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Molecular Cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
Nature, ISSN 0028-0836, 09/2003, Volume 425, Issue 6954, pp. 191 - 196
Journal Article
Science, ISSN 0036-8075, 4/2008, Volume 320, Issue 5874, pp. 362 - 365
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e81162
Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is... 
OXIDATIVE STRESS | REACTIVE OXYGEN | CIS-DIAMMINEDICHLOROPLATINUM | PLATINUM(II) COMPOUNDS | MULTIDISCIPLINARY SCIENCES | RAT-KIDNEY MITOCHONDRIA | ALPHA-LIPOIC ACID | INDUCED NEPHROTOXICITY | SACCHAROMYCES-CEREVISIAE | NUCLEOTIDE EXCISION-REPAIR | ENERGETIC METABOLISM | DNA Repair - drug effects | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Apoptosis - drug effects | Saccharomyces cerevisiae - genetics | Humans | DNA Adducts - chemistry | Saccharomyces cerevisiae - drug effects | Mitochondria - metabolism | Cisplatin - pharmacology | DNA - metabolism | Mitochondria - drug effects | Reactive Oxygen Species - agonists | Saccharomyces cerevisiae - metabolism | DNA - chemistry | Animals | Cell Nucleus - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | DNA Damage | Cell Nucleus - drug effects | Care and treatment | DNA replication | Cell death | Oncology, Experimental | Protein biosynthesis | Mitochondrial DNA | Research | Genetic transcription | Cisplatin | Cancer | Oxidative stress | Phosphorylation | Yeast | Transcription | Toxicity | Pathogenesis | DNA damage | Cytotoxicity | Oncology | Biochemistry | Saccharomyces | Drug development | Kinases | Tissues | Blockage | Anticancer properties | Signal transduction | Mitochondria | Antitumor agents | Biocompatibility | Stress response | Damage | Drug dosages | Deoxyribonucleic acid--DNA | Adducts | Killing | Medical research | Hematology | Exposure | Tumor cell lines | Studies | DNA biosynthesis | Survival analysis | Protein synthesis | Medical prognosis | Cell lines | DNA adducts | Saccharomyces cerevisiae | Tumors | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Cell Metabolism, ISSN 1550-4131, 2011, Volume 13, Issue 6, pp. 668 - 678
Here we show that yeast strains with reduced target of rapamycin (TOR) signaling have greater overall mitochondrial electron transport chain activity during... 
TRANSCRIPTION FACTORS | MOLECULAR-MECHANISM | STATIONARY-PHASE | OXIDATIVE STRESS | BUDDING YEAST | INCREASED RESPIRATION | CALORIC RESTRICTION | SCH9 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Protein Kinases - metabolism | Protein Kinases - genetics | Adaptation, Physiological - drug effects | Multiprotein Complexes - genetics | Saccharomyces cerevisiae - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Colony Count, Microbial | Membrane Potential, Mitochondrial - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Microbiological Phenomena - genetics | Superoxides - metabolism | Membrane Potential, Mitochondrial - genetics | Protein-Serine-Threonine Kinases - metabolism | Microbiological Phenomena - drug effects | Saccharomyces cerevisiae - physiology | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Saccharomyces cerevisiae Proteins - genetics | Gene Knockout Techniques | Sirolimus - pharmacology | Dinitrophenols - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Vitamin K 3 - pharmacology | Oxygen Consumption - genetics | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - growth & development | Medical colleges | Chronologies | Superoxide | TOR protein | Reactive oxygen species | Menadione | Conservation | Acidification | Superoxide dismutase | Rapamycin | Longevity | Media (transport) | Electron transport chain | Mitochondria | Life span | Membrane potential | Electron transport | ATP | Manganese
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2009, Volume 11, Issue 11, pp. 1305 - 1314
Journal Article