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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 2042 - 2047
Mice homozygous for the Tyr208Asn amino acid substitution in the carboxy terminus of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1)... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GENE | TAK1 | AUTOIMMUNITY | INNATE | ACTIVATED PROTEIN-KINASES | STRESS | Inflammation - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neutrophil Infiltration | Sweet Syndrome - genetics | Signal Transduction - immunology | MAP Kinase Kinase Kinase 5 - metabolism | Disease Models, Animal | Neutrophils - pathology | Sweet Syndrome - immunology | MAP Kinase Kinase Kinase 5 - genetics | Neutrophils - enzymology | MAP Kinase Kinase Kinases - genetics | Neutrophils - immunology | Sweet Syndrome - pathology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | Sweet Syndrome - enzymology | Inflammation - genetics | Mice | Inflammation - enzymology | MAP Kinase Kinase Kinase 5 - immunology | Neutrophils | Physiological aspects | Development and progression | Models | Inflammation | Skin | Autoimmune diseases | Dermatitis | Health aspects | Mitogen-activated protein kinases | Splenomegaly | SHP-1 protein | TAK1 protein | MAP kinase | Homology | Leukocytes (neutrophilic) | Interleukin 1 receptors | Kinases | Amino acid substitution | Clonal deletion | Interleukin 1 | Skin diseases | Syk protein | Mutation | Apoptosis
Journal Article
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 635 - 648
Mice carrying a hypomorphic point mutation in the gene ( mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we... 
myeloid cells | SYK | RIPK3 | MLKL | autoinflammation | Ptpn6 | IL-1β | IL-1α | MyD88 | SHP1 | TAK1 | necrosis | RIPK1 | MOTH-EATEN MICE | SIGNALING PATHWAYS | STERILE INFLAMMATION | GENE | APOPTOTIC CELL-DEATH | PHOSPHATASE | IN-VIVO | IMMUNOLOGY | SHP-1 | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Interleukin-1alpha - immunology | Skin Diseases - genetics | Humans | Immunoblotting | Interleukin-1alpha - metabolism | Syk Kinase - immunology | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Syk Kinase - genetics | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Skin Diseases - metabolism | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Skin Diseases - immunology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Models, Immunological | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Syk Kinase - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Inflammation - genetics | Mutation | Myeloid Differentiation Factor 88 - metabolism | Disease | SHP-1 protein | Crosstalk | Interleukin | Licenses | Interleukin 1 receptors | Kinases | Phosphatase | Inflammatory diseases | Proteins | Coding | Rodents | Interleukin 1 | Post-translation | Bone marrow | Skin diseases | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Activation analysis | Immune system | Tyrosine | TAK1 protein | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Roles | Scaffolding | Point mutation | MyD88 protein | Syk protein
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 2012, Volume 36, Issue 1, pp. 32 - 42
C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense.... 
CELLS | RESPONSES | ACTIVATION | CANDIDA-ALBICANS | PATTERN-RECOGNITION RECEPTOR | TYROSINE KINASE | HOST-DEFENSE | DECTIN-2 | IMMUNOLOGY | T-LYMPHOCYTES | FUNGAL-INFECTIONS
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 06/2015, Volume 13, Issue 6, pp. 1139 - 1150
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 2, pp. 313 - 328
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 759 - 770
Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary,... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article