS | PTERIDINES | ENZYMES | SUBSTRATES | SULFONAMIDES | MUTATIONS | 60 APPLIED LIFE SCIENCES | RESIDUES
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0152132
Journal Article