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Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, p. 14244
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80414
Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus crucially diversifies antibody biological effector functions. CSR involves... 
ACTIVATION-INDUCED DEAMINASE | PROTEIN-KINASE-A | FC-RECEPTOR | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | CYCLE ARREST | HIV-1 VPR | HIV-1-INFECTED PATIENTS | LIVING CELLS | Cyclic AMP-Dependent Protein Kinases - metabolism | Uracil-DNA Glycosidase - metabolism | Optical Imaging | 14-3-3 Proteins - physiology | Humans | Models, Molecular | Gene Products, vpr - metabolism | Protein Isoforms - physiology | 14-3-3 Proteins - metabolism | B-Lymphocytes - immunology | Protein Isoforms - metabolism | Recombination, Genetic | Cytidine Deaminase - metabolism | Immunoglobulin Switch Region | Models, Genetic | Immunoglobulin Class Switching - genetics | Enzymes | Immunoglobulins | B cells | Viral proteins | DNA | Protein kinase A | Phosphorylation | Recombination | Transcription | Pathogenesis | Science | Activation-induced cytidine deaminase | Viruses | DNA glycosylase | Proteins | Biological effects | Vpr protein | Immunology | Human immunodeficiency virus--HIV | Cell cycle | Catalysis | Assembly | Deoxyribonucleic acid--DNA | Antigens | Replication protein A | Protein A | Adaptors | Loci | Mutants | Class switching | Medicine | 14-3-3 protein | Lymphocytes B | Heavy chains | Uracil-DNA glycosidase | Uracil | Scaffolds | Binding sites | Core making | Cytidine deaminase | Deoxyribonucleic acid | HIV | Human immunodeficiency virus
Journal Article
Frontiers in Bioscience, ISSN 1093-9946, 06/2011, Volume 17, Issue 7, pp. 2594 - 2615
Toll-like receptors (TLRs) are a family of conserved pattern recognition receptors (PRRs). Engagement of B cell TLRs by microbe-associated molecular patterns... 
Autoimmunity | Natural antibodies | Secondary lymphoid organs | CD41 | MAMPs | Activation-induced cytidine deaminase | T-independent antibody responses | Innate immunity | Germline transcription | Lipid A | Class switch DNA recombination | B cell | NF-κB | Germinal center | Polyclonal | SHM | Adjuvant | Microbe-associated molecular patterns | CpG | Immune Deficiency | Immunoglobulin Ig | TLR | AID | Endosome | Toll-like receptor | Antigen-Specific | CSR | Antibody | Cytokine | Adaptive immunity | Vaccine | Antigen | BCR | T-dependent responses | Signaling | Somatic hypermutation | Lipopolysaccharides LPS | B cell receptor | CD40 | Innate Immunity | CELL BIOLOGY | Natural Antibodies | Activation-Induced Cytidine Deaminase | T-INDEPENDENT ACTIVATION | NF-KAPPA-B | INDUCED CYTIDINE DEAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Somatic Hypermutation | SYSTEMIC AUTOIMMUNE-DISEASE | Germline Transcription | ACTIVATION-INDUCED DEAMINASE | Germinal Center | NF-kappa B | Microbe-Associated Molecular Patterns | TOLL-LIKE RECEPTORS | PATTERN-RECOGNITION RECEPTORS | ANTIGEN RECEPTOR | Adaptive Immunity | ANTIBODY-MEDIATED IMMUNITY | Secondary Lymphoid Organs | Humans | Receptors, Antigen, B-Cell - metabolism | Autoantibodies - biosynthesis | Signal Transduction - immunology | Models, Immunological | Animals | B-Lymphocytes - immunology | Recombination, Genetic | Antibody Formation | T-Lymphocytes - immunology | Toll-Like Receptors - metabolism | Autoantibodies - genetics | Immunoglobulin Class Switching
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2012, Volume 46, Issue 2, pp. 125 - 135
Journal Article
Autoimmunity, ISSN 0891-6934, 2/2015, Volume 48, Issue 1, pp. 1 - 12
Abstract Ig class switch DNA recombination (CSR) in B cells is crucial to the maturation of antibody responses. It requires IgH germline IH-CH transcription... 
lipopolysaccharides | Antibody | T-independent antibody response | class switch DNA recombination | B cells | CpG | B cell receptor | Toll-like receptor | Class switch DNA recombination | Lipopolysaccharides | CROSS-REGULATION | ACTIVATION | RECOGNITION | INNATE | MICRORNAS | IMMUNOLOGY | AUTOIMMUNE | TOLL-LIKE RECEPTORS | AID | NF-KAPPA-B | EXPRESSION | Toll-Like Receptor 2 - genetics | Calcium - metabolism | Lipopeptides - pharmacology | Toll-Like Receptor 9 - genetics | Calcium - immunology | Immunoglobulin G - classification | Toll-Like Receptor 9 - immunology | Immunoglobulin G - biosynthesis | Recombination, Genetic | Toll-Like Receptor 7 - immunology | CD40 Antigens - genetics | Cell Differentiation | Immunoglobulin Class Switching - drug effects | Membrane Glycoproteins - immunology | Toll-Like Receptor 7 - genetics | B-Lymphocytes - cytology | Signal Transduction | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Toll-Like Receptor 4 - genetics | Imidazoles - pharmacology | Toll-Like Receptor 4 - immunology | Receptors, Antigen, B-Cell - immunology | Membrane Glycoproteins - genetics | Receptor Cross-Talk - immunology | Toll-Like Receptor 1 - genetics | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD40 Ligand - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Receptors, Antigen, B-Cell - genetics | Mice | Toll-Like Receptor 1 - immunology | CD40 Antigens - immunology | Cytokines - biosynthesis | antibody, AID | cytokine | immunoglobulin | B cell receptor (BCR) | lipopolysaccharides (LPS) | germinal center | Toll-like Receptor (TLR) | class switch DNA recombination (CSR)
Journal Article
Critical Reviews in Immunology, ISSN 1040-8401, 2007, Volume 27, Issue 4, pp. 367 - 397
Expression and activity of activation-induced cytidine deaminase (AID) encoded by the aicda gene are essential for immunoglobulin (Ig) gene somatic... 
Immunoglobulin (Ig) | B cell | Class switch DNA recombination (CSR) | Germinal center reaction | Plasmacytoid differentiation | Posttranslational modifications | Enhanceosome | Signal transduction pathways | Activation-induced cytidine deaminase (AID) | enhanceosome | plasmacytoid differentiation | transcription factors | HYPER-IGM SYNDROME | INDUCED CYTIDINE DEAMINASE | HUMAN B-CELLS | ANTIBODY DIVERSIFICATION ENZYME | SINGLE-STRANDED-DNA | IMMUNOLOGY | germinal center reaction | PLASMA-CELL DIFFERENTIATION | ACTIVATION-INDUCED DEAMINASE | posttranslational modifications | TOLL-LIKE RECEPTORS | CHRONIC LYMPHOCYTIC-LEUKEMIA | somatic hypermutation (SHM) | activation-induced cytidine deaminase (AID) | immunoglobulin (Ig) | class switch DNA recombination (CSR) | NF-KAPPA-B | signal transduction pathways | Phosphorylation | Somatic Hypermutation, Immunoglobulin | Signal Transduction | Lymphocyte Activation | Cytidine Deaminase - genetics | Germinal Center - immunology | Humans | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Cell Differentiation - genetics | Animals | B-Lymphocytes - immunology | Recombination, Genetic | Cytidine Deaminase - metabolism | Hyper-IgM Immunodeficiency Syndrome - immunology | Hyper-IgM Immunodeficiency Syndrome - metabolism | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Receptors, Immunologic - metabolism | post-translational modifications
Journal Article