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Nature (London), ISSN 1476-4687, 08/2003, Volume 425, Issue 6954, pp. 191 - 196
Journal Article
Molecular cell, ISSN 1097-2765, 09/2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine | Index Medicus
Journal Article
Molecular cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, pp. 514 - 525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Interaction Maps - drug effects | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | RecQ Helicases - genetics | Saccharomyces cerevisiae - drug effects | Antineoplastic Agents - therapeutic use | Synthetic Lethal Mutations | Gene Regulatory Networks - drug effects | Molecular Targeted Therapy | Dose-Response Relationship, Drug | Saccharomyces cerevisiae - metabolism | Gene Expression Regulation, Fungal - drug effects | Transfection | RNA Interference | Time Factors | Uterine Cervical Neoplasms - metabolism | Cell Cycle Proteins - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Genes, Tumor Suppressor | Uterine Cervical Neoplasms - mortality | Cell Survival - drug effects | Genetic Predisposition to Disease | Cell Cycle Proteins - metabolism | Kaplan-Meier Estimate | Uterine Cervical Neoplasms - drug therapy | Saccharomyces cerevisiae Proteins - genetics | Uterine Cervical Neoplasms - genetics | Phenotype | Signal Transduction - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | HeLa Cells | Mutation | Precision Medicine - methods | Antimitotic agents | Care and treatment | Analysis | Drug therapy, Combination | Antineoplastic agents | Health aspects | Phosphotransferases | Cancer | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 02/2016, Volume 530, Issue 7591, pp. 485 - 489
...). The Gal11/Med15 KIX domain engages pleiotropic drug resistance transcription factor (Pdr1) orthologues, which are key regulators of the multidrug resistance... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fluconazole - pharmacology | Mediator Complex - metabolism | Transcriptional Activation - drug effects | Thiourea - pharmacology | Candidiasis - microbiology | Trans-Activators - chemistry | Ketoconazole - pharmacology | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Fungal - drug effects | Mediator Complex - chemistry | Drug Resistance, Multiple, Fungal - drug effects | Candidiasis - drug therapy | Protein Binding - drug effects | Nuclear Magnetic Resonance, Biomolecular | Binding Sites - drug effects | Antifungal Agents - pharmacology | Protein Structure, Tertiary | Hydrazines - pharmacology | Drug Resistance, Fungal - drug effects | Hydrazines - pharmacokinetics | Models, Molecular | Thiourea - pharmacokinetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Candida glabrata - metabolism | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | Mice | Candida glabrata - genetics | Thiourea - analogs & derivatives | Candida glabrata - drug effects | Fungal Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Prevention | Drug resistance in microorganisms | Gene mutations | Yeast fungi | Physiological aspects | Genetic aspects | Research | Fungi | Transcription factors | Genes | Mutation | Fungal infections | RNA polymerase | Drug resistance | Urogenital system | Index Medicus
Journal Article
Molecular biology of the cell, ISSN 1059-1524, 09/2010, Volume 21, Issue 17, pp. 3080 - 3092
Journal Article
Nature (London), ISSN 1476-4687, 01/2010, Volume 463, Issue 7277, pp. 113 - 117
.... Although the essential mechanism of CDK activation of DNA replication in Saccharomyces cerevisiae has been established, exactly how DDK acts has been unclear... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hydroxyurea - pharmacology | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Substrate Specificity | G1 Phase - drug effects | Minichromosome Maintenance Complex Component 4 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | DNA-Binding Proteins - antagonists & inhibitors | Microbial Viability - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Genes, Essential | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae Proteins - metabolism | S Phase - physiology | Saccharomyces cerevisiae - enzymology | Cell Proliferation - drug effects | S Phase - drug effects | DNA Damage | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | DNA replication | Interphase | Analysis | Physiological aspects | Genetic aspects | Research | Biological control systems | Protein kinases | Proteins | Cell division | Kinases | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 03/2017, Volume 543, Issue 7644, pp. 257 - 260
Journal Article