X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (13326) 13326
Publication (2537) 2537
Book Chapter (255) 255
Conference Proceeding (216) 216
Book Review (128) 128
Newsletter (82) 82
Dissertation (37) 37
Newspaper Article (28) 28
Magazine Article (25) 25
Patent (17) 17
Government Document (16) 16
Trade Publication Article (8) 8
Data Set (5) 5
Book / eBook (4) 4
Reference (4) 4
Web Resource (2) 2
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (6929) 6929
humans (4758) 4758
animals (4467) 4467
biochemistry & molecular biology (3377) 3377
proteins (2321) 2321
switch (2242) 2242
mice (2101) 2101
switches (1848) 1848
cell biology (1835) 1835
research (1483) 1483
analysis (1481) 1481
article (1413) 1413
immunology (1403) 1403
molecular sequence data (1356) 1356
expression (1351) 1351
gene expression (1170) 1170
multidisciplinary sciences (1147) 1147
female (1141) 1141
male (1082) 1082
protein (1055) 1055
mutation (1052) 1052
dna (1012) 1012
amino acid sequence (1007) 1007
protein binding (967) 967
escherichia-coli (965) 965
signal transduction (932) 932
biology (927) 927
class-switch recombination (922) 922
activation (909) 909
biophysics (900) 900
base sequence (869) 869
models, molecular (866) 866
physiological aspects (866) 866
class switch recombination (845) 845
cancer (830) 830
binding (800) 800
genetic aspects (796) 796
research article (786) 786
genes (777) 777
somatic hypermutation (745) 745
cells (722) 722
phosphorylation (722) 722
chemistry, multidisciplinary (713) 713
gene-expression (704) 704
oncology (690) 690
binding sites (680) 680
genetics & heredity (664) 664
microbiology (640) 640
transcription (633) 633
cell line (628) 628
b-lymphocytes - immunology (620) 620
protein conformation (617) 617
crystal-structure (616) 616
models, biological (614) 614
molecular switch (568) 568
kinetics (549) 549
enzymes (548) 548
biotechnology & applied microbiology (546) 546
fluorescence (519) 519
molecular biology (518) 518
cells, cultured (506) 506
in-vivo (504) 504
apoptosis (497) 497
medicine (496) 496
transcription, genetic (492) 492
protein structure, tertiary (486) 486
gene expression regulation (480) 480
adult (476) 476
biochemistry (476) 476
mechanism (476) 476
science (459) 459
biochemical research methods (452) 452
deoxyribonucleic acid--dna (448) 448
ligands (445) 445
gene (444) 444
rna (444) 444
differentiation (443) 443
dna-binding proteins - metabolism (443) 443
cell line, tumor (424) 424
life sciences (422) 422
genetics (420) 420
dna-binding proteins - genetics (419) 419
mice, inbred c57bl (415) 415
transcription factors (414) 414
dna repair (406) 406
biological sciences (401) 401
middle aged (395) 395
health aspects (394) 394
medicine, research & experimental (386) 386
phenotype (385) 385
identification (380) 380
bacteria (377) 377
mice, knockout (374) 374
genetic research (373) 373
immunoglobulins (373) 373
kinases (372) 372
genes, switch (369) 369
bacterial proteins - metabolism (368) 368
rats (368) 368
transcription factors - metabolism (368) 368
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Engineering & Comp. Sci. - Stacks (1) 1
Gerstein Science - Processing (1) 1
Gerstein Science - Stacks (1) 1
Online Resources - Online (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (13727) 13727
Chinese (23) 23
Japanese (21) 21
French (20) 20
German (15) 15
Spanish (4) 4
Portuguese (2) 2
Croatian (1) 1
Persian (1) 1
Polish (1) 1
Russian (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 50 - 54
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by... 
CRB2 | RECRUITMENT | FISSION YEAST | METHYLATION | CHROMATIN | DEPENDENT RESPONSE | RESECTION | MULTIDISCIPLINARY SCIENCES | SITES | DOUBLE-STRAND BREAKS | CLASS-SWITCH RECOMBINATION | Schizosaccharomyces pombe Proteins - chemistry | Histones - chemistry | Nucleosomes - chemistry | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Male | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - deficiency | Cell Cycle Proteins - chemistry | Intracellular Signaling Peptides and Proteins - deficiency | Ubiquitination | Schizosaccharomyces pombe Proteins - metabolism | Female | Lysine - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Schizosaccharomyces | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Signal Transduction | Cell Cycle Proteins - metabolism | Nucleosomes - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - deficiency | Amino Acid Motifs | Chromosomal Proteins, Non-Histone - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Protein Binding | Mice | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromosomal Proteins, Non-Histone - chemistry | Ubiquitin | Research | Properties | DNA repair | DNA damage | Proteins | DNA methylation | Mutation | Experiments | Recruitment
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 972 - 988.e23
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining... 
DNA damage repair | proximity labeling | shieldin | proteomics | 53BP1 | PARP inhibitors | telomere maintenance | antibody class-switch recombination | NHEJ | BRCA1 | PATHWAYS | CELLS | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASS-SWITCH RECOMBINATION | HOMOLOGOUS RECOMBINATION | DOUBLE-STRAND BREAK | TELOMERES | CELL BIOLOGY | Mad2 Proteins - metabolism | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | DNA Breaks, Double-Stranded | Mad2 Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Telomere-Binding Proteins - genetics | RNA Interference | BRCA1 Protein - metabolism | Trans-Activators - genetics | Immunoglobulin Class Switching - drug effects | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | DNA End-Joining Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Tumor Suppressor p53-Binding Protein 1 - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Tumor Suppressor p53-Binding Protein 1 - antagonists & inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | BRCA1 Protein - antagonists & inhibitors | Mad2 Proteins - genetics | Cell Line, Tumor | Trans-Activators - metabolism | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | DNA damage | Genomics | Antibodies | Genomes | DNA repair | Proteins | Viral antibodies | Telomeres | Evolutionary biology | Analysis | DNA | Genetic research | Mass spectrometry
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 01/2018, Volume 285, Issue 1, pp. 46 - 71
Assembly and disassembly of protein–protein complexes needs to be dynamically controlled and phosphoswitches based on linear motifs are crucial in this... 
mitogen‐activated kinases | PDZ domain | protein phosphorylation | extracellular signal–regulated kinase | linear‐binding motif | signal transduction | mitogen-activated kinases | linear-binding motif | LOCALIZATION | extracellular signal-regulated kinase | DOMAIN | ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | MAGI-1 PDZ1 | BINDING | Phosphorylation | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Humans | Serine - genetics | Substrate Specificity | Crystallography, X-Ray | Binding Sites - genetics | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Serine - metabolism | Molecular Dynamics Simulation | Mitogen-Activated Protein Kinase 1 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | HEK293 Cells | Protein Binding | Protein Conformation | Enzyme Activation | Mitogen-Activated Protein Kinase 3 - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Cellular signal transduction | Epidermal growth factor | Mitogens | Protein kinases | Protein-protein interactions | Protein binding | Binding | Residues | Nuclear magnetic resonance--NMR | Switches | Extracellular signal-regulated kinase | Kinases | Masks | Substrates | Data bases | MAGI-1 protein | Proteins | Dynamic control | Cores | Ribosomal protein S6 kinase | Signaling | Allosteric properties | Databases | Signal processing | Protein interaction | Dismantling
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 14973 - 14985
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 52, pp. 22399 - 22406
Intracellular membrane fusion is mediated by the concerted action of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18... 
Proteins | Peptide initiation factors | Neurons | SNARE proteins | Amino acids | Liposomes | Exocytosis | PC12 cells | Synapses | P branes | 3-DIMENSIONAL STRUCTURE | DISTINCT MODES | SEC1/MUNC18 PROTEINS | NEURONAL SNARE COMPLEX | SM PROTEIN | MULTIDISCIPLINARY SCIENCES | REGULATED EXOCYTOSIS | CA2+-TRIGGERED EXOCYTOSIS | T-SNARE | SYNAPTIC VESICLE FUSION | CONFORMATIONAL SWITCH | SNARE Proteins - genetics | Vesicular Transport Proteins - metabolism | Caenorhabditis elegans Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Munc18 Proteins - metabolism | Male | Green Fluorescent Proteins - genetics | Syntaxin 1 - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Multiprotein Complexes - metabolism | SNARE Proteins - chemistry | Syntaxin 1 - genetics | Time Factors | Munc18 Proteins - chemistry | Female | Syntaxin 1 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Caenorhabditis elegans - metabolism | Munc18 Proteins - genetics | Membrane Fusion | Caenorhabditis elegans - genetics | Vesicular Transport Proteins - genetics | Models, Molecular | Vesicular Transport Proteins - chemistry | Phosphoproteins - genetics | Microscopy, Confocal | Multiprotein Complexes - chemistry | Animals | Protein Binding | Protein Conformation | Mutation | Amino Acid Motifs - genetics | Caenorhabditis elegans Proteins - genetics | SNARE Proteins - metabolism | Cellular proteins | Membrane fusion | Cell membranes | Research | Peptides | Protein binding | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 2009, Volume 34, Issue 3, pp. 285 - 297
The DNA double-strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates... 
PROTEINS | MOLIMMUNO | DNA | B-CELLS | GENOMIC INSTABILITY | CYTIDINE DEAMINASE AID | SOMATIC HYPERMUTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | DEPENDENT PROTEIN-KINASE | CLASS-SWITCH RECOMBINATION | CELL-CYCLE ARREST | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | CELL BIOLOGY | Genomic Instability | Fibroblasts - physiology | Molecular Sequence Data | Tripartite Motif-Containing Protein 28 | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Lymphocytes - physiology | Base Sequence | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Immunoglobulin Class Switching | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Thymus Gland - cytology | Tumor Suppressor Protein p53 - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Lymphocytes - cytology | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Mice, Knockout | Animals | DNA Repair | Fibroblasts - cytology | Mice | Apoptosis - physiology | Immunoglobulins | Automated teller machines | Tumor proteins | T cells | Phosphotransferases | Apoptosis
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 126, Issue 3, pp. 529 - 542
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo. Through analysis of 53BP1 complexes... 
PROTEIN | P53-DEPENDENT APOPTOSIS | REGULATES APOPTOSIS | BETA-TRCP | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR | CLASS-SWITCH RECOMBINATION | CELL-CYCLE ARREST | CHECKPOINT | CANCER | P53 | CELL BIOLOGY | Humans | Ubiquitin - metabolism | Apoptosis - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Trans-Activators - genetics | Apoptosis Regulatory Proteins - genetics | DNA Damage - genetics | Fibroblasts | Genes, cdc - physiology | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Endopeptidases - metabolism | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endopeptidases - genetics | Adaptor Proteins, Signal Transducing - genetics | Checkpoint Kinase 2 | Trans-Activators - metabolism | Mice | HeLa Cells | Tumor Suppressor p53-Binding Protein 1 | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin Thiolesterase | Proteins | Research | Proteases | Analysis | Oncology, Experimental | Cancer
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 1, pp. 51 - 64
The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two... 
BRCT DOMAINS | ACTIVATION | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | TUMOR-SUPPRESSOR | CLASS-SWITCH RECOMBINATION | P53 PATHWAY | PROTEINS | CELL BIOLOGY | Gamma Rays | Endonucleases - genetics | Tumor Suppressor p53-Binding Protein 1 - chemistry | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Protein Multimerization | CRISPR-Associated Protein 9 | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | MCF-7 Cells | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Ubiquitin Thiolesterase - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Tumor Suppressor p53-Binding Protein 1 - metabolism | Promoter Regions, Genetic | Protein Conformation, alpha-Helical | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin Thiolesterase - genetics | Gene Editing | Protein Conformation, beta-Strand | DNA Repair | Protein Binding | Bacterial Proteins - metabolism | Tumor Suppressor Protein p53 - chemistry | Ubiquitin Thiolesterase - chemistry | Oligomers | Ubiquitin | Ionizing radiation | Chromatin | Proteases | Genes | Genomics | DNA | Tumor proteins | DNA repair
Journal Article