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Nature chemical biology, ISSN 1552-4450, 11/2014, Volume 10, Issue 11, pp. 921 - 923
Journal Article
INORGANIC CHEMISTRY, ISSN 0020-1669, 08/2018, Volume 57, Issue 15, pp. 8769 - 8777
alpha-Ketoglutarate-dependent nonheme halogenases catalyze the halogenation of aliphatic C-H bonds in the biosynthesis pathway of many natural products. An... 
ACTIVE-SITE | BIOSYNTHESIS | SYRB2 | CYTC3 | HYDROXYLATION | REACTIVITY | ALPHA-KETOGLUTARATE | INTERMEDIATE | GIF CHEMISTRY | CATALYTIC CYCLE | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2016, Volume 138, Issue 8, pp. 2484 - 2487
The non-heme iron halogenases CytC3 and SyrB2 catalyze C–H bond halogenation in the biosynthesis of some natural products via S = 2 oxoiron­(IV)–halide... 
FUNCTIONALIZATION | ELUCIDATION | SYRB2 | HYDROXYLATION | REACTIVITY | ALIPHATIC HALOGENASE | INTERMEDIATE | OXYGEN REBOUND MECHANISM | KETOGLUTARATE DIOXYGENASE | CHEMISTRY, MULTIDISCIPLINARY | IRON(IV)-OXO | Models, Molecular | Iron Compounds - chemistry | Nonheme Iron Proteins - chemistry | Oxidoreductases - chemistry | Halogenation
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2016, Volume 55, Issue 27, pp. 7717 - 7722
Journal Article
ACS CATALYSIS, ISSN 2155-5435, 06/2019, Volume 9, Issue 6, pp. 4930 - 4943
Biosynthetic enzyme complexes selectively catalyze challenging chemical transformations, including alkane functionalization (e.g., halogenation of threonine,... 
halogenases | DIOXYGEN ACTIVATION | MOLECULAR-DYNAMICS | CRYSTAL-STRUCTURE | QUANTUM MECHANICS/MOLECULAR MECHANICS | CHEMISTRY, PHYSICAL | non-heme iron | ALPHA-KETOGLUTARATE | ALIPHATIC HALOGENASE | QM/MM | natural product biosynthesis | hydrogen bonding | substrate specificity | IRON HALOGENASE SYRB2 | NONHEME FE(II) | C-H | CATALYTIC CYCLE
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 19, pp. 5780 - 5784
The elucidation of enigmatic enzymatic chlorination timing in ambiguine indole alkaloid biogenesis led to the discovery and characterization of AmbO5 protein... 
non-heme iron enzyme | halogenase | C−H activation | evolution | alkaloid biogenesis | C-H activation | SYRB2 | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | HAPALOSIPHON-WELWITSCHII | BIOSYNTHESIS | HAPALINDOLE | INTERMEDIATE | GENERATION | CHLORINATION | Enzymes | Alkaloids | Biosynthesis | Catalysis | Heme | Index Medicus
Journal Article
Journal of Chemical Theory and Computation, ISSN 1549-9618, 2018, Volume 15, Issue 2, pp. 1317 - 1328
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 16, pp. 11233 - 11241
Journal Article