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Biochemical Journal, ISSN 0264-6021, 06/2006, Volume 396, Issue 3, pp. 401 - 409
Unlike most other endogenous messengers that are deposited in vesicles, processed on demand and/or secreted in a regulated fashion, NO (nitric oxide) is a... 
Nitric oxide synthase | Differential activation | Protein-protein interaction | Subcellular targeting | Acylation cycle | Intracellular trafficking | ENDOTHELIAL NO SYNTHASE | PDZ DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | intracellular trafficking | PLASMA-MEMBRANE | S-NITROSYLATION | FATTY ACYLATION | PALMITOYLATION SITES | subcellular targeting | differential activation | acylation cycle | protein-protein interaction | INDEPENDENT ENOS ACTIVATION | nitric oxide synthase | PROTEIN THIOESTERASE | DEPENDENT ACTIVATION | Animals | Humans | Nitric Oxide Synthase Type I - metabolism | Protein Transport - physiology | Nitric Oxide Synthase - metabolism | Nitric Oxide Synthase Type III - metabolism | Subcellular Fractions - enzymology | Acylation | Biochemistry, Molecular Biology | Nitric Oxide Synthase Type III | Cellular Biology | Protein Transport | Life Sciences | Nitric Oxide Synthase Type I | Nitric Oxide Synthase | Food and Nutrition | Biomolecules | Subcellular Processes | Subcellular Fractions | Molecular biology | PM, plasma membrane | eNOS, endothelial NOS | EBP50, ezrin | PI3K, phosphoinositide 3-kinase | iNOS, inducible NOS | protein–protein interaction | CaM, calmodulin | Review | [Ca2+]i, intracellular Ca2+ concentration | Hsp90, heat-shock protein 90 | sGC, soluble NO-sensitive guanylate cyclase | radixin | LDL, low-density lipoprotein | NOSIP, NOS-interacting protein | nNOS, neuronal NOS | PECAM, platelet | endothelial cell-adhesion molecule | NOSTRIN, NOS trafficking inducer | VEGF, vascular endothelial growth factor | NOS, nitric oxide synthase | moesin-binding phosphoprotein-50 | EC, endothelial cell | NMDA, N-methyl-D-aspartate | PSD, post-synaptic density
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 11/2018, Volume 186, Issue 3, pp. 613 - 632
Journal Article
Oxidative medicine and cellular longevity, ISSN 1942-0994, 2014, Volume 2014, pp. 1 - 12
Journal Article
Journal Article
Biophysical Journal, ISSN 0006-3495, 07/2012, Volume 103, Issue 1, pp. 109 - 117
H4B is an essential catalytic cofactor of the mNOSs. It acts as an electron donor and activates the ferrous heme-oxygen complex intermediate during Arg... 
mammalian nitric oxide synthase | eNOS | ferric heme-nitrosyl complex | CPET | EPR | (6R)-5,6,7,8-tetrahydro-L-biopterin | high-spin hexacoordinated iron | HS-5c | L-arginine | inducible nitric oxide synthase | mNOS | endothelial nitric oxide synthase | iNOS | bsNOS | nitric oxide synthase | concerted proton electron transfer | NOHA | nitric oxide | NOSoxy | neuronal nitric oxide synthase | hydroxy-L-arginine | bacNOS | bacterial NOS-like proteins | NOS-like protein isolated from Bacillus subtilis | oxygenase domain of NOS | ferrous heme-oxygen complex | NOS | electron paramagnetic resonance | ferrous heme-nitrosyl complex | Arg | nNOS | PROTEIN | BIOPHYSICS | BACILLUS-SUBTILIS | SUBUNIT DIMERIZATION | SUBSTRATE | L-ARGININE | OXYGENASE DOMAIN | HEME-DIOXY REDUCTION | SINGLE-TURNOVER | 2ND HALF-REACTION | LOW-TEMPERATURE | Escherichia coli - enzymology | Electron Spin Resonance Spectroscopy | Oxidation-Reduction | Species Specificity | Rats | Bacillus subtilis - enzymology | Biopterin - analogs & derivatives | Arginine - analogs & derivatives | Biopterin - metabolism | Biopterin - chemistry | Animals | Free Radicals - metabolism | Bacterial Proteins - metabolism | Nitric Oxide Synthase - metabolism | Arginine - metabolism | Nitric Oxide Synthase Type II - metabolism | Proteins | Nitrogen oxide | Iron compounds | Arginine | Nitric oxide | Chemical properties | Comparative analysis | Endothelium | Free Radicals | Bacillus subtilis | Escherichia coli | Nitric Oxide Synthase Type II | Bacterial Proteins | Life Sciences | Nitric Oxide Synthase | Biopterin | mNOS, mammalian nitric oxide synthase | FeIIO2, ferrous heme-oxygen complex | eNOS, endothelial nitric oxide synthase | EPR, electron paramagnetic resonance | NOSoxy, oxygenase domain of NOS | bsNOS, NOS–like protein isolated from Bacillus subtilis | FeIINO, ferrous heme-nitrosyl complex | HS-5c, high-spin hexacoordinated iron | Proteins and Nucleic Acids | NOS, nitric oxide synthase | Arg, L-arginine | FeIIINO, ferric heme-nitrosyl complex | H4B, (6R)-5,6,7,8-tetrahydro-L-biopterin | NOHA, Nω-hydroxy-L-arginine | NO, nitric oxide | iNOS, inducible nitric oxide synthase | CPET, concerted proton electron transfer | nNOS, neuronal nitric oxide synthase | bacNOS, bacterial NOS-like proteins
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 568, Issue 7752, pp. 351 - 356
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies.... 
S-NITROSYLATION | INHIBITION | DYSFUNCTION | MODEL | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | Humans | Heart Failure - physiopathology | Diet, High-Fat - adverse effects | Male | Heart Failure - prevention & control | Myocytes, Cardiac - enzymology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Endoribonucleases - metabolism | Signal Transduction | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Heart Failure - metabolism | Nitrosative Stress | Stroke Volume | Myocytes, Cardiac - pathology | Phenotype | Animals | Nitric Oxide Synthase Type II - genetics | X-Box Binding Protein 1 - metabolism | Myocytes, Cardiac - metabolism | Mice | X-Box Binding Protein 1 - genetics | Nitric Oxide Synthase Type II - metabolism | Heart failure | Care and treatment | Diagnosis | Health aspects | Nitric oxide | Heart | Genetic suppression | Kinases | High fat diet | Proteins | Arginine | Protein folding | Heart diseases | Hypertension | Obesity | Phenotypes | Inositol | Splicing | Cardiomyocytes | Pharmacology | Inflammation | Metabolism | Morbidity | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Musculoskeletal system | Diet | Myocardium | Endonuclease | Ejection fraction
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 10/2016, Volume 100, Issue 20, pp. 8633 - 8649
Acetohydroxyacid synthase, a thiamine diphosphate-dependent enzyme, can condense either two pyruvate molecules to form acetolactate for synthesizing L-valine... 
Life Sciences | Biotechnology | Acetohydroxyacid synthase | Microbiology | Microbial Genetics and Genomics | AHAS | FAD | Catabolic acetolactate synthase | CALS | Pyruvate oxidase-like subfamily |