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Cell, ISSN 0092-8674, 05/2008, Volume 133, Issue 4, pp. 727 - 741
and are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either or deficiency, we... 
SYSBIO | HUMDISEASE | SIGNALING | Resource
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 52, Issue 5, pp. 831 - 843
Beta amyloid (Aβ), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer's... 
SYSBIO | HUMDISEASE | MOLNEURO | RECEPTOR SUBUNIT GLUR2 | DOMAIN-CONTAINING PROTEINS | GLUTAMATE RECEPTORS | RAPID REDISTRIBUTION | HIPPOCAMPUS IN-VIVO | ALZHEIMERS-DISEASE | LONG-TERM DEPRESSION | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | TRANSGENIC MICE | MOLECULAR-MECHANISMS
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2009, Volume 36, Issue 5, pp. 894 - 899
Many sensory systems (e.g., vision and hearing) show a response that is proportional to the fold-change in the stimulus relative to the background, a feature... 
SYSBIO | SIGNALING | STEM-CELLS | ROBUSTNESS | CHEMOTAXIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | ADAPTATION | DYNAMICS | NETWORKS | EXPRESSION | CELL BIOLOGY | Models, Theoretical | Signal Transduction | Gene Expression Regulation | Genetic regulation
Journal Article
Neuron, ISSN 0896-6273, 07/2009, Volume 63, Issue 2, pp. 230 - 243
The entorhinal cortex (EC) is regarded as the gateway to the hippocampus and thus is essential for learning and memory. Whereas the EC expresses a high density... 
SYSBIO | SYSNEURO | MOLNEURO | Proteins | Ligands | Kinases | Neurons | Rodents | Camps
Journal Article
Cell, ISSN 0092-8674, 08/2009, Volume 138, Issue 4, pp. 760 - 773
Many signaling systems show adaptation—the ability to reset themselves after responding to a stimulus. We computationally searched all possible three-node... 
SYSBIO | BACTERIAL CHEMOTAXIS | MOTIFS | CELLS | ROBUSTNESS | DESIGN | POSITIVE FEEDBACK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CALCIUM | SENSITIVITY | TRANSDUCTION | CELL BIOLOGY | Adaptation, Physiological | Feedback, Physiological | Signal Transduction | Models, Biological | Computer Simulation | Enzymes - metabolism | Enzymes | Analysis | Universities and colleges
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 63, Issue 2, pp. 230 - 243
The entorhinal cortex (EC) is regarded as the gateway to the hippocampus and thus is essential for learning and memory. Whereas the EC expresses a high density... 
MOLNEURO | SYSNEURO | SYSBIO
Journal Article