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Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5968, pp. 1004 - 1007
Journal Article
CELL, ISSN 0092-8674, 10/2003, Volume 115, Issue 1, pp. 25 - 35
The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells,... 
OUTER-MEMBRANE VESICLES | HOST-CELLS | IN-VITRO | HEAT-LABILE ENTEROTOXIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI K-12 | GENERAL SECRETORY PATHWAY | SHEA | PROTEIN SECRETION | HEMOLYSIN-E | CELL BIOLOGY | Oxidation-Reduction | Protein Disulfide-Isomerases - metabolism | Humans | Bacterial Proteins - chemistry | Hemolysin Proteins - chemistry | Bacterial Toxins - chemistry | Cell Membrane - chemistry | Bacterial Toxins - metabolism | Animals | Transport Vesicles - metabolism | Cytotoxins - chemistry | Escherichia coli - metabolism | Cytotoxins - metabolism | Bacterial Proteins - metabolism | Polymers - chemistry | Cell Membrane - metabolism | Membrane Proteins - metabolism | HeLa Cells | Escherichia coli - ultrastructure | Hemolysin Proteins - metabolism | Polymers - metabolism | Salmonella - metabolism | Transport Vesicles - ultrastructure | Bacterial toxins | Physiological aspects | Gram-negative bacteria | Secretion | Biological transport | Bacterial Toxins/chemistry/metabolism | Cytotoxins/chemistry/metabolism | Salmonella/metabolism | Cell Membrane/chemistry/metabolism | Escherichia coli/metabolism/ultrastructure | Bacterial Proteins/chemistry/metabolism | Transport Vesicles/metabolism/ultrastructure | Membrane Proteins/metabolism | Hemolysin Proteins/chemistry/metabolism | Polymers/chemistry/metabolism | Hela Cells | Protein Disulfide-Isomerase/metabolism
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 242 - 246
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF... 
PATHWAYS | TOLL-LIKE-RECEPTORS | NECROSIS-FACTOR RECEPTOR | PROTEIN | TRADD | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SUPERFAMILY | BACTERIAL EFFECTOR | FAMILY | NLEB | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Protein Biosynthesis | Humans | Virulence | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Male | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | fas Receptor - metabolism | Multiprotein Complexes - metabolism | Enteropathogenic Escherichia coli - metabolism | Enteropathogenic Escherichia coli - pathogenicity | Receptors, Tumor Necrosis Factor, Type I - chemistry | TNF Receptor-Associated Death Domain Protein - metabolism | Acylation | Disease Models, Animal | Protein Structure, Tertiary | Signal Transduction | Mice, Inbred C57BL | Fas-Associated Death Domain Protein - metabolism | Escherichia coli Infections - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Fas-Associated Death Domain Protein - chemistry | N-Acetylglucosaminyltransferases - metabolism | Multiprotein Complexes - chemistry | Animals | TNF Receptor-Associated Death Domain Protein - chemistry | Escherichia coli Infections - pathology | Virulence Factors - metabolism | Mice | HeLa Cells | Arginine - metabolism | Apoptosis | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Arginine | Cytokines | Cell death | Tumor necrosis factor | Escherichia coli | Genetic aspects | Research | Properties | Salmonella | Microbiology | Kinases | Bacteriology
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2007, Volume 282, Issue 26, pp. 18810 - 18818
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays an important role in host defense and inflammatory diseases. The maturation and secretion of... 
LISTERIA-MONOCYTOGENES | IL-1-BETA-CONVERTING ENZYME | IL-1-BETA SECRETION | MICE DEFICIENT | P2X RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | MATURATION | HUMAN MONOCYTES | ATP | INTERLEUKIN-1-BETA CONVERTING-ENZYME | Potassium - metabolism | Escherichia coli Infections - physiopathology | Lipopolysaccharides - metabolism | Caspase 1 - metabolism | Salmonella Infections - metabolism | Salmonella Infections - physiopathology | Salmonella typhimurium | Adenosine Triphosphate - pharmacology | Flagellin - pharmacology | Extracellular Space - metabolism | Mice, Mutant Strains | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - genetics | Flagellin - metabolism | Macrophages - microbiology | Staphylococcus aureus | Staphylococcal Infections - metabolism | Calcium-Binding Proteins - metabolism | Listeriosis - metabolism | Escherichia coli Infections - metabolism | Apoptosis Regulatory Proteins - metabolism | Bacterial Infections - physiopathology | Receptors, Purinergic P2X7 | Macrophages - metabolism | Animals | Extracellular Space - microbiology | Listeriosis - physiopathology | Receptors, Purinergic P2 - metabolism | Lipopolysaccharides - pharmacology | Staphylococcal Infections - physiopathology | Cytosol - metabolism | Macrophages - drug effects | Cytosol - microbiology | Mice | Bacterial Infections - metabolism
Journal Article
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7444, pp. 233 - 237
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, p. e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 490, Issue 7418, pp. 107 - 111
Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1)... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents
Journal Article
Molecular Genetics and Metabolism, ISSN 1096-7192, 09/2016, Volume 119, Issue 1-2, pp. 57 - 67
Journal Article
Molecular Microbiology, ISSN 0950-382X, 09/2011, Volume 81, Issue 5, pp. 1144 - 1165
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e36019
Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia... 
INDUCED CELL-DEATH | PROINFLAMMATORY CYTOKINE | LEGIONELLA-PNEUMOPHILA | DENDRITIC CELLS | BACTERIA-FACED MACROPHAGES | CHROMATIN PROTEIN HMGB1 | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME | NF-KAPPA-B | III SECRETION SYSTEM | NALP3 INFLAMMASOME | Caspase 7 - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Caspase 1 - metabolism | Yersinia - pathogenicity | Interleukin-1beta - metabolism | HMGB1 Protein - metabolism | bcl-2-Associated X Protein - deficiency | Macrophages - microbiology | Yersinia pestis - metabolism | Yersinia Infections - pathology | Yersinia enterocolitica - pathogenicity | Yersinia Infections - microbiology | bcl-2-Associated X Protein - metabolism | Cathepsin B - metabolism | Caspase Inhibitors | Mice, Knockout | Macrophages - metabolism | Yersinia pseudotuberculosis - metabolism | Caspase 1 - deficiency | Yersinia enterocolitica - metabolism | Mice | Enzyme Activation | Yersinia pseudotuberculosis - pathogenicity | bcl-2 Homologous Antagonist-Killer Protein - deficiency | Caspase 8 - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | GTPase-Activating Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Necrosis - pathology | Yersinia Infections - metabolism | Protease Inhibitors - pharmacology | Protein Isoforms - metabolism | Female | Yersinia pestis - pathogenicity | bcl-2-Associated X Protein - genetics | GTPase-Activating Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Bacterial Proteins - genetics | Cells, Cultured | Yersinia - metabolism | Cathepsin B - antagonists & inhibitors | Necrosis - metabolism | Mitochondria - metabolism | Immunity, Innate | Animals | Caspase 1 - genetics | Protein Binding | Bacterial Proteins - metabolism | Protein Isoforms - genetics | Cathepsins | Disease susceptibility | Interleukins | Macrophages | Necrosis | Apoptosis | Salmonella | Bcl-2 protein | Downstream effects | Cytotoxicity | ADP | HMGB1 protein | Caspase-3 | Caspase-1 | Pseudotuberculosis | Signal transduction | Mitochondria | Cell activation | Stress response | Pathogens | Cytokines | Mortality | IL-1β | Metabolism | Gene expression | Caspase-8 | High mobility group proteins | Infectious diseases | Inhibitors | Isoforms | Oxidative stress | Reactive oxygen species | Microscopic analysis | Bax protein | Toxicity | Interleukin | Homology | Infections | Activation | Kinases | Yersinia enterocolitica | Ribose | Cathepsin B | Cell survival | Secretion | Poly(ADP-ribose) polymerase | Caspase | Lymphoma | Polymerase | Lymphocytes B | Cell death | B-cell lymphoma
Journal Article